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This meeting took place in 2020
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Tissue Plasticity: Preservation and Alteration of Cellular Identity (EK6)
Organizer(s) Ophir Klein, Ramesh A. Shivdasani and Stacey S. Huppert
October 5—7, 2020
Virtual at your computer • , CO USA
Abstract Deadline: Sep 14, 2020
Scholarship Deadline: Oct 3, 2020
Discounted Registration Deadline:
Part of the Keystone Symposia Global Health Series, supported by the Bill & Melinda Gates Foundation
Summary of Meeting:
Cellular plasticity, the ability to acquire new identities or adopt alternative fates, occurs in normal physiology and disease states. Researchers are just beginning to understand how plasticity contributes to homeostasis and regeneration in the setting of tissue injury. Alterations in cell fate can be harnessed to treat disease, but uncontrolled plasticity can destabilize cell commitment and contribute toward neoplasia. The cellular and molecular underpinnings of cellular plasticity provide insights into disease processes and enable new therapies. This conference will explore the diverse mechanisms that underlie plasticity in different tissues and contexts. By bringing together leading scientists in stem cell, developmental, regenerative, and cancer biology, this interdisciplinary conference will highlight common principles and unique features of cellular plasticity in different tissues and examine the therapeutic potential of this process. The conference represents a unique opportunity for researchers in diverse fields to visit evolving concepts in cellular plasticity and the molecular mechanisms and physiological consequences of altered adult cell identity in vivo. While the topic has been included marginally at other conferences (i.e., conferences on stem cell biology, regeneration, epigenetics, and cancer) only this Keystone Symposia conference, first held in 2019, has focused on cellular plasticity across mammalian tissues. This conference will assemble speakers from diverse disciplines and organ systems to identify cross-cutting themes and provide a forum for investigators to explore common underlying mechanistic principles and therapeutic potential.
View Scholarships/Awards
Cellular plasticity, the ability to acquire new identities or adopt alternative fates, occurs in normal physiology and disease states. Researchers are just beginning to understand how plasticity contributes to homeostasis and regeneration in the setting of tissue injury. Alterations in cell fate can be harnessed to treat disease, but uncontrolled plasticity can destabilize cell commitment and contribute toward neoplasia. The cellular and molecular underpinnings of cellular plasticity provide insights into disease processes and enable new therapies. This conference will explore the diverse mechanisms that underlie plasticity in different tissues and contexts. By bringing together leading scientists in stem cell, developmental, regenerative, and cancer biology, this interdisciplinary conference will highlight common principles and unique features of cellular plasticity in different tissues and examine the therapeutic potential of this process. The conference represents a unique opportunity for researchers in diverse fields to visit evolving concepts in cellular plasticity and the molecular mechanisms and physiological consequences of altered adult cell identity in vivo. While the topic has been included marginally at other conferences (i.e., conferences on stem cell biology, regeneration, epigenetics, and cancer) only this Keystone Symposia conference, first held in 2019, has focused on cellular plasticity across mammalian tissues. This conference will assemble speakers from diverse disciplines and organ systems to identify cross-cutting themes and provide a forum for investigators to explore common underlying mechanistic principles and therapeutic potential.
View Scholarships/Awards
No registration fees are used to fund entertainment or alcohol at this conference
The meeting will begin on Monday, October 5 with . Conference events conclude on Wednesday, October 7 with a from to , followed by . We recommend return travel on Thursday, October 8 in order to fully experience the meeting.
MONDAY, OCTOBER 5
TUESDAY, OCTOBER 6
WEDNESDAY, OCTOBER 7
Conference Program Print | View meeting in 12 hr (am/pm) time
The meeting will begin on Monday, October 5 with . Conference events conclude on Wednesday, October 7 with a from to , followed by . We recommend return travel on Thursday, October 8 in order to fully experience the meeting.
