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MEETING POSTPONED: Transposable Elements at the Crossroads of Evolution, Health and Disease (X1)


Organizer(s) Kathleen H. Burns, Harmit S. Malik and Irina Arkhipova
February 27—March 3, 2022
Whistler Conference Centre • Whistler, BC Canada
Abstract Deadline: Nov 23, 2021
Scholarship Deadline: Nov 17, 2021
Discounted Registration Deadline: Jan 4, 2022

Sponsored by Cell Research

Summary of Meeting:
Transposable elements are omnipresent in every domain of life and play an eminent role in shaping biological properties of living organisms. The field of transposon research has significantly expanded with the realization that mobile DNA constitutes a major component of most genomes and that transposable element sequences, while generally mutagenic, can be co-opted to benefit host species. Moreover, rapid development of tools to study transposon activities enables the efforts to differentiate their causal and epiphenomenal effects. There is a pressing need to understand the many ways in which mobile DNA affects genome evolution and shapes its function under normal and pathological states. The aims of this conference are to: 1) Apply recent advances in genomics, proteomics and bioinformatics towards an overview of transposon integration into genomic compartments, epigenetic processes and regulatory networks over evolutionary time scales; 2) Expand structural and mechanistic insights into the nature of transposition processes affecting genome dynamics and integrity; 3) Close the gaps in understanding transposon mobilization and its control at the molecular, cellular, organismal, and population levels, highlighting the impact on carcinogenesis, neurodegeneration and aging; 4) Showcase the applications of fundamental knowledge on mobile element-host interactions to the burgeoning fields of genome engineering, biomedicine, plant and environmental sciences. Accelerating advances in the field will attract new investigators who will benefit greatly from this meeting, while giving the long-standing experts reasons to reconvene, share methodologies, and promote new collaborations between leading international groups on the broadest possible scale, exploring all kingdoms of life.

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No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


The meeting will begin on Sunday, February 27 with registration from 16:00 to 20:00 and a welcome mixer from 18:00 to 20:00. Conference events conclude on Thursday, March 3 with a closing plenary session from 17:00 to 19:00, followed by a social hour. We recommend return travel on Friday, March 4 in order to fully experience the meeting.

SUNDAY, FEBRUARY 27

16:00—20:00
Arrival and Registration

Grand Foyer
18:00—20:00
Welcome Mixer
No registration fees are used to fund alcohol served at this function.

Grand Foyer

MONDAY, FEBRUARY 28

07:00—08:00
Breakfast

Grand Foyer
08:00—09:00
Welcome and Keynote Address

Sea to Sky B
Michael D. Purugganan, New York University, USA
Plant Evolutionary Genomics

08:00—11:00
In Sickness and in Health: Transposons in Disease, Immunology, and Therapeutics

Sea to Sky B
Vera Gorbunova, University of Rochester, USA
Transposable Elements in Aging

Coffee Break

E. Alice Lee, Boston Children's Hospital & Harvard Medical School, USA
Transposable Elements in Neurobiology

Barrett Steinberg, Tessera Therapeutics, USA
Engineering Mobile Genetic Elements to Write the Genome

Beatrice Bodega, Istituto Nazionale di Genetica Molecolare, Italy
Short Talk: LINE1 are Spliced in Non-canonical Transcript Variants to Regulate T Cell Quiescence and Exhaustion

Jean-David Larouche, Université de Montréal, Canada
Short Talk: Transposable Elements have Distinct Expression Profiles in Antigen-presenting Cells of the Thymus

Helen Rowe, QMUL, UK
Short Talk: The HUSH Complex Epigenetic Regulation of LINE-1 Elements and Type I Interferons

11:15—17:00
On Own for Lunch

11:15—13:00
Poster Setup

Sea to Sky A
13:00—22:00
Poster Viewing

Sea to Sky A
14:30—16:30
Workshop 1: TEs as Friends, Foes or Both

Sea to Sky B
Han Altae-Tran, Broad Institute, USA
Evolutionary Origins of Cas9 and Cas12 Reveal New Classes of RNA-guided Nucleases: OMEGA Systems

Mikel Zaratiegui, Rutgers University, USA
Transposon Extermination Reveals Their Adaptive Fitness Contribution

Pierre Bourguet, Gregor Mendel Institute, Austria
The H2A.W Histone Variant Contributes to Transposon Silencing

Kirsten C. Sadler, New York University Abu Dhabi, United Arab Emirates
Diversity of Transposon Regulation by Epigenetic and Immunological Mechanisms in Mice and Zebrafish

Julius Judd, Cornell University, USA
SARS-CoV2 Accessory Protein ORF3a Upregulates Young LINE1 Elements by Interfering with a Zinc-finger Protein Associated with a Novel Chromatin Repressive Complex

