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Fairmont Hotel Vancouver Floorplan

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MEETING POSTPONED: Ubiquitin Biology (J5)


Organizer(s) Eric J. Bennett, Nicolas H. Thomä and Niels Mailand
January 23—26, 2022
Fairmont Hotel Vancouver • Vancouver, BC Canada
Abstract Deadline: Nov 9, 2021
Scholarship Deadline: Oct 26, 2021
Discounted Registration Deadline: Nov 23, 2021

Sponsored by Astellas Pharma Inc. and Genentech, Inc.


Summary of Meeting:
Protein ubiquitylation regulates nearly every critical cellular pathway and emerging evidence has demonstrated that defects within the ubiquitin proteasome system can directly lead human disease, most notably neurodegenerative disorders. This has fueled a recent expansion of drug development efforts to harness the ubiquitin proteasome system to both aid in its functionality during disease progression and to specify individual targets for degradation. Several key questions regarding ubiquitin biology remain unanswered. Can individual cellular pathways, like DNA repair, be specifically manipulated by altering the activity of ubiquitin pathway enzymes? What are the major factors that limit ubiquitin proteasome function during disease pathogenesis? How do infectious diseases impact the ubiquitin system, and can we utilize these diverse mechanisms to develop new tools and paradigms to manipulate the ubiquitin system? The specific goals of the proposed meeting are: 1- Establish detailed connections between the diverse cellular pathways regulated by the ubiquitin system. 2- Determine the structural rules defining how individual proteins are specifically targeted by ubiquitin pathway enzymes. 3- Identify emerging themes using by pathogens to subvert the ubiquitin system 4- Foster enhanced collaboration between academia and the biotechnology industry toward the goal of developing therapeutics targeting the ubiquitin system. This joint meeting with “Targeted Protein Degradation” will provide a cross-disciplinary understanding of the various genetic and chemical approaches to identify mechanisms to specifically target individual proteins for degradation. One key outcome will be the establishment of collaborations between ubiquitin biologists studying how individual pathways are regulated by ubiquitin and industry leaders developing tools to both activate and inhibit ubiquitin pathway components.

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No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


The meeting will begin on Sunday, January 23 with registration from 16:00 to 20:00 and a welcome mixer from 18:00 to 20:00. Conference events conclude on Wednesday, January 26 with a closing plenary session from 17:00 to 19:00, followed by a social hour. We recommend return travel on Thursday, January 27 in order to fully experience the meeting.

SUNDAY, JANUARY 23

16:00—20:00
Arrival and Registration

British/Columbia Foyer
18:00—20:00
Welcome Mixer
No registration fees are used to fund alcohol served at this function.

British/Columbia Foyer

MONDAY, JANUARY 24

07:00—08:00
Breakfast

Pacific Ballroom
08:00—09:00
Welcome and Keynote Address

British Ballroom
* Eric J. Bennett, University of California, San Diego, USA
Session Chair

Ivan Dikic, Goethe University Medical School, Germany
Ubiquitination and Remodeling of Organelles

08:00—09:00
Welcome and Keynote Address

Columbia Ballroom
Benjamin L. Ebert, Dana-Farber Cancer Institute, USA
Targeted Protein Degradation for the Treatment of Cancer

09:00—11:45
Regulating Nuclear Function with Ubiquitin

British Ballroom
* Michael Rape, University of California, Berkeley, USA
Session Chair

Goran Kokic, Max Planck Institute for Biophysical Chemistry, Germany
Transcription-coupled DNA Repair: Lessons Learned on the Ubiquitylation of Complex Substrates

Coffee Break

Tom Deegan, University of Edinburgh, UK
Short Talk: A Conserved Mechanism for Regulating Replisome Ubiquitylation and Disassembly in Eukaryotes

Jo R. Morris, University of Birmingham, UK
SUMOylation in the DNA Double-Strand Break Response

Niels Mailand, University of Copenhagen, Denmark
Ubiquitin-Dependent Signaling in the DNA Damage Response

