Keystone Resort Floorplan
This meeting took place in 2022
Here are the related meetings in 2024:
Neurodegenerative Diseases (Z3)
For a complete list of the meetings for the upcoming/current season, see our meeting list, or search for a meeting.
Neurodegeneration: The Biological Pathways Driving the Future of Therapeutic Development (Z2)
Organizer(s) Dimitri Krainc and Alfred Sandrock
June 5—9, 2022
Keystone Resort • Keystone, CO USA
Abstract Deadline: Mar 1, 2022
Scholarship Deadline: Feb 22, 2022
Discounted Registration Deadline: Apr 5, 2022
Sponsored by Biogen, Ionis Pharmaceuticals, Inc., Lilly USA, LLC, Merck & Co., Inc. and PhenoVista Biosciences
Joint Meeting:
Neuro-Immune Interactions in the Central Nervous System (Z1)
Summary of Meeting:
Neurodegenerative diseases remain one of the main concerns for aging populations across the world. Elucidating the molecular mechanisms underlying these diseases thus remains a priority for developing effective therapeutics to combat them. Recent genetic studies linked to these diseases have pointed to functional defects in several key cellular organelles and pathways that appear to drive neurodegeneration, including endolysosomal, mitochondrial and synaptic dysfunctions. However, there is still much to be learned regarding the precise roles of these pathways in disease progression, their contribution to neuronal vulnerability, and how to effectively target these pathways in patients. Important mechanistic themes in neurodegenerative disease include the genetics of neuro-immune interactions, the involvement of synaptic molecular events, the role of endolysosomal, autophagic and mitochondrial dysfunction, the potential contribution of dynamic inter-organelle contact sites in neurons, and translational considerations including the use of biomarkers and gene therapy. The goal of this conference is to bring together fundamental basic scientists who are experts in these areas of cell biology, together with clinicians and medical researchers, and scientists investigating therapeutic strategies for neurodegeneration. By combining these different fields of expertise, this conference will stimulate cross-fertilization, in-depth interactions and insightful discussions on disease pathogenesis and strategies for advancing drug development for neurodegenerative disorders. Finally, this conference is being paired with a conference on Neuro-Immune Interactions in the Central Nervous System. This combination will be beneficial in that it will emphasize the crossover between neurodegeneration and neuroimmunology. As neuroimmunology is a recently reinvigorated field, this meeting will provide a critical opportunity to foster cross-disciplinary thinking.
View Scholarships/Awards
Neurodegenerative diseases remain one of the main concerns for aging populations across the world. Elucidating the molecular mechanisms underlying these diseases thus remains a priority for developing effective therapeutics to combat them. Recent genetic studies linked to these diseases have pointed to functional defects in several key cellular organelles and pathways that appear to drive neurodegeneration, including endolysosomal, mitochondrial and synaptic dysfunctions. However, there is still much to be learned regarding the precise roles of these pathways in disease progression, their contribution to neuronal vulnerability, and how to effectively target these pathways in patients. Important mechanistic themes in neurodegenerative disease include the genetics of neuro-immune interactions, the involvement of synaptic molecular events, the role of endolysosomal, autophagic and mitochondrial dysfunction, the potential contribution of dynamic inter-organelle contact sites in neurons, and translational considerations including the use of biomarkers and gene therapy. The goal of this conference is to bring together fundamental basic scientists who are experts in these areas of cell biology, together with clinicians and medical researchers, and scientists investigating therapeutic strategies for neurodegeneration. By combining these different fields of expertise, this conference will stimulate cross-fertilization, in-depth interactions and insightful discussions on disease pathogenesis and strategies for advancing drug development for neurodegenerative disorders. Finally, this conference is being paired with a conference on Neuro-Immune Interactions in the Central Nervous System. This combination will be beneficial in that it will emphasize the crossover between neurodegeneration and neuroimmunology. As neuroimmunology is a recently reinvigorated field, this meeting will provide a critical opportunity to foster cross-disciplinary thinking.
View Scholarships/Awards
No registration fees are used to fund entertainment or alcohol at this conference
The meeting will begin on Sunday, June 5 with registration from 16:00 to 20:00 and a welcome mixer from 18:00 to 20:00. Conference events conclude on Thursday, June 9 with a closing plenary session from 17:00 to 19:00, followed by a social hour. We recommend return travel on Friday, June 10 in order to fully experience the meeting.
