Eldorado Hotel & Spa Floorplan
This meeting took place in 2022
Here are the related meetings in 2024:
Regulatory RNAs: Emerging Mechanisms (J8)
For a complete list of the meetings for the upcoming/current season, see our meeting list, or search for a meeting.
Small Regulatory RNAs: From Bench to Bedside (E1)
Organizer(s) Frank J. Slack, Jörg Vogel, Ivan Martinez and Karyn Schmidt
May 1—4, 2022
Eldorado Hotel & Spa • Santa Fe, NM USA
Abstract Deadline: Feb 15, 2022
Scholarship Deadline: Feb 15, 2022
Discounted Registration Deadline: Mar 1, 2022
Sponsored by Cell Research
Summary of Meeting:
RNA-based therapeutics are already approved for a variety of human diseases. A large and diverse set of small regulatory RNAs have emerged as key regulators of gene expression during development and cellular homeostasis and are frequently mis-expressed in human disease. Their small size and molecular properties make small RNAs amenable as targets and therapeutics and provide physicians with a powerful new battery of agents to diagnose and treat disease. However, while thousands of small RNAs are known, relatively little is known about their roles and targets, and there is still a limited application of these molecules in the clinic. The specific aims of this meeting serve to address these deficiencies and are as follows: 1) Focus on the exciting biology of small regulatory RNAs, highlighting the best current research into the role that small RNAs play in fundamental processes; 2) Focus on the latest efforts to harness the power of these RNAs as agents in the fight against disease and provide the basic understanding that will drive the invention of powerful clinical tools; 3) Attract the best researchers working in small RNAs to one place for critical discussions that will advance the field and accelerate the bench to bedside use of this technology; and 4) Provide a stimulating environment where students, postdocs and junior investigators can present and discuss their research with the best minds in the field.
View Scholarships/Awards
RNA-based therapeutics are already approved for a variety of human diseases. A large and diverse set of small regulatory RNAs have emerged as key regulators of gene expression during development and cellular homeostasis and are frequently mis-expressed in human disease. Their small size and molecular properties make small RNAs amenable as targets and therapeutics and provide physicians with a powerful new battery of agents to diagnose and treat disease. However, while thousands of small RNAs are known, relatively little is known about their roles and targets, and there is still a limited application of these molecules in the clinic. The specific aims of this meeting serve to address these deficiencies and are as follows: 1) Focus on the exciting biology of small regulatory RNAs, highlighting the best current research into the role that small RNAs play in fundamental processes; 2) Focus on the latest efforts to harness the power of these RNAs as agents in the fight against disease and provide the basic understanding that will drive the invention of powerful clinical tools; 3) Attract the best researchers working in small RNAs to one place for critical discussions that will advance the field and accelerate the bench to bedside use of this technology; and 4) Provide a stimulating environment where students, postdocs and junior investigators can present and discuss their research with the best minds in the field.
View Scholarships/Awards
No registration fees are used to fund entertainment or alcohol at this conference
The meeting will begin on Sunday, May 1 with registration from 16:00 to 20:00 and a welcome mixer from 18:00 to 20:00. Conference events conclude on Wednesday, May 4 with a closing plenary session from 17:00 to 19:00, followed by a social hour. We recommend return travel on Thursday, May 5 in order to fully experience the meeting.
SUNDAY, MAY 1
MONDAY, MAY 2
TUESDAY, MAY 3
WEDNESDAY, MAY 4
THURSDAY, MAY 5
Conference Program Print | View meeting in 12 hr (am/pm) time
The meeting will begin on Sunday, May 1 with registration from 16:00 to 20:00 and a welcome mixer from 18:00 to 20:00. Conference events conclude on Wednesday, May 4 with a closing plenary session from 17:00 to 19:00, followed by a social hour. We recommend return travel on Thursday, May 5 in order to fully experience the meeting.
SUNDAY, MAY 1
18:00—20:00
Welcome Mixer
No registration fees are used to fund alcohol served at this function.
