Virtual at your computer Floorplan
This meeting took place in 2020
Here are the related meetings in 2024:
Autophagy and Disease (J5)
For a complete list of the meetings for the upcoming/current season, see our meeting list, or search for a meeting.
Autophagy: Mechanisms and Disease (EK7)
Organizer(s) Patricia Boya, Felix Randow and Masaaki Komatsu
October 5—8, 2020
Virtual at your computer • , CO USA
Abstract Deadline: Sep 14, 2020
Scholarship Deadline: Sep 22, 2020
Discounted Registration Deadline:
Part of the Keystone Symposia Global Health Series, supported by the Bill & Melinda Gates Foundation
Sponsored by Astellas Pharma Inc., AstraZeneca and Cell Research
Sponsored by Astellas Pharma Inc., AstraZeneca and Cell Research
Summary of Meeting:
Autophagy is an intracellular pathway for degradation that allows for the recycling of cellular components inside lysosomes to sustain tissue homeostasis. Countless effort has been devoted to help unravel the molecular mechanisms that regulate this pathway, but many questions remain unresolved. Therefore, this conference program gathers an interdisciplinary group of scientists to address the current and future challenges in the field such as discussions on the existence of non-canonical forms of the pathway and how selectivity is achieved. This conference also addresses the minimal requirements to generate functional autophagosomes and the molecular bases of autophagy regulation. One of the major themes of this conference is a session which reviews how model systems such as plants, worms and mice help to unravel the physiological roles of this essential pathway and why this research can also be applied to find new therapies for human diseases. For example, while it is now clear that many human pathologies have alterations in autophagy, how scientists could potentially manipulate the pathway in vivo is a major challenge that will be addressed at this conference. Finally, this conference provides a unique frame to display the current research and future challenges of the field during physiological and pathological conditions.
View Scholarships/Awards
Autophagy is an intracellular pathway for degradation that allows for the recycling of cellular components inside lysosomes to sustain tissue homeostasis. Countless effort has been devoted to help unravel the molecular mechanisms that regulate this pathway, but many questions remain unresolved. Therefore, this conference program gathers an interdisciplinary group of scientists to address the current and future challenges in the field such as discussions on the existence of non-canonical forms of the pathway and how selectivity is achieved. This conference also addresses the minimal requirements to generate functional autophagosomes and the molecular bases of autophagy regulation. One of the major themes of this conference is a session which reviews how model systems such as plants, worms and mice help to unravel the physiological roles of this essential pathway and why this research can also be applied to find new therapies for human diseases. For example, while it is now clear that many human pathologies have alterations in autophagy, how scientists could potentially manipulate the pathway in vivo is a major challenge that will be addressed at this conference. Finally, this conference provides a unique frame to display the current research and future challenges of the field during physiological and pathological conditions.
View Scholarships/Awards
No registration fees are used to fund entertainment or alcohol at this conference
The meeting will begin on Monday, October 5 with . Conference events conclude on Thursday, October 8 with a from to , followed by . We recommend return travel on Friday, October 9 in order to fully experience the meeting.
MONDAY, OCTOBER 5
TUESDAY, OCTOBER 6
WEDNESDAY, OCTOBER 7
THURSDAY, OCTOBER 8
Conference Program Print | View meeting in 12 hr (am/pm) time
The meeting will begin on Monday, October 5 with . Conference events conclude on Thursday, October 8 with a from to , followed by . We recommend return travel on Friday, October 9 in order to fully experience the meeting.
