Keystone Symposia

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This meeting took place in 2021


Here are the related meetings in 2024:
Immunometabolism: From Mechanisms to Pathways to Therapies (C3)

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Integrating Metabolism and Immunity (EK16)


Organizer(s) Marc Y. Donath, Tom Thuren, Bruce M. Spiegelman and Diane Mathis
January 25—28, 2021
Virtual at your computer • , CO USA
Abstract Deadline: Dec 16, 2020
Scholarship Deadline: Nov 1, 2020
Discounted Registration Deadline:

Sponsored by AbbVie Inc., Astellas Pharma Inc., Cell Research, Merck & Co., Inc. and Novo Nordisk A/S


Summary of Meeting:
Traditionally, metabolism and immunity have been perceived as two distinct systems with distinct functions: metabolism regulates the disposal and transformation of nutrients, whereas the immune system is responsible for host defense. However, in a broader sense, these two processes are both an organism’s response to stressors, with the aim of restoring homeostasis. An increasing amount of evidence has demonstrated that the chronic activation of the immune system associated with overnutrition may be deleterious, contributing importantly to diabetes and long-term complications, such as cardiovascular disorders. Such dysregulation of the immune system may reflect the duration and magnitude of the metabolic stress, along with genetic predispositions. Accordingly, anti-inflammatory treatments of metabolic diseases emerge as therapies interfering with the pathogenesis of these illnesses and offer disease-modifying potential. Therefore, it is critical that clinical translation be based on an understanding of the physiology and pathophysiology of the role of the immune system in metabolism. This conference will bring together basic scientists and clinicians from both disciplines in order to spark innovative ways of understanding the interactions between the immune system and metabolism. The conference organizers anticipate that the conference will lead to the development of novel therapeutic concepts based on the pathways underlying the pathogenesis of diseases rather than on the manifestation of symptoms belonging to a specific clinical discipline.

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Conference Program    Print  |   View meeting in 12 hr (am/pm) time


The meeting will begin on Monday, January 25 with . Conference events conclude on Thursday, January 28 with a closing plenary session from 12:00 to , followed by . We recommend return travel on Friday, January 29 in order to fully experience the meeting.

MONDAY, JANUARY 25

08:00—08:40
Welcoming Remarks and Keynote Address (8am Denver/Mountain Time Start)

* Diane Mathis, Harvard Medical School, USA
Session Chair

* Marc Y. Donath, University Hospital Basel, Switzerland
Session Chair

Bruce M. Spiegelman, Dana-Farber Cancer Institute, USA
Adipose Inflammation: Many Players and Many Regulatory Functions

08:00—08:40
Welcoming Remarks and Keynote Address (8am Denver/Mountain Time Start)

* Erik A. Sahai, Francis Crick Institute, UK
Session Chair

* Alec Kimmelman, New York University Langone Medical Center, USA
Session Chair

* Johanna A. Joyce, University of Lausanne, Switzerland
Session Chair

Matthew G. Vander Heiden, Massachusetts Institute of Technology, USA
Impact of Nutrient Availability on Cancer Metabolic Dependencies

08:40—10:10
Immunometabolism: The Metabolic View (8:40am Denver/Mountain Time Start)

* Janelle S. Ayres, The Salk Institute for Biological Studies, USA
Session Chair

* Diane Mathis, Harvard Medical School, USA
Control of Metabolism by Immune Cells

Vishwa Deep Dixit, Yale University, USA
Immunometabolic Regulation of Aging

Ana Domingos, University of Oxford, UK
Neuroimmunometabolism

Emily Vohralik, UNSW Sydney, Australia
Short Talk: Regulation of Adipose Tissue Beiging by Krüppel-Like Factor 3 (KLF3) and Eosinophils

Coffee Break

08:40—10:15
Metabolic Effects on the Immune System (8:40am Denver/Mountain Time Start)

* Erik A. Sahai, Francis Crick Institute, UK
Session Chair

* M. Celeste Simon, University of Pennsylvania, USA
Metabolic Symbioses in Stressful Tumor Microenvironments