08:00—09:00
Welcome and Keynote Address
*
Ivan Martinez,
West Virginia University, USA
Session Chair
Session Chair
Joan A. Steitz,
Yale University, USA
Viral Noncoding RNAs: New Insights into RNA Structure
Viral Noncoding RNAs: New Insights into RNA Structure
09:00—11:15
Small Regulatory RNAs and Cancer
*
Frank J. Slack,
BIDMC Cancer Center/Harvard Medical School, USA
Session Chair
Session Chair
Joshua T. Mendell,
University of Texas Southwestern Medical Center, USA
Regulation of microRNA Stability
Regulation of microRNA Stability
Coffee Break
George A. Calin,
University of Texas MD Anderson Cancer Center, USA
Chomsky, Patterns and Non-coding RNAs
Chomsky, Patterns and Non-coding RNAs
Christine Eischen,
Thomas Jefferson University, USA
miRNA that Regulate Tumorigenesis
miRNA that Regulate Tumorigenesis
Aurora Esquela-Kerscher,
Eastern Virginia Medical School, USA
Short Talk: The miR-888 Cluster Members as Clinical Targets for Prostate Cancer
Short Talk: The miR-888 Cluster Members as Clinical Targets for Prostate Cancer
14:30—16:30
Workshop: Emerging Topics in Small RNAs
*
Aurora Esquela-Kerscher,
Eastern Virginia Medical School, USA
Session Chair
Session Chair
Mariagrazia Volpe,
Telethon Institute of Genetics and Medicine, Italy
AAV-mediated Inhibition of miR-181a/b as Gene-independent Therapeutic Tool for Mitochondrial Diseases
AAV-mediated Inhibition of miR-181a/b as Gene-independent Therapeutic Tool for Mitochondrial Diseases
Francesco Angelelli,
Inserm 1065, C3M, France
Deciphering the Complexity of miRNA-binding Activity and Mediated Repression
Deciphering the Complexity of miRNA-binding Activity and Mediated Repression
Alessandra Cataldo,
Fondazione IRCCS Istituto dei Tumori di Milano, Italy
MiR-302b-based Therapy Impacts Both Tumor and Immune Cells
MiR-302b-based Therapy Impacts Both Tumor and Immune Cells
Bing Yang,
National Institute of Health, USA
The Developmentally-timed Decay of an Essential MicroRNA Family is Seed Sequence-dependent
The Developmentally-timed Decay of an Essential MicroRNA Family is Seed Sequence-dependent
Maria Kral,
Institute of Diabetes Research, Germany
Targeting miRNA-mediated Immune Activation in Islet Autoimmunity
Targeting miRNA-mediated Immune Activation in Islet Autoimmunity
Laura Sala,
National Cancer Institute, USA
In Vivo Characterization of Endogenous AGO2 Subcellular Localization
In Vivo Characterization of Endogenous AGO2 Subcellular Localization
Eric Van Nostrand,
Baylor College of Medicine, USA
Scalable and Deep Profiling of mRNA Targets for Individual MicroRNAs with Chimeric eCLIP
Scalable and Deep Profiling of mRNA Targets for Individual MicroRNAs with Chimeric eCLIP
Analisa DiFeo,
University of Michigan, USA
Therapeutic Targeting of miR-181a to Modulate Tumor Immune Response
Therapeutic Targeting of miR-181a to Modulate Tumor Immune Response
17:00—19:00
MicroRNAs and Therapeutics
*
Karyn Schmidt,
Alnylam Pharmaceuticals, USA
Session Chair
Session Chair
Ivan Martinez,
West Virginia University, USA
MicroRNAs and Viral Infections
MicroRNAs and Viral Infections
Vishal Patel,
University of Texas Southwestern Medical Center, USA
AntimiRs as Therapy in Human Disease
AntimiRs as Therapy in Human Disease
Murugaiyan Gopal,
Harvard Medical School, USA
Short Talk: Therapeutic Targeting of miRNA-92a in Central Nervous System Autoimmunity
Short Talk: Therapeutic Targeting of miRNA-92a in Central Nervous System Autoimmunity
08:00—11:00
Diverse Small Regulatory RNAs
*
Shobha Vasudevan,
Massachusetts General Hospital, USA
Session Chair
Session Chair
Richard I. Gregory,
Boston Children's Hospital/Harvard Medical School, USA
RNA Modification of ncRNAs
RNA Modification of ncRNAs
Jörg Vogel,
University of Würzburg, Germany
Learning from Small RNAs to Edit the Human Microbiota
Learning from Small RNAs to Edit the Human Microbiota
Coffee Break
Gisela T. Storz,
National Institutes of Health, USA
RNA-mediated Regulation within Protein-coding Sequences
RNA-mediated Regulation within Protein-coding Sequences
Daniel Cifuentes,
Boston University, USA
Short Talk: The miR-144/Hmgn2 Regulatory Axis Orchestrates Chromatin Regulation during Erythropoiesis
Short Talk: The miR-144/Hmgn2 Regulatory Axis Orchestrates Chromatin Regulation during Erythropoiesis
Ruben Garcia Martin,
Joslin Diabetes Center / Harvard Medical School, USA
Short Talk: Defining the miRNA Codes Controlling Exosomal Secretion vs. Cellular Retention
Short Talk: Defining the miRNA Codes Controlling Exosomal Secretion vs. Cellular Retention
15:00—16:30
Career Roundtable
Christine Eischen,
Thomas Jefferson University, USA
Stefan Engelhardt,
Technical University of Munich, Germany
John T. Powers,
