Santa Fe Community Convention Center Floorplan
This meeting took place in 2020
Here are the related meetings in 2024:
Cardiometabolic Diseases: The Role of Ethnic Diversity in Precision Medicine (X3)
For a complete list of the meetings for the upcoming/current season, see our meeting list, or search for a meeting.
Diabetes: Glucose Control and Beyond (J5)
Organizer(s) Alan D. Attie and Deborah M. Muoio
January 27—31, 2020
Santa Fe Community Convention Center • Santa Fe, NM USA
Discounted Abstract Deadline: Oct 2, 2019
Abstract Deadline: Oct 30, 2019
Scholarship Deadline: Oct 2, 2019
Discounted Registration Deadline: Dec 3, 2019
Sponsored by Novo Nordisk A/S
Joint Meeting:
Islet Biology: From Gene to Cell to Micro-Organ (J6)
Summary of Meeting:
Modern technology has created a favorable climate for the “perfect metabolic storm”. Triggered by lifestyle habits that promote overnutrition and inactivity, Westernized societies are experiencing epidemic rates of obesity and its attendant co-morbidities. Foremost among these is type 2 diabetes mellitus, which is projected to reach a global prevalence of 10% by the year 2045. This grim epidemiological forecast has inspired intense efforts to unravel the molecular mechanisms that link positive energy balance to glucose intolerance and metabolic decline. This conference will assemble international leaders and rising stars in diverse biomedical disciplines with common interests in understanding and combatting cardiometabolic diseases. The program showcases new insights into the molecular underpinnings of obesity-induced dysfunction of the major peripheral organs that coordinate energy flux and glucose control: skeletal and cardiac muscles, the pancreas, adipose tissue, the liver and gut. Thematic emphasis will center on nutrient sensing and signaling, inter-organ crosstalk, mechanisms of insulin resistance, mitochondrial bioenergetics, islet biology and genetics of diabetes. A major goal of the conference is to provide a forum that encourages interactions between basic and translational scientists at all career levels to critically evaluate recent advances and current controversies. Opportunities for interdisciplinary interactions will be further enhanced by the concurrent meeting on Islet Biology: From Gene to Cell to Micro-Organ, which will consider metabolism in relation to islet function, in addition to studies of islet cell plasticity and differentiation.
View Scholarships/Awards
Modern technology has created a favorable climate for the “perfect metabolic storm”. Triggered by lifestyle habits that promote overnutrition and inactivity, Westernized societies are experiencing epidemic rates of obesity and its attendant co-morbidities. Foremost among these is type 2 diabetes mellitus, which is projected to reach a global prevalence of 10% by the year 2045. This grim epidemiological forecast has inspired intense efforts to unravel the molecular mechanisms that link positive energy balance to glucose intolerance and metabolic decline. This conference will assemble international leaders and rising stars in diverse biomedical disciplines with common interests in understanding and combatting cardiometabolic diseases. The program showcases new insights into the molecular underpinnings of obesity-induced dysfunction of the major peripheral organs that coordinate energy flux and glucose control: skeletal and cardiac muscles, the pancreas, adipose tissue, the liver and gut. Thematic emphasis will center on nutrient sensing and signaling, inter-organ crosstalk, mechanisms of insulin resistance, mitochondrial bioenergetics, islet biology and genetics of diabetes. A major goal of the conference is to provide a forum that encourages interactions between basic and translational scientists at all career levels to critically evaluate recent advances and current controversies. Opportunities for interdisciplinary interactions will be further enhanced by the concurrent meeting on Islet Biology: From Gene to Cell to Micro-Organ, which will consider metabolism in relation to islet function, in addition to studies of islet cell plasticity and differentiation.
View Scholarships/Awards
No registration fees are used to fund entertainment or alcohol at this conference
The meeting will begin on Monday, January 27 with registration from 16:00 to 20:00 and a welcome mixer from 18:00 to 20:00. Conference events conclude on Friday, January 31 with a closing plenary session from 17:00 to 19:00, followed by a social hour and entertainment. We recommend return travel on Saturday, February 1 in order to fully experience the meeting.