Costas A. Lyssiotis, University of Michigan, USA
Metabolic Networks in the Tumor Microenvironment

Siva Karthik Varanasi, The Salk Institute for Biological Studies, USA
Short Talk: Tumor Metabolism Shapes Antigen Presentation and Adaptive Immune Responses

Hilary A. Coller, University of California, Los Angeles, USA
Short Talk: Cancer-Associated Stroma Requires Autophagy to Promote Tumor Growth by Maintaining Melanoma-Associated Fibroblasts and Suppressing Th1-Type Immune Responses

Eline C. Brombacher, LUMC, Netherlands
Short Talk: Activation of Nutrient-Sensor AMPK in Tumor-Associated Dendritic Cells Promotes Tolerogenic Responses and Compromises the Anti-Tumor Immunity

Coffee Break

10:45—12:15
The CNS Microenvironment (10:45am Denver/Mountain Time Start)

* Alec Kimmelman, New York University Langone Medical Center, USA
Session Chair

Frank Winkler, University Hospital Heidelberg, Germany
Brain Tumor Cells Interconnect to a Functional and Resistant Network

Johanna A. Joyce, University of Lausanne, Switzerland
Charting the Immune Landscape across Diverse Brain Cancers

* Michael E. Pacold, New York University Medical Center, USA
Brain Metastasis Adaptation to the Metabolic Niche of the Central Nervous System

Gino Ferraro, Harvard Medical School, Massachusetts General Hospital, USA
Short Talk: Fatty Acid Synthesis is Required for Breast Cancer Brain Metastasis

10:20—12:15
Immunometabolism: The Immunologist View (10:20am Denver/Mountain Time Start)

* Vishwa Deep Dixit, Yale University, USA
Session Chair

Christoph Hess, University Hospital Basel/University of Cambridge, Switzerland
From Patient to Molecular Understanding of Immunometabolism

Luke A. J. O'Neill, Trinity Biomedical Sciences Institute, Ireland
Krebs Cycle Repurposed for Cytokines

Janelle S. Ayres, The Salk Institute for Biological Studies, USA
Metabolic Adaptations in Host-Microbe Interactions

* Ruth A. Franklin, Harvard University, USA
Stress Responses and Disease Tolerance

Katrin Andreasson, Stanford University, USA
Short Talk: Metabolic Reprogramming of Myeloid Cells Reverses Cognitive Decline in Aging

14:00—15:00
Meet the Editors (Joint) (2pm Denver/Mountain Time Start)

Ubaldo E. Martinez Outschoorn, Thomas Jefferson University/Frontiers, USA

Stephanie Ailsa Houston, Journal of Experimental Medicine, USA

Lise Roth, European Molecular Biology Organization, Germany

Catarina Sacristán, Cell Press, USA


TUESDAY, JANUARY 26

08:00—09:30
Clinical Translation: Unmet Needs (8am Denver/Mountain Time Start)

* Luke A. J. O'Neill, Trinity Biomedical Sciences Institute, Ireland
Session Chair

* Morris J. Birnbaum, Retired Pfizer, Inc., USA
Session Chair

Marina Mesquida, F. Hoffmann-La Roche Ltd, Switzerland
Anti-Inflammatory Treatment of Diabetic Eye Complications

Marc Y. Donath, University Hospital Basel, Switzerland
IL-1beta in Physiology and Treatment of Metabolic Diseases

Tom Thuren, Novartis Pharmaceuticals, USA
Requirement to Implement Anti-Inflammatory Treatment of Cardiometabolic Diseases

Elena Carcarino, INSERM, France
Short Talk: Epigenomic Regulation of IL-1B Enhancers in Type 2 Diabetes

Coffee Break

08:00—09:55
Metastatic Colonisation (8am Denver/Mountain Time Start)

* Johanna A. Joyce, University of Lausanne, Switzerland
Session Chair

* Ruth Scherz-Shouval, Weizmann Institute of Science, Israel
Session Chair

Sarah-Maria Fendt, VIB-KU Leuven, Belgium
Metabolic Rewiring Boosting Metastasis Formation

