Whistler Conference Centre Floorplan
This meeting was rescheduled and may have a different Meeting Program and Scholarships/Awards
For a complete list of the meetings for the upcoming/current season, see our meeting list, or search for a meeting.
MEETING POSTPONED: Transposable Elements at the Crossroads of Evolution, Health and Disease (X1)
Organizer(s) Kathleen H. Burns, Harmit S. Malik and Irina Arkhipova
February 27—March 3, 2022
Whistler Conference Centre • Whistler, BC Canada
Abstract Deadline: Nov 23, 2021
Scholarship Deadline: Nov 17, 2021
Discounted Registration Deadline: Jan 4, 2022
Sponsored by Cell Research
Summary of Meeting:
Transposable elements are omnipresent in every domain of life and play an eminent role in shaping biological properties of living organisms. The field of transposon research has significantly expanded with the realization that mobile DNA constitutes a major component of most genomes and that transposable element sequences, while generally mutagenic, can be co-opted to benefit host species. Moreover, rapid development of tools to study transposon activities enables the efforts to differentiate their causal and epiphenomenal effects. There is a pressing need to understand the many ways in which mobile DNA affects genome evolution and shapes its function under normal and pathological states. The aims of this conference are to: 1) Apply recent advances in genomics, proteomics and bioinformatics towards an overview of transposon integration into genomic compartments, epigenetic processes and regulatory networks over evolutionary time scales; 2) Expand structural and mechanistic insights into the nature of transposition processes affecting genome dynamics and integrity; 3) Close the gaps in understanding transposon mobilization and its control at the molecular, cellular, organismal, and population levels, highlighting the impact on carcinogenesis, neurodegeneration and aging; 4) Showcase the applications of fundamental knowledge on mobile element-host interactions to the burgeoning fields of genome engineering, biomedicine, plant and environmental sciences. Accelerating advances in the field will attract new investigators who will benefit greatly from this meeting, while giving the long-standing experts reasons to reconvene, share methodologies, and promote new collaborations between leading international groups on the broadest possible scale, exploring all kingdoms of life.
View Scholarships/Awards
Transposable elements are omnipresent in every domain of life and play an eminent role in shaping biological properties of living organisms. The field of transposon research has significantly expanded with the realization that mobile DNA constitutes a major component of most genomes and that transposable element sequences, while generally mutagenic, can be co-opted to benefit host species. Moreover, rapid development of tools to study transposon activities enables the efforts to differentiate their causal and epiphenomenal effects. There is a pressing need to understand the many ways in which mobile DNA affects genome evolution and shapes its function under normal and pathological states. The aims of this conference are to: 1) Apply recent advances in genomics, proteomics and bioinformatics towards an overview of transposon integration into genomic compartments, epigenetic processes and regulatory networks over evolutionary time scales; 2) Expand structural and mechanistic insights into the nature of transposition processes affecting genome dynamics and integrity; 3) Close the gaps in understanding transposon mobilization and its control at the molecular, cellular, organismal, and population levels, highlighting the impact on carcinogenesis, neurodegeneration and aging; 4) Showcase the applications of fundamental knowledge on mobile element-host interactions to the burgeoning fields of genome engineering, biomedicine, plant and environmental sciences. Accelerating advances in the field will attract new investigators who will benefit greatly from this meeting, while giving the long-standing experts reasons to reconvene, share methodologies, and promote new collaborations between leading international groups on the broadest possible scale, exploring all kingdoms of life.
View Scholarships/Awards
No registration fees are used to fund entertainment or alcohol at this conference
The meeting will begin on Sunday, February 27 with registration from 16:00 to 20:00 and a welcome mixer from 18:00 to 20:00. Conference events conclude on Thursday, March 3 with a closing plenary session from 17:00 to 19:00, followed by a social hour. We recommend return travel on Friday, March 4 in order to fully experience the meeting.
