Keystone Symposia

Eldorado Hotel & Spa Floorplan

This meeting took place in 2022


Here are the related meetings in 2024:
Regulatory RNAs: Emerging Mechanisms (J8)

For a complete list of the meetings for the upcoming/current season, see our meeting list, or search for a meeting.

Small Regulatory RNAs: From Bench to Bedside (E1)


Organizer(s) Frank J. Slack, Jörg Vogel, Ivan Martinez and Karyn Schmidt
May 1—4, 2022
Eldorado Hotel & Spa • Santa Fe, NM USA
Abstract Deadline: Feb 15, 2022
Scholarship Deadline: Feb 15, 2022
Discounted Registration Deadline: Mar 1, 2022

Sponsored by Cell Research

Summary of Meeting:
RNA-based therapeutics are already approved for a variety of human diseases. A large and diverse set of small regulatory RNAs have emerged as key regulators of gene expression during development and cellular homeostasis and are frequently mis-expressed in human disease. Their small size and molecular properties make small RNAs amenable as targets and therapeutics and provide physicians with a powerful new battery of agents to diagnose and treat disease. However, while thousands of small RNAs are known, relatively little is known about their roles and targets, and there is still a limited application of these molecules in the clinic. The specific aims of this meeting serve to address these deficiencies and are as follows: 1) Focus on the exciting biology of small regulatory RNAs, highlighting the best current research into the role that small RNAs play in fundamental processes; 2) Focus on the latest efforts to harness the power of these RNAs as agents in the fight against disease and provide the basic understanding that will drive the invention of powerful clinical tools; 3) Attract the best researchers working in small RNAs to one place for critical discussions that will advance the field and accelerate the bench to bedside use of this technology; and 4) Provide a stimulating environment where students, postdocs and junior investigators can present and discuss their research with the best minds in the field.

View Scholarships/Awards
No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


The meeting will begin on Sunday, May 1 with registration from 16:00 to 20:00 and a welcome mixer from 18:00 to 20:00. Conference events conclude on Wednesday, May 4 with a closing plenary session from 17:00 to 19:00, followed by a social hour. We recommend return travel on Thursday, May 5 in order to fully experience the meeting.

SUNDAY, MAY 1

16:00—20:00
Arrival and Registration

Cava Santa Fe
18:00—20:00
Welcome Mixer
No registration fees are used to fund alcohol served at this function.

Cava Santa Fe

MONDAY, MAY 2

07:00—08:00
Breakfast

Anasazi Ballroom
07:30—08:00
Poster Setup

Anasazi Ballroom
08:00—19:00
Poster Viewing

Anasazi Ballroom
08:00—09:00
Welcome and Keynote Address

Eldorado Grand Ballroom
* Ivan Martinez, West Virginia University, USA
Session Chair

Joan A. Steitz, Yale University, USA
Viral Noncoding RNAs: New Insights into RNA Structure

09:00—11:15
Small Regulatory RNAs and Cancer

Eldorado Grand Ballroom
* Frank J. Slack, BIDMC Cancer Center/Harvard Medical School, USA
Session Chair

Joshua T. Mendell, University of Texas Southwestern Medical Center, USA
Regulation of microRNA Stability

Coffee Break

George A. Calin, University of Texas MD Anderson Cancer Center, USA
Chomsky, Patterns and Non-coding RNAs

Christine Eischen, Thomas Jefferson University, USA
miRNA that Regulate Tumorigenesis

Aurora Esquela-Kerscher, Eastern Virginia Medical School, USA
Short Talk: The miR-888 Cluster Members as Clinical Targets for Prostate Cancer

11:15—12:30
Lunch

Anasazi Ballroom
12:00—14:30
Poster Session 1

Anasazi Ballroom
14:30—16:30
Workshop: Emerging Topics in Small RNAs

Eldorado Grand Ballroom
* Aurora Esquela-Kerscher, Eastern Virginia Medical School, USA
Session Chair