SUNDAY, JUNE 5
MONDAY, JUNE 6
TUESDAY, JUNE 7
WEDNESDAY, JUNE 8
THURSDAY, JUNE 9
FRIDAY, JUNE 10
Conference Program Print | View meeting in 12 hr (am/pm) time
The meeting will begin on Sunday, June 5 with registration from 16:00 to 20:00 and a welcome mixer from 18:00 to 20:00. Conference events conclude on Thursday, June 9 with a closing plenary session from 17:00 to 19:00, followed by a social hour. We recommend return travel on Friday, June 10 in order to fully experience the meeting.
SUNDAY, JUNE 5
18:00—20:00
Welcome Mixer
No registration fees are used to fund alcohol served at this function.
08:00—09:30
Welcome and Keynote Session (Joint) (8:00 am Start)
*
Marco Colonna,
Washington University School of Medicine, USA
Session Chair
Session Chair
*
Dimitri Krainc,
Northwestern University, USA
Session Chair
Session Chair
Thomas C. Südhof,
Stanford School of Medicine, USA
Synapse Biology in Alzheimer's Disease
Synapse Biology in Alzheimer's Disease
David M. Holtzman,
Washington University, USA
Innate Immunity, ApoE, and Neurodegeneration
Innate Immunity, ApoE, and Neurodegeneration
Coffee Break
09:50—11:15
Genetics of Neuro-Immune Interactions (Joint) (9:50 am Start)
David Gate,
Northwestern University, USA
Cerebrospinal Fluid Immunity in Aging and Neurodegenerative Disease
Cerebrospinal Fluid Immunity in Aging and Neurodegenerative Disease
*
Alison Goate,
Icahn School of Medicine at Mount Sinai, USA
Alzheimer's Disease Susceptibility Alleles Implicate Efferocytosis in Microglia
Alzheimer's Disease Susceptibility Alleles Implicate Efferocytosis in Microglia
14:30—16:30
Workshop 1: Neuro-Immune Interactions in Neurological Diseases (2:30 pm Start)
Zahara M. Keulen,
UC Irvine, USA
Neuronal Tau Pathology Alters Human Microglial Morphology, Transcriptome, and Function
Neuronal Tau Pathology Alters Human Microglial Morphology, Transcriptome, and Function
Denise Jurczyszak,
Icahn School of Medicine at Mount Sinai, USA
Investigation of Neuroinflammation in Down Syndrome
Investigation of Neuroinflammation in Down Syndrome
*
Gregory Williams,
La Jolla Institute for Immunology, USA
PINK1 Identified as a Target of Autoantigenic T Cells Responses in Patients with PD
PINK1 Identified as a Target of Autoantigenic T Cells Responses in Patients with PD
Esra Yalcin,
Boston Children's Hospital, USA
Viral Expression of Anti hC4 Nanobody (hC4Nb8) Rescues Schizophrenia like Phenotypes in hC4A Mice
Viral Expression of Anti hC4 Nanobody (hC4Nb8) Rescues Schizophrenia like Phenotypes in hC4A Mice
Sean Ryan,
Sanofi, USA
Microglia Ferroptosis is Prevalent in Neurodegenerative Disease and Regulated by SEC24B
Microglia Ferroptosis is Prevalent in Neurodegenerative Disease and Regulated by SEC24B
Xiaoying Chen,
Washington University School of Medicine, USA
Microglia-mediated T cell Infiltration in Tauopathy
Microglia-mediated T cell Infiltration in Tauopathy
*
Maria Serena Paladini,
University of California San Francisco, USA
Fate Mapping Of Peripherally Derived Macrophages After Traumatic Brain Injury
Fate Mapping Of Peripherally Derived Macrophages After Traumatic Brain Injury
Gabrielle Childers,
University of Alabama at Birmingham, USA
Exploring the Role of B Cells in a Mouse Model of Multiple System Atrophy
Exploring the Role of B Cells in a Mouse Model of Multiple System Atrophy
17:00—19:15
Synaptic Mechanisms and Molecular Events (5:00 pm Start)
*
Pietro V. De Camilli,
Yale University School of Medicine, USA
The VPS13 Family of Lipid Transport Proteins and Neurodegeneration
The VPS13 Family of Lipid Transport Proteins and Neurodegeneration
Morgan H. Sheng,
Broad Institute of MIT and Harvard, USA
Mechanisms of Synapse Loss in Neurodegenerative Disease
