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This meeting took place in 2020
Here are the related meetings in 2024:
Regulation of Barrier Immunity (X8)
Innate Immunity Across the Molecular, Cellular, Tissue and Therapeutic (Z1)
For a complete list of the meetings for the upcoming/current season, see our meeting list, or search for a meeting.
Tissue Immunity (A6)
Organizer(s) Bana Jabri, Daniel Mucida and Ramnik Xavier
January 26—29, 2020
Embassy Suites by Hilton Boulder • Boulder, CO USA
Discounted Abstract Deadline: Sep 26, 2019
Abstract Deadline: Oct 24, 2019
Scholarship Deadline: Sep 26, 2019
Discounted Registration Deadline: Nov 21, 2019
Sponsored by AbbVie Inc., Akebia Therapeutics, BioLegend, Inc., Merck & Co., Inc. and Pfizer Inc.
Summary of Meeting:
How tissues integrate host-microbial signals and regulate immune responses has a critical impact on health and disease. However, our understanding of tissue immunity is limited because of difficulties in accessing the different organs and also due to the inherent complexity and individuality of the cellular circuits present in different tissues. This conference will bring together scientists in the fields of mucosal immunology, neurology, microbiology, metabolism and systems biology. The conference will discuss (i) the diversity of tissue resident T cell subsets and their function and regulation, (ii) the regulation and role of mucosal B cell responses, (iii) the role of the nervous system in the regulation of tissue immunity, (iii) how tissues integrate metabolic and microbial cues to determine which type of immune response to mount, (iv) the existence of innate memory and its role in pathophysiology, and (v) new approaches in the study of tissue immunity. Because of the interdisciplinary nature of the conference and its focus on tissue immunity across organs and cell types, the conference will give investigators a broad perspective on tissue immunity and encourage them to go beyond the traditional disciplinary boundaries. An interactive workshop engage will engage industrial partners to define new approaches to prevent and treat inflammatory disorders and cancer and will highlight new frontiers in tissue immunity, cellular networks and inter-tissue communication in health and disease.
View Scholarships/Awards
How tissues integrate host-microbial signals and regulate immune responses has a critical impact on health and disease. However, our understanding of tissue immunity is limited because of difficulties in accessing the different organs and also due to the inherent complexity and individuality of the cellular circuits present in different tissues. This conference will bring together scientists in the fields of mucosal immunology, neurology, microbiology, metabolism and systems biology. The conference will discuss (i) the diversity of tissue resident T cell subsets and their function and regulation, (ii) the regulation and role of mucosal B cell responses, (iii) the role of the nervous system in the regulation of tissue immunity, (iii) how tissues integrate metabolic and microbial cues to determine which type of immune response to mount, (iv) the existence of innate memory and its role in pathophysiology, and (v) new approaches in the study of tissue immunity. Because of the interdisciplinary nature of the conference and its focus on tissue immunity across organs and cell types, the conference will give investigators a broad perspective on tissue immunity and encourage them to go beyond the traditional disciplinary boundaries. An interactive workshop engage will engage industrial partners to define new approaches to prevent and treat inflammatory disorders and cancer and will highlight new frontiers in tissue immunity, cellular networks and inter-tissue communication in health and disease.
View Scholarships/Awards
No registration fees are used to fund entertainment or alcohol at this conference
The meeting will begin on Sunday, January 26 with registration from 16:00 to 20:00 and a welcome mixer from 18:00 to 20:00. Conference events conclude on Wednesday, January 29 with a closing plenary session and keynote address from 17:00 to 19:00, followed by a social hour and entertainment. We recommend return travel on Thursday, January 30 in order to fully experience the meeting.
SUNDAY, JANUARY 26
MONDAY, JANUARY 27
TUESDAY, JANUARY 28
WEDNESDAY, JANUARY 29
THURSDAY, JANUARY 30
Conference Program Print | View meeting in 12 hr (am/pm) time
The meeting will begin on Sunday, January 26 with registration from 16:00 to 20:00 and a welcome mixer from 18:00 to 20:00. Conference events conclude on Wednesday, January 29 with a closing plenary session and keynote address from 17:00 to 19:00, followed by a social hour and entertainment. We recommend return travel on Thursday, January 30 in order to fully experience the meeting.
SUNDAY, JANUARY 26
16:00—20:00
Arrival and Registration
Foyer
18:00—20:00
Welcome Mixer
No registration fees are used to fund alcohol served at this function.
