Granlibakken Tahoe Floorplan
This meeting took place in 2020
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The Global Virome in Health and Disease (C1)
Organizer(s) David Wang, Frederic D. Bushman and Mya Breitbart
March 1—4, 2020
Granlibakken Tahoe • Tahoe City, CA USA
Discounted Abstract Deadline: Oct 30, 2019
Abstract Deadline: Nov 21, 2019
Scholarship Deadline: Oct 30, 2019
Discounted Registration Deadline: Dec 19, 2019
Supported by the Directors' Fund
Summary of Meeting:
Viruses are the most abundant biological entities on earth, but only recently has it been possible to define the full virome in humans, animals, plants and global environments. Virome signatures have been associated with diverse conditions such as HIV/AIDS, inflammatory bowel disease, malnutrition, graft versus host disease, organ transplantation, and type 1 diabetes, providing novel insights into mechanisms of pathogenesis. Recently, various beneficial roles of the virome have also been identified, thereby broadening our understanding of the commensal microbiome. However, despite these advances, the vast majority of the virome remains undiscovered, and thus many associations with health and disease have yet to be identified. The goals of this conference are to examine the state-of-the art in virome studies, including efforts to define the virome, establish linkages with health and disease, understand interactions between viral and bacterial components of the microbiome, exploit new model systems, and identify mechanisms of immune control. This will be the first conference dedicated solely to the virome, bringing together experts in eukaryotic virology, phage biology, genomics, informatics, public health, model organisms, and immunology. This conference will bridge the distinct research communities that study bacterial and eukaryotic viruses and unify host-based and environmental research frameworks to allow potent new synergies.
View Scholarships/Awards
Viruses are the most abundant biological entities on earth, but only recently has it been possible to define the full virome in humans, animals, plants and global environments. Virome signatures have been associated with diverse conditions such as HIV/AIDS, inflammatory bowel disease, malnutrition, graft versus host disease, organ transplantation, and type 1 diabetes, providing novel insights into mechanisms of pathogenesis. Recently, various beneficial roles of the virome have also been identified, thereby broadening our understanding of the commensal microbiome. However, despite these advances, the vast majority of the virome remains undiscovered, and thus many associations with health and disease have yet to be identified. The goals of this conference are to examine the state-of-the art in virome studies, including efforts to define the virome, establish linkages with health and disease, understand interactions between viral and bacterial components of the microbiome, exploit new model systems, and identify mechanisms of immune control. This will be the first conference dedicated solely to the virome, bringing together experts in eukaryotic virology, phage biology, genomics, informatics, public health, model organisms, and immunology. This conference will bridge the distinct research communities that study bacterial and eukaryotic viruses and unify host-based and environmental research frameworks to allow potent new synergies.
View Scholarships/Awards
No registration fees are used to fund entertainment or alcohol at this conference
The meeting will begin on Sunday, March 1 with registration from 16:00 to 20:00 and a welcome mixer and light meal from 18:00 to 20:00. Conference events conclude on Wednesday, March 4 with a closing plenary session from 17:00 to 19:00, followed by dinner and entertainment. We recommend return travel on Thursday, March 5 in order to fully experience the meeting.
SUNDAY, MARCH 1
MONDAY, MARCH 2
TUESDAY, MARCH 3
WEDNESDAY, MARCH 4
THURSDAY, MARCH 5
Conference Program Print | View meeting in 12 hr (am/pm) time
The meeting will begin on Sunday, March 1 with registration from 16:00 to 20:00 and a welcome mixer and light meal from 18:00 to 20:00. Conference events conclude on Wednesday, March 4 with a closing plenary session from 17:00 to 19:00, followed by dinner and entertainment. We recommend return travel on Thursday, March 5 in order to fully experience the meeting.
SUNDAY, MARCH 1
18:00—20:00
Welcome Mixer
No registration fees are used to fund alcohol served at this function.
