Keystone Symposia

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This meeting took place in 2023



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B Cell Biology in the Context of Infectious Diseases, Autoimmunity and B Cell Cancers (Z5)


Organizer(s) Facundo D. Batista, Susan K. Pierce, Oliver Bannard, Mauro Gaya and Michelle Linterman
June 6—10, 2023
Keystone Resort • Keystone, CO USA
Abstract Deadline: Mar 21, 2023
Scholarship Deadline: Mar 21, 2023
Discounted Registration Deadline: Apr 6, 2023

Sponsored by Michelson Philanthropies


Summary of Meeting:
It is now well appreciated that effective B cell antibody responses are essential for human health and protection against deadly infectious diseases and that on the flipside B cell antibodies are mediators of devastating autoimmune diseases and when released from normal control mechanisms B cell malignancies are common and many remain untreatable. It is also becoming increasingly clear that the mature B cell compartment is highly heterogeneous and that antigen-driven fates of individual B cells are dependent on a several factors including the affinity of the B cell antigen receptor (BCR) and how the BCR is wired to the B cell’s activation machinery as well as the quality of the immune environment defined by both antigen-specific T cells and innate immune cells responding to pathogen-derived signals. In this context the generation of long-lived protective immunity versus B cell malignancies or systemic autoimmunity may represent the spectrum of outcomes resulting from different combinations of BCR affinity and wiring and the T cell and innate signals experienced by B cells during activation. If so our ability to rationally manipulate B cell responses to develop vaccines against infectious diseases and therapies for autoimmune diseases and B cell cancers may be greatly accelerated by gaining a detailed understanding of the fundamentals of B cell biology and translating this knowledge to clinical and basic research addressing the most pressing public health priorities of our times in acute and chronic infectious diseases, autoimmunity and B cell malignancies.

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No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 24 hr (international) time


The meeting will begin on Tuesday, June 6 with registration from 16:00 to 20:00 and a welcome mixer from 18:00 to 20:00. Conference events conclude on Saturday, June 10 with a closing plenary session from 17:00 to 19:00, followed by a social hour. We recommend return travel on Sunday, June 11 in order to fully experience the meeting.

TUESDAY, JUNE 6

4:00—8:00 PM
Arrival and Registration

Longs Peak Foyer
6:00—8:00 PM
Welcome Mixer
No registration fees are used to fund alcohol served at this function.

Longs Peak Foyer

WEDNESDAY, JUNE 7

7:00—8:00 AM
Breakfast

Colorado Rockies Ballroom
8:00—9:30 AM
Welcoming Remarks and Keystone Session (Joint)

Grays/Longs Peaks
* Facundo D. Batista, Massachusetts Institute of Technology and Harvard University, USA

* Hanneke Schuitemaker, Janssen Vaccines & Prevention B.V., Netherlands

William Schief, The Scripps Research and IAVI, USA
Germline Targeting Strategies: mRNA EOD/Trimer Studies

Rafi Ahmed, Emory University School of Medicine, USA
B Cell Biology in the Context of Infectious Diseases, Autoimmunity and B Cell Cancers

Coffee Break

9:50—11:30 AM
How B Cells Function in Infectious Diseases (Joint)

Grays/Longs Peaks
* Frances E. Lund, University of Alabama at Birmingham, USA

Shane Crotty, La Jolla Institute for Immunology, USA
Immune Memory to SARS-CoV-2 and COVID-19 Vaccines, and Lessons for HIV Vaccine Development

Michel C. Nussenzweig, HHMI/Rockefeller University, USA
Development of B Cell Memory

Susan Moir, NIAID, National Institutes of Health, USA
B Cell Responses to Chronic and Repeated Antigen Exposures: Lessons from HIV and SARS-CoV-2

11:30 AM—1:00 PM
Hands-On Computer Workshop on Los Alamos HIV Sequence Database and Tools (Joint)

Castle Peak 1-2
* Brian T. Foley, Los Alamos National Lab, USA

11:30 AM—5:00 PM
On Own for Lunch

11:30 AM—1:00 PM
Poster Setup

Colorado Rockies Ballroom
1:00—10:00 PM
Poster Viewing

Colorado Rockies Ballroom
2:30—4:30 PM
Workshop 1: B Cells in Infection and Inflammation

Longs Peak
* Michelle A. Linterman, Babraham Institute, UK

* Elliott D. SoRelle, Duke University, USA

Matthew C. Woodruff, Emory University, USA
Acute Tolerance Loss and Naive-Derived Autoantibodies: Implications for COVID-19 and Beyond

