INEC Killarney Convention Centre Floorplan
This meeting took place in 2023
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Hypoxia: From Basic Mechanisms to Emerging Therapies (E2)
Organizer(s) Sonia Rocha, Edurne Berra and M. Celeste Simon
May 28—31, 2023
INEC Killarney Convention Centre • Killarney, Co. Kerry Ireland
Abstract Deadline: Mar 13, 2023
Scholarship Deadline: Mar 13, 2023
Discounted Registration Deadline: Mar 28, 2023
Supported by the Directors' Fund
Summary of Meeting:
Oxygen is essential for life, as such, mechanisms involving sensing and responding to changes in oxygen availability have evolved to allow for organisms to withstand these events. Such adaptive mechanisms act across a multitude of scales and timelines, from changes in atomic structure, through large changes in organisms' function. Hypoxia plays a role in a variety of development processes but also participates, and sometimes, contributes to numerous human pathologies. This area of research thus involves a variety of disciplines, from basic discovery science, through to more applied ones such as medicine and drug discovery, highlighting its breath and importance. The Keystone Symposia conference on hypoxia research is the main home for all hypoxia related research. This meeting aims to bring together all disciplines and research areas involved in hypoxia. We hope to address gaps in our knowledge of responses to changes in oxygen availability; highlight new techniques and reagents to enhance therapeutic targeting of the hypoxic response in general; inform on novel systems where hypoxia research can be conducted to reveal novel mechanisms; and understand how therapeutic targeting of this pathway can allow for better clinical outcome in a variety of diseases. We hope that by sharing knowledge, enhancing collaborations, and training participants from diverse backgrounds, we will improve our knowledge and applications to improve life.
View Scholarships/Awards
Oxygen is essential for life, as such, mechanisms involving sensing and responding to changes in oxygen availability have evolved to allow for organisms to withstand these events. Such adaptive mechanisms act across a multitude of scales and timelines, from changes in atomic structure, through large changes in organisms' function. Hypoxia plays a role in a variety of development processes but also participates, and sometimes, contributes to numerous human pathologies. This area of research thus involves a variety of disciplines, from basic discovery science, through to more applied ones such as medicine and drug discovery, highlighting its breath and importance. The Keystone Symposia conference on hypoxia research is the main home for all hypoxia related research. This meeting aims to bring together all disciplines and research areas involved in hypoxia. We hope to address gaps in our knowledge of responses to changes in oxygen availability; highlight new techniques and reagents to enhance therapeutic targeting of the hypoxic response in general; inform on novel systems where hypoxia research can be conducted to reveal novel mechanisms; and understand how therapeutic targeting of this pathway can allow for better clinical outcome in a variety of diseases. We hope that by sharing knowledge, enhancing collaborations, and training participants from diverse backgrounds, we will improve our knowledge and applications to improve life.
View Scholarships/Awards
No registration fees are used to fund entertainment or alcohol at this conference
The meeting will begin on Sunday, May 28 with registration from 16:00 to 20:00 and a welcome mixer from 18:00 to 20:00. Conference events conclude on Wednesday, May 31 with a closing plenary session from 17:00 to 19:00, followed by a social hour. We recommend return travel on Thursday, June 1 in order to fully experience the meeting.
SUNDAY, MAY 28
MONDAY, MAY 29
TUESDAY, MAY 30
WEDNESDAY, MAY 31
THURSDAY, JUNE 1
Conference Program Print | View meeting in 12 hr (am/pm) time
The meeting will begin on Sunday, May 28 with registration from 16:00 to 20:00 and a welcome mixer from 18:00 to 20:00. Conference events conclude on Wednesday, May 31 with a closing plenary session from 17:00 to 19:00, followed by a social hour. We recommend return travel on Thursday, June 1 in order to fully experience the meeting.
SUNDAY, MAY 28
16:00—20:00
Arrival and Registration (4pm Start)
INEC Foyer
18:00—20:00
Welcome Mixer
No registration fees are used to fund alcohol served at this function.
