Keystone Symposia

INEC Killarney Convention Centre Floorplan

This meeting took place in 2023



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Hypoxia: From Basic Mechanisms to Emerging Therapies (E2)


Organizer(s) Sonia Rocha, Edurne Berra and M. Celeste Simon
May 28—31, 2023
INEC Killarney Convention Centre • Killarney, Co. Kerry Ireland
Abstract Deadline: Mar 13, 2023
Scholarship Deadline: Mar 13, 2023
Discounted Registration Deadline: Mar 28, 2023

Supported by the Directors' Fund

Summary of Meeting:
Oxygen is essential for life, as such, mechanisms involving sensing and responding to changes in oxygen availability have evolved to allow for organisms to withstand these events. Such adaptive mechanisms act across a multitude of scales and timelines, from changes in atomic structure, through large changes in organisms' function. Hypoxia plays a role in a variety of development processes but also participates, and sometimes, contributes to numerous human pathologies. This area of research thus involves a variety of disciplines, from basic discovery science, through to more applied ones such as medicine and drug discovery, highlighting its breath and importance. The Keystone Symposia conference on hypoxia research is the main home for all hypoxia related research. This meeting aims to bring together all disciplines and research areas involved in hypoxia. We hope to address gaps in our knowledge of responses to changes in oxygen availability; highlight new techniques and reagents to enhance therapeutic targeting of the hypoxic response in general; inform on novel systems where hypoxia research can be conducted to reveal novel mechanisms; and understand how therapeutic targeting of this pathway can allow for better clinical outcome in a variety of diseases. We hope that by sharing knowledge, enhancing collaborations, and training participants from diverse backgrounds, we will improve our knowledge and applications to improve life.

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No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 24 hr (international) time


The meeting will begin on Sunday, May 28 with registration from 16:00 to 20:00 and a welcome mixer from 18:00 to 20:00. Conference events conclude on Wednesday, May 31 with a closing plenary session from 17:00 to 19:00, followed by a social hour. We recommend return travel on Thursday, June 1 in order to fully experience the meeting.

SUNDAY, MAY 28

4:00—8:00 PM
Arrival and Registration (4pm Start)

INEC Foyer
6:00—8:00 PM
Welcome Mixer
No registration fees are used to fund alcohol served at this function.

INEC Foyer

MONDAY, MAY 29

8:00—9:00 AM
Welcome and Keynote Address (8am Start)

INEC Main Auditorium
* M. Celeste Simon, University of Pennsylvania, USA

Navdeep S. Chandel, Northwestern University, USA
Mitochondria as Signaling Organelles

9:00—11:15 AM
Mitochondria and Metabolism (9am Start)

INEC Main Auditorium
* Edurne Berra, CIC bioGUNE, Spain

Isha Jain, University of California, San Francisco, USA
Turning the Oxygen and Vitamin Dials

Coffee Break

Jared Rutter, University of Utah, USA
Energy Sensing and Metabolism

Sarah-Maria Fendt, VIB-KU Leuven, Belgium
Nutrient Dependencies of Metastasis Formation

Elise Belaidi, LBTI-CNRS UMR5305, France
Short Talk: Metformin Improves Infarct Size in Mice Exposed to Chronic Intermittent Hypoxia Through Mitochondrial Stress and HIF-1 Activity Modulation

11:15 AM—5:00 PM
On Own for Lunch

11:15 AM—1:00 PM
Poster Setup

INEC Foyer
1:00—10:00 PM
Poster Viewing

INEC Foyer
1:00—2:00 PM
Career Roundtable (1pm Start)

INEC Main Auditorium
Roslyn Nicole Crowder, Stetson University, USA

Zhenhai Gao, NiKang Therapeutics, USA

2:30—4:30 PM
Workshop 1: Normoxia, Physioxia and Hypoxia Responses (2:30pm Start)

INEC Main Auditorium
* Amato J. Giaccia, University of Oxford, UK

Brian M.W. Ortmann, University of Cambridge/Newcastle, UK
The Role of SET1B in Renal Cancer

Ram Prosad Chakrabarty, Northwestern University Feinberg School of Medicine, USA
L-2-hydroxyglutarate (L-2-HG) is a Signaling Molecule that Controls Mammalian Development

Justin Perry, Memorial Sloan Kettering Cancer Center, USA
Novel Adaptation Supports Enhanced Macrophage Efferocytosis in Limited-oxygen Environments