SUNDAY, FEBRUARY 27
MONDAY, FEBRUARY 28
TUESDAY, MARCH 1
WEDNESDAY, MARCH 2
THURSDAY, MARCH 3
FRIDAY, MARCH 4
Conference Program Print | View meeting in 12 hr (am/pm) time
The meeting will begin on Sunday, February 27 with registration from 16:00 to 20:00 and a welcome mixer from 18:00 to 20:00. Conference events conclude on Thursday, March 3 with a closing plenary session from 17:00 to 19:00, followed by a social hour. We recommend return travel on Friday, March 4 in order to fully experience the meeting.
SUNDAY, FEBRUARY 27
18:00—20:00
Welcome Mixer
No registration fees are used to fund alcohol served at this function.
08:00—09:00
Welcome and Keynote Address
Michael D. Purugganan,
New York University, USA
Plant Evolutionary Genomics
Plant Evolutionary Genomics
08:00—11:00
In Sickness and in Health: Transposons in Disease, Immunology, and Therapeutics
Vera Gorbunova,
University of Rochester, USA
Transposable Elements in Aging
Transposable Elements in Aging
Coffee Break
E. Alice Lee,
Boston Children's Hospital & Harvard Medical School, USA
Transposable Elements in Neurobiology
Transposable Elements in Neurobiology
Barrett Steinberg,
Tessera Therapeutics, USA
Engineering Mobile Genetic Elements to Write the Genome
Engineering Mobile Genetic Elements to Write the Genome
Beatrice Bodega,
Istituto Nazionale di Genetica Molecolare, Italy
Short Talk: LINE1 are Spliced in Non-canonical Transcript Variants to Regulate T Cell Quiescence and Exhaustion
Short Talk: LINE1 are Spliced in Non-canonical Transcript Variants to Regulate T Cell Quiescence and Exhaustion
Jean-David Larouche,
Université de Montréal, Canada
Short Talk: Transposable Elements have Distinct Expression Profiles in Antigen-presenting Cells of the Thymus
Short Talk: Transposable Elements have Distinct Expression Profiles in Antigen-presenting Cells of the Thymus
Helen Rowe,
QMUL, UK
Short Talk: The HUSH Complex Epigenetic Regulation of LINE-1 Elements and Type I Interferons
Short Talk: The HUSH Complex Epigenetic Regulation of LINE-1 Elements and Type I Interferons
14:30—16:30
Workshop 1: TEs as Friends, Foes or Both
Han Altae-Tran,
Broad Institute, USA
Evolutionary Origins of Cas9 and Cas12 Reveal New Classes of RNA-guided Nucleases: OMEGA Systems
Evolutionary Origins of Cas9 and Cas12 Reveal New Classes of RNA-guided Nucleases: OMEGA Systems
Mikel Zaratiegui,
Rutgers University, USA
Transposon Extermination Reveals Their Adaptive Fitness Contribution
Transposon Extermination Reveals Their Adaptive Fitness Contribution
Pierre Bourguet,
Gregor Mendel Institute, Austria
The H2A.W Histone Variant Contributes to Transposon Silencing
The H2A.W Histone Variant Contributes to Transposon Silencing
Kirsten C. Sadler,
New York University Abu Dhabi, United Arab Emirates
Diversity of Transposon Regulation by Epigenetic and Immunological Mechanisms in Mice and Zebrafish
Diversity of Transposon Regulation by Epigenetic and Immunological Mechanisms in Mice and Zebrafish
Julius Judd,
Cornell University, USA
SARS-CoV2 Accessory Protein ORF3a Upregulates Young LINE1 Elements by Interfering with a Zinc-finger Protein Associated with a Novel Chromatin Repressive Complex
SARS-CoV2 Accessory Protein ORF3a Upregulates Young LINE1 Elements by Interfering with a Zinc-finger Protein Associated with a Novel Chromatin Repressive Complex
Michelle S. Longworth,
Cleveland Clinic Lerner Research Institute, USA
LINE-1 Induces Super Condensin Complex Formation and Condensin-mediated Type I IFN Expression