MONDAY, JANUARY 27
TUESDAY, JANUARY 28
WEDNESDAY, JANUARY 29
THURSDAY, JANUARY 30
FRIDAY, JANUARY 31
SATURDAY, FEBRUARY 1
Conference Program Print | View meeting in 12 hr (am/pm) time
The meeting will begin on Monday, January 27 with registration from 16:00 to 20:00 and a welcome mixer from 18:00 to 20:00. Conference events conclude on Friday, January 31 with a closing plenary session from 17:00 to 19:00, followed by a social hour and entertainment. We recommend return travel on Saturday, February 1 in order to fully experience the meeting.
MONDAY, JANUARY 27
18:00—20:00
Welcome Mixer
No registration fees are used to fund alcohol served at this function.
08:00—09:00
Welcome and Keynote Address (Joint)
*
Patrick MacDonald,
University of Alberta, Canada
Session Chair
Session Chair
*
Alan D. Attie,
University of Wisconsin-Madison, USA
Session Chair
Session Chair
Morris J. Birnbaum,
Retired Pfizer, Inc., USA
The Development of Therapeutics for T2DM and Related Diseases
The Development of Therapeutics for T2DM and Related Diseases
09:00—11:30
All About Insulin: Signaling, Secretion, and Action (Joint)
*
Patrick MacDonald,
University of Alberta, Canada
Session Chair
Session Chair
*
Barbara B. Kahn,
Beth Israel Deaconess Medical Center, Harvard Medical School, USA
Session Chair
Session Chair
Michael P. Czech,
University of Massachusetts Medical School, USA
Molecular Mechanisms of Insulin Resistance
Molecular Mechanisms of Insulin Resistance
Coffee Break
Maureen Anne Gannon,
Vanderbilt University Medical Center, USA
Promoting β-cell Survival and Preserving Functional β-cell Mass by Targeting PGE2 Receptors
Promoting β-cell Survival and Preserving Functional β-cell Mass by Targeting PGE2 Receptors
Morris F. White,
Boston Children's Hospital, Harvard Medical School, USA
The Systemic Integration of Hepatic Insulin Resistance
The Systemic Integration of Hepatic Insulin Resistance
Arya Mani,
Yale University, USA
Short Talk: Mutations in the Cela2a Gene Unravel the Function of the Encoded Protein as a Novel Incretin
Short Talk: Mutations in the Cela2a Gene Unravel the Function of the Encoded Protein as a Novel Incretin
Amelia K. Linnemann,
Indiana University School of Medicine, USA
Short Talk: IFN-alpha Mediates Heterogenous ROS Accumulation in Human Islet Beta-Cells
Short Talk: IFN-alpha Mediates Heterogenous ROS Accumulation in Human Islet Beta-Cells
14:30—15:30
Workshop: Therapeutic Strategies for Targeting Insulin Action
*
Silvia Corvera,
University of Massachusetts Medical School, USA
Session Chair
Session Chair
Thiago M. Batista,
Joslin Diabetes Center, USA
Dissection of Protein Phosphorylation Networks Underlying Muscle Insulin Resistance in Type 2 Diabetes
Dissection of Protein Phosphorylation Networks Underlying Muscle Insulin Resistance in Type 2 Diabetes
Jaroslawna Meister,
NIDDK, National Institutes of Health, USA
Role of β2-adrenergic Receptor Signaling in Skeletal Muscle Glucose Metabolism
Role of β2-adrenergic Receptor Signaling in Skeletal Muscle Glucose Metabolism
Paul M. Titchenell,
University of Pennsylvania, USA
Regulation of Skeletal Muscle Metabolism by Insulin Signaling
Regulation of Skeletal Muscle Metabolism by Insulin Signaling
Jacqueline Stoeckli,
University of Sydney, Australia
ABHD15: A Novel Player in Insulin Regulation of Lipolysis in Adipocytes
ABHD15: A Novel Player in Insulin Regulation of Lipolysis in Adipocytes
14:30—16:30
Workshop 1: What Do GWAS Genes Do in Islets?
