Keystone Symposia

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This meeting took place in 2020


Here are the related meetings in 2024:
Autophagy and Disease (J5)

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Autophagy: Mechanisms and Disease (EK7)


Organizer(s) Patricia Boya, Felix Randow and Masaaki Komatsu
October 5—8, 2020
Virtual at your computer • , CO USA
Abstract Deadline: Sep 14, 2020
Scholarship Deadline: Sep 22, 2020
Discounted Registration Deadline:

Part of the Keystone Symposia Global Health Series, supported by the Bill & Melinda Gates Foundation
Sponsored by Astellas Pharma Inc., AstraZeneca and Cell Research

Summary of Meeting:
Autophagy is an intracellular pathway for degradation that allows for the recycling of cellular components inside lysosomes to sustain tissue homeostasis. Countless effort has been devoted to help unravel the molecular mechanisms that regulate this pathway, but many questions remain unresolved. Therefore, this conference program gathers an interdisciplinary group of scientists to address the current and future challenges in the field such as discussions on the existence of non-canonical forms of the pathway and how selectivity is achieved. This conference also addresses the minimal requirements to generate functional autophagosomes and the molecular bases of autophagy regulation. One of the major themes of this conference is a session which reviews how model systems such as plants, worms and mice help to unravel the physiological roles of this essential pathway and why this research can also be applied to find new therapies for human diseases. For example, while it is now clear that many human pathologies have alterations in autophagy, how scientists could potentially manipulate the pathway in vivo is a major challenge that will be addressed at this conference. Finally, this conference provides a unique frame to display the current research and future challenges of the field during physiological and pathological conditions.

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Conference Program    Print  |   View meeting in 12 hr (am/pm) time


The meeting will begin on Monday, October 5 with . Conference events conclude on Thursday, October 8 with a from to , followed by . We recommend return travel on Friday, October 9 in order to fully experience the meeting.

MONDAY, OCTOBER 5

06:00—06:35
Welcoming Remarks and Keynote Address: Beth Levine Lecture (6am Denver/Mountain Time Start)

* Patricia Boya, University of Fribourg, Switzerland
Session Chair

Eric H. Baehrecke, University of Massachusetts Chan Medical School, USA
Autophagy, Mitochondria and Disease

06:35—07:45
Mini Symposium to Honor Beth Levine (6:35am Denver/Mountain Time Start)

* Patricia Boya, University of Fribourg, Switzerland
Session Chair

* Eric H. Baehrecke, University of Massachusetts Chan Medical School, USA
Session Chair

Herbert (Skip) W. Virgin, Washington University School of Medicine, USA
Beth Levine: A Legacy of Science, Collaboration, Community and Mentorship

Ana Maria Cuervo, Albert Einstein College of Medicine, USA
Beth Levine: A Legacy of Science, Collaboration, Community and Mentorship

Malene Hansen, Buck Institute for Research on Aging, USA
Beth Levine: A Legacy of Science, Collaboration, Community and Mentorship

Xiaonan Dong, University of Texas Southwestern Medical Center, USA
Short Talk: Role of Sorting Nexins in Virophagy

Yang Liu, University of Texas Southwestern Medical Center, USA
Short Talk: Crosstalk between TLR9 and Beclin 1 in Muscle

Salwa Sebti, University of Texas Southwestern Medical Center, USA
Short Talk: Role of Autophagy and Beclin 1 in Aging

07:45—08:00
Break (7:45am Denver/Mountain Time Start)

08:00—10:00
New Insights into the Molecular Regulation of Autophagy (8am Denver/Mountain Time Start)

* Felix Randow, Medical Research Council, UK
Session Chair

David C. Rubinsztein, Cambridge Institute for Medical Research, UK
A DNM2 Centronuclear Myopathy Mutation Reveals a Link between Recycling Endosome Scission and Autophagy

* Fulvio Reggiori, Aarhus University, Denmark
Molecular Regulation of Autophagosome Formation

Noboru Mizushima, University of Tokyo, Japan
Molecular Mechanism of Large-Scale Organelle Degradation in the Lens

Olatz Pampliega, Achucarro Basque Center for Neuroscience, Spain
Short Talk: Amyloid beta Modulates Neuronal Autophagy through the Primary Cilium

Chunmei Chang, University of California, Berkeley, USA
Short Talk: Reconstituting Cargo Triggered LC3 Lipidation in Autophagy

Thomas J. Mercer, Francis Crick Institute, UK
Short Talk: Examining the Regulation of Autophagy via Identification and Characterisation of ULK Kinase Substrates

11:00—13:00
Poster Session 1 (11am Denver/Mountain Time Start)


TUESDAY, OCTOBER 6

06:00—10:00
Selective and Non-Canonical Autophagy (6am Denver/Mountain Time Start)

Ana Maria Cuervo, Albert Einstein College of Medicine, USA
Chaperone Mediated Autophagy

* Richard J. Youle, NINDS, National Institutes of Health, USA
Mitophagy

* Anne Simonsen, University of Oslo, Norway
Regulation of Autophagy by Lipid-Binding Proteins

Martin McMahon, University of Utah School of Medicine, USA
Combined Targeting of RAS Signaling Plus Autophagy as a Future Treatment Strategy for Cancer

Coffee Break

Patricia Boya, University of Fribourg, Switzerland
New Links between Autophagy and Developmental Cell Death