Mikala Egeblad, Cold Spring Harbor Laboratory, USA
Activating a Collaborative Innate-Adaptive Immune Response to Restrain Metastasis

Matthew F. Krummel, University of California, San Francisco, USA
Imaging the Tumor Microenvironment in Five Dimensions

Heather Christofk, University of California, Los Angeles, USA
Targeting Cancer Asparagine Dependence

Kevin B. Walsh, Genentech, USA
Short Talk: VEGF Blockade Augments CD8+ T Cell Activity by Amplifying Tumor Hypoxia

Coffee Break

10:25—12:15
The Pancreatic Tumor Microenvironment (10:25am Denver/Mountain Time Start)

* Johanna A. Joyce, University of Lausanne, Switzerland
Session Chair

Lewis C. Cantley, Dana Farber Cancer Institute, USA
Insulin and Cancer

* Mara H. Sherman, Memorial Sloan Kettering Cancer Center, USA
Mechanisms and Consequences of Pancreatic Cancer Stromal Evolution

Andrea M. Amitrano, University of Rochester School of Medicine & Dentistry, USA
Short Talk: Regulation of CD8+ T Cell Metabolism and Migration with Optogenetics

Patricia Altea Manzano, VIB-KU Leuven Center for Cancer Biology, Belgium
[NOT AVAILABLE ON DEMAND] Short Talk: Environmental Fatty Acids Support Changes in Histone Acetylation that Promote Breast Cancer Metastasis

Felix Hartmann, Stanford University, USA
Short Talk: Single-Cell Metabolic Regulome Profiling of Human Immune Cells in the Tumor Microenvironment

Tanya Schild, Weill Cornell Medicine, USA
Short Talk: NADK Regulation by Oncogenic KRAS Signaling is Essential for PDAC

10:00—11:45
Insulin Production and Action (10:00am Denver/Mountain Time Start)

* Marc Y. Donath, University Hospital Basel, Switzerland
Session Chair

Alan R. Saltiel, University of California, San Diego, USA
Inflammatory Links Between Obesity and Energy Metabolism

Bruce Verchere, University of British Columbia, Canada
Islet Amyloid Polypeptide and Islet Inflammation

* Elise Dalmas, INSERM, France
Innate Immunity in the Pancreatic Islet Niche

Feyza Engin, University of Wisconsin-Madison, USA
Short Talk: Targeting Beta Cell Unfolded Protein Response in Type 1 Diabetes

Katia Monsorno, University of Lausanne, Switzerland
Short Talk: Lactate Metabolism in the Control of Microglial Function

12:00—13:00
Poster Session 1 (12pm Denver/Mountain Time Start)

13:00—14:00
Career Roundtable (Joint) (1pm Denver/Mountain Time Start)

Donita C. Brady, University of Pennsylvania, USA

Matthew G. Vander Heiden, Massachusetts Institute of Technology, USA

Tom Thuren, Novartis Pharmaceuticals, USA


WEDNESDAY, JANUARY 27

08:00—10:00
Adipose Tissues (8am Denver/Mountain Time Start)

* Elise Dalmas, INSERM, France
Session Chair

* Bruce M. Spiegelman, Dana-Farber Cancer Institute, USA
Session Chair

Rinke Stienstra, Wageningen University and RadboudUMC, Netherlands
Obesity and Diabetes: An Immunometabolic Perspective

Paul Cohen, Rockefeller University, USA
The Adipose Tissue Microenvironment in Health and Disease

Jun Wu, University of Michigan, USA
[NOT AVAILABLE ON DEMAND] Immune-Beige Adipocyte Communication

Inbar Shteinberg, Tel Aviv University, Israel
Short Talk: Distinctive Effects of Alarmins S100A8 and S100A9 on Adaptive Thermogenesis

Katelyn D. Miller, Wistar Institute, USA
Short Talk: Inhibition of Acetate Metabolism Enhances Host Anti-Tumor Immunity

Pegah Poursharifi, University of Montreal-CRCHUM, Canada
Short Talk: Suppression of ABHD6 Promotes Healthy Expansion of Adipose Tissue in Obesity

Coffee Break

08:00—09:40
Identifying the Metabolic Dependencies of Cancer Cells (8am Denver/Mountain Time Start)

