Snowbird Resort Floorplan
This meeting took place in 2022
Here are the related meetings in 2024:
Innate Immunity Across the Molecular, Cellular, Tissue and Therapeutic (Z1)
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Innate Immunity: Complement and Beyond (D1)
Organizer(s) Claudia Kemper, Christoph J. Binder and Feng Shao
April 3—6, 2022
Snowbird Resort • Snowbird, UT USA
Abstract Deadline: Jan 6, 2022
Scholarship Deadline: Jan 6, 2022
Discounted Registration Deadline: Feb 2, 2022
Sponsored by AstraZeneca and Genmab A/S
Summary of Meeting:
Innate immunity is a pillar of the host’s defense against infection and noxious self. Pathogen or danger recognition systems (PRRs) including TLRs, inflammasomes, and RIG-I-like receptors are broadly recognized as central nodes of innate immune responses and have a solid place in the immunologists’ hearts. The complement system, however, albeit being the evolutionary oldest PRR, is often perceived as the ‘Stiefkind’ of innate immunity and generally evokes less excitement. This view is changing: complement has recently been up-graded from a mere lytic pathogen-killer to an intracellularly-active orchestrator of normal cell physiology. This, together with the realization that an increasing number of human diseases, among those COVID-19, involve complement perturbations has spurred a regained interest in complement biology and its therapeutic targeting. Our knowledge, however, of how complement exerts non-canonical activities and how it intersects with other PRRs is sparse. This conference will provide a timely account of recent paradigm shifts in our understanding of complement/PRR-instructed immunity with a specific eye on emerging roles in basic cellular processes including regulation of chromatin structure, metabolism, cell death, clearance of cellular debris/corpses, and maintenance of normal CNS function. A second focus is on exploring how aberrant function of these new PRR activities contribute to infection and autoimmunity but also to less intuitive clinical conditions like changes in cognition and behavior. This holistic and ‘complement-inclusive’ vantage-point on PRR biology brings together interdisciplinary investigators from academia and industry for cross-fertilization of novel ideas and collaborations towards biomedical progress in harnessing complement to combat human disease.
View Scholarships/Awards
Innate immunity is a pillar of the host’s defense against infection and noxious self. Pathogen or danger recognition systems (PRRs) including TLRs, inflammasomes, and RIG-I-like receptors are broadly recognized as central nodes of innate immune responses and have a solid place in the immunologists’ hearts. The complement system, however, albeit being the evolutionary oldest PRR, is often perceived as the ‘Stiefkind’ of innate immunity and generally evokes less excitement. This view is changing: complement has recently been up-graded from a mere lytic pathogen-killer to an intracellularly-active orchestrator of normal cell physiology. This, together with the realization that an increasing number of human diseases, among those COVID-19, involve complement perturbations has spurred a regained interest in complement biology and its therapeutic targeting. Our knowledge, however, of how complement exerts non-canonical activities and how it intersects with other PRRs is sparse. This conference will provide a timely account of recent paradigm shifts in our understanding of complement/PRR-instructed immunity with a specific eye on emerging roles in basic cellular processes including regulation of chromatin structure, metabolism, cell death, clearance of cellular debris/corpses, and maintenance of normal CNS function. A second focus is on exploring how aberrant function of these new PRR activities contribute to infection and autoimmunity but also to less intuitive clinical conditions like changes in cognition and behavior. This holistic and ‘complement-inclusive’ vantage-point on PRR biology brings together interdisciplinary investigators from academia and industry for cross-fertilization of novel ideas and collaborations towards biomedical progress in harnessing complement to combat human disease.
View Scholarships/Awards
No registration fees are used to fund entertainment or alcohol at this conference
The meeting will begin on Sunday, April 3 with registration from 16:00 to 20:00 and a welcome mixer from 18:00 to 20:00. Conference events conclude on Wednesday, April 6 with a closing plenary session from 17:00 to 19:00, followed by a social hour. We recommend return travel on Thursday, April 7 in order to fully experience the meeting.
SUNDAY, APRIL 3
MONDAY, APRIL 4
TUESDAY, APRIL 5
WEDNESDAY, APRIL 6
THURSDAY, APRIL 7
Conference Program Print | View meeting in 12 hr (am/pm) time
The meeting will begin on Sunday, April 3 with registration from 16:00 to 20:00 and a welcome mixer from 18:00 to 20:00. Conference events conclude on Wednesday, April 6 with a closing plenary session from 17:00 to 19:00, followed by a social hour. We recommend return travel on Thursday, April 7 in order to fully experience the meeting.