Mariagrazia Volpe, Telethon Institute of Genetics and Medicine, Italy
AAV-mediated Inhibition of miR-181a/b as Gene-independent Therapeutic Tool for Mitochondrial Diseases

Francesco Angelelli, Inserm 1065, C3M, France
Deciphering the Complexity of miRNA-binding Activity and Mediated Repression

Alessandra Cataldo, Fondazione IRCCS Istituto dei Tumori di Milano, Italy
MiR-302b-based Therapy Impacts Both Tumor and Immune Cells

Bing Yang, National Institute of Health, USA
The Developmentally-timed Decay of an Essential MicroRNA Family is Seed Sequence-dependent

Maria Kral, Institute of Diabetes Research, Germany
Targeting miRNA-mediated Immune Activation in Islet Autoimmunity

Laura Sala, National Cancer Institute, USA
In Vivo Characterization of Endogenous AGO2 Subcellular Localization

Eric Van Nostrand, Baylor College of Medicine, USA
Scalable and Deep Profiling of mRNA Targets for Individual MicroRNAs with Chimeric eCLIP

Analisa DiFeo, University of Michigan, USA
Therapeutic Targeting of miR-181a to Modulate Tumor Immune Response

16:30—17:00
Coffee Available

Concourse
17:00—19:00
MicroRNAs and Therapeutics

Eldorado Grand Ballroom
* Karyn Schmidt, Alnylam Pharmaceuticals, USA
Session Chair

Ivan Martinez, West Virginia University, USA
MicroRNAs and Viral Infections

Vishal Patel, University of Texas Southwestern Medical Center, USA
AntimiRs as Therapy in Human Disease

Raman Bahal, University of Connecticut, USA
Multiple OncomiRs Targeting for Glioma Therapy

Murugaiyan Gopal, Harvard Medical School, USA
Short Talk: Therapeutic Targeting of miRNA-92a in Central Nervous System Autoimmunity

19:00—21:00
On Own for Dinner


TUESDAY, MAY 3

07:00—08:00
Breakfast

Anasazi Ballroom
08:00—11:00
Diverse Small Regulatory RNAs

Eldorado Grand Ballroom
* Shobha Vasudevan, Massachusetts General Hospital, USA
Session Chair

Richard I. Gregory, Boston Children's Hospital/Harvard Medical School, USA
RNA Modification of ncRNAs

Jörg Vogel, University of Würzburg, Germany
Learning from Small RNAs to Edit the Human Microbiota

Coffee Break

Sandra L. Wolin, NCI, National Institutes of Health, USA
Damaged tRNAs as Signaling Molecules

Gisela T. Storz, National Institutes of Health, USA
RNA-mediated Regulation within Protein-coding Sequences

Daniel Cifuentes, Boston University, USA
Short Talk: The miR-144/Hmgn2 Regulatory Axis Orchestrates Chromatin Regulation during Erythropoiesis

Ruben Garcia Martin, Joslin Diabetes Center / Harvard Medical School, USA
Short Talk: Defining the miRNA Codes Controlling Exosomal Secretion vs. Cellular Retention

11:00—17:00
On Own for Lunch

11:00—13:00
Poster Setup

Anasazi Ballroom
13:00—22:00
Poster Viewing

Anasazi Ballroom
15:00—16:30
Career Roundtable

DeVargas
Christine Eischen, Thomas Jefferson University, USA

Stefan Engelhardt, Technical University of Munich, Germany

John T. Powers, Dell Medical School at The University of Texas at Austin, USA

16:30—17:00
Coffee Available

Concourse
17:00—19:00
Small Regulatory RNA Functions and Non-Canonical Pathways

Eldorado Grand Ballroom
* Gisela T. Storz, National Institutes of Health, USA
Session Chair

Shobha Vasudevan, Massachusetts General Hospital, USA
Post-transcriptional Mechanisms in Chemoresistant, Quiescent Cancer Cells