Mechanisms of Synapse Loss in Neurodegenerative Disease
Maria Grazia Spillantini,
University of Cambridge, UK
Synaptic Dysfunction in Parkinson's Disease
Synaptic Dysfunction in Parkinson's Disease
Volker Haucke,
Leibniz Forschungsinstitut für Molekulare Pharmakologie, Germany
The Alzheimer´s Disease Risk Factor CALM Controls Synaptic Plasticity by a GluA1-specific Endocytic Mechanism
The Alzheimer´s Disease Risk Factor CALM Controls Synaptic Plasticity by a GluA1-specific Endocytic Mechanism
Emma L. Clayton,
King's College London, UK
Short Talk: A Novel Synaptopathy- Defective Synaptic Vesicle Protein Trafficking in the Mutant CHMP2B Mouse Model of Frontotemporal dementia
Short Talk: A Novel Synaptopathy- Defective Synaptic Vesicle Protein Trafficking in the Mutant CHMP2B Mouse Model of Frontotemporal dementia
17:00—19:00
Understanding Immune Receptors in the CNS (5:00 pm Start)
Greg E. Lemke,
The Salk Institute for Biological Studies, USA
TAM Receptor Regulation of Neurodegenerative Disease
TAM Receptor Regulation of Neurodegenerative Disease
*
Marco Colonna,
Washington University School of Medicine, USA
ITAM Signaling in Neurodegeneration
ITAM Signaling in Neurodegeneration
Hugo Peluffo,
Institut Pasteur de Montevideo/UDELAR/Universitat de Barcelona, Uruguay
Short Talk: CD300f Immune Receptor Contributes To Healthy Aging By Regulating Inflammaging, Metabolism And Cognitive Decline
Short Talk: CD300f Immune Receptor Contributes To Healthy Aging By Regulating Inflammaging, Metabolism And Cognitive Decline
Jose Ledo,
Rockefeller University / Boston Children's Hospital - Harvard Medical School, USA
Short Talk: Microglia Modulate Neuronal Activity and Learning and Memory via Presenilin 1-Trem2
Short Talk: Microglia Modulate Neuronal Activity and Learning and Memory via Presenilin 1-Trem2
Nelli Blank,
University Bonn, LIMES Institute, Germany
Short Talk: Impact of Aging and Cxcr4-deficiency on the Immune Response of Microglia and Monocytes upon Experimental Stroke
Short Talk: Impact of Aging and Cxcr4-deficiency on the Immune Response of Microglia and Monocytes upon Experimental Stroke
James Hamilton,
Eli Lilly and Company, USA
Short Talk: TREM2 Limits Age-related Neurodegeneration and Modifies ß-amyloid Environment to Restrict Tau Seeding and Spreading
Short Talk: TREM2 Limits Age-related Neurodegeneration and Modifies ß-amyloid Environment to Restrict Tau Seeding and Spreading
19:15—20:15
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
08:00—11:00
Autophagy and Disease (8:00 am Start)
*
Ivan Dikic,
Goethe University Medical School, Germany
ER-phagy: From Molecular Principles to Pathogenesis of Neuropathies
ER-phagy: From Molecular Principles to Pathogenesis of Neuropathies
Xinnan Wang,
Stanford University School of Medicine, USA
Converging Cellular Pathways in Parkinson's Disease
Converging Cellular Pathways in Parkinson's Disease
Coffee Break
Elizabeth A. Eckman,
Biomedical Research Institute of New Jersey, USA
Regulation of Intravesicular Aβ by ECE-1: Implications for Aβ Aggregation and Secretion
Regulation of Intravesicular Aβ by ECE-1: Implications for Aβ Aggregation and Secretion
Rebecca Wallings,
University of Florida, USA
Short Talk: Bi-phasic, Age-dependent Alterations in Lysosomal Function and Immune Responses in R1441C-Lrrk2 Macrophages
Short Talk: Bi-phasic, Age-dependent Alterations in Lysosomal Function and Immune Responses in R1441C-Lrrk2 Macrophages
Kang-Chieh Huang,
Indiana University Purdue University Indianapolis, USA
Short Talk: Autophagy Impairment Contributes to Neurodegeneration via Repression of mTORC1 Signaling in a Human Pluripotent Stem Cell Model of Glaucoma-Associated Neurodegeneration