*
Karen L. Mohlke,
University of North Carolina at Chapel Hill, USA
Session Chair
Session Chair
*
James D. Johnson,
University of British Columbia, Canada
Session Chair
Session Chair
Joseph Angleson,
University of Denver, USA
Melanocortin Receptor-4 Regulates α-Cell Function and the Counter-Regulatory Response to Insulin-Induced Hypoglycemia in Mice
Melanocortin Receptor-4 Regulates α-Cell Function and the Counter-Regulatory Response to Insulin-Induced Hypoglycemia in Mice
Malin Fex,
Lund University, Sweden
Loss of Melatonin Type 1A Receptor Results in Dysregulated Whole-Body Metabolism Characterised by Hyperglucagonemia, Glucose Intolerance and Enhanced Insulin Secretion
Loss of Melatonin Type 1A Receptor Results in Dysregulated Whole-Body Metabolism Characterised by Hyperglucagonemia, Glucose Intolerance and Enhanced Insulin Secretion
YongKyung Kim,
University of Colorado Anschutz Medical Campus, USA
PTPN2 Plays a Novel Role in the Beta Cells to Regulate Mitochondrial Function in Type 1 Diabetes Progression
PTPN2 Plays a Novel Role in the Beta Cells to Regulate Mitochondrial Function in Type 1 Diabetes Progression
Taiyi Kuo,
Columbia University, USA
Identification of C2CD4A as a Human Diabetes Susceptibility Gene with a Role in β-Cell Insulin Secretion
Identification of C2CD4A as a Human Diabetes Susceptibility Gene with a Role in β-Cell Insulin Secretion
Haopeng Lin,
Alberta Diabetes Institute, Canada
SENP1 in Compensation and Failure of Insulin Secretion with High-Fat Diet
SENP1 in Compensation and Failure of Insulin Secretion with High-Fat Diet
Dapeng Yang,
Memorial Sloan Kettering Cancer Center, USA
Sequential CRISPR Screening Uncovers a Novel Role of HHEX in Specifying Human Pancreatic Differentiation
Sequential CRISPR Screening Uncovers a Novel Role of HHEX in Specifying Human Pancreatic Differentiation
Taylor S. Morriseau,
University of Manitoba, Canada
New Insights into the HNF-1αG319S Variant in Early-Onset T2D Among Manitoba Indigenous Youth
New Insights into the HNF-1αG319S Variant in Early-Onset T2D Among Manitoba Indigenous Youth
15:30—16:30
Panel Discussion
*
David E. James,
University of Sydney, Australia
Session Chair
Session Chair
*
Deborah M. Muoio,
Duke University Medical Center, USA
Session Chair
Session Chair
Morris J. Birnbaum,
Retired Pfizer, Inc., USA
Michael P. Czech,
University of Massachusetts Medical School, USA
Peter A. Crawford,
University of Minnesota, USA
Daniel P. Kelly,
University of Pennsylvania, USA
Barbara B. Kahn,
Beth Israel Deaconess Medical Center, Harvard Medical School, USA
17:00—19:00
Novel Approaches for Monitoring Carbon Traffic Control
*
Peter A. Crawford,
University of Minnesota, USA
Session Chair
Session Chair
Joshua D. Rabinowitz,
Princeton University, USA
Isotope Tracing for Deciphering Metabolic Network Usage
Isotope Tracing for Deciphering Metabolic Network Usage
David H. Wasserman,
Vanderbilt University School of Medicine, USA
Extramyocellular Barriers to Insulin-Stimulated Muscle Glucose Uptake
Extramyocellular Barriers to Insulin-Stimulated Muscle Glucose Uptake
Barbara M. Bakker,
University Medical Center Groningen, Netherlands
Modeling for Young and Old: Tackling the Complexity of Fatty Acid Oxidation in Metabolic Disease
Modeling for Young and Old: Tackling the Complexity of Fatty Acid Oxidation in Metabolic Disease
Maciek R. Antoniewicz,
University of Delaware, USA
Short Talk: Metabolite Cross-Feeding Interactions in Adipocyte-Hepatocyte Co-Cultures Elucidated with a Novel 13C-Metabolic Flux Analysis Technique