MONDAY, OCTOBER 5
06:00—06:35
Welcoming Remarks and Keynote Address: Beth Levine Lecture (6am Denver/Mountain Time Start)
*
Patricia Boya,
University of Fribourg, Switzerland
Session Chair
Session Chair
Eric H. Baehrecke,
University of Massachusetts Chan Medical School, USA
Autophagy, Mitochondria and Disease
Autophagy, Mitochondria and Disease
06:35—07:45
Mini Symposium to Honor Beth Levine (6:35am Denver/Mountain Time Start)
*
Patricia Boya,
University of Fribourg, Switzerland
Session Chair
Session Chair
*
Eric H. Baehrecke,
University of Massachusetts Chan Medical School, USA
Session Chair
Session Chair
Herbert (Skip) W. Virgin,
Washington University School of Medicine, USA
Beth Levine: A Legacy of Science, Collaboration, Community and Mentorship
Beth Levine: A Legacy of Science, Collaboration, Community and Mentorship
Ana Maria Cuervo,
Albert Einstein College of Medicine, USA
Beth Levine: A Legacy of Science, Collaboration, Community and Mentorship
Beth Levine: A Legacy of Science, Collaboration, Community and Mentorship
Malene Hansen,
Buck Institute for Research on Aging, USA
Beth Levine: A Legacy of Science, Collaboration, Community and Mentorship
Beth Levine: A Legacy of Science, Collaboration, Community and Mentorship
Xiaonan Dong,
University of Texas Southwestern Medical Center, USA
Short Talk: Role of Sorting Nexins in Virophagy
Short Talk: Role of Sorting Nexins in Virophagy
Yang Liu,
University of Texas Southwestern Medical Center, USA
Short Talk: Crosstalk between TLR9 and Beclin 1 in Muscle
Short Talk: Crosstalk between TLR9 and Beclin 1 in Muscle
Salwa Sebti,
University of Texas Southwestern Medical Center, USA
Short Talk: Role of Autophagy and Beclin 1 in Aging
Short Talk: Role of Autophagy and Beclin 1 in Aging
07:45—08:00
Break (7:45am Denver/Mountain Time Start)
08:00—10:00
New Insights into the Molecular Regulation of Autophagy (8am Denver/Mountain Time Start)
*
Felix Randow,
Medical Research Council, UK
Session Chair
Session Chair
David C. Rubinsztein,
Cambridge Institute for Medical Research, UK
A DNM2 Centronuclear Myopathy Mutation Reveals a Link between Recycling Endosome Scission and Autophagy
A DNM2 Centronuclear Myopathy Mutation Reveals a Link between Recycling Endosome Scission and Autophagy
*
Fulvio Reggiori,
Aarhus University, Denmark
Molecular Regulation of Autophagosome Formation
Molecular Regulation of Autophagosome Formation
Noboru Mizushima,
University of Tokyo, Japan
Molecular Mechanism of Large-Scale Organelle Degradation in the Lens
Molecular Mechanism of Large-Scale Organelle Degradation in the Lens
Olatz Pampliega,
Achucarro Basque Center for Neuroscience, Spain
Short Talk: Amyloid beta Modulates Neuronal Autophagy through the Primary Cilium
Short Talk: Amyloid beta Modulates Neuronal Autophagy through the Primary Cilium
Chunmei Chang,
University of California, Berkeley, USA
Short Talk: Reconstituting Cargo Triggered LC3 Lipidation in Autophagy
Short Talk: Reconstituting Cargo Triggered LC3 Lipidation in Autophagy
Thomas J. Mercer,
Francis Crick Institute, UK
Short Talk: Examining the Regulation of Autophagy via Identification and Characterisation of ULK Kinase Substrates
Short Talk: Examining the Regulation of Autophagy via Identification and Characterisation of ULK Kinase Substrates
11:00—13:00
Poster Session 1 (11am Denver/Mountain Time Start)
06:00—10:00
Selective and Non-Canonical Autophagy (6am Denver/Mountain Time Start)
Ana Maria Cuervo,
Albert Einstein College of Medicine, USA
Chaperone Mediated Autophagy
Chaperone Mediated Autophagy
*
Richard J. Youle,
NINDS, National Institutes of Health, USA
Mitophagy
