This meeting took place in 2023
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B Cell Biology in the Context of Infectious Diseases, Autoimmunity and B Cell Cancers (Z5)
Organizer(s) Facundo D. Batista, Susan K. Pierce, Oliver Bannard, Mauro Gaya and Michelle Linterman
June 6—10, 2023
Keystone Resort • Keystone, CO USA
Abstract Deadline: Mar 21, 2023
Scholarship Deadline: Mar 21, 2023
Discounted Registration Deadline: Apr 6, 2023
Sponsored by Michelson Philanthropies
Joint Meeting:
HIV Vaccines, Immunoprophylaxis and Drugs (Z6)
Summary of Meeting:
It is now well appreciated that effective B cell antibody responses are essential for human health and protection against deadly infectious diseases and that on the flipside B cell antibodies are mediators of devastating autoimmune diseases and when released from normal control mechanisms B cell malignancies are common and many remain untreatable. It is also becoming increasingly clear that the mature B cell compartment is highly heterogeneous and that antigen-driven fates of individual B cells are dependent on a several factors including the affinity of the B cell antigen receptor (BCR) and how the BCR is wired to the B cell’s activation machinery as well as the quality of the immune environment defined by both antigen-specific T cells and innate immune cells responding to pathogen-derived signals. In this context the generation of long-lived protective immunity versus B cell malignancies or systemic autoimmunity may represent the spectrum of outcomes resulting from different combinations of BCR affinity and wiring and the T cell and innate signals experienced by B cells during activation. If so our ability to rationally manipulate B cell responses to develop vaccines against infectious diseases and therapies for autoimmune diseases and B cell cancers may be greatly accelerated by gaining a detailed understanding of the fundamentals of B cell biology and translating this knowledge to clinical and basic research addressing the most pressing public health priorities of our times in acute and chronic infectious diseases, autoimmunity and B cell malignancies.
View Meeting Program
It is now well appreciated that effective B cell antibody responses are essential for human health and protection against deadly infectious diseases and that on the flipside B cell antibodies are mediators of devastating autoimmune diseases and when released from normal control mechanisms B cell malignancies are common and many remain untreatable. It is also becoming increasingly clear that the mature B cell compartment is highly heterogeneous and that antigen-driven fates of individual B cells are dependent on a several factors including the affinity of the B cell antigen receptor (BCR) and how the BCR is wired to the B cell’s activation machinery as well as the quality of the immune environment defined by both antigen-specific T cells and innate immune cells responding to pathogen-derived signals. In this context the generation of long-lived protective immunity versus B cell malignancies or systemic autoimmunity may represent the spectrum of outcomes resulting from different combinations of BCR affinity and wiring and the T cell and innate signals experienced by B cells during activation. If so our ability to rationally manipulate B cell responses to develop vaccines against infectious diseases and therapies for autoimmune diseases and B cell cancers may be greatly accelerated by gaining a detailed understanding of the fundamentals of B cell biology and translating this knowledge to clinical and basic research addressing the most pressing public health priorities of our times in acute and chronic infectious diseases, autoimmunity and B cell malignancies.
View Meeting Program
Scholarships/Awards
Burroughs Wellcome Fund ECITA Scholarship Recipients
Mohamed Khass
Western Michigan University, USA
Haolin Liu
National Jewish Health, USA
Keystone Symposia Donor Funds Scholarship Recipients
Cherrelle Dacon
National Institutes of Health, USA
National Institute of Allergy and Infectious Diseases (NIAID) Scholarship Recipients
Cristian G. Beccaria
San Raffaele Scientific Institute, San Raffaele Hospital, Italy
Laurine Binet
University of Aix-Marseille, France
Jaime L. Chao
University of Washington, USA
Renan Villanova Homem de Carvalho
Rockefeller University, USA
Lachlan P. Deimel
University of Oxford, UK
Raul Fernando Reyes-Huerta
Universidad Nacional Autonoma de Mexico, Mexico
Christopher Risley
UAB, USA
Ellen Shrock
Harvard University, USA
Clara Young
Garvan Institute, Australia
Stephanie Watts Scholarship Recipients
Christopher Jondle
Western Michigan University Homer Stryker M.D. School of Medicine, USA
Keystone Symposia Global Health Travel Award Recipients, funded by the Bill & Melinda Gates Foundation
Makka Adam
Yirgalem Hospital Medical college, Ethiopia
Laura Almada
CIBICI-Universidad Nacional De Cordoba, Argentina
Yamila Natali Gazzoni
CIBICI, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, Argentina
Sanjeev Kumar
International Center for Genetic Engineering and Biotechnology, India
Thanh Hoa Le
Institute of Biotechnology, Vietnam Academy of Science and Technology, Vietnam
Ricardo Luís Louzada da Silva
Federal University of Sergipe, Brazil
Adedayo Olubunmi Makinde
University of Ibadan, Nigeria
Jose Luis Maravillas-Montero
Universidad Nacional Autónoma de México, Mexico
Lamech Malagho Mwapagha
Namibia University of Science and Technology, Namibia
Kaustuv Nayak
International Centre for Genetic Engineering and Biotechnology, India
Olawunmi Rashidat Oyerinde
Mountain Top University, Nigeria
Anna Julia Pietrobon
University of Sao Paulo, Brazil
Kittikorn Wangriatisak
Mahidol University, Thailand