Keystone Symposia

Granlibakken Tahoe Floorplan

This meeting took place in 2020



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The Global Virome in Health and Disease (C1)


Organizer(s) David Wang, Frederic D. Bushman and Mya Breitbart
March 1—4, 2020
Granlibakken Tahoe • Tahoe City, CA USA
Discounted Abstract Deadline: Oct 30, 2019
Abstract Deadline: Nov 21, 2019
Scholarship Deadline: Oct 30, 2019
Discounted Registration Deadline: Dec 19, 2019

Supported by the Directors' Fund

Summary of Meeting:
Viruses are the most abundant biological entities on earth, but only recently has it been possible to define the full virome in humans, animals, plants and global environments. Virome signatures have been associated with diverse conditions such as HIV/AIDS, inflammatory bowel disease, malnutrition, graft versus host disease, organ transplantation, and type 1 diabetes, providing novel insights into mechanisms of pathogenesis. Recently, various beneficial roles of the virome have also been identified, thereby broadening our understanding of the commensal microbiome. However, despite these advances, the vast majority of the virome remains undiscovered, and thus many associations with health and disease have yet to be identified. The goals of this conference are to examine the state-of-the art in virome studies, including efforts to define the virome, establish linkages with health and disease, understand interactions between viral and bacterial components of the microbiome, exploit new model systems, and identify mechanisms of immune control. This will be the first conference dedicated solely to the virome, bringing together experts in eukaryotic virology, phage biology, genomics, informatics, public health, model organisms, and immunology. This conference will bridge the distinct research communities that study bacterial and eukaryotic viruses and unify host-based and environmental research frameworks to allow potent new synergies.

View Scholarships/Awards
No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


The meeting will begin on Sunday, March 1 with registration from 16:00 to 20:00 and a welcome mixer and light meal from 18:00 to 20:00. Conference events conclude on Wednesday, March 4 with a closing plenary session from 17:00 to 19:00, followed by dinner and entertainment. We recommend return travel on Thursday, March 5 in order to fully experience the meeting.

SUNDAY, MARCH 1

16:00—20:00
Arrival and Registration

Pre Function
18:00—20:00
Welcome Mixer
No registration fees are used to fund alcohol served at this function.

Granhall
18:00—20:00
Light Meal - Provided by Granlibakken

Granhall

MONDAY, MARCH 2

07:00—08:00
Breakfast

Granhall
08:00—09:00
Welcome and Keynote Address

Mountain/Lake
* David Wang, Washington University School of Medicine, USA
Session Chair

Forest Rohwer, San Diego State University, USA
Phage Behaving Badly and Clinical Workarounds

09:00—11:30
The Global Virome and Beyond

Mountain/Lake
* Amy Kistler, Chan Zuckerberg Biohub, USA
Session Chair

Mya Breitbart, University of South Florida, USA
Deciphering the “Dissolved”: Ecological Roles of Aquatic Viruses

Coffee Break

Chantal Abergel, CNRS Aix-Marseille Université, France
The Concept of Virus in the Giant Virus Era

Edward C. Holmes, University of Sydney, Australia
Exploring the Eukaryotic Virome

João Trindade Marques, Universidade Federal de Minas Gerais, Brazil
Short Talk: The Global Virome of Vector Mosquitoes

Adriana Messyasz, Oregon State University, USA
Short Talk: Metagenomic Analysis of Viral Communities in Bleached and Non-Bleached Coral Tissue Uncovers a Novel Coral Megavirus

11:30—17:00
On Own for Lunch

11:30—13:00
Poster Setup

Bay
13:00—22:00
Poster Viewing

Bay
16:30—17:00
Coffee Available

Pre Function
17:00—19:00
Beneficial and Commensal Viromes

Mountain/Lake
* Evelien M. Adriaenssens, Quadram Institute Bioscience, UK
Session Chair

Susan M. Lehman, U.S. Food and Drug Administration, USA
Thinking about Phage Therapy as a Microbial Ecology Puzzle

Robert Edwards, San Diego State University, USA
crAssphage: The Most Abundant Virus in the Human Enteric Virome

Ken H. Cadwell, University of Pennsylvania, USA
Immunomodulation by the Enteric Virome

Karthik R. Chamakura, Texas A&M University, USA
Short Talk: The ssRNA Phages as a Source for Peptide Antibiotics

Cynthia Monaco, University of Rochester Medical Center, USA
Short Talk: Transkingdom Interactions in the Female Reproductive Tract

19:00—20:00
Dinner

Granhall
19:00—20:00
Social Hour
No registration fees are used to fund alcohol served at this function.