SUNDAY, APRIL 3
18:00—20:00
Welcome Mixer
No registration fees are used to fund alcohol served at this function.
08:00—09:00
Welcome and Keynote Address
*
Claudia Kemper,
NHLBI, National Institutes of Health, USA
Session Chair
Session Chair
V. Michael Holers,
University of Colorado Denver, USA
Complement Therapeutics: A Long and Winded Road
Complement Therapeutics: A Long and Winded Road
09:00—11:00
Food for Thought - Complement and Normal Cell Physiology
*
Terje Espevik,
Norwegian University of Science and Technology, Norway
Session Chair
Session Chair
*
Claudia Kemper,
NHLBI, National Institutes of Health, USA
An Unexpected Force from Within: Complement as Key Controller of Basic Cellular Pathways
An Unexpected Force from Within: Complement as Key Controller of Basic Cellular Pathways
Coffee Break
Jose A. Villadangos,
University of Melbourne, Australia
Cannibalistic Cooperation between Marginal Zone B cells and Dendritic Cells Mediated by Complement
Cannibalistic Cooperation between Marginal Zone B cells and Dendritic Cells Mediated by Complement
Mihir V. Pendse,
University of Texas Southwestern Medical Center, USA
Short Talk: Macrophages Regulate Gastrointestinal Motility Through Complement Component 1q
Short Talk: Macrophages Regulate Gastrointestinal Motility Through Complement Component 1q
14:30—16:30
Workshop 1
*
Ashley Frazer-Abel,
University of Colorado, USA
Session Chair
Session Chair
Arthur G. Affleck IV,
Oregon Health & Science University, USA
A Gut Feeling About Complement in Early Onset Colorectal Cancer
A Gut Feeling About Complement in Early Onset Colorectal Cancer
Marilia I. Cascalho,
University of Michigan, USA
C3d a Novel Immunotherapy for Cancer
C3d a Novel Immunotherapy for Cancer
Sanjaya K. Sahu,
Washington University in Saint Louis, USA
Intracellular Complement Protein Factor B Promotes Cell Survival
Intracellular Complement Protein Factor B Promotes Cell Survival
Carlos Donado,
Harvard Medical School, USA
Granzyme K Elicits a New Pathway for Complement Activation
Granzyme K Elicits a New Pathway for Complement Activation
Doris Wilflingseder,
Insbruck Medical University, Austria
Blocking C5aR in Non-immune Respiratory Cells Prevents Inflated Local C3 Mobilization and Inflammation During Acute SARS-CoV-2 Infection
Blocking C5aR in Non-immune Respiratory Cells Prevents Inflated Local C3 Mobilization and Inflammation During Acute SARS-CoV-2 Infection
*
Joerg Koehl,
University of Luebeck, Germany
C5aR1 Mediates Several Functions of Inflammatory Eosinophils driving Experimental Allergic Asthma
C5aR1 Mediates Several Functions of Inflammatory Eosinophils driving Experimental Allergic Asthma
Lukas Scheibler,
Apellis Pharmaceuticals, USA
Inhibition of VEGF and Complement C3 for the Treatment of Neovascular AMD
Inhibition of VEGF and Complement C3 for the Treatment of Neovascular AMD
17:00—19:15
Complementing PRR Activities during Host Protection
Thirumala-Devi Kanneganti,
St. Jude Children's Research Hospital, USA
Targeting PANoptosis for the Treatment of Inflammatory and Infectious Diseases
Targeting PANoptosis for the Treatment of Inflammatory and Infectious Diseases
Jose Ordovas-Montanes,
Boston Children's Hospital and Harvard Medical School, USA
Single-cell Biology of Barrier Tissues and COVID-19
Single-cell Biology of Barrier Tissues and COVID-19
*
Sanjay Ram,
University of Massachusetts, USA
An Epic Evolutionary Fight: Complement and Bacteria
An Epic Evolutionary Fight: Complement and Bacteria
*
Brooke A. Napier,
Portland State University, USA
Short Talk: Macrophage Intrinsic C3aR Works as an Inhibitory GPCR to Enhance TLR4 Endocytosis and TRIF-mediated Signaling
Short Talk: Macrophage Intrinsic C3aR Works as an Inhibitory GPCR to Enhance TLR4 Endocytosis and TRIF-mediated Signaling
Terje Espevik,
Norwegian University of Science and Technology, Norway
Role of the Complement System in Inflammasome Activation Mediated by Cholesterol Crystals
Role of the Complement System in Inflammasome Activation Mediated by Cholesterol Crystals
19:15—20:15
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
08:00—11:00
Pores and Pyroptosis – Beyond Inflammasomes
Judy Lieberman,
Harvard University, USA
Gasdermin D Permeabilization of Mitochondrial Inner and Outer Membranes: A point of No Return for Pyroptosis?
