Fairmont Hotel Vancouver Floorplan
This meeting was rescheduled and may have a different Meeting Program and Scholarships/Awards
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MEETING POSTPONED: Ubiquitin Biology (J5)
Organizer(s) Eric J. Bennett, Nicolas H. Thomä and Niels Mailand
January 23—26, 2022
Fairmont Hotel Vancouver • Vancouver, BC Canada
Abstract Deadline: Nov 9, 2021
Scholarship Deadline: Oct 26, 2021
Discounted Registration Deadline: Nov 23, 2021
Sponsored by Astellas Pharma Inc. and Genentech, Inc.
Joint Meeting:
MEETING POSTPONED: Targeted Protein Degradation (J6)
Summary of Meeting:
Protein ubiquitylation regulates nearly every critical cellular pathway and emerging evidence has demonstrated that defects within the ubiquitin proteasome system can directly lead human disease, most notably neurodegenerative disorders. This has fueled a recent expansion of drug development efforts to harness the ubiquitin proteasome system to both aid in its functionality during disease progression and to specify individual targets for degradation. Several key questions regarding ubiquitin biology remain unanswered. Can individual cellular pathways, like DNA repair, be specifically manipulated by altering the activity of ubiquitin pathway enzymes? What are the major factors that limit ubiquitin proteasome function during disease pathogenesis? How do infectious diseases impact the ubiquitin system, and can we utilize these diverse mechanisms to develop new tools and paradigms to manipulate the ubiquitin system? The specific goals of the proposed meeting are: 1- Establish detailed connections between the diverse cellular pathways regulated by the ubiquitin system. 2- Determine the structural rules defining how individual proteins are specifically targeted by ubiquitin pathway enzymes. 3- Identify emerging themes using by pathogens to subvert the ubiquitin system 4- Foster enhanced collaboration between academia and the biotechnology industry toward the goal of developing therapeutics targeting the ubiquitin system. This joint meeting with “Targeted Protein Degradation” will provide a cross-disciplinary understanding of the various genetic and chemical approaches to identify mechanisms to specifically target individual proteins for degradation. One key outcome will be the establishment of collaborations between ubiquitin biologists studying how individual pathways are regulated by ubiquitin and industry leaders developing tools to both activate and inhibit ubiquitin pathway components.
View Scholarships/Awards
Protein ubiquitylation regulates nearly every critical cellular pathway and emerging evidence has demonstrated that defects within the ubiquitin proteasome system can directly lead human disease, most notably neurodegenerative disorders. This has fueled a recent expansion of drug development efforts to harness the ubiquitin proteasome system to both aid in its functionality during disease progression and to specify individual targets for degradation. Several key questions regarding ubiquitin biology remain unanswered. Can individual cellular pathways, like DNA repair, be specifically manipulated by altering the activity of ubiquitin pathway enzymes? What are the major factors that limit ubiquitin proteasome function during disease pathogenesis? How do infectious diseases impact the ubiquitin system, and can we utilize these diverse mechanisms to develop new tools and paradigms to manipulate the ubiquitin system? The specific goals of the proposed meeting are: 1- Establish detailed connections between the diverse cellular pathways regulated by the ubiquitin system. 2- Determine the structural rules defining how individual proteins are specifically targeted by ubiquitin pathway enzymes. 3- Identify emerging themes using by pathogens to subvert the ubiquitin system 4- Foster enhanced collaboration between academia and the biotechnology industry toward the goal of developing therapeutics targeting the ubiquitin system. This joint meeting with “Targeted Protein Degradation” will provide a cross-disciplinary understanding of the various genetic and chemical approaches to identify mechanisms to specifically target individual proteins for degradation. One key outcome will be the establishment of collaborations between ubiquitin biologists studying how individual pathways are regulated by ubiquitin and industry leaders developing tools to both activate and inhibit ubiquitin pathway components.
View Scholarships/Awards
No registration fees are used to fund entertainment or alcohol at this conference
The meeting will begin on Sunday, January 23 with registration from 16:00 to 20:00 and a welcome mixer from 18:00 to 20:00. Conference events conclude on Wednesday, January 26 with a closing plenary session from 17:00 to 19:00, followed by a social hour. We recommend return travel on Thursday, January 27 in order to fully experience the meeting.