MONDAY, OCTOBER 5
08:00—08:10
Welcoming Remarks (Organizers) (8am Denver/Mountain Time Start)
08:10—08:40
Keynote Address (8:10am Denver/Mountain Time Start)
*
Ophir Klein,
University of California, San Francisco, USA
Session Chair
Session Chair
Magdalena D. Zernicka-Goetz,
University of Cambridge, UK
Developmental Plasticity, Cell Fate Specification and Morphogenesis in the Early Mouse and Human Embryo
Developmental Plasticity, Cell Fate Specification and Morphogenesis in the Early Mouse and Human Embryo
08:40—10:45
Plasticity in the Early Embryo (8:40am Denver/Mountain Time Start)
*
Daniel Klimmeck,
EMBO Journal, Germany
Session Chair
Session Chair
*
Ramesh A. Shivdasani,
Dana-Farber Cancer Institute, USA
Session Chair
Session Chair
Angela Nieto,
Instituto de Neurociencias de Alicante, CSIC-UMH, Spain
Cell Plasticity in Development and Disease
Cell Plasticity in Development and Disease
Coffee Break
Aaron M. Zorn,
Cincinnati Children's Hospital Medical Center, USA
A Single Cell Road Map of Foregut Progenitors Identity
A Single Cell Road Map of Foregut Progenitors Identity
Tatjana Sauka-Spengler,
University of Oxford, UK
Heads or Tails: Differential FoxD3 Autoregulation Controls Developmental Switch Between the Neural Crest and Neuromesodermal Progenitors
Heads or Tails: Differential FoxD3 Autoregulation Controls Developmental Switch Between the Neural Crest and Neuromesodermal Progenitors
Shashank "Sha" Gandhi,
California Institute of Technology, USA
Short Talk: Reprogramming Axial Level Identity to Rescue Neural-Crest-Related Congenital Heart Defects
Short Talk: Reprogramming Axial Level Identity to Rescue Neural-Crest-Related Congenital Heart Defects
10:45—11:00
Panel Discussion with Speakers (10:45am Denver/Mountain Time Start)
*
Daniel Klimmeck,
EMBO Journal, Germany
Session Chair
Session Chair
*
Ramesh A. Shivdasani,
Dana-Farber Cancer Institute, USA
Session Chair
Session Chair
12:30—13:30
Career Roundtable (12:30pm Denver/Mountain Time Start)
Shingo Kajimura,
Harvard Medical School, Beth Israel Deaconess Medical Center, USA
Juanita L. Merchant,
University of Arizona College of Medicine, USA
Sara Lin,
NHLBI, USA
13:30—15:00
Poster Session 1 (1:30pm Denver/Mountain Time Start)
15:00—17:45
Tissue Plasticity from Invertebrates to Vertebrates (3pm Denver/Mountain Time Start)
*
Misty Riddle,
Harvard Medical School, USA
Session Chair
Session Chair
*
Kathleen DelGiorno,
Vanderbilt University, USA
Session Chair
Session Chair
Xin Sun,
University of California, San Diego, USA
Fate Choices in Lung Development
Fate Choices in Lung Development
Leanne Jones,
University of California, San Francisco, USA
Ablation and Replacement of Fly Stem Cells: Plasticity in the Epithelium
Ablation and Replacement of Fly Stem Cells: Plasticity in the Epithelium
Yingzi Yang,
Harvard School of Dental Medicine, USA
Skeletal Stem Cells and GPCR Signaling
Skeletal Stem Cells and GPCR Signaling
Coffee Break
Benjamin Ohlstein,
UT Southwestern Medical Center, USA
Amitosis and Plasticity
Amitosis and Plasticity
Ophir Klein,
University of California, San Francisco, USA
Plasticity and Regeneration in the Intestinal Crypt
Plasticity and Regeneration in the Intestinal Crypt
Bo Wang,
Stanford University, USA
Short Talk: Genetic Chimerism Causes Regeneration Defects in the Planarian
Short Talk: Genetic Chimerism Causes Regeneration Defects in the Planarian
17:45—18:00
Panel Discussion with Speakers (5:45pm Denver/Mountain Time Start)
*
Misty Riddle,
Harvard Medical School, USA
Session Chair
Session Chair
*
Kathleen DelGiorno,
Vanderbilt University, USA
Session Chair
Session Chair
08:00—10:45
Epigenetics, Transcription and Plasticity (8am Denver/Mountain Time Start)
*
Michal Shoshkes-Carmel,
Hebrew University, Israel
Session Chair
Session Chair
*
Frederic Michon,
Hopital Saint Eloi, France
Session Chair
Session Chair
Shingo Kajimura,
Harvard Medical School, Beth Israel Deaconess Medical Center, USA
Molecular Control of Fat and Muscle Plasticity
Molecular Control of Fat and Muscle Plasticity
Valerie Horsley,
Yale University, USA
All Aboard: Adipocyte Function in Tissue Repair
All Aboard: Adipocyte Function in Tissue Repair
Ramesh A. Shivdasani,
Dana-Farber Cancer Institute, USA
Tissue Plasticity in a Human Disease: The Enigma of Barrett's Metaplasia
Tissue Plasticity in a Human Disease: The Enigma of Barrett's Metaplasia