Dell Medical School at The University of Texas at Austin, USA
17:00—19:00
Small Regulatory RNA Functions and Non-Canonical Pathways
*
Gisela T. Storz,
National Institutes of Health, USA
Session Chair
Session Chair
Shobha Vasudevan,
Massachusetts General Hospital, USA
Post-transcriptional Mechanisms in Chemoresistant, Quiescent Cancer Cells
Post-transcriptional Mechanisms in Chemoresistant, Quiescent Cancer Cells
Martin J. Simard,
CRCHU de Québec-Université Laval, Canada
Function and Regulation of the microRNA Pathway in Animals
Function and Regulation of the microRNA Pathway in Animals
Monika Gullerova,
University of Oxford, Wadham College, UK
Dicer Dependent tRNA Derived Small RNA in Gene Expression Regulation
Dicer Dependent tRNA Derived Small RNA in Gene Expression Regulation
Elena Piskounova,
Weill Cornell Medicine, USA
Short Talk: tRNA Wobble Modifications as Drivers of the Adaptive Proteome in Metastasis
Short Talk: tRNA Wobble Modifications as Drivers of the Adaptive Proteome in Metastasis
Soo Mi Lee,
Harvard Medical School, USA
Short Talk: Cellular microRNA-127-3p Suppresses Oncogenic Herpesvirus-induced Transformation and Tumorigenesis via Down-regulation of SKP2
Short Talk: Cellular microRNA-127-3p Suppresses Oncogenic Herpesvirus-induced Transformation and Tumorigenesis via Down-regulation of SKP2
19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
08:00—11:00
Therapeutic Opportunities for Small RNAs
*
George A. Calin,
University of Texas MD Anderson Cancer Center, USA
Session Chair
Session Chair
Mofang Liu,
Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, China
Remote Presentation: The Roles of PIWI/piRNAs in Gene Regulation and Diseases
Remote Presentation: The Roles of PIWI/piRNAs in Gene Regulation and Diseases
Stefan Engelhardt,
Technical University of Munich, Germany
Targeted miRNA Therapeutics
Targeted miRNA Therapeutics
Coffee Break
Karyn Schmidt,
Alnylam Pharmaceuticals, USA
Mechanistic Insights and Advances in RNAi Therapeutics Platform
Mechanistic Insights and Advances in RNAi Therapeutics Platform
Frank J. Slack,
BIDMC Cancer Center/Harvard Medical School, USA
Towards Personalized microRNA Therapeutics
Towards Personalized microRNA Therapeutics
John T. Powers,
Dell Medical School at The University of Texas at Austin, USA
Short Talk: Multiple Isoforms of let-7 Antagonist H19 lncRNA are Highly Expressed in MYCN Non-amplified Neuroblastoma
Short Talk: Multiple Isoforms of let-7 Antagonist H19 lncRNA are Highly Expressed in MYCN Non-amplified Neuroblastoma
17:00—18:45
Emerging Technologies and Novel Application for Small RNAs
*
Sandra L. Wolin,
NCI, National Institutes of Health, USA
Session Chair
Session Chair
William J. Greenleaf,
Stanford University, USA
Remote Presentation: Highthroughput Analysis Reveals Rules for Target RNA Binding and Cleavage by Ago2
Remote Presentation: Highthroughput Analysis Reveals Rules for Target RNA Binding and Cleavage by Ago2
Sabrina R. Leslie,
UBC, Canada
CLiC: High Resolution Single Molecule Imaging
CLiC: High Resolution Single Molecule Imaging
Ioannis S. Vlachos,
Beth Israel Deaconess Medical Center, USA
3' Untranslated Regions (3'UTRs) and MicroRNAs Controlling the Cancer Immune Landscape and Response to Immunotherapy
3' Untranslated Regions (3'UTRs) and MicroRNAs Controlling the Cancer Immune Landscape and Response to Immunotherapy
Byunghee Yoo,
Massachusetts General Hospital and Harvard Medical School, USA
Short Talk: RNAi-based PD-L1 Inhibitor, MN-siPDL1, Demonstrates Efficacy in Highly Aggressive Models of PDAC
Short Talk: RNAi-based PD-L1 Inhibitor, MN-siPDL1, Demonstrates Efficacy in Highly Aggressive Models of PDAC
19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
*Session Chair †Invited, not yet responded.
Keystone Symposia thanks our Sponsor(s) for generously supporting this meeting:
We gratefully acknowledge additional support from these exhibitors at this conference:
Please stop by to meet these exhibitors during the conference.
We gratefully acknowledge the generous grant for this conference provided by:
We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:
Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:
Click here to view more of these organizations
If your organization is interested in joining these entities in support of Keystone
Symposia, please contact: John Monson,
Director of Corporate Relations, Email: johnm@keystonesymposia.org, Phone:+1 970-262-2690 Click here for more information on Industry Support and Recognition Opportunities. If you are interested in becoming an advertising/marketing in-kind partner, please contact: Josh May, Director, Technology and Digital Media, Email: joshuam@keystonesymposia.org, Phone:+1 970-262-1179 |