Xin Gao, JCSMR, the Australian National University, Australia
B Cells Engaging with Whole Parasites can take up Bystander Surface Antigens to Obtain Help from T Cells with Multiple Specificities

Zgjim Osmani, Erasmus University Medical Center, Netherlands
The Distinct Effects of HBsAg in Blood and Liver of Chronic Hepatitis B Patients are Restricted to Memory B-, NK-, and CD8 T Cell Subsets

Mohini K. Gray, Centre for Inflammation Research, UK
CD11c+ve Double-negative-2 B Cells Constitute a Major Targetable Pathogenic B Cell Subset within the Diseased Rheumatoid Synovium

Luke Muir, University College London, UK
Small Transient Increases in HIV-1 Viral Load Induce a Potent Humoral Immune Response and Associated B Cell Dysfunction

Daniel D. Pinschewer, University of Basel, Switzerland
Follicular T Helper Cell Response and Antibody-mediated Viral Load Control in “Immunologically Tolerant” Congenitally Infected Mice

Ellen Shrock, Harvard University, USA
Viral Epitope Profiling of COVID-19 Patients Reveals Cross-reactivity and Correlates of Severity

2:30—4:30 PM
Workshop 1

Grays Peak
Daniel Morris, University of Pennsylvania, USA
Glycan-deficient SHIVs to Elicit Broadly Neutralizing HIV-1 Antibodies in Macaques

* Kevin Wiehe, Duke University, USA
Mutation-guided Vaccine Design: A Process for Developing Boosting Immunogens for HIV Broadly Neutralizing Antibody Induction

Ashwin Nicholas Skelly, University of Pennsylvania, USA
Elicitation of V3 Glycan-directed Cross-neutralizing Antibodies in Sequentially Immunized, SHIV-infected Rhesus Macaques

Yoann Aldon, Amsterdam UMC, Netherlands
gp41-free Native-like HIV-1 Env Trimers: Beyond Structure-guided Design

Mitch Brinkkemper, University of Amsterdam, Netherlands
Highly Stabilized and Densily Glycosylated HIV-1 Env Trimers Co-displayed on Two-component Nanoparticles do not Elicit bNAb Responses

Maria Belen Palacio, Wistar Institute, USA
A Novel Strategy to Generate Knock-in Mice for HIV Vaccine Development

Parham Ramezani-Rad, La Jolla Institute for Immunology, USA
A Membrane-Bound Native-like HIV Envelope Trimer mRNA Vaccine in Animal Models

4:30—5:00 PM
Coffee Available

Longs Peak Foyer
5:00—7:00 PM
Control and Modulation of B Cell Responses

Longs Peak
* Shane Crotty, La Jolla Institute for Immunology, USA

* Pavel Tolar, University College London, UK

Frances E. Lund, University of Alabama at Birmingham, USA
Regulation of Effector Memory B Cell Development and Function

Mauro N. Gaya, Luminy Center for Immunology in Marseille, France
B Cell Immunity in the Lung Airways

Jenny Jiang, University of Pennsylvania, USA
High-Throughput and High-Dimensional Profiling of Antigen-Specific T cells

Renan Villanova Homem de Carvalho, Rockefeller University, USA
Short Talk: Clonal Replacement Sustains Long-lived Germinal Centers Primed by Respiratory Viruses

Martin Turner, Babraham Institute, UK
Short Talk: Post-transcriptional Regulation of B Cell Selection in Germinal Centres

5:00—7:00 PM
Rational Vaccine Design

Grays Peak
* Marit van Gils, Amsterdam UMC, Netherlands

Barton F. Haynes, Duke University Medical Center, USA
Duke CHAVD Immunogen Design and Clinical Trials Results

Hannah R. Shrader, National Institutes of Health Vaccine Research Center, USA
Short Talk: Engineering Multispecific HIV-1 Neutralizing Antibodies Based on Complementarity of CD4 Binding Site Broadly-Neutralizing Antibodies

Manyuan Ma, The Scripps Research, USA
Short Talk: An HIV Vaccine Initiated V2 Apex Broadly Neutralizing Antibody-like Responses in Non-human Primates

Sean Callaghan, The Scripps Research Institute, USA
Short Talk: Development of B Cell Lineage-based CAP256.SU HIV Germline-targeting Nanoparticle Immunogen that can Efficiently Engage V2-apex bnAb Precursors