María Torres López, University of Seville, Spain
Role of Intracellular ATP in Oxygen and Low Glucose Sensing in Arterial Chemoreceptor

Brennan J. Wadsworth, Karolinska Institutet, Sweden
Hypoxia-induced Metabolite 2-hydroxybutyrate Regulates Oxidative Metabolism via Metabolic Control of Compartmental ADP Ribosylation

Ananda S. Mirchandani, University of Edinburgh, UK
Hypoxia Inhibits Emergency Monopoiesis in Acute Lung Injury and Hinders Inflammation Resolution

Amanda Becker, Northwestern University Feinberg School of Medicine, USA
Hypoxia Stimulates Neonatal HIF-1a Dependent Macrophage Secretion of IGF-1, a Cardiomyocyte Mitogen

Einav Gross, Hebrew University of Jerusalem, Israel
Ferritin Regulation by HIF-1 and Neurosignals in the Nematode C. Elegans

4:30—5:00 PM
Coffee Available

INEC Foyer
5:00—7:00 PM
Hypoxia Signaling in Tumor and Immune Cells (5pm Start)

INEC Main Auditorium
* Sonia Rocha, University of Liverpool, UK

Paul Boutros, University of California, Los Angeles, USA
Mutational Signatures in Hypoxic Tumors

Marina P. Kreutz, Universitat Regensburg, Germany
Oncometabolism and Immune Cells

Jane A. McKeating, Oxford University, UK
Virus and the HIF System

Amato J. Giaccia, University of Oxford, UK
Hypoxia and Tumor Immune Escape

7:00—8:00 PM
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

INEC Foyer
7:30—10:00 PM
Poster Session 1 (7:30pm Start)

INEC Foyer

TUESDAY, MAY 30

8:00—11:00 AM
PHD and FIH Enzymes Substrates and Functions (8am Start)

INEC Main Auditorium
* Cormac Taylor, University College Dublin, Ireland

Qing Zhang, UT Southwestern Medical Center, USA
Histone H3 Hydroxylation by EGLN2 (PHD1) Regulates Mammalian Gene Expression

Angus I. Lamond, University of Dundee, UK
Mass Spectrometry in the Quest for PHD Targets

Coffee Break

Daniel J. Peet, University of Adelaide, Australia
Development of Novel Screening Systems to Identify Regulators of FIH, Hypoxia and other Signalling Pathways

Ana Garcia, CIC bioGUNE, Spain
Short Talk: Factor Inhibiting HIF (FIH) Promotes Lung Cancer Progression

Valentina Sancisi, Azienda USL Reggio Emilia IRCCS, USA
Short Talk: PHD2 (EGLN1) is a Novel Therapeutic Target in KRAS-mutated Lung Carcinoma

Silvia Strocchi, Azienda USL-IRCCS di Reggio Emilia, Italy
Short Talk: Implementing an Organoid Platform to Assess Efficacy of PHD Inhibitors as Anti-cancer Agents

Jimena Druker, University of Dundee, UK
Short Talk: RepoMan is a Novel Cell Cycle-regulated PHD1- Dependent Target

11:00 AM—5:00 PM
On Own for Lunch

11:00 AM—1:00 PM
Poster Setup

INEC Foyer
1:00—10:00 PM
Poster Viewing

INEC Foyer
2:30—4:30 PM
Roundtable Discussion: The Future of Hypoxia Research (2:30pm Start)

INEC Main Auditorium
* M. Celeste Simon, University of Pennsylvania, USA

Cormac Taylor, University College Dublin, Ireland

Peter J. Ratcliffe, Francis Crick Institute, UK

Amato J. Giaccia, University of Oxford, UK

José López-Barneó, University of Seville, Spain

4:30—5:00 PM
Coffee Available

INEC Foyer
5:00—7:00 PM
Model Organisms to Study Hypoxia Responses (5pm Start)

INEC Main Auditorium
* Peter J. Ratcliffe, Francis Crick Institute, UK

Joaquín M. Espinosa, Linda Crnic Institute for Down Syndrome, USA
Multiomics Approaches to Investigate Hypoxic Signaling in Health and Disease

Irina Manov, University of Haifa, Israel
The Co-Evolution of Hypoxia Tolerance, Longevity and Healthy Aging in the Subterranean Blind Mole Rat, Spalax: Hypotheses and Molecular Mechanisms

Ernestina Schipani, University of Pennsylvania, USA
How Hypoxia and Mitochondria Shape up the Skeleton