Stefan Müller, Goethe-University Frankfurt, Germany
Short Talk: Safeguarding Proteome and Genome Integrity by Sumo-ubiquitin Networks

Imke Leonie Lemmer, LMU Munich, Germany
Short Talk: Nfe2l1 Shapes the Muscle Ubiquitome to Regulate Fiber Type and Metabolic Fitness

09:00—11:15
Proteolysis Targeting Chimeras (PROTACs)

Columbia Ballroom
Alessio Ciulli, University of Dundee, School of Life Sciences, UK
Structural Chemical Biology and Insights into PROTAC Mechanism of Action

Coffee Break

Nathanael Gray, Stanford University, USA
Targeting Kinases Via Protein Degradation

Shaomeng Wang, University of Michigan, USA
Targeting Transcriptional Factor STAT3 and Other STAT Proteins by PROTAC

Bikash Adhikari, University of Wuerzburg, Germany
Short Talk: Targeted Protein Degradation of Oncogenic Proteins using PROTACs

Charlotte Crowe, University of Dundee, UK
Short Talk: Novel Biophysical Assays for Small-Molecule Mediated Ternary Complex Formation and Ubiquitination

11:45—17:00
On Own for Lunch

11:45—13:00
Poster Setup

Pacific Ballroom
13:00—22:00
Poster Viewing

Pacific Ballroom
14:30—16:30
Career Roundtable (Joint)

16:30—17:00
Coffee Available

British/Columbia Foyer
17:00—19:00
Mechanisms of Protein Ubiquitylation and Degradation (Joint)

British/Columbia Ballroom
* Ingrid E. Wertz, Lyterian Therapeutics, USA
Session Chair

Brenda A. Schulman, Max Planck Institute of Biochemistry, Germany
Cullin-RING E3 Ligation Mechanisms

Weaam Ibrahim Mohamed, Institute of Biochemistry, Switzerland
Short Talk: Regulation of RING E3 Ubiquitin Ligases by Oligomerization: What do we Learn from CRL4(DCAF1) and the hGID Complexes?

Kylie J. Walters, NCI, National Institutes of Health, USA
Outskirts of the Proteasome: Substrate Receptors and Beyond

Nicolas H. Thomä, Friedrich Miescher Institute for Biomedical Research, Switzerland
The Zinc Finger Degrome

Hadir Marei, Genentech, Roche, USA
Short Talk: Leveraging E3 Ubiquitin Ligases as Cell Surface Degraders

19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Pacific Ballroom
19:30—22:00
Poster Session 1

Pacific Ballroom

TUESDAY, JANUARY 25

07:00—08:00
Breakfast

Pacific Ballroom
07:30—08:00
Poster Setup

Pacific Ballroom
08:00—19:00
Poster Viewing

Pacific Ballroom
08:00—11:00
Strategies for Therapeutic Targeting of the Ubiquitin Proteasome System (Joint)

British/Columbia Ballroom
* Brenda A. Schulman, Max Planck Institute of Biochemistry, Germany
Session Chair

Sara Buhrlage, Dana-Farber Cancer Institute, USA
Approaches to Identify New DUB Inhibitors

Mikko Taipale, University of Toronto, Canada
Functional Proteomics by Induced Proximity

Coffee Break

Eva d'Hennezel, Novartis Institutes of Biomedical Research, USA
Strategies for Therapeutic Targeting of the UPS

Simone Bonazzi, Novartis Institutes for Biomedical Research, USA
Strategies for Therapeutic Targeting of the UPS (cont)

Ingrid E. Wertz, Lyterian Therapeutics, USA
Identification, Development, and Characterization of Inhibitors for Deubiquitinating Enzymes

Mandeep Kaur Mann, University of Toronto, Canada
Short Talk: Discovery of First-in-class USP5 Inhibitors