Short Talk: Metabolite Cross-Feeding Interactions in Adipocyte-Hepatocyte Co-Cultures Elucidated with a Novel 13C-Metabolic Flux Analysis Technique
Jose M. Orozco,
Massachusetts Institute of Technology, USA
Short Talk: Dihydroxyacetone Phosphate Signals Glucose Availability to mTORC1
Short Talk: Dihydroxyacetone Phosphate Signals Glucose Availability to mTORC1
17:00—19:00
Islet Plasticity
*
Jean Buteau,
University of Alberta, Canada
Session Chair
Session Chair
*
Bridget Wagner,
Broad Institute, USA
Session Chair
Session Chair
George K. Gittes,
Children's Hospital of Pittsburgh of UPMC, USA
Beta Cell Neogenesis and Protection
Beta Cell Neogenesis and Protection
Julie B. Sneddon,
University California, San Francisco, USA
Elucidating Human Endocrine Cell Fate Selection
Elucidating Human Endocrine Cell Fate Selection
Seung K. Kim,
Stanford University, USA
Alternative Systems to Study Pancreatic Islet Development and Function
Alternative Systems to Study Pancreatic Islet Development and Function
Christine A. Beamish,
Houston Methodist Research Institute, USA
Short Talk: Loss of Endocrine Cell Identity Correlates with Pre-Surgical HOMA-β in Patients with Chronic Pancreatitis Undergoing Islet Auto-Transplantation
Short Talk: Loss of Endocrine Cell Identity Correlates with Pre-Surgical HOMA-β in Patients with Chronic Pancreatitis Undergoing Islet Auto-Transplantation
Mathieu Latreille,
Imperial College London, UK
Short Talk: Beta-Cell Dedifferentiation Is Associated with Epithelial-Mesenchymal Transition In Diabetes
Short Talk: Beta-Cell Dedifferentiation Is Associated with Epithelial-Mesenchymal Transition In Diabetes
08:00—11:00
Ketones and Ketogenesis; Super-Fuel or Nuclear Signal?
*
Judith A. Simcox,
University of Wisconsin - Madison, USA
Session Chair
Session Chair
Richard Veech,
NIAAA, National Institutes of Health, USA
The Effects of Ketone Body Metabolism on the Great Controlling Nucleotide Couples and their Application to Common Diseases
The Effects of Ketone Body Metabolism on the Great Controlling Nucleotide Couples and their Application to Common Diseases
Peter A. Crawford,
University of Minnesota, USA
Tracing the Role of Intrahepatic Ketone Turnover in Fatty Liver Disease
Tracing the Role of Intrahepatic Ketone Turnover in Fatty Liver Disease
Coffee Break
Justin Lengfeld,
University of Minnesota, USA
Short Talk: Chronic Low-Dose Ethanol Intake Exacerbates High-Fat Diet Induced Hepatic Fibrosis
Short Talk: Chronic Low-Dose Ethanol Intake Exacerbates High-Fat Diet Induced Hepatic Fibrosis
Meilian Liu,
University of New Mexico Health Sciences Center, USA
Short Talk: Adipocyte COX-2/PGE2 Pathway is Required for Intermittent Fasting-Induced Treg Development and Improvement of Insulin Sensitivity
Short Talk: Adipocyte COX-2/PGE2 Pathway is Required for Intermittent Fasting-Induced Treg Development and Improvement of Insulin Sensitivity
08:00—11:15
Visualizing Islet Function in vitro, in situ, and in vivo
*
Amelia K. Linnemann,
Indiana University School of Medicine, USA
Session Chair
Session Chair
*
Wen-hong Li,
UTSW Medical Ctr, USA
Session Chair
Session Chair
Sebastian Barg,
Uppsala University, Sweden
Exocytosis of Insulin and Glucagon Granules in Type-2 Diabetes
Exocytosis of Insulin and Glucagon Granules in Type-2 Diabetes
Joana Almaca,
University of Miami, USA
Control of Islet Hormone Secretion by Vascular Pericytes
Control of Islet Hormone Secretion by Vascular Pericytes
Coffee Break
Robin A. Kimmel,
University Innsbruck, Austria
In Vivo Imaging of Pancreatic Islet Morphogenesis in Zebrafish
In Vivo Imaging of Pancreatic Islet Morphogenesis in Zebrafish