Foyer
08:30—09:30
Welcome and Keynote Address
Pearl Street Ballroom
*
Piotr Bielecki,
Celsius Therapeutics, USA
Session Chair
Session Chair
Richard M. Locksley,
HHMI/University of California, San Francisco, USA
Type 2 Immunity and Tissue Resilience
Type 2 Immunity and Tissue Resilience
09:30—12:00
Tissue-Resident T Cells
Pearl Street Ballroom
*
Daniel Mucida,
Rockefeller University, USA
Session Chair
Session Chair
Coffee Break
Laura K. Mackay,
University of Melbourne, Australia
Targeting Tissue-Resident Memory T Cell Subsets
Targeting Tissue-Resident Memory T Cell Subsets
Ivaylo I. Ivanov,
Columbia University, USA
Dissecting the Differential Roles of ILC3 and T Cells in Mucosal Immunity
Dissecting the Differential Roles of ILC3 and T Cells in Mucosal Immunity
Toufic Mayassi,
University of Chicgao, USA
Insights into Tissue-Resident Immunity and Intraepithelial gamma delta Biology from Celiac Disease
Insights into Tissue-Resident Immunity and Intraepithelial gamma delta Biology from Celiac Disease
12:00—17:00
On Own for Lunch
12:00—13:00
Poster Setup
Pearl Street Ballroom
13:00—22:00
Poster Viewing
Pearl Street Ballroom
14:30—16:30
Workshop 1: Immune Responses across Tissues
Pearl Street Ballroom
*
Daria Esterházy,
University of Chicago, USA
Session Chair
Session Chair
*
Xingbin Ai,
Massachusetts General Hospital, USA
Session Chair
Session Chair
Nicholas Bessman,
Weill Cornell Medicine, USA
Dendritic Cell-Derived Hepcidin Sequesters Iron from the Microbiota to Promote Mucosal Healing
Dendritic Cell-Derived Hepcidin Sequesters Iron from the Microbiota to Promote Mucosal Healing
Quynh Nguyen,
University of California, San Diego, USA
Transcriptional Programming of Intestinal CD4+ Tissue-Resident Memory T Cells
Transcriptional Programming of Intestinal CD4+ Tissue-Resident Memory T Cells
Susan Christo,
University of Melbourne, Australia
The Local Microenvironment Drives the Identity of Tissue-Resident Memory T Cells
The Local Microenvironment Drives the Identity of Tissue-Resident Memory T Cells
Jack McGinty,
University of Washington, USA
Tuft Cell-Derived Leukotrienes Drive Rapid Activation of Anti-Helminth Immunity in the Small Intestine
Tuft Cell-Derived Leukotrienes Drive Rapid Activation of Anti-Helminth Immunity in the Small Intestine
Zachary Earley,
University of Chicago, USA
GATA4 Controls Regionalization of Intestinal Immunity Through Restricting Bacterial Colonization
GATA4 Controls Regionalization of Intestinal Immunity Through Restricting Bacterial Colonization
Angelina Bilate,
Rockefeller University, USA
Instructive Role of the T Cell Receptor on Lymphocyte Plasticity at the Intestinal Border
Instructive Role of the T Cell Receptor on Lymphocyte Plasticity at the Intestinal Border
Madelene W. Dahlgren,
University of California, San Francisco, USA
Adventitial Stromal Cells Define Group 2 Innate Lymphoid Cell Tissue Niches
Adventitial Stromal Cells Define Group 2 Innate Lymphoid Cell Tissue Niches
Emily E. Thornton,
University of Oxford, UK
Commensal-Reactive, IL-23 Responsive T Cells Promote Gut Barrier Immunity
Commensal-Reactive, IL-23 Responsive T Cells Promote Gut Barrier Immunity
16:30—17:00
Coffee Available
Foyer
17:00—19:00
Innate Memory in Tissues
Pearl Street Ballroom
*
Fiona M. Powrie,
University of Oxford, UK
Session Chair
Session Chair
Mihai G. Netea,
Radboud University, Netherlands
Trained Immunity: A Memory for Innate Host Defense
Trained Immunity: A Memory for Innate Host Defense
Marco Colonna,
Washington University School of Medicine, USA
Tissue Imprinting of Innate-Like-Lymphocytes
Tissue Imprinting of Innate-Like-Lymphocytes
Michael G. Constantinides,
The Scripps Research Institute, USA
Short Talk: MAIT Cells are Imprinted by the Microbiota in Early Life and Promote Tissue Repair