LINE-1 Induces Super Condensin Complex Formation and Condensin-mediated Type I IFN Expression
Ilke Demirci,
Karolinska Institute, Sweden
Large-scale Analysis of Human Specific LINE-1 in Single Cells
Large-scale Analysis of Human Specific LINE-1 in Single Cells
Nelson C. Lau,
Boston University School of Medicine, USA
Small RNAs as a Brain Response to Transposon Transcripts
Small RNAs as a Brain Response to Transposon Transcripts
17:00—19:00
Genomic Battlegrounds: Evolutionary Conflicts and Arms Races in the Mobilome
Harmit S. Malik,
Fred Hutchinson Cancer Research Center, USA
Mobile Elements and Genetic Conflict
Mobile Elements and Genetic Conflict
Zhao Zhang,
Duke University, USA
Chasing the Jumping Genes
Chasing the Jumping Genes
Tetsuji Kakutani,
University of Tokyo, Japan
Transposon Epigenetic Control in Arabidopsis
Transposon Epigenetic Control in Arabidopsis
Paul J. Lehner,
Cambridge Institute of Therapeutic Immunology and Infectious Disease, UK
Short Talk: Genome Surveillance through Repression of Intronless Mobile Elements by the HUSH Complex
Short Talk: Genome Surveillance through Repression of Intronless Mobile Elements by the HUSH Complex
Mathilde Gauchier†,
NICHD, USA
Short Talk: Retrotransposons and their Silencing Re-enforcement by Schlafen Endoribonucleases during Mammalian Development
Short Talk: Retrotransposons and their Silencing Re-enforcement by Schlafen Endoribonucleases during Mammalian Development
19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
08:00—11:00
Epigenomics and Epitranscriptomics of Transposition and Interactions with the Environment
Irina Arkhipova,
Marine Biological Laboratory, USA
Bacterial N4-Methylcytosine as an Epigenetic Mark in Eukaryotic DNA
Bacterial N4-Methylcytosine as an Epigenetic Mark in Eukaryotic DNA
Coleen T. Murphy,
Princeton University, USA
The Role of the Cer1 Retrotransposon in the Horizontal Transfer of Transgenerational Memory
The Role of the Cer1 Retrotransposon in the Horizontal Transfer of Transgenerational Memory
Coffee Break
Oded Rechavi,
Tel Aviv University, Israel
Heritable Small RNAs
Heritable Small RNAs
Zsuzsanna Izsvak,
Max-Delbrück Center, Germany
Transposon Regulation in Early Development
Transposon Regulation in Early Development
Josien van Wolfswinkel,
Yale University, USA
Short Talk: Transposable Elements in Regulation of Planarian Stem Cells
Short Talk: Transposable Elements in Regulation of Planarian Stem Cells
Emeline Roger,
Institut Curie, France
Short Talk: A Novel Chromatin Pathway Involved in Transposable Element Regulation
Short Talk: A Novel Chromatin Pathway Involved in Transposable Element Regulation
Isaac F. López-Moyado,
La Jolla Institute for Immunology, USA
Short Talk: Profound TET Deficiency Results in Heterochromatin Dysfunction and Derepression of Repeat Elements
Short Talk: Profound TET Deficiency Results in Heterochromatin Dysfunction and Derepression of Repeat Elements
17:00—19:00
Structural and Mechanistic Underpinnings of Transposition across the Kingdoms of Life
Orsolya Barabas,
University of Geneva, Switzerland
Transposable Element-Mediated DNA Rearrangements
Transposable Element-Mediated DNA Rearrangements
Phoebe A. Rice,
University of Chicago, USA
Replication-related and Other Conserved Genes of the SCC-like Family of Genomic Islands in Firmicutes.
Replication-related and Other Conserved Genes of the SCC-like Family of Genomic Islands in Firmicutes.