Yu Hsuan Carol Yang,
Max Planck Institute for Heart and Lung Research, Germany
Short Talk: Innervation Modulates the Functional Connectivity between Pancreatic Endocrine Cells
Short Talk: Innervation Modulates the Functional Connectivity between Pancreatic Endocrine Cells
Nicole Hallahan,
University of Sydney, Australia
Short Talk: Reconstruction of the Polar Domains of Pancreatic Beta-Cells Affects Synaptic Protein Localisation and GSIS
Short Talk: Reconstruction of the Polar Domains of Pancreatic Beta-Cells Affects Synaptic Protein Localisation and GSIS
Barak Blum,
University of Wisconsin, USA
Short Talk: Roundabout Receptors Regulate Three-Dimensional Architecture and Facilitate Synchronized Ca2+ Oscillations In Vivo in the Islet of Langerhans
Short Talk: Roundabout Receptors Regulate Three-Dimensional Architecture and Facilitate Synchronized Ca2+ Oscillations In Vivo in the Islet of Langerhans
17:00—19:00
Supercomplexities of Mitochondrial Dynamics and Bioenergetics
*
Dave Pagliarini,
Washington University in St. Louis, USA
Session Chair
Session Chair
Jared Rutter,
University of Utah, USA
Metabolism and Cellular Decisions
Metabolism and Cellular Decisions
Orian S. Shirihai,
University of California, Los Angeles, USA
Mitochondrial Heterogeneity in the Adipocyte
Mitochondrial Heterogeneity in the Adipocyte
Deborah M. Muoio,
Duke University Medical Center, USA
Understanding and Preventing Lipid-Induced Mitochondrial Stress
Understanding and Preventing Lipid-Induced Mitochondrial Stress
Ayon Ibrahim,
University of Pennsylvania, USA
Short Talk: Mitochondrial ATP Production Drives Endothelial Fatty Acid Uptake and Transport
Short Talk: Mitochondrial ATP Production Drives Endothelial Fatty Acid Uptake and Transport
Heather A. Lawson,
Washington University in St. Louis, USA
Short Talk: Natural Brown Adipose Expansion and Remission of Hyperglycemia in Obese SM/J Mice
Short Talk: Natural Brown Adipose Expansion and Remission of Hyperglycemia in Obese SM/J Mice
17:00—19:00
Molecular and Functional Analysis of Islet Cell Heterogeneity
*
Claes B. Wollheim,
University of Geneva Medical Centre, Switzerland
Session Chair
Session Chair
*
Maureen Anne Gannon,
Vanderbilt University Medical Center, USA
Session Chair
Session Chair
Wen-hong Li,
UTSW Medical Ctr, USA
Functional Heterogeneity of Islet beta Cells
Functional Heterogeneity of Islet beta Cells
Anna Martinez Casals,
Science for Life Laboratories, Sweden
Single Cell Protein Variability in Pancreas by CODEX Highly-Multiplexed Imaging
Single Cell Protein Variability in Pancreas by CODEX Highly-Multiplexed Imaging
James C. Lo,
Weill Cornell Medicine, USA
Short Talk: Adipsin Blocks Beta Cell Failure in Diabetic Mice and Associates with Protection from Diabetes in Humans
Short Talk: Adipsin Blocks Beta Cell Failure in Diabetic Mice and Associates with Protection from Diabetes in Humans
Lydia Amanda Farack,
Weizmann Institute of Science, Israel
Short Talk: Transcriptional Heterogeneity of Beta Cells in the Intact Pancreas Reveals Division of Labor between ‘Basal Secretor' Extreme Beta Cells and ‘Glucose Responder' Non-Extreme Beta Cells
Short Talk: Transcriptional Heterogeneity of Beta Cells in the Intact Pancreas Reveals Division of Labor between ‘Basal Secretor' Extreme Beta Cells and ‘Glucose Responder' Non-Extreme Beta Cells
19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
08:00—11:00
Molecules Mediating Tissue Crosstalk
*
Mark A. Herman,
Duke University Medical Center, USA
Session Chair
Session Chair
Mark A. Febbraio,
Monash Institute of Pharmaceutical Sciences, Australia