Gasdermin D Permeabilization of Mitochondrial Inner and Outer Membranes: A point of No Return for Pyroptosis?
Feng Shao,
National Institute of Biological Sciences, China
Remote Presentation: Pyroptosis in Antibacterial and Antitumor Immunity
Remote Presentation: Pyroptosis in Antibacterial and Antitumor Immunity
Coffee Break
*
Susan Lea,
NCI, National Institutes of Health, USA
Poking Holes - Structural Control of Lytic Complement
Poking Holes - Structural Control of Lytic Complement
Thomas J. Schall,
ChemoCentryx, USA
Taming, not Killing, the Beast: Novel Complement- Targeting Strategies
Taming, not Killing, the Beast: Novel Complement- Targeting Strategies
*
Alex G. Johnson,
Dana-Farber Cancer Institute, Harvard Medical School, USA
Short Talk: Bacterial Gasdermins Reveal an Ancient Mechanism of Immune Cell Death
Short Talk: Bacterial Gasdermins Reveal an Ancient Mechanism of Immune Cell Death
Pooja Parameswaran,
University of Massachusetts Medical School, USA
Short Talk: An E3 Ubiquitin Ligase Encoded by HSV-1 Inhibits NLRP1-dependent Pyroptosis in Primary Human Keratinocytes
Short Talk: An E3 Ubiquitin Ligase Encoded by HSV-1 Inhibits NLRP1-dependent Pyroptosis in Primary Human Keratinocytes
14:30—16:30
Workshop 2
*
Markus A. Bosmann,
Boston University Medical School, USA
Session Chair
Session Chair
*
Dianna Nord,
University of Florida, USA
Session Chair
Session Chair
Antonio Gregorio Dias Junior,
University of California, Berkeley, USA
Complement-mediated Lysis of Virions and Infected Cells is Associated with Protection from Symptomatic Dengue 3 Virus Infection
Complement-mediated Lysis of Virions and Infected Cells is Associated with Protection from Symptomatic Dengue 3 Virus Infection
Xiaoyu Zhao,
University of Virginia, USA
Inducible Nitric Oxide Synthase at GBP2-targeted Toxoplasma Gondii Vacuoles Mediates Parasite Killing in Murine Myeloid Cells
Inducible Nitric Oxide Synthase at GBP2-targeted Toxoplasma Gondii Vacuoles Mediates Parasite Killing in Murine Myeloid Cells
Wilfried Posch,
Medical University of Innsbruck, Austria
Complement Enables Immune Sensing of HIV-1 and Early Type I Interferon Responses via Dendritic Cells
Complement Enables Immune Sensing of HIV-1 and Early Type I Interferon Responses via Dendritic Cells
Alexandra R. Lucas,
Arizona State University, USA
Virus-derived Serpin Blocks Complement and Urokinase-type Plasminogen Receptor (uPAR), Significantly Reducing Lung Inflammation in SARS-CoV-2 Infected Mice
Virus-derived Serpin Blocks Complement and Urokinase-type Plasminogen Receptor (uPAR), Significantly Reducing Lung Inflammation in SARS-CoV-2 Infected Mice
Elisabeth De Leeuw,
Inflammation Research Center, Belgium
Efficacy and Safety of the Investigational Complement C5 inhibitor Zilucoplan in Patients Hospitalized with Covid-19: An RCT
Efficacy and Safety of the Investigational Complement C5 inhibitor Zilucoplan in Patients Hospitalized with Covid-19: An RCT
Hrishikesh S. Kulkarni,
Washington University School of Medicine, USA
Lung Epithelial Cell-derived C3 Protects Against Pneumonia-induced Lung Injury
Lung Epithelial Cell-derived C3 Protects Against Pneumonia-induced Lung Injury
Daniel L. Seiler,
University of Luebeck, Germany
C5aR2 Deficiency Ameliorates Inflammation in Murine Epidermolysis Bullosa Acquisita by Regulating C5a- and FcγR-mediated Functions of Neutrophils
C5aR2 Deficiency Ameliorates Inflammation in Murine Epidermolysis Bullosa Acquisita by Regulating C5a- and FcγR-mediated Functions of Neutrophils
17:00—19:00
Mopping up the Mess – with Complements from C3