INEC Foyer
08:00—09:00
Welcome and Keynote Address (8am Start)
INEC Main Auditorium
*
M. Celeste Simon,
University of Pennsylvania, USA
Navdeep S. Chandel,
Northwestern University, USA
Mitochondria as Signaling Organelles
Mitochondria as Signaling Organelles
09:00—11:15
Mitochondria and Metabolism (9am Start)
INEC Main Auditorium
*
Edurne Berra,
CIC bioGUNE, Spain
Isha Jain,
University of California, San Francisco, USA
Turning the Oxygen and Vitamin Dials
Turning the Oxygen and Vitamin Dials
Coffee Break
Jared Rutter,
University of Utah - Dept Biochemistry, USA
Energy Sensing and Metabolism
Energy Sensing and Metabolism
Sarah-Maria Fendt,
VIB-KU Leuven, Belgium
Nutrient Dependencies of Metastasis Formation
Nutrient Dependencies of Metastasis Formation
Elise Belaidi,
LBTI-CNRS UMR5305, France
Short Talk: Metformin Improves Infarct Size in Mice Exposed to Chronic Intermittent Hypoxia Through Mitochondrial Stress and HIF-1 Activity Modulation
Short Talk: Metformin Improves Infarct Size in Mice Exposed to Chronic Intermittent Hypoxia Through Mitochondrial Stress and HIF-1 Activity Modulation
11:15—17:00
On Own for Lunch
11:15—13:00
Poster Setup
INEC Foyer
13:00—22:00
Poster Viewing
INEC Foyer
13:00—14:00
Career Roundtable (1pm Start)
INEC Main Auditorium
Roslyn Nicole Crowder,
Stetson University, USA
Zhenhai Gao,
NiKang Therapeutics, USA
14:30—16:30
Workshop 1: Normoxia, Physioxia and Hypoxia Responses (2:30pm Start)
INEC Main Auditorium
*
Amato J. Giaccia,
University of Oxford, UK
Brian M.W. Ortmann,
University of Cambridge/Newcastle, UK
The Role of SET1B in Renal Cancer
The Role of SET1B in Renal Cancer
Ram Prosad Chakrabarty,
Northwestern University Feinberg School of Medicine, USA
L-2-hydroxyglutarate (L-2-HG) is a Signaling Molecule that Controls Mammalian Development
L-2-hydroxyglutarate (L-2-HG) is a Signaling Molecule that Controls Mammalian Development
Justin Perry,
Memorial Sloan Kettering Cancer Center, USA
Novel Adaptation Supports Enhanced Macrophage Efferocytosis in Limited-oxygen Environments
Novel Adaptation Supports Enhanced Macrophage Efferocytosis in Limited-oxygen Environments
María Torres López,
University of Seville, Spain
Role of Intracellular ATP in Oxygen and Low Glucose Sensing in Arterial Chemoreceptor
Role of Intracellular ATP in Oxygen and Low Glucose Sensing in Arterial Chemoreceptor
Brennan J. Wadsworth,
Karolinska Institutet, Sweden
Hypoxia-induced Metabolite 2-hydroxybutyrate Regulates Oxidative Metabolism via Metabolic Control of Compartmental ADP Ribosylation
Hypoxia-induced Metabolite 2-hydroxybutyrate Regulates Oxidative Metabolism via Metabolic Control of Compartmental ADP Ribosylation
Ananda S. Mirchandani,
University of Edinburgh, UK
Hypoxia Inhibits Emergency Monopoiesis in Acute Lung Injury and Hinders Inflammation Resolution
Hypoxia Inhibits Emergency Monopoiesis in Acute Lung Injury and Hinders Inflammation Resolution
Amanda Becker,
Northwestern University Feinberg School of Medicine, USA
Hypoxia Stimulates Neonatal HIF-1a Dependent Macrophage Secretion of IGF-1, a Cardiomyocyte Mitogen
Hypoxia Stimulates Neonatal HIF-1a Dependent Macrophage Secretion of IGF-1, a Cardiomyocyte Mitogen
Einav Gross,
Hebrew University of Jerusalem, Israel
Ferritin Regulation by HIF-1 and Neurosignals in the Nematode C. Elegans
Ferritin Regulation by HIF-1 and Neurosignals in the Nematode C. Elegans
16:30—17:00
Coffee Available
INEC Foyer
17:00—19:00
Hypoxia Signaling in Tumor and Immune Cells (5pm Start)
INEC Main Auditorium
*
Sonia Rocha,
University of Liverpool, UK
Paul Boutros,
University of California, Los Angeles, USA
Mutational Signatures in Hypoxic Tumors
Mutational Signatures in Hypoxic Tumors
Marina P. Kreutz,
Universitat Regensburg, Germany
Oncometabolism and Immune Cells