Extracellular Vesicles Mediating Cross-Talk during Exercise
Extracellular Vesicles Mediating Cross-Talk during Exercise
Coffee Break
Judith A. Simcox,
University of Wisconsin - Madison, USA
Role of Acylcarnitines as Peripheral Metabolic Signals
Role of Acylcarnitines as Peripheral Metabolic Signals
Barbara B. Kahn,
Beth Israel Deaconess Medical Center, Harvard Medical School, USA
Lipokines as Nutrient Sensors and Signals
Lipokines as Nutrient Sensors and Signals
Silvia Corvera,
University of Massachusetts Medical School, USA
Short Talk: A Placenta to Adipose Tissues Signaling Axis Controls IGF-1 Availability and Insulin Sensitivity in Pregnancy
Short Talk: A Placenta to Adipose Tissues Signaling Axis Controls IGF-1 Availability and Insulin Sensitivity in Pregnancy
Peter K. Jackson,
Stanford University, USA
Short Talk: Omega-3 Fatty Acids Activate Ciliary FFAR4/GPR120 to Trigger cAMP-Dependent Differentiation of Preadipocytes
Short Talk: Omega-3 Fatty Acids Activate Ciliary FFAR4/GPR120 to Trigger cAMP-Dependent Differentiation of Preadipocytes
08:00—11:15
Stem Cells and Micro-Organs
*
Malin Fex,
Lund University, Sweden
Session Chair
Session Chair
*
Jochen Lang,
Université de Bordeaux, France
Session Chair
Session Chair
Jennifer E. Bruin,
Carleton University, Canada
Environmental Toxins and Embryonic Pancreas Development
Environmental Toxins and Embryonic Pancreas Development
Burcak Yesildag,
InSphero AG, Switzerland
Biomimetic Microtissues: Novel Methods for Studying Islet Biology in Health and Disease
Biomimetic Microtissues: Novel Methods for Studying Islet Biology in Health and Disease
Coffee Break
Anne Grapin-Botton,
University of Copenhagen, Denmark
Three Dimensional Models of Human Pancreas Organogenesis to Understand Diabetes
Three Dimensional Models of Human Pancreas Organogenesis to Understand Diabetes
Mark D. Ungrin,
University of Calgary, Canada
Generation and Characterization of Human Pseudoislets
Generation and Characterization of Human Pseudoislets
Phillip L. Lewis,
Cincinnati Children's Hospital Medical Center, USA
Short Talk: Development of a Fluidic Platform to Study Insulin Secretion from Pluripotent Stem Cell-Derived Human Insulin-Secreting Cells
Short Talk: Development of a Fluidic Platform to Study Insulin Secretion from Pluripotent Stem Cell-Derived Human Insulin-Secreting Cells
Ali Hasan Shilleh,
University of Colorado, Anschutz Medical Campus, Barbara Davis Center, USA
Short Talk: Determining the Fate of Stem Cell Derived Pancreatic β-like Cells (sBCs) Upon Transplantation Using Genetic Lineage Tracing
Short Talk: Determining the Fate of Stem Cell Derived Pancreatic β-like Cells (sBCs) Upon Transplantation Using Genetic Lineage Tracing
Katharina Scheibner,
Helmholtz Zentrum Munich, Germany
Short Talk: New Approaches to Produce Beta Cells from Human Stem Cells
Short Talk: New Approaches to Produce Beta Cells from Human Stem Cells
17:00—19:00
Gut Control of Metabolism
*
Kristina Schoonjans,
École Polytechnique Fédérale de Lausanne – EPFL, Switzerland
Session Chair
Session Chair
Darleen A. Sandoval,
University of Colorado, USA
Using Bariatric Surgery to Understand the Regulatory Role of the Gut in Metabolism
Using Bariatric Surgery to Understand the Regulatory Role of the Gut in Metabolism
Mark A. Herman,
Duke University Medical Center, USA
Molecular Aspects of Fructose-Induced Metabolic Dysregulation
Molecular Aspects of Fructose-Induced Metabolic Dysregulation
Eric Yen,
University of Wisconsin-Madison, USA
Intestinal Lipid Processing and Pancreatic Islet Function: A Gut Reaction?