Joshua Tan, NIAID, National Institutes of Health, USA
Short Talk: Broadly Neutralizing Antibodies Target the Coronavirus Fusion Peptide

Torben Schiffner, Leipzig University, Germany
Short Talk: Vaccine Induction of Broadly Neutralizing Antibody Precursors to HIV gp41

Christopher A. Cottrell, The Scripps Research Institute, USA
Short Talk: Germline-targeting, mRNA-delivered, Nanoparticle Immunogens Prime and Boost VRC01-class B Cell Responses in Stringent Mouse Models

7:00—8:00 PM
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Colorado Rockies Ballroom
7:30—10:00 PM
Poster Session 1

Colorado Rockies Ballroom

THURSDAY, JUNE 8

7:00—8:00 AM
Breakfast

Colorado Rockies Ballroom
7:30—8:00 AM
Poster Setup

Colorado Rockies Ballroom
8:00 AM—7:00 PM
Poster Viewing

Colorado Rockies Ballroom
8:00—11:00 AM
Rational Vaccine and Adjuvant (Joint)

Grays/Longs Peaks
* Susan Moir, NIAID, National Institutes of Health, USA

Darrell J. Irvine, Massachusetts Institute of Technology, USA
Controlled Modulation of B Cell Responses

Michelle A. Linterman, Babraham Institute, UK
Spatial Dysregulation of T Follicular Helper Cells Impairs Vaccine Responses in Aging

Coffee Break

Andrew B. Ward, The Scripps Research Institute, USA
HIV Structural Studies and Implications for Vaccine Development

Mangala Rao, Walter Reed Army Institute of Research, USA
Short Talk: HIV-1 gp120 Envelope Protein Mixed with Army Liposome Formulation ALFQ Induces Potent and Durable Antigen-specific Humoral Immune Responses in Nonhuman Primates

Sudhir Pai Kasturi, Emory University, USA
Short Talk: B Cell Receptor Sequencing of Blood and Bone Marrow Antibody Secreting Cells Reveals Higher Clonal Overlap and Superior Ability of 3M-052-alum

Stephen J. Elledge, Harvard Medical School, USA
Short Talk: Germline-encoded Amino Acid-binding Motifs Drive Immunodominant Public Antibody Responses

Daniel Lingwood, Harvard Medical School, USA
Short Talk: Allelic Polymorphism Controls Immune Tolerance and Vaccine-Elicitation of Human Broadly Neutralizing Antibodies Against Influenza Virus

11:00 AM—12:30 PM
Michelson Awards Luncheon

Colorado Rockies Ballroom
Jenna Guthmiller, University of Colorado SOM, USA
Mapping Preexisting Mucosal B Cell Specificities Engaged by Potential Universal Influenza Vaccines

Romain Guyon, University of Oxford, UK
Demonstration of New Single-dose Vaccine Technology towards a First-in-Man Clinical Application

Brittany Hartwell, University of Minnesota, USA
Engineering Albumin-hitchhiking Intranasal Vaccines with Enhanced Transmucosal Uptake to Promote Immunity

Joshua Tan, NIAID, National Institutes of Health, USA
Searching for Common Ground: The Conserved Coronavirus Fusion Peptide is a Target of Broadly Neutralizing Antibodies

12:30—2:30 PM
Poster Session 2

Colorado Rockies Ballroom
2:30—4:30 PM
Workshop 2: Dynamics of B Cell Memory

Longs Peak
* Mauro N. Gaya, Luminy Center for Immunology in Marseille, France

* Kim Good-Jacobson, Monash University, Australia

Brian J. Laidlaw, Washington University in St. Louis, USA
CD62L Expression Marks a Functionally Distinct Subset of Memory B Cells in Mice and Humans

Pascal Chappert, Institut Necker Enfants Malades, France
Omicron BA.1 Breakthrough Infection Drives Long-term Remodeling of the Memory B Cell Repertoire in Vaccinated Individuals

Manon Termote, Karolinska Institutet, Sweden
Antigen Affinity and Pre-existing Antibodies Dictate Memory B Cell Entry into Secondary Germinal Centers

Allyssa Phelps, McMaster University, Canada
Pathogenic IgE-fated B Cell Memory Retains Functional Plasticity