Short Talk: Autophagy Impairment Contributes to Neurodegeneration via Repression of mTORC1 Signaling in a Human Pluripotent Stem Cell Model of Glaucoma-Associated Neurodegeneration
Dan Dou,
University of Pennsylvania, USA
Short Talk: LRRK2 Hyperactivity Induced by Parkinson's Disease-associated Mutations Disrupts Autophagic Vesicle Transport along the Axon
Short Talk: LRRK2 Hyperactivity Induced by Parkinson's Disease-associated Mutations Disrupts Autophagic Vesicle Transport along the Axon
Celia McKee,
Washington University in St. Louis, USA
Short Talk: The Astrocyte Circadian Clock Regulates Autophagy and Endolysosome Function
Short Talk: The Astrocyte Circadian Clock Regulates Autophagy and Endolysosome Function
08:00—11:00
Microglia, Other Glial Cells and Macrophages in Neurodegenerative Diseases (8:00 am Start)
*
Michael T. Heneka,
University of Luxembourg, Luxembourg
Microglia Support Neurons through Tunneling Nanotubes
Microglia Support Neurons through Tunneling Nanotubes
Rosa C. Paolicelli,
University of Lausanne, Switzerland
Metabolic Control of Microglial Function
Metabolic Control of Microglial Function
Coffee Break
Marco Prinz,
University of Freiburg, Germany
Origin and Fate of Brain Macrophages
Origin and Fate of Brain Macrophages
Dorothy Schafer,
University of Massachusetts Chan Medical School, USA
Microglial-Astrocyte Wnt Signaling: A Key Regulator of Neural Circuit Remodeling
Microglial-Astrocyte Wnt Signaling: A Key Regulator of Neural Circuit Remodeling
Mickaël Audrain,
AC Immune, Switzerland
Short Talk: Microglia and the NLRP3 Inflammasome Pathway Contribute to Tau-mediated Pathology in vivo
Short Talk: Microglia and the NLRP3 Inflammasome Pathway Contribute to Tau-mediated Pathology in vivo
14:30—16:30
Workshop: Cellular Pathways Driving Disease (2:30 pm Start)
*
Dimitri Krainc,
Northwestern University, USA
Session Chair
Session Chair
Kelsey Babcock,
Brown University, USA
Linking Defects in the Quiescent Neural Stem Cell Pool to Impaired Adult Hippocampal Neurogenesis in Alzheimer's Disease
Linking Defects in the Quiescent Neural Stem Cell Pool to Impaired Adult Hippocampal Neurogenesis in Alzheimer's Disease
Tianmin Fu,
Ohio State University, USA
Roles of TMEM175 in Lysosomal pH Homeostasis and Parkinson's Diseases
Roles of TMEM175 in Lysosomal pH Homeostasis and Parkinson's Diseases
Kelsey Krus,
Washington University in St. Louis, USA
Loss of Stathmin-2, a Hallmark of TDP-43-Associated ALS, Causes Motor Neuropathy
Loss of Stathmin-2, a Hallmark of TDP-43-Associated ALS, Causes Motor Neuropathy
Anthony Flamier,
Whitehead Institute, USA
Impact Of DNA Methylation Changes on Alzheimer's Disease
Impact Of DNA Methylation Changes on Alzheimer's Disease
Brian P. Hafler,
Yale University, USA
Topological Analysis of Single-cell Hierarchy Reveals Inflammatory Glial Landscape of Macular Degeneration
Topological Analysis of Single-cell Hierarchy Reveals Inflammatory Glial Landscape of Macular Degeneration
Drew A. Gillett,
University of Florida, USA
BMP Modification in a Progranulin (PGRN) Deficient Cell Line
BMP Modification in a Progranulin (PGRN) Deficient Cell Line
Patrick W. Sheehan,
Washington University in St. Louis, USA
Glia Reprogram Circadian Gene Transcription During Aging and Disease
Glia Reprogram Circadian Gene Transcription During Aging and Disease
Andy P. Tsai,
Indiana University School of Medicine, USA
Impact of PLCG2 Variants on Microglial Biology and Disease Pathogenesis in Alzheimer's Disease
Impact of PLCG2 Variants on Microglial Biology and Disease Pathogenesis in Alzheimer's Disease
14:30—16:30
Workshop 2: IPSC and Organoids for the Study of Neurodegeneration (2:30 pm Start)
*
Alice Buonfiglioli,
Icahn School of Medicine at Mount Sinai, USA