Fred Dyda,
NIDDK, National Institutes of Health, USA
The Structure of Helraiser, a Helitron DNA Transposase from the Little Brown Bat, Provides Mechanistic Insight into Eukaryotic Replicative Transposition
The Structure of Helraiser, a Helitron DNA Transposase from the Little Brown Bat, Provides Mechanistic Insight into Eukaryotic Replicative Transposition
Elizabeth H. Kellogg,
Cornell University, USA
Short Talk: Structural and Mechanistic Studies of CRISPR-associated Transposons
Short Talk: Structural and Mechanistic Studies of CRISPR-associated Transposons
Irma Querques,
University of Zurich, Switzerland
Short Talk: Target Site Selection and Remodelling in RNA-guided Transposition
Short Talk: Target Site Selection and Remodelling in RNA-guided Transposition
19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
08:00—11:00
Transposable Elements in Cancer
Kathleen H. Burns,
Dana Farber Cancer Institute | Harvard Medical School, USA
LINE-1 Expression and Retrotransposition in Cancer
LINE-1 Expression and Retrotransposition in Cancer
Ting Wang,
Washington University, USA
Transposable Elements in Development and Driving Gene Expression in Cancer
Transposable Elements in Development and Driving Gene Expression in Cancer
Coffee Break
Bradley E. Bernstein,
Dana-Farber Cancer Institute, USA
Epigenetic and Topologic Changes that Restrain Malignancies
Epigenetic and Topologic Changes that Restrain Malignancies
Katherine Chiappinelli,
George Washington University, USA
Epigenetic Regulation of Transposable Elements and the Innate Immune Response in Cancer
Epigenetic Regulation of Transposable Elements and the Innate Immune Response in Cancer
Victoria P. Belancio,
Tulane University, USA
Short Talk: Analysis of Epigenetic Features Characteristic of L1 loci Expressed in Human Cells
Short Talk: Analysis of Epigenetic Features Characteristic of L1 loci Expressed in Human Cells
Ozgen Deniz,
Imperial College London, UK
Short Talk: The Roles of Transposable Elements in Acute Myeloid Leukemia
Short Talk: The Roles of Transposable Elements in Acute Myeloid Leukemia
Deepak K. Jha,
Children's Hospital Boston, USA
Short Talk: Role of Transposable Elements in Hematopoiesis and Cancer
Short Talk: Role of Transposable Elements in Hematopoiesis and Cancer
17:00—19:00
Transposon Domestication and Co-Option at the DNA, RNA and Protein Levels
Cedric Feschotte,
Cornell University, USA
Transposon Domestication
Transposon Domestication
Miguel Branco,
Queen Mary University of London, UK
Placental Gene Regulation by Transposable Elements
Placental Gene Regulation by Transposable Elements
Edward B. Chuong,
University of Colorado Boulder, USA
Transposon Repurposing in Gene Networks
Transposon Repurposing in Gene Networks
Helen S. Mueller,
Memorial Sloan Kettering Cancer Center, USA
Short Talk: Elucidating DNA Damage Repair Signaling Activated by the DNA Transposase PGBD5
Short Talk: Elucidating DNA Damage Repair Signaling Activated by the DNA Transposase PGBD5
Mohamad Ali Najia,
MIT, USA
Short Talk: Transposable Element Regulation of Hematopoietic Lineage Decisions
Short Talk: Transposable Element Regulation of Hematopoietic Lineage Decisions
19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
08:00—11:00
Transpositions across Genomic and Cellular Compartments
José R. Penadés,
Imperial College London, UK
Transposons and Virulence and Resistance Factors
Transposons and Virulence and Resistance Factors
Coffee Break
Amanda Larracuente,
University of Rochester, USA
Selfish DNAs and Satellites
Selfish DNAs and Satellites
Fangpu Han,
Chinese Academy of Sciences, China
Plant Chromosome Biology
Plant Chromosome Biology
Henry L. Levin,
NIH, USA
Short Talk: Identification of an Integrase-independent Pathway of Retrotransposition
Short Talk: Identification of an Integrase-independent Pathway of Retrotransposition