SUNDAY, JANUARY 23
MONDAY, JANUARY 24
TUESDAY, JANUARY 25
WEDNESDAY, JANUARY 26
THURSDAY, JANUARY 27
Conference Program Print | View meeting in 12 hr (am/pm) time
The meeting will begin on Sunday, January 23 with registration from 16:00 to 20:00 and a welcome mixer from 18:00 to 20:00. Conference events conclude on Wednesday, January 26 with a closing plenary session from 17:00 to 19:00, followed by a social hour. We recommend return travel on Thursday, January 27 in order to fully experience the meeting.
SUNDAY, JANUARY 23
18:00—20:00
Welcome Mixer
No registration fees are used to fund alcohol served at this function.
08:00—09:00
Welcome and Keynote Address
*
Eric J. Bennett,
University of California, San Diego, USA
Session Chair
Session Chair
Ivan Dikic,
Goethe University Medical School, Germany
Ubiquitination and Remodeling of Organelles
Ubiquitination and Remodeling of Organelles
08:00—09:00
Welcome and Keynote Address
Benjamin L. Ebert,
Dana-Farber Cancer Institute, USA
Targeted Protein Degradation for the Treatment of Cancer
Targeted Protein Degradation for the Treatment of Cancer
09:00—11:45
Regulating Nuclear Function with Ubiquitin
*
Michael Rape,
University of California, Berkeley, USA
Session Chair
Session Chair
Goran Kokic,
Max Planck Institute for Biophysical Chemistry, Germany
Transcription-coupled DNA Repair: Lessons Learned on the Ubiquitylation of Complex Substrates
Transcription-coupled DNA Repair: Lessons Learned on the Ubiquitylation of Complex Substrates
Coffee Break
Tom Deegan,
University of Edinburgh, UK
Short Talk: A Conserved Mechanism for Regulating Replisome Ubiquitylation and Disassembly in Eukaryotes
Short Talk: A Conserved Mechanism for Regulating Replisome Ubiquitylation and Disassembly in Eukaryotes
Jo R. Morris,
University of Birmingham, UK
SUMOylation in the DNA Double-Strand Break Response
SUMOylation in the DNA Double-Strand Break Response
Niels Mailand,
University of Copenhagen, Denmark
Ubiquitin-Dependent Signaling in the DNA Damage Response
Ubiquitin-Dependent Signaling in the DNA Damage Response
Stefan Müller,
Goethe-University Frankfurt, Germany
Short Talk: Safeguarding Proteome and Genome Integrity by Sumo-ubiquitin Networks
Short Talk: Safeguarding Proteome and Genome Integrity by Sumo-ubiquitin Networks
Imke Leonie Lemmer,
LMU Munich, Germany
Short Talk: Nfe2l1 Shapes the Muscle Ubiquitome to Regulate Fiber Type and Metabolic Fitness
Short Talk: Nfe2l1 Shapes the Muscle Ubiquitome to Regulate Fiber Type and Metabolic Fitness
09:00—11:15
Proteolysis Targeting Chimeras (PROTACs)
Alessio Ciulli,
University of Dundee, School of Life Sciences, UK
Structural Chemical Biology and Insights into PROTAC Mechanism of Action
Structural Chemical Biology and Insights into PROTAC Mechanism of Action
Coffee Break
Nathanael Gray,
Stanford University, USA
Targeting Kinases Via Protein Degradation
Targeting Kinases Via Protein Degradation
Shaomeng Wang,
University of Michigan, USA
Targeting Transcriptional Factor STAT3 and Other STAT Proteins by PROTAC
Targeting Transcriptional Factor STAT3 and Other STAT Proteins by PROTAC
Bikash Adhikari,
University of Wuerzburg, Germany
Short Talk: Targeted Protein Degradation of Oncogenic Proteins using PROTACs
Short Talk: Targeted Protein Degradation of Oncogenic Proteins using PROTACs
Charlotte Crowe,
University of Dundee, UK
Short Talk: Novel Biophysical Assays for Small-Molecule Mediated Ternary Complex Formation and Ubiquitination
Short Talk: Novel Biophysical Assays for Small-Molecule Mediated Ternary Complex Formation and Ubiquitination
17:00—19:00
Mechanisms of Protein Ubiquitylation and Degradation (Joint)
*
Ingrid E. Wertz,
Lyterian Therapeutics, USA
Session Chair
Session Chair
Brenda A. Schulman,
Max Planck Institute of Biochemistry, Germany
Cullin-RING E3 Ligation Mechanisms
Cullin-RING E3 Ligation Mechanisms
Weaam Ibrahim Mohamed,
Institute of Biochemistry, Switzerland
Short Talk: Regulation of RING E3 Ubiquitin Ligases by Oligomerization: What do we Learn from CRL4(DCAF1) and the hGID Complexes?