* Erik A. Sahai, Francis Crick Institute, UK
Session Chair

Karen H. Vousden, Francis Crick Institute, UK
[NOT AVAILABLE ON DEMAND] Metabolic Control of Invasion and Metastasis

Eileen P. White, Rutgers Cancer Institute of New Jersey, USA
Autophagy and Systemic Metabolism

Navdeep S. Chandel, Northwestern University, USA
Mitochondrial Regulation of Cancer

* Donita C. Brady, University of Pennsylvania, USA
New Sides for an Old Coin: Copper as an Intracellular Mediator of Autophagy via ULK1/2 Kinase Signaling

Coffee Break

10:10—12:10
Therapeutic Targeting of Metabolism and the TME (10:10am Denver/Mountain Time Start)

* Erik A. Sahai, Francis Crick Institute, UK
Session Chair

Shannon J. Turley, Genentech, Inc., USA
Evolving Stromal-Immune Axis in Cancer Immunology and Immunotherapy

* Marcia C. Haigis, Harvard Medical School, USA
Dissecting the Tumor-Immune Metabolic Crosstalk in the Tumor Microenvironment

Valerie M. Weaver, University of California, San Francisco, USA
Interplay between Tissue Fibrosis, Metabolic Reprogramming and Inflammation in Tumor Evolution

Natalya N. Pavlova, Memorial Sloan Kettering Cancer Center, USA
Short Talk: Translation in Amino Acid-Poor Environments is Limited by tRNAGln Charging

Thomas Hanigan, The Scripps Research Institute, USA
Short Talk: Small Molecule Inhibition of OXA1L Selectively Kills ZFHX3 Mutant NSCLC from Imbalanced Cytidine Pool Expansion

Arin Aurora, University of Texas Southwestern Medical Center, USA
Short Talk: Metastasizing Melanoma Cells Exhibit Increased Dependence on the Pentose Phosphate Pathway to Manage Oxidative Stress

10:10—12:10
Liver (10:10am Denver/Mountain Time Start)

* Gwendalyn J. Randolph, Washington University, USA
Session Chair

* Alan R. Saltiel, University of California, San Diego, USA
Session Chair

Michael Karin, University of California, San Diego, USA
Mitochondrial DNA Metabolism and IL-1 Mediated Inflammation

Evanna Mills, Dana-Farber Cancer Institute, USA
Thermogenic Fat as a Modifier of the Immune Response

Morris J. Birnbaum, Retired Pfizer, Inc., USA
Therapeutic Approaches for the Treatment of Non-Alcoholic Fatty Liver Disease

Han Wang, Ohio State University, Comprehensive Cancer Center, USA
Short Talk: Neutrophil Extracellular Traps Promote the Differentiation of Tregs through Metabolic Reprogramming to Impair Cancer Immunosurveillance in NASH Liver

Sabine Daemen, Washington University in St. Louis, USA
Short Talk: Recruited Monocyte-Derived Macrophages Regulate Hepatic Crown-Like Structure Formation and Liver Fibrosis in NASH

Jin Young Huh, Seoul National University, South Korea
Short Talk: Tank-Binding Kinase 1 Regulates the Localization of acyl-CoA synthetase ACSL1 to Control Hepatic Fatty Acid Oxidation


THURSDAY, JANUARY 28

08:00—09:45
Muscle/Cardiovascular (8am Denver/Mountain Time Start)

* Ana Domingos, University of Oxford, UK
Session Chair

Helga Ellingsgaard, Centre for Physical Activity Research, Copenhagen, Denmark
IL-6, a Physiological Regulator of Adipose Tissue Mass in Humans

* Mark A. Febbraio, Monash Institute of Pharmaceutical Sciences, Australia
Treatment of Type 2 Diabetes and Age-Related Sarcopenia with the Designer Cytokine IC7Fc

Amy J. Wagers, Harvard University, USA
Stem Cell Metabolism and Muscle Regeneration

Shuang Zhang, Harvard Medical School/Massachusetts General Hospital, USA
Short Talk: Bone Marrow Adipocytes Fuel Fatty Acid Metabolism Directed Myelopoiesis after Myocardial Infarction