Ashley Philip Dudey†, University of East Anglia, UK
Short Talk: Developing Novel WWP1 and WWP2 Ubiquitin Ligase Ligands and Inhibitors

11:00—12:30
Lunch

Pacific Ballroom
12:00—14:30
Poster Session 2

Pacific Ballroom
14:30—16:30
Workshop: Emerging Themes in Ubiquitin Biology

British Ballroom
* Eric J. Bennett, University of California, San Diego, USA
Session Chair

Thang V. Nguyen, University of Missouri, School of Medicine, USA
USP15 Antagonizes CRL4CRBN-mediated Ubiquitylation of Glutamine Synthetase and Neo-substrates

Darren M. O'Hara, Almac Discovery, UK
Discovery of a Novel USP19 Inhibitor with Muscle Sparing Activity in vivo

Jason Q. Tang, University of Toronto, Canada
Expanding the Druggable Space for USPs by Targeting Accessory Domains

Sammy Villa, University of California, USA
The OTUD6 Deubiquitinase Associates with the 40S Ribosome to Regulate Translation and the Response to Stressors in Drosophila

Jonathan W. Bushman, Harvard Medical School, USA
Proteomics-Based Identification of DUB Substrates Using Selective Inhibitors

Alexa Nadine Wilson, Dalhousie University, Canada
Stressed Out: How a Herpesvirus E3 Ubiquitin Ligase Targets the Cellular Stress Response

Ivan Mwebaza, Case Western Reserve University, USA
Mycobacterium Tuberculosis Derived Mannosylated Lipoarabinomannan Upregulates E3 Ligases that Mediate Degradation of Proximal TCR Signaling Kinases in Human CD4+ T Cells Leading to Suboptimal Activation

16:30—17:00
Coffee Available

British/Columbia Foyer
17:00—19:00
Ubiquitin-Dependent Quality Control Mechanisms

British Ballroom
* James A. Olzmann, University of California, Berkeley, USA
Session Chair

Eric J. Bennett, University of California, San Diego, USA
Ribosome Associated Quality Control Mechanisms

Miguel A. Prado, Harvard Medical School - USA & ISPA-FINBA, Spain
Short Talk: Global Remodeling of the Proteome in Terminal Differentiation

Sonya Neal, University of California, San Diego, USA
The Role of Rhomboid Pseudoprotease Dfm1 in ERADicating Misfolded Membrane Proteins

Olivia Rissland, University of Colorado School of Medicine, USA
Short Talk: Clearance of Maternal Proteins during Early Embryogenesis

Susan Shao, Harvard Medical School, USA
Mechanisms of Ribosome-Associated Protein Degradation

17:00—19:00
Novel Approaches to Protein Degradation/Homeostasis for Therapeutics

Columbia Ballroom
Speaker to be Announced

Eric S. Fischer, Dana-Farber Cancer Institute, USA
How Structural Biology will Transform Targeted Protein Degradation?

Hannah B L Jones, University of Oxford, UK
Short Talk: Cell Based High-throughput Screening of DUB Inhibitors using Activity-based Probe Profiling (ABPP-HT)

Erika Maria Lopez-Alfonzo, University of California, Berkeley, USA
Short Talk: Mechanistic Dissection of Functional Asymmetries in the Proteasomal AAA+ Motor Using smFRET

Jort S.A. van der Geest, University Medical Center Utrecht, Netherlands
Short Talk: Targeted Degradation of the Mutant PLN Protein in p.Arg14del PLN Associated Cardiomyopathy

19:00—21:00
On Own for Dinner


WEDNESDAY, JANUARY 26

07:00—08:00
Breakfast

Pacific Ballroom
08:00—11:00
New Paradigms in Protein Ubiquitylation

British Ballroom
* Susan Shao, Harvard Medical School, USA
Session Chair

Satpal Virdee, University of Dundee, UK
Non-lysine Ubiquitination and Deubiquitination

Joshua L. Andersen, Brigham Young University, USA
Short Talk: TNK1 is a Ubiquitin-sensing Kinase that can be Targeted to Block Tumor Growth