Short Talk: Regulation of RING E3 Ubiquitin Ligases by Oligomerization: What do we Learn from CRL4(DCAF1) and the hGID Complexes?
Kylie J. Walters,
NCI, National Institutes of Health, USA
Outskirts of the Proteasome: Substrate Receptors and Beyond
Outskirts of the Proteasome: Substrate Receptors and Beyond
Nicolas H. Thomä,
Friedrich Miescher Institute for Biomedical Research, Switzerland
The Zinc Finger Degrome
The Zinc Finger Degrome
Hadir Marei,
Genentech, Roche, USA
Short Talk: Leveraging E3 Ubiquitin Ligases as Cell Surface Degraders
Short Talk: Leveraging E3 Ubiquitin Ligases as Cell Surface Degraders
19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
08:00—11:00
Strategies for Therapeutic Targeting of the Ubiquitin Proteasome System (Joint)
*
Brenda A. Schulman,
Max Planck Institute of Biochemistry, Germany
Session Chair
Session Chair
Sara Buhrlage,
Dana-Farber Cancer Institute, USA
Approaches to Identify New DUB Inhibitors
Approaches to Identify New DUB Inhibitors
Coffee Break
Eva d'Hennezel,
Novartis Institutes of Biomedical Research, USA
Strategies for Therapeutic Targeting of the UPS
Strategies for Therapeutic Targeting of the UPS
Simone Bonazzi,
Novartis Institutes for Biomedical Research, USA
Strategies for Therapeutic Targeting of the UPS (cont)
Strategies for Therapeutic Targeting of the UPS (cont)
Ingrid E. Wertz,
Lyterian Therapeutics, USA
Identification, Development, and Characterization of Inhibitors for Deubiquitinating Enzymes
Identification, Development, and Characterization of Inhibitors for Deubiquitinating Enzymes
Mandeep Kaur Mann,
University of Toronto, Canada
Short Talk: Discovery of First-in-class USP5 Inhibitors
Short Talk: Discovery of First-in-class USP5 Inhibitors
Ashley Philip Dudey†,
University of East Anglia, UK
Short Talk: Developing Novel WWP1 and WWP2 Ubiquitin Ligase Ligands and Inhibitors
Short Talk: Developing Novel WWP1 and WWP2 Ubiquitin Ligase Ligands and Inhibitors
14:30—16:30
Workshop: Emerging Themes in Ubiquitin Biology
*
Eric J. Bennett,
University of California, San Diego, USA
Session Chair
Session Chair
Thang V. Nguyen,
University of Missouri, School of Medicine, USA
USP15 Antagonizes CRL4CRBN-mediated Ubiquitylation of Glutamine Synthetase and Neo-substrates
USP15 Antagonizes CRL4CRBN-mediated Ubiquitylation of Glutamine Synthetase and Neo-substrates
Darren M. O'Hara,
Almac Discovery, UK
Discovery of a Novel USP19 Inhibitor with Muscle Sparing Activity in vivo
Discovery of a Novel USP19 Inhibitor with Muscle Sparing Activity in vivo
Jason Q. Tang,
University of Toronto, Canada
Expanding the Druggable Space for USPs by Targeting Accessory Domains
Expanding the Druggable Space for USPs by Targeting Accessory Domains
Sammy Villa,
University of California, USA
The OTUD6 Deubiquitinase Associates with the 40S Ribosome to Regulate Translation and the Response to Stressors in Drosophila
The OTUD6 Deubiquitinase Associates with the 40S Ribosome to Regulate Translation and the Response to Stressors in Drosophila
Jonathan W. Bushman,
Harvard Medical School, USA
Proteomics-Based Identification of DUB Substrates Using Selective Inhibitors
Proteomics-Based Identification of DUB Substrates Using Selective Inhibitors
Alexa Nadine Wilson,
Dalhousie University, Canada
Stressed Out: How a Herpesvirus E3 Ubiquitin Ligase Targets the Cellular Stress Response
Stressed Out: How a Herpesvirus E3 Ubiquitin Ligase Targets the Cellular Stress Response
Ivan Mwebaza,