Intestinal Lipid Processing and Pancreatic Islet Function: A Gut Reaction?
Marc Liesa,
University of California, Los Angeles, USA
Short Talk: Mitochondrial ABCB10 Increases Bilirubin Actions on the Redox State to Promote Insulin Resistance and Steatosis in Liver
Short Talk: Mitochondrial ABCB10 Increases Bilirubin Actions on the Redox State to Promote Insulin Resistance and Steatosis in Liver
Sophie L. Lewandowski,
University of Wisconsin-Madison, USA
Short Talk: Additive Effects of β-Cell Pyruvate Kinase Activation and GLP-1 Receptor Signaling on Insulin Secretion
Short Talk: Additive Effects of β-Cell Pyruvate Kinase Activation and GLP-1 Receptor Signaling on Insulin Secretion
17:00—19:00
Inflammation, Killing, and Islet Dysfunction
*
Bruce Verchere,
University of British Columbia, Canada
Session Chair
Session Chair
*
Rebecca Hull,
University of Washington, USA
Session Chair
Session Chair
Anette-Gabriele Ziegler,
Helmholtz Zentrum München, Germany
Islet Autoimmunity
Islet Autoimmunity
Irina Maria Stefana,
University of Oxford, UK
Hyperphosphorylated Tau is Expressed in Human Pancreatic Islets and Accumulates in the β-cell Cytoplasm during Ageing
Hyperphosphorylated Tau is Expressed in Human Pancreatic Islets and Accumulates in the β-cell Cytoplasm during Ageing
Rebecca Hull,
University of Washington, USA
Islet Inflammation in CFRD
Islet Inflammation in CFRD
Mollie Huber,
University of Florida, USA
Short Talk: Investigating Type 1 Diabetes Pathogenesis Using Live Pancreas Tissue Slices
Short Talk: Investigating Type 1 Diabetes Pathogenesis Using Live Pancreas Tissue Slices
Diane C. Saunders,
Vanderbilt University Medical Center, USA
Short Talk: Macrophages Are a Prominent Immune Cell Population in the Developing Human Pancreas
Short Talk: Macrophages Are a Prominent Immune Cell Population in the Developing Human Pancreas
19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
08:00—09:00
Keynote Address (Joint)
*
Maureen Anne Gannon,
Vanderbilt University Medical Center, USA
Session Chair
Session Chair
*
Anna L. Gloyn,
Stanford University, USA
Session Chair
Session Chair
Maike Sander,
University of California, San Diego, USA
Metabolic Influences on Pancreatic Beta Cells
Metabolic Influences on Pancreatic Beta Cells
09:00—11:30
Genetics/Genomics of T2D (Joint)
*
Maureen Anne Gannon,
Vanderbilt University Medical Center, USA
Session Chair
Session Chair
*
Anna L. Gloyn,
Stanford University, USA
Unravelling Mechanisms for Pancreatic Islet Dysfunction from GWAS
Unravelling Mechanisms for Pancreatic Islet Dysfunction from GWAS
Coffee Break
Karen L. Mohlke,
University of North Carolina at Chapel Hill, USA
Adipose Tissue Genomics and Type 2 Diabetes
Adipose Tissue Genomics and Type 2 Diabetes
Marcus M. Seldin,
University of California, Irvine, USA
Short Talk: Systems Genetics Approaches to Dissect Inter-tissue Communication
Short Talk: Systems Genetics Approaches to Dissect Inter-tissue Communication
Christopher Emfinger,
University of Wisconsin-Madison, USA
Short Talk: Zfp148 Regulates a Transcriptional Network Suppressing Insulin Secretion
Short Talk: Zfp148 Regulates a Transcriptional Network Suppressing Insulin Secretion
14:30—16:30
Workshop 2: The Human Islet Research Network - Human Pancreas Analysis Programs
*
Marcela Brissova,
Vanderbilt University, USA
Session Chair
Session Chair
*
Nicolai M. Doliba,
University of Pennsylvania, USA
Session Chair
Session Chair
Catherine Lee May,
University of Pennsylvania, USA
The Human Pancreas Analysis Program – Type 1 Diabetes
The Human Pancreas Analysis Program – Type 1 Diabetes
Alvin C. Powers,
Vanderbilt University School of Medicine, USA