Eva Conde Garcia, Regeneron Pharmaceuticals, USA
Chronic Allergen Exposure Induces Allergen-specific IgA via Distinct Pathways that Generate IgAs of Different Affinity, with Potential Consequences for the Allergic Response

Zhixin Jing, National Institute of Allergy and Infectious Diseases, USA
Fine-tuning Spatial-temporal Dynamics and Surface Receptor Expression Support Plasma Cell-intrinsic Longevity

Haewon Sohn, NIAID, National Institutes of Health, USA
The Mechanosensitive Ion Channel Piezo1 is Required for B Cell Responses to Membrane-presented Antigens

Theresa Pinter, IMP, Austria
Control of B Cell Development and Function by the SAGA Complex

2:30—4:30 PM
Workshop 2

Grays Peak
Christopher A. Gonelli, National Institutes of Health, USA
Apparent Protection from SIV-specific bNAb Immunoprophylaxis May Represent Delayed Viremia after Subclinical SIV Infection in Rhesus Macaques

Flavio Matassoli, National Institutes of Health, USA
Assessing the Frequency of Naïve B Cells Potentially Capable of Producing Broad Neutralizing Antibodies for HIV

Daniel Reeves, Fred Hutchinson Cancer Research Center, USA
VRC01 Reduced Breakthrough Viral Loads in the HIV Antibody Mediated Prevention (AMP) Studies

Stephen A. Migueles, National Institutes of Health, USA
HIV Vaccines Induce Hypofunctional CD8+ T Cells with Low Structural Avidity

Dania Figueroa Acosta, Icahn School of Medicine at Mount Sinai, USA
Abundance of Uncleaved Env on the Cell Surface is Modulated by Endocytic Recycling and Alters the Sensitivity of Cell-to-cell Infection

Sam Charaf, NIAID, USA
The Level of VRC01-class Precursors Determines the Efficacy of Sequential Immunization Regimens to Elicit VRC01-Class Broadly Neutralizing Antibodies in Transgenic Mice

* Morgane Rolland, Henry M Jackson Foundation, USA
HIV-1 Acute Infection Multiple Founder Variants as Vaccine Candidates

4:30—5:00 PM
Coffee Available

Longs Peak Foyer
5:00—7:00 PM
Antigen Driven Activation, Selection and Metabolic Re-Programming

Longs Peak
* Brian J. Laidlaw, Washington University in St. Louis, USA

* Martin Turner, Babraham Institute, UK

Pavel Tolar, University College London, UK
Regulation of Antigen Persistence in Germinal Centers

Gabriel D. Victora, Rockefeller University, USA
Evolution of Antibody Responses to Infection and Immunization

Stephanie C. Eisenbarth, Northwestern Univ Feinberg Sch Med, USA
The IgA B Cell Response in the Gut to Food Antigens

Nuria Martínez-Martín, CBMSO-CSIC, Spain
Short Talk: Defective Mitochondria Remodelling in B Cells Leads to an Aged Immune Response

Henry Sutton, La Jolla Institute of Immunology, USA
Short Talk: The Benefit of Long-lasting Germinal Centers to Antigen-specific B Cell Responses

5:00—7:00 PM
Translational HIV Vaccine Research

Grays Peak
Alejandro Balazs, Massachusetts General Hospital, USA
Antibody-mediated Prevention of Vaginal HIV Transmission is Dictated by IgG Subclass in Humanized Mice

* Devin Sok, International AIDS Vaccine Initiative, USA
IAVI Vaccine and Passive Antibody Trials in Africa

Louis J. Picker, Oregon Health & Science University, USA
Understanding the “Control and Clear” Efficacy of RhCMV/SIV Vaccine Vectors

Karlijn van der Straten, Amsterdam UMC, Netherlands
Short Talk: Safety, Tolerability and Immunogenicity of a Phase 1 HIV Vaccination Trial using ConM SOSIP.v7 gp140, Adjuvanted with MPLA Liposomes

Shuishu Wang, NIAID, National Institutes of Health, USA
Short Talk: Prefusion-Stabilized BG505 Envelope Trimer Elicits Fusion Peptide-Directed HIV-Neutralizing Antibodies in Humans

7:00—8:00 PM
On Own for Dinner
No registration fees are used to fund alcohol served at this function.