Jennifer Martinez, NIEHS, National Institutes of Health, USA
Non-Canonical Autophagy Mediates Immunotolerant Mechanisms

Andrea KH Stavoe, University of Texas Health Science Center at Houston, USA
Short Talk: Aging Represses Autophagosome Biogenesis but not Autophagosome Transport or Maturation in Neurons

Caroline Mauvezin, Universitat de Barcelona, Spain
Short Talk: Autophagy and Lysosomal Degradation Ensure Accurate Chromosomal Segregation to Prevent Genomic Instability

Chris Shoemaker, Dartmouth College, USA
Short Talk: Receptor-Mediated Clustering of FIP200 Bypasses the Role of LC3 Lipidation in Autophagy

Yasuhiro Yamamoto, University of Tokyo, Japan
Short Talk: Selective Autophagy of NEK9 Regulates Primary Cilia Formation

11:00—12:00
Meet the Editors (11am Denver/Mountain Time Start)

Sadaf Shadan, Nature, UK

Stella M. Hurtley, Science, UK

Elisabetta Argenzio, EMBO Journal, Germany

Petra Gross, Journal of Cell Science, The Company of Biologists, UK


WEDNESDAY, OCTOBER 7

06:00—10:00
Autophagy and Organelle Crosstalk (6am Denver/Mountain Time Start)

Ivan Dikic, Goethe University Medical School, Germany
ER-Phagy

* Alicia Melendez, Queens College - CUNY, USA
Autophagy in Germline Development

Rosa Puertollano, NHLBI, National Institutes of Health, USA
Emerging New Roles of Lysosomes in Cellular Response to Stress

Felix Randow, Medical Research Council, UK
Autophagy and Bacterial Infection

Coffee Break

Tassula Proikas-Cezanne, University of Tuebingen, Germany
Regulation of WIPI Beta-Propeller Function in Autophagy

* Masaaki Komatsu, Juntendo University School of Medicine, Japan
ER-phagy Mediated by the Ufm1-System

Carmine Settembre, Telethon Foundation, Italy
Short Talk: Selective Autophagy of the Endoplasmic Reticulum (ER-phagy): From Cellular Functions to Signalling Regulation

Paul J. Wrighton, Brigham and Women's Hospital, USA
Short Talk: Live and Quantitative Imaging Reveals in vivo Dynamics and Molecular Basis of Physiological-Stress Induced Mitophagy

Thanh N. Nguyen, Monash University, Australia
Short Talk: Atg4 Family Proteins Drive Phagophore Growth Independently of the LC3/GABARAP Lipidation System

10:00—12:00
Poster Session 2 (10am Denver/Mountain Time Start)

12:00—13:00
Career Roundtable (12pm Denver/Mountain Time Start)

Jennifer Martinez, NIEHS, National Institutes of Health, USA

Alicia Melendez, Queens College - CUNY, USA

Leon O. Murphy, Casma Therapeutics, USA


THURSDAY, OCTOBER 8

06:00—10:00
Autophagy and Disease, New Therapeutic Opportunities (6am Denver/Mountain Time Start)

* Patricia Boya, University of Fribourg, Switzerland
Session Chair

Guido Kroemer, Cordeliers Research Center, France
Autophagy and Obesity

Anna Katharina Simon, University of Oxford, UK
Cell-Extrinsic Role of Autophagy in Inflammation

Hong Zhang, Chinese Academy of Sciences, China
Inositol Polyphosphate Multikinase Inhibits Liquid-Liquid Phase Separation of TFEB to Regulate Autophagy Activity

* Martin Graef, Cornell University, USA
Autophagy and Cellular Aging

Coffee Break

Leon O. Murphy, Casma Therapeutics, USA
New Mechanistic Insight into the Regulation of TFEB at the Lysosome

Herbert (Skip) W. Virgin, Washington University School of Medicine, USA
New Therapies for Infectious Diseases

Aditya Murthy, Gilead Sciences, USA
Short Talk: Multiplexed Proteomics in Macrophages Uncovers Novel Roles of Autophagy in Anti-Microbial Immunity

Yasin Dagdas, Gregor Mendel Institute, Austria
Short Talk: A Cross-Kingdom Conserved ER-Phagy Receptor Maintains Endoplasmic Reticulum Homeostasis during Stress

Yanxiang (Jessie) Guo, Rutgers University, USA
Short Talk: Autophagy Compensates for Lkb1 Loss to Maintain Adult Mice Homeostasis and Survival

Nicolas Dupont, INSERM U1151 Université de Paris, France
Short Talk: The Primary Cilium and Lipophagy Translate Mechanical Forces to Direct Metabolic Adaptation of Kidney Epithelial Cells

10:00—10:10
Closing Remarks (Organizers) (10am Denver/Mountain Time Start)


*Session Chair †Invited, not yet responded.



Keystone Symposia thanks our Sponsors(s) for generously supporting this meeting:

Astellas Pharma Inc. AstraZeneca
Cell Research
 

We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1R13CA254442-01

Funding for this conference was made possible (in part) by 1R13CA254442-01 from the National Institutes of Health. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention by trade names, commercial practices, or organizations imply endorsement by the U.S. Government.


We gratefully acknowledge additional support for this conference from:

Novus Biologicals

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