José López-Barneó, University of Seville, Spain
Mitochondrial Acute O2 Sensing and Signaling

7:00—8:00 PM
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

INEC Foyer
7:30—10:00 PM
Poster Session 2 (7:30pm Start)

INEC Foyer

WEDNESDAY, MAY 31

8:00—11:00 AM
New Aspects of Hypoxia Signalling (8am Start)

INEC Main Auditorium
* Daniel J. Peet, University of Adelaide, Australia

Edurne Berra, CIC bioGUNE, Spain
DUBs in Hypoxia

Cormac Taylor, University College Dublin, Ireland
Spatial Organization of Glycolytic Enzymes in Hypoxia

Coffee Break

Sonia Rocha, University of Liverpool, UK
Oxygen as a Signalling Molecule in Cells

Harrison Alexander Feldman, University of Cincinnati / Cincinnati Children's Hospital, USA
Short Talk: A Hypoxia-Inducible Factor 2 Alpha Transcriptomic Program Regulating Function and Dysfunction in Human NK Cells

Paul Grevitt, Barts Cancer Institute, UK
Short Talk: Coenzyme A Synthase (CoAsy): A Novel Regulator of HIF Stability and Activity

11:00 AM—5:00 PM
On Own for Lunch

2:30—4:30 PM
Workshop 2: Novel Methods to Detect Hypoxia and its Responses (2:30pm Start)

INEC Main Auditorium
* Isha Jain, University of California, San Francisco, USA

Jacopo Arrigoni, University of Milan, Italy
Combined In Vitro and Air-Liquid Interface Models Enable Investigation of Alternative Tumor-Infiltrating Regulatory T Cell Responses to Hypoxia

Julián Aragonés Lopez, Research Institute Princesa, Spain
Erythroid-Deficient SLC7A5 Mice as An In Vivo Model to Study Hypoxia

Timothy P. Allen, University of Adelaide, Australia
Development and Application of a Dual Fluorescent HIF Sensor for Small Molecule Discovery and Genetic screening

Debarun Patra, Indian Institute of Technology Ropar, India
HypoxamiR-210 Promotes Obesity-induced Adipose Tissue Inflammation via Targeting SOCS1/NF-κB

Alison Elizabeth Roennfeldt, University of Adelaide, Australia
A Translatable Cell-based High throughput Screening System to Screen for Novel Hypoxia Transcriptional Regulators

Eleanor Minogue, Cambridge University, UK
Hypoxia Induced Glutarate Regulates T Cell Fate and Function

4:30—5:00 PM
Coffee Available

INEC Foyer
5:00—6:45 PM
Therapeutic Applications in Hypoxia Response and Disease (5pm Start)

INEC Main Auditorium
* José López-Barneó, University of Seville, Spain

Claudia Diehl, University of Dundee, School of Life Sciences, UK
Development of Novel VHL Ligands and VHL-based homoPROTACs

Volker H. Haase, Vanderbilt University, USA
Pharmacological Targeting of HIF-prolyl hydroxylases

M. Celeste Simon, University of Pennsylvania, USA
Oxygen Availability and Tumor Microenvironments

Ana Gabriela Cristancho, Children's Hospital of Philadelphia, USA
Short Talk: Early Disruption of Epigenetic and Transcriptomic Organization after Prenatal Hypoxia Predicts Persistent Functional Deficits in Glutamatergic Neurons

6:45—7:00 PM
Meeting Wrap-Up: Outcomes and Future Directions (Organizers) (6:45pm Start)

INEC Main Auditorium
7:00—8:00 PM
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

INEC Foyer

THURSDAY, JUNE 1

8:00—8:00 AM
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge additional support from these exhibitors at this conference:

Don Whitley Scientific Limited
Please stop by to meet these exhibitors during the conference.


We gratefully acknowledge additional support for this conference from:

The Baker Company

We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:


Click here to view more of these organizations


Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


Click here to view more of these organizations


If your organization is interested in joining these entities in support of Keystone Symposia, please contact: John Monson, Director of Corporate Relations, Email: johnm@keystonesymposia.org,
Phone:+1 970-262-2690

Click here for more information on Industry Support and Recognition Opportunities.

If you are interested in becoming an advertising/marketing in-kind partner, please contact:
Josh May, Director, Technology and Digital Media, Email: joshuam@keystonesymposia.org,
Phone:+1 970-262-1179