FRIDAY, JUNE 9

7:00—8:00 AM
Breakfast

Colorado Rockies Ballroom
8:00—11:00 AM
Affinity Based Selection and Fate Decisions: Long Lived Plasma Cells and Memory B Cells

Longs Peak
* Gabriel D. Victora, Rockefeller University, USA

Frances Eun-Hyung Lee, Emory University, USA
Differential Ability to Modulate Antibody Secretion in Human Long-lived Plasma Cells

Oliver Bannard, University of Oxford, UK
Plasma Cell Differentiation during Infection

Coffee Break

Tomohiro Kurosaki, Osaka University, Japan
Requirement for Optimal BCR Signal Strength in Efficient Positive Selection of Germinal Center (GC) B Cells

Vassilis Glaros, Karolinska Institutet, Sweden
Short Talk: The Marginal Zone B Cell Molecular Program is a Niche-induced State Associated with Long-term Persistence of B Cell Memory

Kim Good-Jacobson, Monash University, Australia
Short Talk: Formation and Plasticity of Memory B Cell Epigenetic Identity in Chronic Viral Infection

Sarah F. Andrews, National Institutes of Health, USA
Short Talk: The B Cell Response to Influenza Vaccination is Shaped by Influenza Virus Exposure Fifty Years Ago

Christopher Risley, UAB, USA
Short Talk: T-bet Regulates the Maintenance and ASC Differentiation Potential of the Lymph Node and Lung Effector Memory B Cell Compartments

8:00—11:00 AM
Broadly Neutralizing Antibodies and Passive Immunization Against HIV and SARS-CoV-2

Grays Peak
Marit van Gils, Amsterdam UMC, Netherlands
Complementary Antibody Lineages Achieve Neutralization Breadth In An HIV-1 Infected Elite Neutralizer

* Laura M. Walker, Moderna, USA
Evolution of Antibody Immunity Following Omicron Breakthrough Infection

Coffee Break

Margaret Juliana McElrath, Fred Hutchinson Cancer Research Center, USA
HVTN Updates: Adjuvants and SOSIP Trimer Trials

Matheus Oliveira de Souza, Ragon Institute of MGH, MIT and Harvard, USA
Short Talk: Engineering VRC07-523-LS FR3-03 for Enhanced HIV-1 Neutralization Potency and Breadth

Greg Whitehill, University of Pennsylvania, USA
Short Talk: Neutralizing Antibodies Selective for Autologous Plasma Virus Develop after Early ARTi

Alexandra Trkola, University of Zürich, Switzerland
Short Talk: Multi-specificity Creates HIV-1 Elite Broadly Neutralizing Capacity

11:00 AM—12:30 PM
Hands-On Computer Workshop on Los Alamos HIV Immunology Database and Tools (Joint)

Castle Peak 1-2
* Brian T. Foley, Los Alamos National Lab, USA

11:00 AM—5:00 PM
On Own for Lunch

11:00 AM—1:00 PM
Poster Setup

Colorado Rockies Ballroom
1:00—10:00 PM
Poster Viewing

Colorado Rockies Ballroom
3:00—4:30 PM
Career Roundtable (Joint)

Grays/Longs Peaks
Glenda E. Gray, South African Medical Research Council, South Africa

Louis M. Staudt, NCI, National Institutes of Health, USA

Erik Jongert, GlaxoSmithKline, Belgium

Julie Ake, Walter Reed Army Institute of Research, USA

Stephanie C. Eisenbarth, Northwestern Univ Feinberg Sch Med, USA

Alejandro Balazs, Massachusetts General Hospital, USA

4:30—5:00 PM
Coffee Available

Longs Peak Foyer
5:00—7:00 PM
Activation and Redemption of the Autoreactive B Cell Repertoire in Autoimmune

Longs Peak
* Carola G. Vinuesa, Francis Crick Institute, UK

* Tomohiro Kurosaki, Osaka University, Japan

Ignacio Sanz, Emory University, School of Medicine, USA
B Cells and their Effector Progeny in Autoimmune Disease

Christopher C. Goodnow, Garvan Institute of Medical Research, Australia
Virus-induced Autoantibodies: Redemption or Pathological Evolution through B Cell Mutations in V(D)J-regions and Lymphoma Driver Genes

Jennifer L. Gommerman, University of Toronto, Canada
B Cells and BAFF in Multiple Sclerosis

Taiichiro Shirai, Osaka University, Japan
Short Talk: Inhibition of the COMMD3/8 Complex Suppresses Humoral Immune Responses and Autoimmunity