The Human Pancreas Analysis Program - Type 2 Diabetes
The Human Pancreas Analysis Program - Type 2 Diabetes
Xiaoqing Dai,
University of Alberta, Canada
Pancreatic α-cell Function and Identity in Type 1 Diabetes Mellitus
Pancreatic α-cell Function and Identity in Type 1 Diabetes Mellitus
Matthew Haemmerle,
University of Pennsylvania, USA
The PCBP RNA Binding Proteins as Post-Transcriptional Regulators of β Cell Identity
The PCBP RNA Binding Proteins as Post-Transcriptional Regulators of β Cell Identity
Tiffany Richardson,
Vanderbilt University, USA
Pancreatic Islet and Exocrine Tissue Innervation is Not Altered in Type 1 Diabetes
Pancreatic Islet and Exocrine Tissue Innervation is Not Altered in Type 1 Diabetes
Rafael Arrojo e Drigo,
The Salk Institute Research Institute, USA
Aging of Human Endocrine Pancreatic Cell Types Is Heterogeneous and Sex-Specific
Aging of Human Endocrine Pancreatic Cell Types Is Heterogeneous and Sex-Specific
17:00—18:45
From Systems Biology to Metabolic Physiology
*
Barbara M. Bakker,
University Medical Center Groningen, Netherlands
Session Chair
Session Chair
Kristina Schoonjans,
École Polytechnique Fédérale de Lausanne – EPFL, Switzerland
Emerging Roles of Bile Acid Signaling in Metabolism and Stemness
Emerging Roles of Bile Acid Signaling in Metabolism and Stemness
Dave Pagliarini,
Washington University in St. Louis, USA
Regulation of Mitochondrial Metabolism by Reversible Phosphorylation
Regulation of Mitochondrial Metabolism by Reversible Phosphorylation
David E. James,
University of Sydney, Australia
The Role of Reactive Oxygen Species in Insulin Resistance
The Role of Reactive Oxygen Species in Insulin Resistance
Takumi Kitamoto,
Columbia University, USA
Short Talk: The Genomic Architecture of the FoxO1 Response to Fasting and Refeeding in Liver
Short Talk: The Genomic Architecture of the FoxO1 Response to Fasting and Refeeding in Liver
17:00—18:45
Novel Approaches to Single Cell Biology
*
Mathieu Latreille,
Imperial College London, UK
Session Chair
Session Chair
*
Julie B. Sneddon,
University California, San Francisco, USA
Session Chair
Session Chair
Heiko Lickert,
Institute of Diabetes and Regeneration, Germany
Deciphering Mechanisms of β-Cell Failure and Regeneration by Single Cell RNA Sequencing
Deciphering Mechanisms of β-Cell Failure and Regeneration by Single Cell RNA Sequencing
Diego Balboa,
Centre for Genomic Regulation, Spain
Improving Diabetes Disease Modelling with Single Cell RNA Sequencing of Stem Cell Derived Pancreatic Cells
Improving Diabetes Disease Modelling with Single Cell RNA Sequencing of Stem Cell Derived Pancreatic Cells
Patrick MacDonald,
University of Alberta, Canada
Connecting Single-Cell Function and Transcriptomics
Connecting Single-Cell Function and Transcriptomics
Rachel E. Jennings,
University of Manchester, UK
Short Talk: A Single Cell Atlas of the Developing Human Pancreas
Short Talk: A Single Cell Atlas of the Developing Human Pancreas
19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
20:00—23:00
Entertainment
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.
*Session Chair †Invited, not yet responded.
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If your organization is interested in joining these entities in support of Keystone
Symposia, please contact: John Monson,
Director of Corporate Relations, Email: johnm@keystonesymposia.org, Phone:+1 970-262-2690 Click here for more information on Industry Support and Recognition Opportunities. If you are interested in becoming an advertising/marketing in-kind partner, please contact: Josh May, Director, Technology and Digital Media, Email: joshuam@keystonesymposia.org, Phone:+1 970-262-1179 |