Short Talk: MAIT Cells are Imprinted by the Microbiota in Early Life and Promote Tissue Repair
Judith Agudo,
Dana-Farber Cancer Institute, USA
Short Talk: Quiescent Tissue-Resident Stem Cells Evade Immune Surveillance
Short Talk: Quiescent Tissue-Resident Stem Cells Evade Immune Surveillance
19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
Pearl Street Ballroom
19:30—22:00
Poster Session 1
Pearl Street Ballroom
08:30—11:30
Neuronal Control of Tissue Immunity
Pearl Street Ballroom
*
Ramnik Xavier,
Massachusetts General Hospital, USA
Microbial Metabolites in Health and Disease
Microbial Metabolites in Health and Disease
Gloria Choi,
Massachusetts Institute of Technology, USA
Neural Circuits and the Immune System
Neural Circuits and the Immune System
Coffee Break
Daniel Mucida,
Rockefeller University, USA
Adrenergic Signaling in Muscularis Macrophages Limits Neuronal Death Following Enteric Infection
Adrenergic Signaling in Muscularis Macrophages Limits Neuronal Death Following Enteric Infection
Lorena Riol Blanco,
Genentech, Inc., USA
Nodose Sensory Neurons Require TMC3 to Restrain Lung Damage
Nodose Sensory Neurons Require TMC3 to Restrain Lung Damage
William Khoury-Hanold,
Yale University, USA
Short Talk: Bitter Taste Sensing in the Gastrointestinal Tract Controls Allergic Sensitization
Short Talk: Bitter Taste Sensing in the Gastrointestinal Tract Controls Allergic Sensitization
11:30—17:00
On Own for Lunch
11:30—13:00
Poster Setup
Pearl Street Ballroom
13:00—22:00
Poster Viewing
Pearl Street Ballroom
14:30—16:30
Career Roundtable
Pearl Street Ballroom
David B. Masopust,
University of Minnesota, USA
Dan A. Erkes,
American Association for Cancer Research, USA
Ramnik Xavier,
Massachusetts General Hospital, USA
Fiona M. Powrie,
University of Oxford, UK
Ursula Weiss,
Nature Publishing Group, UK
16:30—17:00
Coffee Available
Foyer
17:00—19:00
Mucosal B Cell Responses
Pearl Street Ballroom
Matteo Iannacone,
San Raffaele Scientific Institute & University, Italy
Spatiotemporal Dynamics and Genomic Landscape of CD8+ T Cells Undergoing Intrahepatic Priming
Spatiotemporal Dynamics and Genomic Landscape of CD8+ T Cells Undergoing Intrahepatic Priming
*
Ludvig M. Sollid,
University of Oslo, Norway
Antigen-Specific B Cell Responses Implicated in Celiac Disease
Antigen-Specific B Cell Responses Implicated in Celiac Disease
Valerie Abadie,
University of Chicago, USA
Contribution of the Humoral Response to the Pathogenesis of Celiac Disease
Contribution of the Humoral Response to the Pathogenesis of Celiac Disease
Priyadharshini Devarajan,
University of Massachusetts Medical School, USA
Short Talk: Generation of Tissue-Restricted CD4 Effectors, TFH and ThCTL, Requires Signals from Antigen in the Tissue Site and from Infection at an Effector Checkpoint
Short Talk: Generation of Tissue-Restricted CD4 Effectors, TFH and ThCTL, Requires Signals from Antigen in the Tissue Site and from Infection at an Effector Checkpoint
19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
Pearl Street Ballroom
19:30—22:00
Poster Session 2
Pearl Street Ballroom
08:30—11:45
Molecular and Metabolic Control of Inflammation
Pearl Street Ballroom
*
Ramnik Xavier,
Massachusetts General Hospital, USA
Session Chair
Session Chair
Fiona M. Powrie,
University of Oxford, UK
Talk Title to be Announced
Talk Title to be Announced
Coffee Break
Luke A. J. O'Neill,
Trinity Biomedical Sciences Institute, Ireland
Krebs Cycle Reborn in Macrophages
Krebs Cycle Reborn in Macrophages
Matthew G. Vander Heiden,
Massachusetts Institute of Technology, USA
Influence of Nutrient Availability on Tissue Metabolism
Influence of Nutrient Availability on Tissue Metabolism
Graham Barlow,
Stanford University, USA
Short Talk: Hierarchical Tissue Factors Orchestrate Autoimmune Insulitis in Human Type I Diabetes