*
Christoph J. Binder,
Medical University of Vienna, Austria
Keeping the Clearance of Dead Cells Under Control
Keeping the Clearance of Dead Cells Under Control
*
Lubka T. Roumenina,
INSERM UMRS1138 Cordeliers Research Center, France
Complement in Cancer - Mopping Up or Making the Mess
Complement in Cancer - Mopping Up or Making the Mess
Nikolina Papac-Milicevic,
Medical University Vienna, Austria
Short Talk: Malondialdehyde Epitopes Modulate Opsonization and Efferocytosis
Short Talk: Malondialdehyde Epitopes Modulate Opsonization and Efferocytosis
Markus A. Bosmann,
Boston University Medical School, USA
Short Talk: Mopping up the Mess of C5a Receptor Redundancy
Short Talk: Mopping up the Mess of C5a Receptor Redundancy
19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
08:00—11:00
Complement Makes for a Beautiful Mind
*
Carlos Donado,
Harvard Medical School, USA
Session Chair
Session Chair
Daniel S. Reich,
NINDS, National Institutes of Health, USA
What Drives Nonresolving Inflammation in Multiple Sclerosis?
What Drives Nonresolving Inflammation in Multiple Sclerosis?
Dorothy Schafer,
University of Massachusetts Chan Medical School, USA
Complement at the Synapse and Beyond: Implications for Neurological Disease
Complement at the Synapse and Beyond: Implications for Neurological Disease
Coffee Break
*
Andrea J. Tenner,
University of California, Irvine, USA
Strategic Targeting of Complement to Control Neuroinflammation in Alzheimer's Disease
Strategic Targeting of Complement to Control Neuroinflammation in Alzheimer's Disease
Jonathan Kipnis,
Washington University School of Medicine, USA
Innate Signals Regulating Cognitive Function and Behavior
Innate Signals Regulating Cognitive Function and Behavior
Marlene Kanmogne,
Washington University in St. Louis, USA
Short Talk: The Complement Receptor C3aR Promotes Myeloid Cell Survival and CD8 T Cell Recruitment During West Nile Virus neuroinvasive disease
Short Talk: The Complement Receptor C3aR Promotes Myeloid Cell Survival and CD8 T Cell Recruitment During West Nile Virus neuroinvasive disease
Yingying Zhang,
Boston Children's Hospital, USA
Short Talk: Spatial Transcriptomic Profiling of the Complement System in Mouse Brain During Development
Short Talk: Spatial Transcriptomic Profiling of the Complement System in Mouse Brain During Development
14:30—16:30
Career Roundtable
Thirumala-Devi Kanneganti,
St. Jude Children's Research Hospital, USA
Fergus R. Byrne,
Boehringer Ingelheim, USA
17:00—18:45
The Road Less Traveled - Emerging New Paradigms
*
Kate A. Fitzgerald,
University of Massachusetts Medical School, USA
New Mechanisms of Innate Immune Regulation
New Mechanisms of Innate Immune Regulation
*
Behdad Afzali,
NIDDK, National Institutes of Health, USA
Not What We Thought – Unconventional Roles for Complement in Kidney Disease
Not What We Thought – Unconventional Roles for Complement in Kidney Disease
Christoph Hess,
University Hospital Basel/University of Cambridge, Switzerland
Shaping Memory with Magnesium
Shaping Memory with Magnesium
Natalia Kunz,
NIH, USA
Short Talk: A ‘Sweet Spot' for Complement: CD46 Controls T Cell Activity Via Orchestration of Classic Enzymatic and Moonlighting Functions of Glycolytic Enzymes
Short Talk: A ‘Sweet Spot' for Complement: CD46 Controls T Cell Activity Via Orchestration of Classic Enzymatic and Moonlighting Functions of Glycolytic Enzymes
19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
*Session Chair †Invited, not yet responded.
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