Juanma Vaquerizas†,
MRC London Institute of Medical Sciences, UK
Short Talk: Transposable Element-driven Reorganisation of 3D Chromatin during Early Embryonic Development
Short Talk: Transposable Element-driven Reorganisation of 3D Chromatin during Early Embryonic Development
Michelle J. Percharde,
MRC London Institute of Medical Sciences, UK
Short Talk: Nucleolar-based Mechanisms of Gene and Transposon Control in Early Development
Short Talk: Nucleolar-based Mechanisms of Gene and Transposon Control in Early Development
14:30—16:30
Workshop 2: Bioinformatic and Multi-omic Tools
Matthew L. Bendall,
Weill Cornell Medicine, USA
Single Cell Retrotranscriptomics with Stellarscope: Developing a Single Cell Transposable Element Atlas of Human Cell Identity
Single Cell Retrotranscriptomics with Stellarscope: Developing a Single Cell Transposable Element Atlas of Human Cell Identity
Michael Cuoco,
The Salk Institute, USA
Comprehensive Benchmarking of Transposable Element RNA-seq Quantification Methods
Comprehensive Benchmarking of Transposable Element RNA-seq Quantification Methods
Andrew Garven,
Queens University, Canada
The Transposable Elements Expression Landscape in Muscle-Invasive Bladder Cancer
The Transposable Elements Expression Landscape in Muscle-Invasive Bladder Cancer
Cristian Groza,
McGill University, Canada
Genome Graphs Detect Human Polymorphisms in Active Epigenomic States During Influenza Infection
Genome Graphs Detect Human Polymorphisms in Active Epigenomic States During Influenza Infection
Darren Taylor,
Blizard Institute, UK
Locus-Specific Chromatin Profiling of Evolutionarily Young Transposable Elements
Locus-Specific Chromatin Profiling of Evolutionarily Young Transposable Elements
Yilan Wang,
Harvard University, USA
grnTea, a Machine Learning Tool to Detect Transposable Element Insertions in Ancient Human Whole-genome Sequencing Data
grnTea, a Machine Learning Tool to Detect Transposable Element Insertions in Ancient Human Whole-genome Sequencing Data
Shohei Kojima,
RIKEN, Japan
Variation in Human Genomes and Phenotypes Driven by Mobile Genetic Elements
Variation in Human Genomes and Phenotypes Driven by Mobile Genetic Elements
Hani Girgis,
Texas A&M University- Kingsville, USA
LtrDetector: Toward High Quality Annotation of Long Terminal Repeat Retrotransposons
LtrDetector: Toward High Quality Annotation of Long Terminal Repeat Retrotransposons
17:00—18:45
From Ultraconservation to Hypervariability: The Significance of Variation
Jeff F. Miller,
University of California, Los Angeles, USA
Bacterial Adaptation by Diversity-Generating Retroelements
Bacterial Adaptation by Diversity-Generating Retroelements
Vincent Colot,
École Normale Supérieure, France
Genome Dynamics and Epigenetic Variation
Genome Dynamics and Epigenetic Variation
Anna Selmecki,
University of Minnesota, USA
Ploidy Variation in Fungi
Ploidy Variation in Fungi
Blair G. Paul,
Marine Biological Laboratory, USA
Short Talk: Hypermutation in Filamentous Cyanobacteria
Short Talk: Hypermutation in Filamentous Cyanobacteria
*Session Chair †Invited, not yet responded.
Keystone Symposia thanks our Sponsor(s) for generously supporting this meeting:
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:
Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:
Click here to view more of these organizations
If your organization is interested in joining these entities in support of Keystone
Symposia, please contact: John Monson,
Director of Corporate Relations, Email: johnm@keystonesymposia.org, Phone:+1 970-262-2690 Click here for more information on Industry Support and Recognition Opportunities. If you are interested in becoming an advertising/marketing in-kind partner, please contact: Josh May, Director, Technology and Digital Media, Email: joshuam@keystonesymposia.org, Phone:+1 970-262-1179 |