Clara Young, Garvan Institute, Australia
Short Talk: Precursor Self-reactivity and Lymphoma Gene Mutations Drive Pathogenic B Cell Clones in Autoimmune Hepatitis C Virus (HCV)-associated Cryoglobulinemic Vasculitis

5:00—7:00 PM
Next Generation PrEP

Grays Peak
* Rebecca M. Lynch, George Washington University, USA

S. Rahima Benhabbour, University of North Carolina, USA
Harnessing Innovative Engineering to Desing the Next Generation Long-Acting PrEP

Jianliang Xu, Georgia State University, USA
Superpotent Broadly Neutralizing Human-llama Bispecific Antibodies Against HIV-1

Madison Fox, NIAID, NIH, USA
Potent Suppression of Viral Rebound after Analytical Treatment Interruption in ART-suppressed SHIV-infected Animals by a CD4 Binding Site bNAb

7:00—8:00 PM
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Colorado Rockies Ballroom
7:30—10:00 PM
Poster Session 3

Colorado Rockies Ballroom

SATURDAY, JUNE 10

7:00—8:00 AM
Breakfast

Colorado Rockies Ballroom
8:00—11:00 AM
The Impact of Infectious Disease and Inflammation on the B Cell Compartment

Longs Peak
* Sarah F. Andrews, National Institutes of Health, USA

Carola G. Vinuesa, Francis Crick Institute, UK
Mechanisms Underpinning Human Systemic Autoimmunity: Lessons from Inborn Errors of Immunity

Marion Pepper, University of Washington, USA
B Cell Response in Malaria

Coffee Break

Facundo D. Batista, Massachusetts Institute of Technology and Harvard University, USA
Cell Metabolic Re-Programming

Cristian G. Beccaria, San Raffaele Scientific Institute, San Raffaele Hospital, Italy
Short Talk: Deciphering the HBV Specific B Cell-mediated Immune Response in a Mouse Model of HBV Pathogenesis

Lalit Kumar Dubey, Queen Mary University of London, UK
Short Talk: B Cell-Stomal Crosstalk Govern Mesenteric Lymph Node Lymphangiogenesis during Intestinal Helminth Infection

Cherrelle Dacon, National Institutes of Health, USA
Short Talk: Discovery of Human Monoclonal Antibodies against a Cryptic Epitope on the Plasmodium Falciparum Sporozoite Surface

8:00—11:00 AM
Update on HIV Vaccine Trials

Grays Peak
* Julie Ake, Walter Reed Army Institute of Research, USA

Hanneke Schuitemaker, Janssen Vaccines & Prevention B.V., Netherlands
Ad26 Vaccines for COVID and HIV

Hyman Scott, University of California, San Francisco, USA
Priming Vaccine Regimen with Adjuvented 426c Core to Induce CD4bs Antibodies (HVTN 301)

Coffee Break

Glenda E. Gray, South African Medical Research Council, South Africa
Next Generation of Efficacy Studies; Vaccine Development in era of Long Acting PrEP

Wilton B. Williams, Duke University School of Medicine, USA
Short Talk: HIV Polyclonal Neutralizing Antibody Responses Elicited by gp41 MPER Peptide-Liposome in Humans

Benjamin Leach, National Institutes of Health, USA
Short Talk: Low-Avidity CD8+ T Cells Induced by Ad5/HIV Vaccines Exhibit Impaired Cytotoxic Granule Polarization

11:00 AM—5:00 PM
On Own for Lunch

2:30—4:30 PM
Workshop 3: Germinal Centers: Antibody Affinity Maturation and Differentiation

Longs Peak
* Oliver Bannard, University of Oxford, UK

* Nuria Martínez-Martín, CBMSO-CSIC, Spain

Christopher James Jara, Garvan Institute of Medical Research, Australia
Clonal Redemption of a Human IGHV4-34 Autoantibody in a Mouse Model

Sharon Kagan Ben Tikva, Weizmann Institute of Science, Israel
Myc Transcriptional Bursts Promote B Cell Selection by T Cells in Germinal Centers

Laurine Binet, University of Aix-Marseille, France
Single-cell and Spatial Analyses of Intermediate States in GC B to PC Differentiation

Avneesh Gautam, Brigham and Women's Hospital, USA
Vast Antibody Affinity Birth Potential through Somatic Hypermutation

Oliver Philip Skinner, Peter Doherty Institute, University of Melbourne, Australia
Mapping B-cell Fate and Clonal Dynamics during Malaria