A New Cerebral Organoid Culture Model to Study the Effects of Novel Drugs Targeting Microglia
A New Cerebral Organoid Culture Model to Study the Effects of Novel Drugs Targeting Microglia
Jean Paul Chadarevian,
UC Irvine, USA
Harnessing iPSC-derived Microglia to Delivery Therapeutics in the Brain
Harnessing iPSC-derived Microglia to Delivery Therapeutics in the Brain
Olivia Teter,
UCSF, USA
Uncovering Regulators of Synaptic Pruning by CRISPRi in an iPSC-derived Microglia-neuron Co-culture System
Uncovering Regulators of Synaptic Pruning by CRISPRi in an iPSC-derived Microglia-neuron Co-culture System
Marvin Reich,
German Center for Neurodegenerative Diseases, Germany
Neuron-microglia Crosstalk in a Human iPSC-based FTD Model
Neuron-microglia Crosstalk in a Human iPSC-based FTD Model
*
Amanda McQuade,
Institute for Neurodegenerative Diseases, UCSF, USA
Dampening Purinergic Signaling in TREM2-knockout iPSC-microglia Rescues Chemotactic Deficit
Dampening Purinergic Signaling in TREM2-knockout iPSC-microglia Rescues Chemotactic Deficit
Caleb C. Stokes,
University of Washington, USA
Single Cell RNA Sequencing of Zika Infection in Human Neural Tissues Reveals an Astrocyte-Driven Innate Immune Response Governed by Interferon Beta
Single Cell RNA Sequencing of Zika Infection in Human Neural Tissues Reveals an Astrocyte-Driven Innate Immune Response Governed by Interferon Beta
Sandra Siegert,
Institute of Science and Technology Austria, Austria
How MorphOMICs Challenges Current Morphological Analysis Strategies and Links Shape to Function.
How MorphOMICs Challenges Current Morphological Analysis Strategies and Links Shape to Function.
Juan J. Ramirez,
Duke University, USA
An Astrocyte to Microglia Signaling Pathway that Controls the Balance Between Synapse Formation and Synapse Elimination
An Astrocyte to Microglia Signaling Pathway that Controls the Balance Between Synapse Formation and Synapse Elimination
17:00—19:00
Endolysosomal Dysfunction in Neurodegeneration (5:00 pm Start)
Dimitri Krainc,
Northwestern University, USA
Convergence of Mitochondrial and Lysosomal Dysfunction
Convergence of Mitochondrial and Lysosomal Dysfunction
*
Ralph A. Nixon,
New York University, Langone Medical Center, USA
Defective Endolysosomal Function in Alzheimer's Disease
Defective Endolysosomal Function in Alzheimer's Disease
Roberto Zoncu,
University of California, Berkeley, USA
mTOR and Lysosomes in Nutrient Sensing and Growth Control
mTOR and Lysosomes in Nutrient Sensing and Growth Control
Hankum Park,
Seoul National University, South Korea
Short Talk: Spatial Snapshots of Amyloid Precursor Protein Intramembrane Processing via Early Endosome Proteomics
Short Talk: Spatial Snapshots of Amyloid Precursor Protein Intramembrane Processing via Early Endosome Proteomics
Sofia Massaro Tieze,
Yale University, USA
Short Talk: Molecular Characterization of Lipofuscin Pathology in Neuronal Ceroid Lipofuscinosis
Short Talk: Molecular Characterization of Lipofuscin Pathology in Neuronal Ceroid Lipofuscinosis
17:00—19:00
The Role of Brain Immune System in Shaping the CNS Connectivity (5:00 pm Start)
Jun R. Huh,
Harvard Medical School, USA
Impact of Gut Bacteria in Neurodevelopmental Abnormalities
Impact of Gut Bacteria in Neurodevelopmental Abnormalities
*
Katerina Akassoglou,
Gladstone Institutes, University of California, San Francisco, USA
Microglia Regulation of Brain Network Hyperexcitability
Microglia Regulation of Brain Network Hyperexcitability
Anne Schaefer,
Icahn School of Medicine at Mount Sinai, MPI Ageing, USA
Control of Neuronal Activity by Microglia
Control of Neuronal Activity by Microglia
Jerika J. Barron,
University of California, San Francisco, USA