08:00—09:00
Welcome and Keynote Address
*
David Wang,
Washington University School of Medicine, USA
Session Chair
Session Chair
09:00—11:30
The Global Virome and Beyond
*
Amy Kistler,
Chan Zuckerberg Biohub, USA
Session Chair
Session Chair
Mya Breitbart,
University of South Florida, USA
Deciphering the “Dissolved”: Ecological Roles of Aquatic Viruses
Deciphering the “Dissolved”: Ecological Roles of Aquatic Viruses
Coffee Break
João Trindade Marques,
Universidade Federal de Minas Gerais, Brazil
Short Talk: The Global Virome of Vector Mosquitoes
Short Talk: The Global Virome of Vector Mosquitoes
Adriana Messyasz,
Oregon State University, USA
Short Talk: Metagenomic Analysis of Viral Communities in Bleached and Non-Bleached Coral Tissue Uncovers a Novel Coral Megavirus
Short Talk: Metagenomic Analysis of Viral Communities in Bleached and Non-Bleached Coral Tissue Uncovers a Novel Coral Megavirus
17:00—19:00
Beneficial and Commensal Viromes
*
Evelien M. Adriaenssens,
Quadram Institute Bioscience, UK
Session Chair
Session Chair
Susan M. Lehman,
U.S. Food and Drug Administration, USA
Thinking about Phage Therapy as a Microbial Ecology Puzzle
Thinking about Phage Therapy as a Microbial Ecology Puzzle
Robert Edwards,
San Diego State University, USA
crAssphage: The Most Abundant Virus in the Human Enteric Virome
crAssphage: The Most Abundant Virus in the Human Enteric Virome
Karthik R. Chamakura,
Texas A&M University, USA
Short Talk: The ssRNA Phages as a Source for Peptide Antibiotics
Short Talk: The ssRNA Phages as a Source for Peptide Antibiotics
Cynthia Monaco,
University of Rochester Medical Center, USA
Short Talk: Transkingdom Interactions in the Female Reproductive Tract
Short Talk: Transkingdom Interactions in the Female Reproductive Tract
19:00—20:00
Social Hour
No registration fees are used to fund alcohol served at this function.
08:00—11:00
The Virome in Disease
Frederic D. Bushman,
University of Pennsylvania, USA
The Human Virome in Health and Disease
The Human Virome in Health and Disease
Xavier López,
FISABIO - Public Health and University of Valencia, Spain
Diagnosing Infections by Metagenomics and Uncovering Novel Disease Associations by Interrogation of the Eukaryotic Virome
Diagnosing Infections by Metagenomics and Uncovering Novel Disease Associations by Interrogation of the Eukaryotic Virome
Coffee Break
Eric L. Delwart,
University of California, San Francisco, USA
Koch's Postulates in the Age of Viral Metagenomics
Koch's Postulates in the Age of Viral Metagenomics
Lori R. Holtz,
Washington University, USA
Short Talk: Growth Velocity in Children with Environmental Enteric Dysfunction is Associated with Specific Bacterial and Viral Taxa of the Gastrointestinal Tract in Malawian Children
Short Talk: Growth Velocity in Children with Environmental Enteric Dysfunction is Associated with Specific Bacterial and Viral Taxa of the Gastrointestinal Tract in Malawian Children
Efrem S. Lim,
Arizona State University, USA
Short Talk: Intestinal and Neuronal Inflammation Associated with Virome Alterations in Experimental Gulf War Illness is Reversed by Ribavirin
Short Talk: Intestinal and Neuronal Inflammation Associated with Virome Alterations in Experimental Gulf War Illness is Reversed by Ribavirin
14:30—15:30
Workshop 1: Origins of the Human Virome
*
David Wang,
Washington University School of Medicine, USA
Session Chair
Session Chair
Rabia Maqsood,
Arizona State University, USA
Discordant Transmission of Bacteria and Viruses from Mothers to Babies at Birth
Discordant Transmission of Bacteria and Viruses from Mothers to Babies at Birth
Guanxiang Liang,
University of Pennsylvania, USA
Step-Wise Assembly of the Neonatal Virome Modulated by Breast Feeding
Step-Wise Assembly of the Neonatal Virome Modulated by Breast Feeding
Leen Beller,
KU Leuven / REGA Institute, Belgium
Exploring the Diversity and Dynamics of the Gut Microbiome in Infants in Their First Year of Life
Exploring the Diversity and Dynamics of the Gut Microbiome in Infants in Their First Year of Life
15:30—16:30
Workshop 2: Computational Viromics
*
Robert Edwards,
San Diego State University, USA
Session Chair
Session Chair
Evelien M. Adriaenssens,
Quadram Institute Bioscience, UK
The Importance of Bacteriophage Taxonomy in the Analysis of Gut Virome Data
The Importance of Bacteriophage Taxonomy in the Analysis of Gut Virome Data