Martin J. Simard, CRCHU de Québec-Université Laval, Canada
Function and Regulation of the microRNA Pathway in Animals

Monika Gullerova, University of Oxford, Wadham College, UK
Dicer Dependent tRNA Derived Small RNA in Gene Expression Regulation

Elena Piskounova, Weill Cornell Medicine, USA
Short Talk: tRNA Wobble Modifications as Drivers of the Adaptive Proteome in Metastasis

Soo Mi Lee, Harvard Medical School, USA
Short Talk: Cellular microRNA-127-3p Suppresses Oncogenic Herpesvirus-induced Transformation and Tumorigenesis via Down-regulation of SKP2

19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Anasazi Ballroom
19:30—22:00
Poster Session 2

Anasazi Ballroom

WEDNESDAY, MAY 4

07:00—08:00
Breakfast

Anasazi Ballroom
08:00—11:00
Therapeutic Opportunities for Small RNAs

Eldorado Grand Ballroom
* George A. Calin, University of Texas MD Anderson Cancer Center, USA
Session Chair

Mofang Liu, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, China
Remote Presentation: The Roles of PIWI/piRNAs in Gene Regulation and Diseases

Stefan Engelhardt, Technical University of Munich, Germany
Targeted miRNA Therapeutics

Coffee Break

Karyn Schmidt, Alnylam Pharmaceuticals, USA
Mechanistic Insights and Advances in RNAi Therapeutics Platform

Frank J. Slack, BIDMC Cancer Center/Harvard Medical School, USA
Towards Personalized microRNA Therapeutics

John T. Powers, Dell Medical School at The University of Texas at Austin, USA
Short Talk: Multiple Isoforms of let-7 Antagonist H19 lncRNA are Highly Expressed in MYCN Non-amplified Neuroblastoma

11:00—17:00
On Own for Lunch

16:30—17:00
Coffee Available

Concourse
17:00—18:45
Emerging Technologies and Novel Application for Small RNAs

Eldorado Grand Ballroom
* Sandra L. Wolin, NCI, National Institutes of Health, USA
Session Chair

William J. Greenleaf, Stanford University, USA
Remote Presentation: Highthroughput Analysis Reveals Rules for Target RNA Binding and Cleavage by Ago2

Sabrina R. Leslie, UBC, Canada
CLiC: High Resolution Single Molecule Imaging

Ioannis S. Vlachos, Beth Israel Deaconess Medical Center, USA
3' Untranslated Regions (3'UTRs) and MicroRNAs Controlling the Cancer Immune Landscape and Response to Immunotherapy

Byunghee Yoo, Massachusetts General Hospital and Harvard Medical School, USA
Short Talk: RNAi-based PD-L1 Inhibitor, MN-siPDL1, Demonstrates Efficacy in Highly Aggressive Models of PDAC

18:45—19:00
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)

Eldorado Grand Ballroom
19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Anasazi Ballroom

THURSDAY, MAY 5

08:00—08:00
Departure


*Session Chair †Invited, not yet responded.



Keystone Symposia thanks our Sponsor(s) for generously supporting this meeting:

Cell Research

We gratefully acknowledge additional support from these exhibitors at this conference:

Eclipse Bioinnovations, Inc.
Please stop by to meet these exhibitors during the conference.


We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1R13CA271453-01

Funding for this conference was made possible (in part) by 1R13CA271453-01 from the National Institutes of Health. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention by trade names, commercial practices, or organizations imply endorsement by the U.S. Government.


We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:



Alnylam Pharmaceuticals, Inc.


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Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


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If your organization is interested in joining these entities in support of Keystone Symposia, please contact: John Monson, Director of Corporate Relations, Email: johnm@keystonesymposia.org,
Phone:+1 970-262-2690

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If you are interested in becoming an advertising/marketing in-kind partner, please contact:
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Phone:+1 970-262-1179