Oncometabolism and Immune Cells
Jane A. McKeating,
Oxford University, UK
Virus and the HIF System
Virus and the HIF System
Amato J. Giaccia,
University of Oxford, UK
Hypoxia and Tumor Immune Escape
Hypoxia and Tumor Immune Escape
19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
INEC Foyer
19:30—22:00
Poster Session 1 (7:30pm Start)
INEC Foyer
08:00—11:00
PHD and FIH Enzymes Substrates and Functions (8am Start)
INEC Main Auditorium
*
Cormac Taylor,
University College Dublin, Ireland
Qing Zhang,
UT Southwestern Medical Center, USA
Histone H3 Hydroxylation by EGLN2 (PHD1) Regulates Mammalian Gene Expression
Histone H3 Hydroxylation by EGLN2 (PHD1) Regulates Mammalian Gene Expression
Angus I. Lamond,
University of Dundee, UK
Mass Spectrometry in the Quest for PHD Targets
Mass Spectrometry in the Quest for PHD Targets
Coffee Break
Daniel J. Peet,
University of Adelaide, Australia
Development of Novel Screening Systems to Identify Regulators of FIH, Hypoxia and other Signalling Pathways
Development of Novel Screening Systems to Identify Regulators of FIH, Hypoxia and other Signalling Pathways
Ana Garcia,
CIC bioGUNE, Spain
Short Talk: Factor Inhibiting HIF (FIH) Promotes Lung Cancer Progression
Short Talk: Factor Inhibiting HIF (FIH) Promotes Lung Cancer Progression
Valentina Sancisi,
Azienda USL Reggio Emilia IRCCS, USA
Short Talk: PHD2 (EGLN1) is a Novel Therapeutic Target in KRAS-mutated Lung Carcinoma
Short Talk: PHD2 (EGLN1) is a Novel Therapeutic Target in KRAS-mutated Lung Carcinoma
Silvia Strocchi,
Azienda USL-IRCCS di Reggio Emilia, Italy
Short Talk: Implementing an Organoid Platform to Assess Efficacy of PHD Inhibitors as Anti-cancer Agents
Short Talk: Implementing an Organoid Platform to Assess Efficacy of PHD Inhibitors as Anti-cancer Agents
Jimena Druker,
University of Dundee, UK
Short Talk: RepoMan is a Novel Cell Cycle-regulated PHD1- Dependent Target
Short Talk: RepoMan is a Novel Cell Cycle-regulated PHD1- Dependent Target
11:00—17:00
On Own for Lunch
11:00—13:00
Poster Setup
INEC Foyer
13:00—22:00
Poster Viewing
INEC Foyer
14:30—16:30
Roundtable Discussion: The Future of Hypoxia Research (2:30pm Start)
INEC Main Auditorium
*
M. Celeste Simon,
University of Pennsylvania, USA
Cormac Taylor,
University College Dublin, Ireland
Peter J. Ratcliffe,
Francis Crick Institute, UK
Amato J. Giaccia,
University of Oxford, UK
José López-Barneó,
University of Seville, Spain
16:30—17:00
Coffee Available
INEC Foyer
17:00—19:00
Model Organisms to Study Hypoxia Responses (5pm Start)
INEC Main Auditorium
*
Peter J. Ratcliffe,
Francis Crick Institute, UK
Joaquín M. Espinosa,
Linda Crnic Institute for Down Syndrome, USA
Multiomics Approaches to Investigate Hypoxic Signaling in Health and Disease
Multiomics Approaches to Investigate Hypoxic Signaling in Health and Disease
Irena Manov,
University of Haifa, Israel
The Co-Evolution of Hypoxia Tolerance, Longevity and Healthy Aging in the Subterranean Blind Mole Rat, Spalax: Hypotheses and Molecular Mechanisms
The Co-Evolution of Hypoxia Tolerance, Longevity and Healthy Aging in the Subterranean Blind Mole Rat, Spalax: Hypotheses and Molecular Mechanisms
Ernestina Schipani,
University of Pennsylvania, USA
How Hypoxia and Mitochondria Shape up the Skeleton
How Hypoxia and Mitochondria Shape up the Skeleton
José López-Barneó,
University of Seville, Spain
Mitochondrial Acute O2 Sensing and Signaling
Mitochondrial Acute O2 Sensing and Signaling
19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
INEC Foyer
19:30—22:00
Poster Session 2 (7:30pm Start)
INEC Foyer
08:00—11:00
New Aspects of Hypoxia Signalling (8am Start)
INEC Main Auditorium
*
Daniel J. Peet,
University of Adelaide, Australia
Edurne Berra,
CIC bioGUNE, Spain
DUBs in Hypoxia
DUBs in Hypoxia