J. Rodney Brister,
NLM, National Institutes of Health, USA
How to Find a Virus – a Public Database Story
How to Find a Virus – a Public Database Story
Moreno Zolfo,
University of Trento, Italy
Detection and Meta-Analysis of Non-Viral Contamination in Viromes with ViromeQC
Detection and Meta-Analysis of Non-Viral Contamination in Viromes with ViromeQC
Michael J. Tisza,
NCI, National Institutes of Health, USA
Cenote-Taker2 Democratizes Virus Discovery and Annotation from Metagenomic Data
Cenote-Taker2 Democratizes Virus Discovery and Annotation from Metagenomic Data
17:00—19:00
The Virome in Model Systems
*
Mya Breitbart,
University of South Florida, USA
Session Chair
Session Chair
David Wang,
Washington University School of Medicine, USA
Novel Lessons from the C. elegans Virome
Novel Lessons from the C. elegans Virome
Adrienne M.S. Correa,
Rice University, USA
Viral Reefscapes: Microbial Interactions with Threatened Coral Hosts and Reef Ecosystems
Viral Reefscapes: Microbial Interactions with Threatened Coral Hosts and Reef Ecosystems
Keir M. Balla,
University of Utah, USA
Short Talk: A Widespread Picornavirus Discovered by Visualizing Zebrafish Immune Responses
Short Talk: A Widespread Picornavirus Discovered by Visualizing Zebrafish Immune Responses
Ryan A. Langlois,
University of Minnesota, USA
Short Talk: Innate Immune Barriers to Inter- and Intra-Species Virus Transmission and Evolution
Short Talk: Innate Immune Barriers to Inter- and Intra-Species Virus Transmission and Evolution
19:00—20:00
Social Hour
No registration fees are used to fund alcohol served at this function.
08:00—11:00
Host-Virus Arms Race
*
Frederic D. Bushman,
University of Pennsylvania, USA
Session Chair
Session Chair
Rotem Sorek,
Weizmann Institute of Science, Israel
Remote Presentation: Novel Antiphage Defense Systems
Remote Presentation: Novel Antiphage Defense Systems
Kimberley Seed,
University of California, Berkeley, USA
Bacteriophage-Host Arms Race in Vibrio cholerae
Bacteriophage-Host Arms Race in Vibrio cholerae
Coffee Break
Karen L. Maxwell,
University of Toronto, Canada
Quorum Sensing Inactivation by a Phage Accessory Protein
Quorum Sensing Inactivation by a Phage Accessory Protein
Kate L. Jeffrey,
Moderna and Harvard Medical School, USA
Divergent Immunomodulation by Healthy and Inflammatory Bowel Disease Human Enteric Viromes
Divergent Immunomodulation by Healthy and Inflammatory Bowel Disease Human Enteric Viromes
Moira Dion,
Université Laval, Canada
Short Talk: Optimizing Phage Host Predictions from Viral Metagenomics Using CRISPR Spacers
Short Talk: Optimizing Phage Host Predictions from Viral Metagenomics Using CRISPR Spacers
Kevin Forsberg,
Fred Hutchinson Cancer Research Center, USA
Short Talk: Functional Metagenomics-Guided Discovery of Potent Cas9 Inhibitors in the Human Microbiome
Short Talk: Functional Metagenomics-Guided Discovery of Potent Cas9 Inhibitors in the Human Microbiome
17:00—18:45
Virome-Bacterial Microbiome Interactions
*
Karen L. Maxwell,
University of Toronto, Canada
Session Chair
Session Chair
Paul E. Turner,
Yale University, USA
Remote Presentation: Phage-Bacteria Interactions in the Evolution of Antibacterial Resistance
Remote Presentation: Phage-Bacteria Interactions in the Evolution of Antibacterial Resistance
Megan T. Baldridge,
Washington University School of Medicine, USA
Norovirus Infection, the Gut Microbiota and Interferon Lambda
Norovirus Infection, the Gut Microbiota and Interferon Lambda
Emily F. Wissel,
Emory University, USA
Short Talk: The Vaginal Virome in Self-Identified African American Women Associated with Bacterial Community during Pregnancy and Preterm Birth
Short Talk: The Vaginal Virome in Self-Identified African American Women Associated with Bacterial Community during Pregnancy and Preterm Birth
Paul Kirchberger,
University of Texas, USA
Short Talk: Intraspecific Conflict in Ubiquitous Single-Stranded DNA Phages Is Caused by Hypervariable Genomic Regions
Short Talk: Intraspecific Conflict in Ubiquitous Single-Stranded DNA Phages Is Caused by Hypervariable Genomic Regions
19:00—20:00
Social Hour
No registration fees are used to fund alcohol served at this function.
20:00—23:00
Entertainment
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.
*Session Chair †Invited, not yet responded.
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