Keystone Resort Floorplan
This meeting took place in 2022
For a complete list of the meetings for the upcoming/current season, see our meeting list, or search for a meeting.
Organoids as Tools for Fundamental Discovery and Translation (X8)
Organizer(s) Jason R. Spence, Melissa Little and Barbara Treutlein
April 3—6, 2022
Keystone Resort • Keystone, CO USA
Abstract Deadline: Jan 6, 2022
Scholarship Deadline: Jan 6, 2022
Discounted Registration Deadline: Feb 3, 2022
Sponsored by AbbVie Inc., Genmab A/S and Merck and Co., Inc.
Joint Meeting:
Engineering Multi-Cellular Living Systems (X7)
Summary of Meeting:
Organoids are complex three-dimensional in vitro organ-like model systems. Organoids can be derived from pluripotent stem cells or primary donor tissue and have been used to address fundamental questions about development, stem cell biology and organ regeneration. Human organoids have highlighted significant unknowns in human biology and have invigorated new exploration into the cellular makeup of human organs during development, in the adult and during disease. Efforts to improve complexity in organoid systems, and to make organoid systems more robust, reproducible and controlled have prompted efforts to benchmark in vitro organoid systems against their in vivo counterparts, and efforts to control organoid systems through bioengineering approaches. The goals of this symposium are to highlight recent and emerging advances that implement organoids as tools to move several areas of biology forward, including improving complexity and maturation, high content drug screening, disease modeling, and understanding development and evolution. We anticipate that attendees will take away from this meeting new scientific knowledge, new methods and new technical capabilities. Moreover, given that the implementation of organoids in basic discovery and translational research spans a wide range of disciplines, it is likely that this meeting will bring together a diverse audience fostering novel cross-disciplinary interactions.
View Scholarships/Awards
Organoids are complex three-dimensional in vitro organ-like model systems. Organoids can be derived from pluripotent stem cells or primary donor tissue and have been used to address fundamental questions about development, stem cell biology and organ regeneration. Human organoids have highlighted significant unknowns in human biology and have invigorated new exploration into the cellular makeup of human organs during development, in the adult and during disease. Efforts to improve complexity in organoid systems, and to make organoid systems more robust, reproducible and controlled have prompted efforts to benchmark in vitro organoid systems against their in vivo counterparts, and efforts to control organoid systems through bioengineering approaches. The goals of this symposium are to highlight recent and emerging advances that implement organoids as tools to move several areas of biology forward, including improving complexity and maturation, high content drug screening, disease modeling, and understanding development and evolution. We anticipate that attendees will take away from this meeting new scientific knowledge, new methods and new technical capabilities. Moreover, given that the implementation of organoids in basic discovery and translational research spans a wide range of disciplines, it is likely that this meeting will bring together a diverse audience fostering novel cross-disciplinary interactions.
View Scholarships/Awards
No registration fees are used to fund entertainment or alcohol at this conference
The meeting will begin on Sunday, April 3 with registration from 16:00 to 20:00 and a welcome mixer from 18:00 to 20:00. Conference events conclude on Wednesday, April 6 with a closing plenary session from 17:00 to 19:15, followed by a social hour. We recommend return travel on Thursday, April 7 in order to fully experience the meeting.
SUNDAY, APRIL 3
MONDAY, APRIL 4
TUESDAY, APRIL 5
WEDNESDAY, APRIL 6
THURSDAY, APRIL 7
Conference Program Print | View meeting in 12 hr (am/pm) time
The meeting will begin on Sunday, April 3 with registration from 16:00 to 20:00 and a welcome mixer from 18:00 to 20:00. Conference events conclude on Wednesday, April 6 with a closing plenary session from 17:00 to 19:15, followed by a social hour. We recommend return travel on Thursday, April 7 in order to fully experience the meeting.
SUNDAY, APRIL 3
18:00—20:00
Welcome Mixer
No registration fees are used to fund alcohol served at this function.