Luis Gerardo Villa-Diaz, Oakland University, USA
Short Talk: Enhanced Ubiquitin Pathway Regulation in Human Pluripotent Stem Cells Cultured in Microgravity Conditions

Coffee Break

Vincent Chu, Harvard Medical School, USA
Short Talk: Selective Destabilization of Polypeptides Synthesized from NMD-targeted Transcripts

Heran Darwin, New York University School of Medicine, USA
Proteasomal Regulation of Mycobacterial Virulence

Emily Troemel, University of California, San Diego, USA
Ubiquitin Signaling within the Intracellular Pathogen Response Pathway

08:00—11:00
Novel Approaches to the Development and Discovery of Molecular Glues

Columbia Ballroom
Anita K. Gandhi, Bristol-Myers Squibb, USA
Emerging CELMoDs in Hematological Malignancies

Daniel K. Nomura, University of California, Berkeley, USA
Reimagining Druggability using Chemoproteomic Platforms

Coffee Break

Georg E. Winter, CeMM Research Center for Molecular Medicine, Austria
Chemical Genomics Approaches to Targeted Protein Degradation

Ekaterina Vinogradova, Rockefeller University, USA
Covalent Small-Molecule Protein Degraders

Carles Galdeano, University of Barcelona, Spain
Short Talk: Expanding the Toolbox of E3 Ligases with Structure-based Approaches

Fatemeh Keramatnia, St. Jude Children's Research Hospital, USA
Short Talk: Targeting GSPT1 by a Novel Cereblon E3 Ligase Modulator for the Treatment of Acute Lymphoblastic Leukemia

11:00—17:00
On Own for Lunch

16:30—17:00
Coffee Available

British/Columbia Foyer
17:00—18:45
Ubiquitin System Dysregulation in Disease

British Ballroom
* Sonya Neal, University of California, San Diego, USA
Session Chair

Michael Rape, University of California, Berkeley, USA
The Role of Heterotypic Ubiquitin Chains in Protein Quality Control

J. Wade Harper, Harvard Medical School, USA
Systematic Analysis of Ubiquitin System Dysfunction in Mitochondrial Disorders

James A. Olzmann, University of California, Berkeley, USA
Lipid Droplet Proteome Dynamics and lipotoxicity

Achim Werner, NIDCR, National Institutes of Health, USA
Short Talk: Ubiquitin-dependent Restriction of CDC42 Signaling Specifies Embryonic Patterning

17:00—18:45
Methodologies and Technologies for the Investigation of Protein Degradation

Columbia Ballroom
Steven P. Gygi, Harvard Medical School, USA
Reimagining Fragment Based Multiplexed Chemical Proteomics for Cell Based Screening of Large Electrophile Libraries

Rajesh Chopra, Apple Tree Partners, USA
Phenotypic Screens for Identifying Modulators of E3 Ligase Function

Speaker to be Announced

Lewis A. Macdonald, University of Edinburgh, UK
Short Talk: Auxin-inducible Protein Degradation in CRISPR-engineered Mice

18:45—19:00
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)

British Ballroom
18:45—19:00
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)

Columbia Ballroom
19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Pacific Ballroom

THURSDAY, JANUARY 27

08:00—08:00
Departure


*Session Chair †Invited, not yet responded.



Keystone Symposia thanks our Sponsors(s) for generously supporting this meeting:

Astellas Pharma Inc. Genentech, Inc.

We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:


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Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


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If your organization is interested in joining these entities in support of Keystone Symposia, please contact: John Monson, Director of Corporate Relations, Email: johnm@keystonesymposia.org,
Phone:+1 970-262-2690

Click here for more information on Industry Support and Recognition Opportunities.

If you are interested in becoming an advertising/marketing in-kind partner, please contact:
Josh May, Director, Technology and Digital Media, Email: joshuam@keystonesymposia.org,
Phone:+1 970-262-1179