Granhall
19:30—22:00
Poster Session 1

Bay

TUESDAY, MARCH 3

07:00—08:00
Breakfast

Granhall
08:00—11:00
The Virome in Disease

Mountain/Lake
Frederic D. Bushman, University of Pennsylvania, USA
The Human Virome in Health and Disease

Xavier López, FISABIO - Public Health and University of Valencia, Spain
Diagnosing Infections by Metagenomics and Uncovering Novel Disease Associations by Interrogation of the Eukaryotic Virome

Coffee Break

Eric L. Delwart, University of California, San Francisco, USA
Koch's Postulates in the Age of Viral Metagenomics

Lori R. Holtz, Washington University, USA
Short Talk: Growth Velocity in Children with Environmental Enteric Dysfunction is Associated with Specific Bacterial and Viral Taxa of the Gastrointestinal Tract in Malawian Children

Efrem S. Lim, Arizona State University, USA
Short Talk: Intestinal and Neuronal Inflammation Associated with Virome Alterations in Experimental Gulf War Illness is Reversed by Ribavirin

11:00—17:00
On Own for Lunch

11:00—13:00
Poster Setup

Bay
13:00—22:00
Poster Viewing

Bay
14:30—15:30
Workshop 1: Origins of the Human Virome

Mountain/Lake
* David Wang, Washington University School of Medicine, USA
Session Chair

Rabia Maqsood, Arizona State University, USA
Discordant Transmission of Bacteria and Viruses from Mothers to Babies at Birth

Guanxiang Liang, University of Pennsylvania, USA
Step-Wise Assembly of the Neonatal Virome Modulated by Breast Feeding

Leen Beller, KU Leuven / REGA Institute, Belgium
Exploring the Diversity and Dynamics of the Gut Microbiome in Infants in Their First Year of Life

15:30—16:30
Workshop 2: Computational Viromics

Mountain/Lake
* Robert Edwards, San Diego State University, USA
Session Chair

Evelien M. Adriaenssens, Quadram Institute Bioscience, UK
The Importance of Bacteriophage Taxonomy in the Analysis of Gut Virome Data

J. Rodney Brister, NLM, National Institutes of Health, USA
How to Find a Virus – a Public Database Story

Moreno Zolfo, University of Trento, Italy
Detection and Meta-Analysis of Non-Viral Contamination in Viromes with ViromeQC

Michael J. Tisza, NCI, National Institutes of Health, USA
Cenote-Taker2 Democratizes Virus Discovery and Annotation from Metagenomic Data

16:30—17:00
Coffee Available

Pre Function
17:00—19:00
The Virome in Model Systems

Mountain/Lake
* Mya Breitbart, University of South Florida, USA
Session Chair

David Wang, Washington University School of Medicine, USA
Novel Lessons from the C. elegans Virome

Adrienne M.S. Correa, Rice University, USA
Viral Reefscapes: Microbial Interactions with Threatened Coral Hosts and Reef Ecosystems

Keir M. Balla, University of Utah, USA
Short Talk: A Widespread Picornavirus Discovered by Visualizing Zebrafish Immune Responses

Ryan A. Langlois, University of Minnesota, USA
Short Talk: Innate Immune Barriers to Inter- and Intra-Species Virus Transmission and Evolution

19:00—20:00
Dinner

Granhall
19:00—20:00
Social Hour
No registration fees are used to fund alcohol served at this function.

Granhall
19:30—22:00
Poster Session 2

Bay

WEDNESDAY, MARCH 4

07:00—08:00
Breakfast

Granhall
08:00—11:00
Host-Virus Arms Race

Mountain/Lake
* Frederic D. Bushman, University of Pennsylvania, USA
Session Chair

Rotem Sorek, Weizmann Institute of Science, Israel
Remote Presentation: Novel Antiphage Defense Systems

Kimberley Seed, University of California, Berkeley, USA
Bacteriophage-Host Arms Race in Vibrio cholerae

Coffee Break

Karen L. Maxwell, University of Toronto, Canada
Quorum Sensing Inactivation by a Phage Accessory Protein

Kate L. Jeffrey, Moderna and Harvard Medical School, USA
Divergent Immunomodulation by Healthy and Inflammatory Bowel Disease Human Enteric Viromes

Moira Dion, Université Laval, Canada
Short Talk: Optimizing Phage Host Predictions from Viral Metagenomics Using CRISPR Spacers

Kevin Forsberg, Fred Hutchinson Cancer Research Center, USA
Short Talk: Functional Metagenomics-Guided Discovery of Potent Cas9 Inhibitors in the Human Microbiome

11:00—17:00
On Own for Lunch

16:30—17:00
Coffee Available

Pre Function
17:00—18:45
Virome-Bacterial Microbiome Interactions

Mountain/Lake
* Karen L. Maxwell, University of Toronto, Canada
Session Chair

Paul E. Turner, Yale University, USA
Remote Presentation: Phage-Bacteria Interactions in the Evolution of Antibacterial Resistance

Megan T. Baldridge, Washington University School of Medicine, USA
Norovirus Infection, the Gut Microbiota and Interferon Lambda

Emily F. Wissel, Emory University, USA
Short Talk: The Vaginal Virome in Self-Identified African American Women Associated with Bacterial Community during Pregnancy and Preterm Birth

Paul Kirchberger, University of Texas, USA
Short Talk: Intraspecific Conflict in Ubiquitous Single-Stranded DNA Phages Is Caused by Hypervariable Genomic Regions

18:45—19:00
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)

Mountain/Lake
19:00—20:00
Dinner

Granhall
19:00—20:00
Social Hour
No registration fees are used to fund alcohol served at this function.

Granhall
20:00—23:00
Entertainment
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.

Granhall

THURSDAY, MARCH 5

11:00—11:00
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1R13AI149881-01

Funding for this conference was made possible (in part) by 1R13AI149881-01 from the National Institutes of Health. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.


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Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


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Phone:+1 970-262-2690

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