Mitophagy
*
Anne Simonsen,
University of Oslo, Norway
Regulation of Autophagy by Lipid-Binding Proteins
Regulation of Autophagy by Lipid-Binding Proteins
Martin McMahon,
University of Utah School of Medicine, USA
Combined Targeting of RAS Signaling Plus Autophagy as a Future Treatment Strategy for Cancer
Combined Targeting of RAS Signaling Plus Autophagy as a Future Treatment Strategy for Cancer
Coffee Break
Patricia Boya,
University of Fribourg, Switzerland
New Links between Autophagy and Developmental Cell Death
New Links between Autophagy and Developmental Cell Death
Jennifer Martinez,
NIEHS, National Institutes of Health, USA
Non-Canonical Autophagy Mediates Immunotolerant Mechanisms
Non-Canonical Autophagy Mediates Immunotolerant Mechanisms
Andrea KH Stavoe,
University of Texas Health Science Center at Houston, USA
Short Talk: Aging Represses Autophagosome Biogenesis but not Autophagosome Transport or Maturation in Neurons
Short Talk: Aging Represses Autophagosome Biogenesis but not Autophagosome Transport or Maturation in Neurons
Caroline Mauvezin,
Universitat de Barcelona, Spain
Short Talk: Autophagy and Lysosomal Degradation Ensure Accurate Chromosomal Segregation to Prevent Genomic Instability
Short Talk: Autophagy and Lysosomal Degradation Ensure Accurate Chromosomal Segregation to Prevent Genomic Instability
Chris Shoemaker,
Dartmouth College, USA
Short Talk: Receptor-Mediated Clustering of FIP200 Bypasses the Role of LC3 Lipidation in Autophagy
Short Talk: Receptor-Mediated Clustering of FIP200 Bypasses the Role of LC3 Lipidation in Autophagy
Yasuhiro Yamamoto,
University of Tokyo, Japan
Short Talk: Selective Autophagy of NEK9 Regulates Primary Cilia Formation
Short Talk: Selective Autophagy of NEK9 Regulates Primary Cilia Formation
11:00—12:00
Meet the Editors (11am Denver/Mountain Time Start)
Sadaf Shadan,
Nature, UK
Stella M. Hurtley,
Science, UK
Elisabetta Argenzio,
EMBO Journal, Germany
Petra Gross,
Journal of Cell Science, The Company of Biologists, UK
06:00—10:00
Autophagy and Organelle Crosstalk (6am Denver/Mountain Time Start)
Ivan Dikic,
Goethe University Medical School, Germany
ER-Phagy
ER-Phagy
*
Alicia Melendez,
Queens College - CUNY, USA
Autophagy in Germline Development
Autophagy in Germline Development
Rosa Puertollano,
NHLBI, National Institutes of Health, USA
Emerging New Roles of Lysosomes in Cellular Response to Stress
Emerging New Roles of Lysosomes in Cellular Response to Stress
Felix Randow,
Medical Research Council, UK
Autophagy and Bacterial Infection
Autophagy and Bacterial Infection
Coffee Break
Tassula Proikas-Cezanne,
University of Tuebingen, Germany
Regulation of WIPI Beta-Propeller Function in Autophagy
Regulation of WIPI Beta-Propeller Function in Autophagy
*
Masaaki Komatsu,
Juntendo University School of Medicine, Japan
ER-phagy Mediated by the Ufm1-System
ER-phagy Mediated by the Ufm1-System
Carmine Settembre,
Telethon Foundation, Italy
Short Talk: Selective Autophagy of the Endoplasmic Reticulum (ER-phagy): From Cellular Functions to Signalling Regulation
Short Talk: Selective Autophagy of the Endoplasmic Reticulum (ER-phagy): From Cellular Functions to Signalling Regulation
Paul J. Wrighton,
Brigham and Women's Hospital, USA
Short Talk: Live and Quantitative Imaging Reveals in vivo Dynamics and Molecular Basis of Physiological-Stress Induced Mitophagy
Short Talk: Live and Quantitative Imaging Reveals in vivo Dynamics and Molecular Basis of Physiological-Stress Induced Mitophagy
Thanh N. Nguyen,
Monash University, Australia
Short Talk: Atg4 Family Proteins Drive Phagophore Growth Independently of the LC3/GABARAP Lipidation System