Dina Chokr, INSERM, Centre de Recherche des Cordeliers, France
Short Talk: Impact of Histone Lysine Demethylase 6B on Adipose Tissue Macrophage Plasticity

Coffee Break

08:00—09:45
Intercellular Signaling Networks in the TME (8am Denver/Mountain Time Start)

* Karin E. de Visser, Netherlands Cancer Institute, Netherlands
How the Genetic Makeup of Breast Cancer Shapes the Immune Landscape

* Erik A. Sahai, Francis Crick Institute, UK
Towards a Holistic Understanding of Tumor Architecture

Ruth Scherz-Shouval, Weizmann Institute of Science, Israel
Transcriptional Heterogeneity of Cancer-Associated Fibroblasts in the Tumor Microenvironment

Hannah Bell, University of Michigan, USA
Short Talk: Microbiota Metabolic Exchange Is Critical for Colorectal Cancer Redox Homeostasis and Growth

Christina Schmidt, University of Cambridge, UK
Short Talk: TRACER, a 3D-Model to Study the Influence of the Microenvironment on the Metabolic Profile of Fumarate Hydratase-Deficient Cells

Coffee Break

10:15—12:00
Metabolic Compartmentalisation (10:15am Denver/Mountain Time Start)

* Ralph J. DeBerardinis, University of Texas Southwestern Medical Center, USA
Compartmentalized Metabolism in Physiological States of Growth

Erika L. Pearce, Johns Hopkins University, USA
Metabolic Regulation of the Immune Metabolism

* Alec Kimmelman, New York University Langone Medical Center, USA
Metabolic Crosstalk in PDAC

Fabricio Loayza-Puch, German Cancer Research Center, Germany
Short Talk: Dual Ribosome Profiling Uncovers Metabolic Limitations in Distinct Cellular Populations of the Tumor Microenvironment

Marina Fukano, Rosalind & Morris Goodman Cancer Research Centre, McGill University, Canada
[NOT AVAILABLE ON DEMAND] Short Talk: Investigating Intra-Tumour Metabolic Heterogeneity in Triple-Negative Breast Cancer

12:00—12:10
Closing Remarks (12pm Denver/Mountain Time Start)

12:10—13:30
Networking Lounge (12:10pm Denver/Mountain Time Start)

10:05—11:50
Cardiovascular (10:05am Denver/Mountain Time Start)

* Paul Cohen, Rockefeller University, USA
Session Chair

* Michael Karin, University of California, San Diego, USA
Session Chair

Eicke Latz, University of Bonn, Germany
Pharmacological Modulation of Cellular Metabolism Controls Macrophage Metabolism

Gwendalyn J. Randolph, Washington University, USA
Immunity and Lipoprotein Trafficking

Matthias Nahrendorf, Massachusetts General Hospital, USA
Post-MI Emergency Hematopoiesis and Metabolism

Jan Van den Bossche, Amsterdam UMC VUmc, Netherlands
Short Talk: Macrophage ATP Citrate Lyase Deficiency Stabilizes Atherosclerotic Plaques

Enyuan Cao, Monash University, Australia
Short Talk: Mesenteric Lymphatic Dysfunction Promotes Insulin Resistance and Represents a Potential Novel Treatment Target in Obesity

11:50—12:00
Closing Remarks (11:50am Denver/Mountain Time Start)

12:00—13:30
Networking Lounge (12pm Denver/Mountain Time Start)


*Session Chair †Invited, not yet responded.



Keystone Symposia thanks our Sponsors(s) for generously supporting this meeting:

AbbVie Inc. Astellas Pharma Inc.
Cell Research Merck & Co., Inc.
Novo Nordisk A/S
 

We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1 R13 DK125009-01

Funding for this conference was made possible (in part) by 1 R13 DK125009-01 from the National Institutes of Health. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention by trade names, commercial practices, or organizations imply endorsement by the U.S. Government.


We gratefully acknowledge additional support for this conference from:

AdipoGen Life Sciences Sable Systems International

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