Coffee Break
Elena Ezhkova,
Icahn School of Medicine at Mount Sinai, USA
Chromatin Regulation of Skin Development and Skin Stem Cells
Chromatin Regulation of Skin Development and Skin Stem Cells
Emily Zion,
Johns Hopkins University, USA
Short Talk: The Role of Histone Inheritance in Establishing Distinct Cell Identities
Short Talk: The Role of Histone Inheritance in Establishing Distinct Cell Identities
Farnaz Shamsi,
Joslin Diabetes Center, USA
Short Talk: Vascular Smooth Muscle-Derived Adipocyte Progenitors are the Cellular Origin of Cold-Induced Brown Adipocytes
Short Talk: Vascular Smooth Muscle-Derived Adipocyte Progenitors are the Cellular Origin of Cold-Induced Brown Adipocytes
10:45—11:00
Panel Discussion with Speakers (10:45am Denver/Mountain Time Start)
*
Michal Shoshkes-Carmel,
Hebrew University, Israel
Session Chair
Session Chair
*
Frederic Michon,
Hopital Saint Eloi, France
Session Chair
Session Chair
13:30—15:00
Poster Session 2 (1:30pm Denver/Mountain Time Start)
15:00—17:45
Inflammation, Renewal and Plasticity (3pm Denver/Mountain Time Start)
*
Nadya L. Lumelsky,
NIDCR, National Institutes of Health, USA
Session Chair
Session Chair
*
Ophir Klein,
University of California, San Francisco, USA
Session Chair
Session Chair
Juanita L. Merchant,
University of Arizona College of Medicine, USA
Gut Inflammation in Disease
Gut Inflammation in Disease
Indira U. Mysorekar,
Washington University School of Medicine, USA
Regulation of Urothelial Plasticity and Regeneration
Regulation of Urothelial Plasticity and Regeneration
Stacey S. Huppert,
Cincinnati Children’s Hospital Medical Center, USA
Hepatic Epithelial Cell Plasticity
Hepatic Epithelial Cell Plasticity
Coffee Break
Shruti Naik,
New York University Langone Health, USA
Eavesdropping on the Conversation between Immune and Epithelial Stem Cells during Tissue Repair
Eavesdropping on the Conversation between Immune and Epithelial Stem Cells during Tissue Repair
Edward E. Morrisey,
University of Pennsylvania, USA
Epithelial Plasticity in Development and Tissue Regeneration
Epithelial Plasticity in Development and Tissue Regeneration
17:45—18:00
Panel Discussion with Speakers (5:45pm Denver/Mountain Time Start)
*
Nadya L. Lumelsky,
NIDCR, National Institutes of Health, USA
Session Chair
Session Chair
*
Ophir Klein,
University of California, San Francisco, USA
Session Chair
Session Chair
08:00—10:45
Cancer Stem Cells and Their Niche (8am Denver/Mountain Time Start)
*
Jonathan Saxe,
Cell Press, USA
Session Chair
Session Chair
*
Stacey S. Huppert,
Cincinnati Children’s Hospital Medical Center, USA
Session Chair
Session Chair
Emmanuelle Passegué,
Columbia University, USA
How Blood Ages
How Blood Ages
Valerie M. Weaver,
University of California, San Francisco, USA
Role of the Extracellular Matrix in Niche Construction
Role of the Extracellular Matrix in Niche Construction
Jason C. Mills,
Washington University, USA
Differentiated Cells Undergo Metaplasia and Tumorigenesis via Paligenosis
Differentiated Cells Undergo Metaplasia and Tumorigenesis via Paligenosis
Coffee Break
Ben Z. Stanger,
University of Pennsylvania, USA
EMT and Cellular Plasticity in Cancer
EMT and Cellular Plasticity in Cancer
Tianliang Sun,
Novartis Institutes for BioMedical Research, Switzerland
Short Talk: The Plasticity of Liver Epithelial Cells during Homeostasis, Regeneration and Tumor Formation
Short Talk: The Plasticity of Liver Epithelial Cells during Homeostasis, Regeneration and Tumor Formation
Adam Pietrobon,
Ottawa Hospital Research Institute, Canada
Short Talk: Loss of TSC1 or TSC2 Drives Lineage-Infidelity and Hamartoma Formation in a Renal Organoid Model of Angiomyolipoma
Short Talk: Loss of TSC1 or TSC2 Drives Lineage-Infidelity and Hamartoma Formation in a Renal Organoid Model of Angiomyolipoma
Rashmi Mishra,
Sanford Burnham Prebys Medical Discovery Institute, USA
Short Talk: Autophagy Drives in vivo Transdifferentiation
Short Talk: Autophagy Drives in vivo Transdifferentiation
10:35—10:50
Panel Discussion with Speakers (10:35am Denver/Mountain Time Start)
*
Jonathan Saxe,
Cell Press, USA
Session Chair
Session Chair
*
Stacey S. Huppert,
Cincinnati Children’s Hospital Medical Center, USA
Session Chair
Session Chair
10:50—11:00
Closing Remarks (Organizers)
*Session Chair †Invited, not yet responded.
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