Cormac Taylor,
University College Dublin, Ireland
Spatial Organization of Glycolytic Enzymes in Hypoxia
Spatial Organization of Glycolytic Enzymes in Hypoxia
Coffee Break
Sonia Rocha,
University of Liverpool, UK
Oxygen as a Signalling Molecule in Cells
Oxygen as a Signalling Molecule in Cells
Harrison Alexander Feldman,
University of Cincinnati / Cincinnati Children's Hospital, USA
Short Talk: A Hypoxia-Inducible Factor 2 Alpha Transcriptomic Program Regulating Function and Dysfunction in Human NK Cells
Short Talk: A Hypoxia-Inducible Factor 2 Alpha Transcriptomic Program Regulating Function and Dysfunction in Human NK Cells
Paul Grevitt,
Barts Cancer Institute, UK
Short Talk: Coenzyme A Synthase (CoAsy): A Novel Regulator of HIF Stability and Activity
Short Talk: Coenzyme A Synthase (CoAsy): A Novel Regulator of HIF Stability and Activity
11:00—17:00
On Own for Lunch
14:30—16:30
Workshop 2: Novel Methods to Detect Hypoxia and its Responses (2:30pm Start)
INEC Main Auditorium
*
Isha Jain,
University of California, San Francisco, USA
Jacopo Arrigoni,
University of Milan, Italy
Combined In Vitro and Air-Liquid Interface Models Enable Investigation of Alternative Tumor-Infiltrating Regulatory T Cell Responses to Hypoxia
Combined In Vitro and Air-Liquid Interface Models Enable Investigation of Alternative Tumor-Infiltrating Regulatory T Cell Responses to Hypoxia
Julián Aragonés Lopez,
Research Institute Princesa, Spain
Erythroid-Deficient SLC7A5 Mice as An In Vivo Model to Study Hypoxia
Erythroid-Deficient SLC7A5 Mice as An In Vivo Model to Study Hypoxia
Timothy P. Allen,
University of Adelaide, Australia
Development and Application of a Dual Fluorescent HIF Sensor for Small Molecule Discovery and Genetic screening
Development and Application of a Dual Fluorescent HIF Sensor for Small Molecule Discovery and Genetic screening
Debarun Patra,
Indian Institute of Technology Ropar, India
HypoxamiR-210 Promotes Obesity-induced Adipose Tissue Inflammation via Targeting SOCS1/NF-κB
HypoxamiR-210 Promotes Obesity-induced Adipose Tissue Inflammation via Targeting SOCS1/NF-κB
Alison Elizabeth Roennfeldt,
University of Adelaide, Australia
A Translatable Cell-based High throughput Screening System to Screen for Novel Hypoxia Transcriptional Regulators
A Translatable Cell-based High throughput Screening System to Screen for Novel Hypoxia Transcriptional Regulators
Eleanor Minogue,
Cambridge University, UK
Hypoxia Induced Glutarate Regulates T Cell Fate and Function
Hypoxia Induced Glutarate Regulates T Cell Fate and Function
16:30—17:00
Coffee Available
INEC Foyer
17:00—18:45
Therapeutic Applications in Hypoxia Response and Disease (5pm Start)
INEC Main Auditorium
*
José López-Barneó,
University of Seville, Spain
Claudia Diehl,
University of Dundee, School of Life Sciences, UK
Development of Novel VHL Ligands and VHL-based homoPROTACs
Development of Novel VHL Ligands and VHL-based homoPROTACs
M. Celeste Simon,
University of Pennsylvania, USA
Oxygen Availability and Tumor Microenvironments
Oxygen Availability and Tumor Microenvironments
Ana Gabriela Cristancho,
Children's Hospital of Philadelphia, USA
Short Talk: Early Disruption of Epigenetic and Transcriptomic Organization after Prenatal Hypoxia Predicts Persistent Functional Deficits in Glutamatergic Neurons
Short Talk: Early Disruption of Epigenetic and Transcriptomic Organization after Prenatal Hypoxia Predicts Persistent Functional Deficits in Glutamatergic Neurons
18:45—19:00
Meeting Wrap-Up: Outcomes and Future Directions (Organizers) (6:45pm Start)
INEC Main Auditorium
19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
INEC Foyer
08:00—08:00
Departure
*Session Chair †Invited, not yet responded.
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