Short Talk: Type 2 Innate Lymphocytes Promote Inhibitory Synapse Development and Social Memory
Short Talk: Type 2 Innate Lymphocytes Promote Inhibitory Synapse Development and Social Memory
Mario R. Capecchi,
University of Utah, USA
Short Talk: Defective Hoxb8 Microglia are Causative for both Chronic Anxiety and OCSD-like Behavior in Mice
Short Talk: Defective Hoxb8 Microglia are Causative for both Chronic Anxiety and OCSD-like Behavior in Mice
08:00—11:00
Mitochondrial Defects in Neurodegeneration (8:00 am Start)
*
Dalton James Surmeier,
Northwestern University, USA
Bioenergetic Determinants of Selective Neuronal Vulnerability in Parkinson's Disease
Bioenergetic Determinants of Selective Neuronal Vulnerability in Parkinson's Disease
Richard J. Youle,
NINDS, National Institutes of Health, USA
Pharmacologic Strategies to Target Mitochondria and Protein Aggregates Toward Autophagy
Pharmacologic Strategies to Target Mitochondria and Protein Aggregates Toward Autophagy
Coffee Break
Yvette C. Wong,
Northwestern University, USA
Mitochondria-Lysosome Contact Sites: Roles and Regulation in Homeostasis and Neurodegenerative Diseases
Mitochondria-Lysosome Contact Sites: Roles and Regulation in Homeostasis and Neurodegenerative Diseases
Anna Barron,
Nanyang Technological University, Singapore
Remote Presentation: Short Talk: Regulation of Microglial Immunometabolic Programming in Alzheimer's Disease
Remote Presentation: Short Talk: Regulation of Microglial Immunometabolic Programming in Alzheimer's Disease
Isaac Pieter Heremans,
UCLouvain, Belgium
Short Talk: Parkinson's Disease Protein PARK7 Prevents Metabolite and Protein Damage Caused by a Glycolytic Metabolite
Short Talk: Parkinson's Disease Protein PARK7 Prevents Metabolite and Protein Damage Caused by a Glycolytic Metabolite
08:00—11:00
Application of Next Generation Technologies to Profile Neuro Immune Interactions (8:00 am Start)
*
Marco Colonna,
Washington University School of Medicine, USA
Session Chair
Session Chair
Soyon Hong,
University College London, UK
Talk Title to be Announced
Talk Title to be Announced
Matheus B. Victor,
Massachusetts Institute of Technology, USA
Talk Title to be Announced
Talk Title to be Announced
Coffee Break
Christopher K. Glass,
University of California, San Diego, USA
Decoding Microglia Enhancers in Health and Disease
Decoding Microglia Enhancers in Health and Disease
Félix Distéfano-Gagné,
Laval University, Canada
Short Talk: Dynamic Regulation of the Microglial Transcriptional Landscape During Neuroinflammatory Response
Short Talk: Dynamic Regulation of the Microglial Transcriptional Landscape During Neuroinflammatory Response
Inbal Benhar,
Weizmann Institute of Science, Israel
Short Talk: Single-Cell Profiling of Non-Neuronal Retinal Cells Reveals Dynamic Multicellular Responses to Central Nervous System Injury
Short Talk: Single-Cell Profiling of Non-Neuronal Retinal Cells Reveals Dynamic Multicellular Responses to Central Nervous System Injury
Ido Amit,
Weizmann Institute, Israel
Remote Presentation: The Power of ONE: Immunology in the Age of Single Cell Genomics
Remote Presentation: The Power of ONE: Immunology in the Age of Single Cell Genomics
14:30—16:30
Career Roundtable (Joint) (2:30 pm Start)
Malu G. Tansey,
University of Florida, USA
Anabella Villalobos,
Biogen, USA
Carole Ho,
Denali Therapeutics Inc., USA
Xinnan Wang,
Stanford University School of Medicine, USA
17:00—19:00
Neuronal Pathways in Disease (5:00 pm Start)
*
Virginia M. Y. Lee,
University of Pennsylvania School of Medicine, USA
Alpha-Synuclein from Patient Lewy Bodies Exhibits Distinct Pathological Activity that can be Propagated in vitro
Alpha-Synuclein from Patient Lewy Bodies Exhibits Distinct Pathological Activity that can be Propagated in vitro