Michelle S. Longworth, Cleveland Clinic Lerner Research Institute, USA
LINE-1 Induces Super Condensin Complex Formation and Condensin-mediated Type I IFN Expression

Ilke Demirci, Karolinska Institute, Sweden
Large-scale Analysis of Human Specific LINE-1 in Single Cells

Nelson C. Lau, Boston University School of Medicine, USA
Small RNAs as a Brain Response to Transposon Transcripts

16:30—17:00
Coffee Available

Grand Foyer
17:00—19:00
Genomic Battlegrounds: Evolutionary Conflicts and Arms Races in the Mobilome

Sea to Sky B
Harmit S. Malik, Fred Hutchinson Cancer Research Center, USA
Mobile Elements and Genetic Conflict

Zhao Zhang, Duke University, USA
Chasing the Jumping Genes

Tetsuji Kakutani, University of Tokyo, Japan
Transposon Epigenetic Control in Arabidopsis

Paul J. Lehner, Cambridge Institute of Therapeutic Immunology and Infectious Disease, UK
Short Talk: Genome Surveillance through Repression of Intronless Mobile Elements by the HUSH Complex

Mathilde Gauchier†, NICHD, USA
Short Talk: Retrotransposons and their Silencing Re-enforcement by Schlafen Endoribonucleases during Mammalian Development

19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Grand Foyer
19:30—22:00
Poster Session 1

Sea to Sky A

TUESDAY, MARCH 1

07:00—08:00
Breakfast

Grand Foyer
08:00—11:00
Epigenomics and Epitranscriptomics of Transposition and Interactions with the Environment

Sea to Sky B
Irina Arkhipova, Marine Biological Laboratory, USA
Bacterial N4-Methylcytosine as an Epigenetic Mark in Eukaryotic DNA

Coleen T. Murphy, Princeton University, USA
The Role of the Cer1 Retrotransposon in the Horizontal Transfer of Transgenerational Memory

Coffee Break

Oded Rechavi, Tel Aviv University, Israel
Heritable Small RNAs

Zsuzsanna Izsvak, Max-Delbrück Center, Germany
Transposon Regulation in Early Development

Josien van Wolfswinkel, Yale University, USA
Short Talk: Transposable Elements in Regulation of Planarian Stem Cells

Emeline Roger, Institut Curie, France
Short Talk: A Novel Chromatin Pathway Involved in Transposable Element Regulation

Isaac F. López-Moyado, La Jolla Institute for Immunology, USA
Short Talk: Profound TET Deficiency Results in Heterochromatin Dysfunction and Derepression of Repeat Elements

11:00—17:00
On Own for Lunch

11:00—13:00
Poster Setup

Sea to Sky A
13:00—22:00
Poster Viewing

Sea to Sky A
16:30—17:00
Coffee Available

Grand Foyer
17:00—19:00
Structural and Mechanistic Underpinnings of Transposition across the Kingdoms of Life

Sea to Sky B
Orsolya Barabas, University of Geneva, Switzerland
Transposable Element-Mediated DNA Rearrangements

Phoebe A. Rice, University of Chicago, USA
Replication-related and Other Conserved Genes of the SCC-like Family of Genomic Islands in Firmicutes.

Fred Dyda, NIDDK, National Institutes of Health, USA
The Structure of Helraiser, a Helitron DNA Transposase from the Little Brown Bat, Provides Mechanistic Insight into Eukaryotic Replicative Transposition

Elizabeth H. Kellogg, Cornell University, USA
Short Talk: Structural and Mechanistic Studies of CRISPR-associated Transposons

Irma Querques, University of Zurich, Switzerland
Short Talk: Target Site Selection and Remodelling in RNA-guided Transposition

19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Grand Foyer
19:30—22:00
Poster Session 2

Sea to Sky A

WEDNESDAY, MARCH 2

07:00—08:00
Breakfast

Grand Foyer
08:00—11:00
Transposable Elements in Cancer

Sea to Sky B/C
Kathleen H. Burns, Dana Farber Cancer Institute | Harvard Medical School, USA
LINE-1 Expression and Retrotransposition in Cancer

Ting Wang, Washington University, USA
Transposable Elements in Development and Driving Gene Expression in Cancer

Coffee Break

Bradley E. Bernstein, Dana-Farber Cancer Institute, USA
Epigenetic and Topologic Changes that Restrain Malignancies

Katherine Chiappinelli, George Washington University, USA
Epigenetic Regulation of Transposable Elements and the Innate Immune Response in Cancer