Short Talk: Hierarchical Tissue Factors Orchestrate Autoimmune Insulitis in Human Type I Diabetes
Jacqueline W. Mays,
NIDCR, National Institutes of Health, USA
Short Talk: Tissue-Resident Memory T Cells May Drive the Pathogenesis of Exocrine Gland Chronic Graft-Versus-Host Disease
Short Talk: Tissue-Resident Memory T Cells May Drive the Pathogenesis of Exocrine Gland Chronic Graft-Versus-Host Disease
Eric Brown,
Broad Institute of MIT and Harvard, USA
Short Talk: Intestinal Microbiome Sphingolipid Signaling Mediates Inflammation and Mucosal Immunity
Short Talk: Intestinal Microbiome Sphingolipid Signaling Mediates Inflammation and Mucosal Immunity
11:45—17:00
On Own for Lunch
14:30—16:30
Workshop 2: New Approaches to Target Tissue Immunity in Autoimmunity and Cancer
Pearl Street Ballroom
*
Shruti Naik,
New York University Langone Health, USA
Session Chair
Session Chair
*
Ricardo R. Cibotti,
NIAMS, National Institutes of Health, USA
Session Chair
Session Chair
Rafael Sanguinetti Czepielewski,
Washington University School of Medicine, USA
Mesenteric Tertiary Lymphoid Organs Block Leukocyte Migration from the Intestine in a Crohn's Disease-Like Mouse Model
Mesenteric Tertiary Lymphoid Organs Block Leukocyte Migration from the Intestine in a Crohn's Disease-Like Mouse Model
Michel Enamorado,
NIAID, National Institutes of Health, USA
Immunity - or Lack of - to Staphylococcus aureus
Immunity - or Lack of - to Staphylococcus aureus
Yisu Gu,
University of Oxford, UK
Spatial Compartmentalisation of Pathobiont-Reactive T Cell Differentiation in Gut Tissue
Spatial Compartmentalisation of Pathobiont-Reactive T Cell Differentiation in Gut Tissue
Duncan McKenzie,
Francis Crick Institute, UK
A Two-Step Molecular Mechanism for Immune Discrimination of Tissue Dysregulation from Normality
A Two-Step Molecular Mechanism for Immune Discrimination of Tissue Dysregulation from Normality
Martina Damo,
University of Chicago, USA
Tissue Type Determines the Outcome of Peripheral T Cell Tolerance Induction
Tissue Type Determines the Outcome of Peripheral T Cell Tolerance Induction
Bernardo S. Reis,
Rockefeller University, USA
Role of Intraepithelial gamma delta Lymphocytes during Colon Cancer Development and Progression
Role of Intraepithelial gamma delta Lymphocytes during Colon Cancer Development and Progression
Zuri Sullivan,
Harvard University, USA
Gammadelta T-Cells Regulate Intestinal Epithelial Response to Nutrient Sensing
Gammadelta T-Cells Regulate Intestinal Epithelial Response to Nutrient Sensing
Shiqun Zhang,
University of Pittsburgh, USA
MrgprD-Expressing Neurons Maintain Cutaneous Mast Cell Homeostasis
MrgprD-Expressing Neurons Maintain Cutaneous Mast Cell Homeostasis
16:30—17:00
Coffee Available
Foyer
17:00—18:00
Microbiota and Tissue Immunity
Pearl Street Ballroom
*
Ivaylo I. Ivanov,
Columbia University, USA
Session Chair
Session Chair
Dan R. Littman,
HHMI/New York University School of Medicine, USA
Gut Microbiota and Systemic Immunity
Gut Microbiota and Systemic Immunity
Jun R. Huh,
Harvard Medical School, USA
Immune Modulatory Roles of Bile Acid Metabolites
Immune Modulatory Roles of Bile Acid Metabolites
18:00—18:45
Closing Keynote Address
Pearl Street Ballroom
*
Ramnik Xavier,
Massachusetts General Hospital, USA
Session Chair
Session Chair
Yasmine Belkaid,
Pasteur Institut, France
Innate Resident T Cells in Skin Immunity
Innate Resident T Cells in Skin Immunity
18:45—19:00
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
Pearl Street Ballroom
19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
Pearl Street Ballroom
20:00—23:00
Entertainment
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.
Pearl Street Ballroom
11:00—11:00
Departure
*Session Chair †Invited, not yet responded.
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