Case Western Reserve University, USA
Mycobacterium Tuberculosis Derived Mannosylated Lipoarabinomannan Upregulates E3 Ligases that Mediate Degradation of Proximal TCR Signaling Kinases in Human CD4+ T Cells Leading to Suboptimal Activation
Mycobacterium Tuberculosis Derived Mannosylated Lipoarabinomannan Upregulates E3 Ligases that Mediate Degradation of Proximal TCR Signaling Kinases in Human CD4+ T Cells Leading to Suboptimal Activation
17:00—19:00
Ubiquitin-Dependent Quality Control Mechanisms
*
James A. Olzmann,
University of California, Berkeley, USA
Session Chair
Session Chair
Eric J. Bennett,
University of California, San Diego, USA
Ribosome Associated Quality Control Mechanisms
Ribosome Associated Quality Control Mechanisms
Miguel A. Prado,
Harvard Medical School - USA & ISPA-FINBA, Spain
Short Talk: Global Remodeling of the Proteome in Terminal Differentiation
Short Talk: Global Remodeling of the Proteome in Terminal Differentiation
Sonya Neal,
University of California, San Diego, USA
The Role of Rhomboid Pseudoprotease Dfm1 in ERADicating Misfolded Membrane Proteins
The Role of Rhomboid Pseudoprotease Dfm1 in ERADicating Misfolded Membrane Proteins
Olivia Rissland,
University of Colorado School of Medicine, USA
Short Talk: Clearance of Maternal Proteins during Early Embryogenesis
Short Talk: Clearance of Maternal Proteins during Early Embryogenesis
17:00—19:00
Novel Approaches to Protein Degradation/Homeostasis for Therapeutics
Speaker to be Announced
Eric S. Fischer,
Dana-Farber Cancer Institute, USA
How Structural Biology will Transform Targeted Protein Degradation?
How Structural Biology will Transform Targeted Protein Degradation?
Hannah B L Jones,
University of Oxford, UK
Short Talk: Cell Based High-throughput Screening of DUB Inhibitors using Activity-based Probe Profiling (ABPP-HT)
Short Talk: Cell Based High-throughput Screening of DUB Inhibitors using Activity-based Probe Profiling (ABPP-HT)
Erika Maria Lopez-Alfonzo,
University of California, Berkeley, USA
Short Talk: Mechanistic Dissection of Functional Asymmetries in the Proteasomal AAA+ Motor Using smFRET
Short Talk: Mechanistic Dissection of Functional Asymmetries in the Proteasomal AAA+ Motor Using smFRET
Jort S.A. van der Geest,
University Medical Center Utrecht, Netherlands
Short Talk: Targeted Degradation of the Mutant PLN Protein in p.Arg14del PLN Associated Cardiomyopathy
Short Talk: Targeted Degradation of the Mutant PLN Protein in p.Arg14del PLN Associated Cardiomyopathy
08:00—11:00
New Paradigms in Protein Ubiquitylation
*
Susan Shao,
Harvard Medical School, USA
Session Chair
Session Chair
Satpal Virdee,
University of Dundee, UK
Non-lysine Ubiquitination and Deubiquitination
Non-lysine Ubiquitination and Deubiquitination
Joshua L. Andersen,
Brigham Young University, USA
Short Talk: TNK1 is a Ubiquitin-sensing Kinase that can be Targeted to Block Tumor Growth
Short Talk: TNK1 is a Ubiquitin-sensing Kinase that can be Targeted to Block Tumor Growth
Luis Gerardo Villa-Diaz,
Oakland University, USA
Short Talk: Enhanced Ubiquitin Pathway Regulation in Human Pluripotent Stem Cells Cultured in Microgravity Conditions
Short Talk: Enhanced Ubiquitin Pathway Regulation in Human Pluripotent Stem Cells Cultured in Microgravity Conditions
Coffee Break
Vincent Chu,
Harvard Medical School, USA
Short Talk: Selective Destabilization of Polypeptides Synthesized from NMD-targeted Transcripts
Short Talk: Selective Destabilization of Polypeptides Synthesized from NMD-targeted Transcripts