Short Talk: Atg4 Family Proteins Drive Phagophore Growth Independently of the LC3/GABARAP Lipidation System
10:00—12:00
Poster Session 2 (10am Denver/Mountain Time Start)
12:00—13:00
Career Roundtable (12pm Denver/Mountain Time Start)
Jennifer Martinez,
NIEHS, National Institutes of Health, USA
Alicia Melendez,
Queens College - CUNY, USA
Leon O. Murphy,
Casma Therapeutics, USA
06:00—10:00
Autophagy and Disease, New Therapeutic Opportunities (6am Denver/Mountain Time Start)
*
Patricia Boya,
University of Fribourg, Switzerland
Session Chair
Session Chair
Guido Kroemer,
Cordeliers Research Center, France
Autophagy and Obesity
Autophagy and Obesity
Anna Katharina Simon,
University of Oxford, UK
Cell-Extrinsic Role of Autophagy in Inflammation
Cell-Extrinsic Role of Autophagy in Inflammation
Hong Zhang,
Chinese Academy of Sciences, China
Inositol Polyphosphate Multikinase Inhibits Liquid-Liquid Phase Separation of TFEB to Regulate Autophagy Activity
Inositol Polyphosphate Multikinase Inhibits Liquid-Liquid Phase Separation of TFEB to Regulate Autophagy Activity
*
Martin Graef,
Cornell University, USA
Autophagy and Cellular Aging
Autophagy and Cellular Aging
Coffee Break
Leon O. Murphy,
Casma Therapeutics, USA
New Mechanistic Insight into the Regulation of TFEB at the Lysosome
New Mechanistic Insight into the Regulation of TFEB at the Lysosome
Herbert (Skip) W. Virgin,
Washington University School of Medicine, USA
New Therapies for Infectious Diseases
New Therapies for Infectious Diseases
Aditya Murthy,
Gilead Sciences, USA
Short Talk: Multiplexed Proteomics in Macrophages Uncovers Novel Roles of Autophagy in Anti-Microbial Immunity
Short Talk: Multiplexed Proteomics in Macrophages Uncovers Novel Roles of Autophagy in Anti-Microbial Immunity
Yasin Dagdas,
Gregor Mendel Institute, Austria
Short Talk: A Cross-Kingdom Conserved ER-Phagy Receptor Maintains Endoplasmic Reticulum Homeostasis during Stress
Short Talk: A Cross-Kingdom Conserved ER-Phagy Receptor Maintains Endoplasmic Reticulum Homeostasis during Stress
Yanxiang (Jessie) Guo,
Rutgers University, USA
Short Talk: Autophagy Compensates for Lkb1 Loss to Maintain Adult Mice Homeostasis and Survival
Short Talk: Autophagy Compensates for Lkb1 Loss to Maintain Adult Mice Homeostasis and Survival
Nicolas Dupont,
INSERM U1151 Université de Paris, France
Short Talk: The Primary Cilium and Lipophagy Translate Mechanical Forces to Direct Metabolic Adaptation of Kidney Epithelial Cells
Short Talk: The Primary Cilium and Lipophagy Translate Mechanical Forces to Direct Metabolic Adaptation of Kidney Epithelial Cells
10:00—10:10
Closing Remarks (Organizers) (10am Denver/Mountain Time Start)
*Session Chair †Invited, not yet responded.
Keystone Symposia thanks our Sponsors(s) for generously supporting this meeting:
We gratefully acknowledge the generous grant for this conference provided by:
We gratefully acknowledge additional support for this conference from:
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:
Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:
Click here to view more of these organizations
If your organization is interested in joining these entities in support of Keystone
Symposia, please contact: John Monson,
Director of Corporate Relations, Email: johnm@keystonesymposia.org, Phone:+1 970-262-2690 Click here for more information on Industry Support and Recognition Opportunities. If you are interested in becoming an advertising/marketing in-kind partner, please contact: Josh May, Director, Technology and Digital Media, Email: joshuam@keystonesymposia.org, Phone:+1 970-262-1179 |