Victoria P. Belancio, Tulane University, USA
Short Talk: Analysis of Epigenetic Features Characteristic of L1 loci Expressed in Human Cells

Ozgen Deniz, Imperial College London, UK
Short Talk: The Roles of Transposable Elements in Acute Myeloid Leukemia

Deepak K. Jha, Children's Hospital Boston, USA
Short Talk: Role of Transposable Elements in Hematopoiesis and Cancer

11:00—17:00
On Own for Lunch

13:00—22:00
Poster Viewing

Sea to Sky A
11:00—13:00
Poster Setup

Sea to Sky A
16:30—17:00
Coffee Available

Grand Foyer
17:00—19:00
Transposon Domestication and Co-Option at the DNA, RNA and Protein Levels

Sea to Sky B
Cedric Feschotte, Cornell University, USA
Transposon Domestication

Miguel Branco, Queen Mary University of London, UK
Placental Gene Regulation by Transposable Elements

Edward B. Chuong, University of Colorado Boulder, USA
Transposon Repurposing in Gene Networks

Helen S. Mueller, Memorial Sloan Kettering Cancer Center, USA
Short Talk: Elucidating DNA Damage Repair Signaling Activated by the DNA Transposase PGBD5

Mohamad Ali Najia, MIT, USA
Short Talk: Transposable Element Regulation of Hematopoietic Lineage Decisions

19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Grand Foyer
19:30—22:00
Poster Session 3

Sea to Sky A

THURSDAY, MARCH 3

07:00—08:00
Breakfast

Grand Foyer
08:00—11:00
Transpositions across Genomic and Cellular Compartments

Sea to Sky B
John V. Moran, University of Michigan Medical School, USA
Studies of a Human Transposable Element

José R. Penadés, Imperial College London, UK
Transposons and Virulence and Resistance Factors

Coffee Break

Amanda Larracuente, University of Rochester, USA
Selfish DNAs and Satellites

Fangpu Han, Chinese Academy of Sciences, China
Plant Chromosome Biology

Henry L. Levin, NIH, USA
Short Talk: Identification of an Integrase-independent Pathway of Retrotransposition

Juanma Vaquerizas†, MRC London Institute of Medical Sciences, UK
Short Talk: Transposable Element-driven Reorganisation of 3D Chromatin during Early Embryonic Development

Michelle J. Percharde, MRC London Institute of Medical Sciences, UK
Short Talk: Nucleolar-based Mechanisms of Gene and Transposon Control in Early Development

11:00—17:00
On Own for Lunch

14:30—16:30
Workshop 2: Bioinformatic and Multi-omic Tools

Sea to Sky B
Matthew L. Bendall, Weill Cornell Medicine, USA
Single Cell Retrotranscriptomics with Stellarscope: Developing a Single Cell Transposable Element Atlas of Human Cell Identity

Michael Cuoco, The Salk Institute, USA
Comprehensive Benchmarking of Transposable Element RNA-seq Quantification Methods

Andrew Garven, Queens University, Canada
The Transposable Elements Expression Landscape in Muscle-Invasive Bladder Cancer

Cristian Groza, McGill University, Canada
Genome Graphs Detect Human Polymorphisms in Active Epigenomic States During Influenza Infection

Darren Taylor, Blizard Institute, UK
Locus-Specific Chromatin Profiling of Evolutionarily Young Transposable Elements

Yilan Wang, Harvard University, USA
grnTea, a Machine Learning Tool to Detect Transposable Element Insertions in Ancient Human Whole-genome Sequencing Data

Shohei Kojima, RIKEN, Japan
Variation in Human Genomes and Phenotypes Driven by Mobile Genetic Elements

Hani Girgis, Texas A&M University- Kingsville, USA
LtrDetector: Toward High Quality Annotation of Long Terminal Repeat Retrotransposons

16:30—17:00
Coffee Available

Grand Foyer
17:00—18:45
From Ultraconservation to Hypervariability: The Significance of Variation

Sea to Sky B
Jeff F. Miller, University of California, Los Angeles, USA
Bacterial Adaptation by Diversity-Generating Retroelements

Vincent Colot, École Normale Supérieure, France
Genome Dynamics and Epigenetic Variation

Anna Selmecki, University of Minnesota, USA
Ploidy Variation in Fungi

Blair G. Paul, Marine Biological Laboratory, USA
Short Talk: Hypermutation in Filamentous Cyanobacteria

18:45—19:00
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)

Sea to Sky B
19:00—20:00
Social Hour with Lite Bites

Grand Foyer

FRIDAY, MARCH 4

08:00—08:00
Departure


*Session Chair †Invited, not yet responded.



Keystone Symposia thanks our Sponsor(s) for generously supporting this meeting:

Cell Research

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