Martin Kampmann,
University of California, San Francisco, USA
CRISPR-based Functional Genomics for Neurological Disease
CRISPR-based Functional Genomics for Neurological Disease
Juliana Laverde Paz,
University of Miami, USA
CRISPR/Cas9-Mediated Excision of ALS/FTD-Causing Hexanucleotide Repeat Expansion in C9ORF72 Rescues Major Disease Mechanisms in vivo and in vitro
CRISPR/Cas9-Mediated Excision of ALS/FTD-Causing Hexanucleotide Repeat Expansion in C9ORF72 Rescues Major Disease Mechanisms in vivo and in vitro
Jennifer Rauch,
University of Massachusetts Amherst, USA
Short Talk: Deciphering the Molecular Features Underlying LRP1-Mediated Tau Spread
Short Talk: Deciphering the Molecular Features Underlying LRP1-Mediated Tau Spread
17:00—19:00
Brain Immune System in Neuroinflammation (5:00 pm Start)
Menna Clatworthy,
University of Cambridge, UK
Plasma Cells in the Meninges
Plasma Cells in the Meninges
*
Malu G. Tansey,
University of Florida, USA
Immune Function and Inflammation in Parkinson's Disease
Immune Function and Inflammation in Parkinson's Disease
Francisco J. Quintana,
Harvard Medical School and the Broad Institute of MIT and Harvard, USA
Impact of Aryl Hydrocarbon Receptor in Multiple Sclerosis
Impact of Aryl Hydrocarbon Receptor in Multiple Sclerosis
Stephanie Ann Michalski,
Saint Louis University School of Medicine, USA
Short Talk: T-lymphocyte and Microglial Paracrine Signaling Promotes Epilepsy-Associated Neuroinflammation
Short Talk: T-lymphocyte and Microglial Paracrine Signaling Promotes Epilepsy-Associated Neuroinflammation
Xiao Le Michelle Zuo,
University of Toronto, Canada
Short Talk: Ageing Promotes Grey Matter Demyelination and Neurodegeneration that is Associated with Meningeal Neutrophil Accumulation in an Animal Model of Multiple Sclerosis
Short Talk: Ageing Promotes Grey Matter Demyelination and Neurodegeneration that is Associated with Meningeal Neutrophil Accumulation in an Animal Model of Multiple Sclerosis
19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
08:00—11:00
Translational Considerations in Neurodegenerative Research (8:00 am Start)
*
Alfred Sandrock,
Voyager Therapeutics, USA
Challenges of Going from Bench to Bedside in Neurology
Challenges of Going from Bench to Bedside in Neurology
Grigorios G. Papageorgiou,
University of New Mexico, USA
A Downregulated Circular RNA in Alzheimer's Disease can Inhibit the Expression of Disease-associated Long APP and MAPT mRNA Isoforms in the Frontal Cortex
A Downregulated Circular RNA in Alzheimer's Disease can Inhibit the Expression of Disease-associated Long APP and MAPT mRNA Isoforms in the Frontal Cortex
Coffee Break
Carole Ho,
Denali Therapeutics Inc., USA
Early Clinical Development: Achieving Proof of Biology and Dose Selection Prior to Registration Enabling Clinical Studies
Early Clinical Development: Achieving Proof of Biology and Dose Selection Prior to Registration Enabling Clinical Studies
Yemima Riani Butler,
University of Michigan, USA
Short Talk: Fibril-specific Nanobody Prevents Prion-like α-Synuclein Spreading
Short Talk: Fibril-specific Nanobody Prevents Prion-like α-Synuclein Spreading
08:00—11:00
Blood Brain Barrier (BBB), Glymphatics and Lymphatics (8:00 am Start)
Jonathan Kipnis,
Washington University School of Medicine, USA
Meningeal Sinuses and Lymphatics in the Epicenter of CNS Immune Surveillance
Meningeal Sinuses and Lymphatics in the Epicenter of CNS Immune Surveillance
*
Zsuzsanna Fabry,
University of Wisconsin, USA
How Does the Meningeal Lymphatics Respond to Neuroinflammation in Autoimmunity, Infection and Trauma?
How Does the Meningeal Lymphatics Respond to Neuroinflammation in Autoimmunity, Infection and Trauma?