Julia Zofia Adamska, Stanford University, USA
Ablation of the RNA-Editing Enzyme ADAR1 in Germinal Center B Cells Results in Impaired Plasma Cell and Memory B Cell Formation

Jaime L. Chao, University of Washington, USA
Spatial Heterogeneity of Vaccine-induced B Cell Responses

2:30—4:30 PM
Workshop 3

Grays Peak
* Alexandra Trkola, University of Zürich, Switzerland

Yanique Serge Gillana Thomas, Northwestern University, USA
Defining the Dynamics of SIV Infection and the Viral Reservoir from Early ART Initiation to Rebound using PET/CT Analysis and a Multi-scale Imaging Approach

Yuqi Zhou, University of Pennsylvania, USA
Chimeric Antigen Receptors Enable Superior Control of HIV Replication by Rapid Killing of Infected Cells

Lutz Gieselmann, Laboratory of Experimental Immunology Cologne, Germany
Large-scale Characterization of a Cohort of HIV-1 Elite Neutralizers Reveals a Novel Highly Broad and Potent CD4 Binding Site bNAb

Kristen A. Rodrigues, Massachusetts Institute of Technology, USA
Optimization of an Alum-anchored Clinical HIV Vaccine Candidate

Steven William de Taeye, Amsterdam UMC, Netherlands
Afucosylated bNAbs Enhance Clearance of HIV-1 Infected Cells through NK Cell Mediated ADCC

Nicholas Bayless, Centivax Inc., USA
Use of Computationally Guided Vaccine Technology to Develop a Broad-Spectrum Vaccine Targeting HIV

4:30—5:00 PM
Coffee Available

Longs Peak Foyer
5:00—6:45 PM
B Cell Malignancy Checkpoints and Targets of Therapies

Longs Peak
* Christopher C. Goodnow, Garvan Institute of Medical Research, Australia

* Jenna Guthmiller, University of Colorado SOM, USA

Louis M. Staudt, NCI, National Institutes of Health, USA
Curing Lymphoma by Understanding B Cell Biology

Sandrine Roulland, Aix Marseille University, France
B Cell State Heterogeneity and Lymphomagenesis

Karin Tarte, INSERM U917 Université de Rennes 1, France
Follicular Lymphoma Microenvironment: Plasticity and Origin

Jaewoo Choi, NIH/NCI, USA
Short Talk: Attacking Oncogenic B Cell Receptor Signaling in Lymphoma With Glucocorticoids

5:00—6:45 PM
Leveraging HIV Prevention Advances for the Cure Agenda

Grays Peak
Julie Ake, Walter Reed Army Institute of Research, USA
Cure Approaches from NHP to Human

* Marina F. Caskey, Rockefeller University, USA
bNabs-Eliciting Vaccine Strategies for HIV Cure

Steven G. Deeks, University of California, San Francisco, USA
Therapeutic Vaccination for HIV Cure

Caroline Subra, Henry Jackson Foundation - Military HIV Research Program Walter Reed Army, USA
Short Talk: Impact of ART and VRC01 Antibody Infusion Alone or in Combination during Acute HIV Infection on Immune Cell Activation

6:45—7:00 PM
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)

Longs Peak
6:45—7:00 PM
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)

Grays Peak
7:00—8:00 PM
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Colorado Rockies Ballroom

SUNDAY, JUNE 11

8:00—8:00 AM
Departure


*Session Chair †Invited, not yet responded.



Keystone Symposia thanks our Sponsor(s) for generously supporting this meeting:

Michelson Philanthropies

We gratefully acknowledge additional support from these exhibitors at this conference:

BioLegend, Inc. Michelson Philanthropies
Please stop by to meet these exhibitors during the conference.


We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1R13AI176860-01

Funding for this conference was made possible (in part) by 1R13AI176860-01 from the National Institutes of Health. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention by trade names, commercial practices, or organizations imply endorsement by the U.S. Government.


We gratefully acknowledge additional support for this conference from:

AdipoGen Life Sciences

We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:


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Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


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If your organization is interested in joining these entities in support of Keystone Symposia, please contact: John Monson, Director of Corporate Relations, Email: johnm@keystonesymposia.org,
Phone:+1 970-262-2690

Click here for more information on Industry Support and Recognition Opportunities.

If you are interested in becoming an advertising/marketing in-kind partner, please contact:
Josh May, Director, Technology and Digital Media, Email: joshuam@keystonesymposia.org,
Phone:+1 970-262-1179