Heran Darwin,
New York University School of Medicine, USA
Proteasomal Regulation of Mycobacterial Virulence
Proteasomal Regulation of Mycobacterial Virulence
Emily Troemel,
University of California, San Diego, USA
Ubiquitin Signaling within the Intracellular Pathogen Response Pathway
Ubiquitin Signaling within the Intracellular Pathogen Response Pathway
08:00—11:00
Novel Approaches to the Development and Discovery of Molecular Glues
Anita K. Gandhi,
Bristol-Myers Squibb, USA
Emerging CELMoDs in Hematological Malignancies
Emerging CELMoDs in Hematological Malignancies
Daniel K. Nomura,
University of California, Berkeley, USA
Reimagining Druggability using Chemoproteomic Platforms
Reimagining Druggability using Chemoproteomic Platforms
Coffee Break
Georg E. Winter,
CeMM Research Center for Molecular Medicine, Austria
Chemical Genomics Approaches to Targeted Protein Degradation
Chemical Genomics Approaches to Targeted Protein Degradation
Ekaterina Vinogradova,
Rockefeller University, USA
Covalent Small-Molecule Protein Degraders
Covalent Small-Molecule Protein Degraders
Carles Galdeano,
University of Barcelona, Spain
Short Talk: Expanding the Toolbox of E3 Ligases with Structure-based Approaches
Short Talk: Expanding the Toolbox of E3 Ligases with Structure-based Approaches
Fatemeh Keramatnia,
St. Jude Children's Research Hospital, USA
Short Talk: Targeting GSPT1 by a Novel Cereblon E3 Ligase Modulator for the Treatment of Acute Lymphoblastic Leukemia
Short Talk: Targeting GSPT1 by a Novel Cereblon E3 Ligase Modulator for the Treatment of Acute Lymphoblastic Leukemia
17:00—18:45
Ubiquitin System Dysregulation in Disease
*
Sonya Neal,
University of California, San Diego, USA
Session Chair
Session Chair
Michael Rape,
University of California, Berkeley, USA
The Role of Heterotypic Ubiquitin Chains in Protein Quality Control
The Role of Heterotypic Ubiquitin Chains in Protein Quality Control
J. Wade Harper,
Harvard Medical School, USA
Systematic Analysis of Ubiquitin System Dysfunction in Mitochondrial Disorders
Systematic Analysis of Ubiquitin System Dysfunction in Mitochondrial Disorders
James A. Olzmann,
University of California, Berkeley, USA
Lipid Droplet Proteome Dynamics and lipotoxicity
Lipid Droplet Proteome Dynamics and lipotoxicity
Achim Werner,
NIDCR, National Institutes of Health, USA
Short Talk: Ubiquitin-dependent Restriction of CDC42 Signaling Specifies Embryonic Patterning
Short Talk: Ubiquitin-dependent Restriction of CDC42 Signaling Specifies Embryonic Patterning
17:00—18:45
Methodologies and Technologies for the Investigation of Protein Degradation
Steven P. Gygi,
Harvard Medical School, USA
Reimagining Fragment Based Multiplexed Chemical Proteomics for Cell Based Screening of Large Electrophile Libraries
Reimagining Fragment Based Multiplexed Chemical Proteomics for Cell Based Screening of Large Electrophile Libraries
Rajesh Chopra,
Apple Tree Partners, USA
Phenotypic Screens for Identifying Modulators of E3 Ligase Function
Phenotypic Screens for Identifying Modulators of E3 Ligase Function
Speaker to be Announced
Lewis A. Macdonald,
University of Edinburgh, UK
Short Talk: Auxin-inducible Protein Degradation in CRISPR-engineered Mice
Short Talk: Auxin-inducible Protein Degradation in CRISPR-engineered Mice
19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
*Session Chair †Invited, not yet responded.
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