Coffee Break
Simone Di Giovanni,
Imperial College London, UK
Neuroimmune Interactions Control the Regenerative Ability of the Nervous System Across the Lifespan
Neuroimmune Interactions Control the Regenerative Ability of the Nervous System Across the Lifespan
Jorge I. Alvarez,
University of Pennsylvania, USA
Short Talk: Heterogeneity in the CNS Endothelium Identifies the Blood Meningeal Barrier as an Orchestrator of Neuroinflammation
Short Talk: Heterogeneity in the CNS Endothelium Identifies the Blood Meningeal Barrier as an Orchestrator of Neuroinflammation
Matthew N. Poy,
Johns Hopkins All Children's Hospital, USA
Short Talk: Glutamatergic Argonaute2 Regulates Formation of the Neurovascular Unit
Short Talk: Glutamatergic Argonaute2 Regulates Formation of the Neurovascular Unit
11:00—12:00
Panel: Challenges Associated with Transforming Novel Human Genetic Insights into Disease-Modifying Therapies (11:00 am Start)
*
Shilpa Sambashivan,
Nura Bio, USA
Session Chair
Session Chair
Arnon Rosenthal,
Alector, USA
Carole Ho,
Denali Therapeutics Inc., USA
Matthew Kennedy,
Merck Research Labs, USA
Marco Colonna,
Washington University School of Medicine, USA
Christian Mirescu,
Vigil Neuroscience, USA
14:30—16:30
Workshop 3: Immunotherapy of Neurodegeneration (2:30 pm Start)
*
Gerard Crowley,
University College London, UK
Chemogenetic Activation of Perforant Pathway Induces Microglial Complement Signalling and Synapse Loss
Chemogenetic Activation of Perforant Pathway Induces Microglial Complement Signalling and Synapse Loss
John F. Tuddenham,
Columbia University, USA
Towards Manipulation of Microglial Subsets in Humans: A Toolkit for Modulating Microglia in a Targeted Fashion
Towards Manipulation of Microglial Subsets in Humans: A Toolkit for Modulating Microglia in a Targeted Fashion
Stephanie Bissel,
Indiana University, USA
Reduced PLCG2 Expression Alters Microglial Responses and Exacerbates Disease Pathology in a Murine Model of Alzheimer's Disease
Reduced PLCG2 Expression Alters Microglial Responses and Exacerbates Disease Pathology in a Murine Model of Alzheimer's Disease
Zena K. Chatila,
Columbia University, USA
Interaction of Alzheimer's Disease Risk Variants and Amyloid on Innate Immune Function
Interaction of Alzheimer's Disease Risk Variants and Amyloid on Innate Immune Function
Hyuncheol Jung,
Korea Advanced Institute of Science and Technology, South Korea
Anti-inflammatory Clearance of Amyloid Beta by a Chimeric Gas6 Fusion Protein
Anti-inflammatory Clearance of Amyloid Beta by a Chimeric Gas6 Fusion Protein
*
Lindsay N. Hayes,
Johns Hopkins University, USA
Prenatal Immune Stress Induces Blunting of Microglia Reactivity that Impairs Striatal Connectivity
Prenatal Immune Stress Induces Blunting of Microglia Reactivity that Impairs Striatal Connectivity
Afsana Sabrin,
Columbia University, USA
Microglial and Astrocyte Signatures in CSF Proteome: Developing Markers for Glial Cell Subtypes in CSF
Microglial and Astrocyte Signatures in CSF Proteome: Developing Markers for Glial Cell Subtypes in CSF
Christina Seitz,
Karolinska Institutet, Sweden
T Cell Responses at Diagnosis of Amyotrophic Lateral Sclerosis Predict Disease Progression
T Cell Responses at Diagnosis of Amyotrophic Lateral Sclerosis Predict Disease Progression
17:00—18:45
Future Directions for Therapeutics (5:00 pm Start)
*
Anabella Villalobos,
Biogen, USA
Therapeutic Modalities for Neuroscience Diseases
Therapeutic Modalities for Neuroscience Diseases
C. Frank Bennett,
Ionis Pharmaceuticals, Inc., USA
Antisense Oligonucleotides for Neurological Diseases: What Are We Learning From the Clinic?
Antisense Oligonucleotides for Neurological Diseases: What Are We Learning From the Clinic?
Jana Mitchell,
Insitro, USA
Machine Learning for Unraveling the Complex Biology of CNS Disease
Machine Learning for Unraveling the Complex Biology of CNS Disease
Juan A. Varela,
University of St Andrews, UK
Short Talk: Clearance of Extracellular Amyloid-beta Aggregates from the Brain at the Nano-scale
Short Talk: Clearance of Extracellular Amyloid-beta Aggregates from the Brain at the Nano-scale
17:00—18:45
Aging, Metabolism and Neurodegeneration (5:00 pm Start)
Tony Wyss-Coray,
Stanford University School of Medicine, USA
Remote Presentation: Systemic Regulation of Brain Aging
Remote Presentation: Systemic Regulation of Brain Aging
*
Katrin Andreasson,
Stanford University, USA
Myeloid Cell Metabolism in Aging
Myeloid Cell Metabolism in Aging
Douglas R. Green,
St. Jude Children's Research Hospital, USA
Perchance to Dream: Sleep and Inflammation
Perchance to Dream: Sleep and Inflammation
Tal Iram,
Stanford University, USA
Short Talk: Young CSF Restores Oligodendrogenesis and Memory in Aged Mice via Fgf17
Short Talk: Young CSF Restores Oligodendrogenesis and Memory in Aged Mice via Fgf17
19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
*Session Chair †Invited, not yet responded.
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