08:00—09:30
Welcome and Keynote Session (Joint)
*
Roger D. Kamm,
Massachusetts Institute of Technology, USA
Session Chair
Session Chair
*
Jason R. Spence,
University of Michigan Health System, USA
Session Chair
Session Chair
Paola Arlotta,
Harvard University, USA
Programming, Reprogramming and Modeling of the Mammalian Cerebral Cortex
Programming, Reprogramming and Modeling of the Mammalian Cerebral Cortex
Matthias Lutolf,
EPF Lausanne, Switzerland
Engineering Epithelial Organoid Development
Engineering Epithelial Organoid Development
Coffee Break
09:50—12:00
Embryoids and Gastruloids for Early Development (Joint)
*
Nuria Montserrat Pulido,
Institute for Bioengineering of Catalonia, Spain
Session Chair
Session Chair
*
Todd C. McDevitt,
Gladstone Institutes, USA
Session Chair
Session Chair
Jianping Fu,
University of Michigan, Ann Arbor, USA
Building Synthetic Human Embryo-Like Structures
Building Synthetic Human Embryo-Like Structures
Magdalena D. Zernicka-Goetz,
University of Cambridge, UK
Development of Cell Lineages and Patterning in the Early Mammalian Embryo
Development of Cell Lineages and Patterning in the Early Mammalian Embryo
Xufeng Xue,
University of Michigan, USA
Short Talk: A Patterned Human Neural Tube Model Using Microfluidics
Short Talk: A Patterned Human Neural Tube Model Using Microfluidics
Sunghee Estelle Park,
University of Pennsylvania, USA
Short Talk: Geometric Engineering of Organoid Culture for Enhanced Organogenesis in a Dish
Short Talk: Geometric Engineering of Organoid Culture for Enhanced Organogenesis in a Dish
17:00—19:00
High Content Screening with Organoids
Jason R. Spence,
University of Michigan Health System, USA
Complex Cell-Cell Interactions in the Developing Human Lung and Gut
Complex Cell-Cell Interactions in the Developing Human Lung and Gut
*
Shuibing Chen,
Weill Cornell Medical College, USA
A Multi-organoid Platform, SARS-CoV-2 Infection and Drug Screening
A Multi-organoid Platform, SARS-CoV-2 Infection and Drug Screening
Filippo Cipriani,
New York Stem Cell Foundation Research Institute, USA
Short Talk: Automated Platform to Derive iPSC-pancreatic Organoids for Population-scale Modeling of Type 2 Diabetes
Short Talk: Automated Platform to Derive iPSC-pancreatic Organoids for Population-scale Modeling of Type 2 Diabetes
Jack Song,
USC, USA
Short Talk: Pluripotent Stem Cell-directed Model of Autosomal Dominant Polycystic Kidney Disease for Disease Mechanism and Drug Discovery
Short Talk: Pluripotent Stem Cell-directed Model of Autosomal Dominant Polycystic Kidney Disease for Disease Mechanism and Drug Discovery
17:00—19:00
Engineering Principles of Developmental Biology and Regeneration
*
Ron Weiss,
Massachusetts Institute of Technology, USA
Mammalian Synthetic Biology, Programmable Organoids, and Neuromorphic Computing in Cells
Mammalian Synthetic Biology, Programmable Organoids, and Neuromorphic Computing in Cells
Kevin Kit Parker,
Harvard University, USA
Building Cardiac Anatomy and Physiology into Muscular Pumps
Building Cardiac Anatomy and Physiology into Muscular Pumps
Alex Hughes,
University of Pennsylvania, USA
Short Talk: Extracting and Building with the Engineering Principles of Kidney Development
Short Talk: Extracting and Building with the Engineering Principles of Kidney Development
Katharine Goodwin,
Princeton University, USA
Short Talk: On Fate and Form: Branching Morphogenesis Instructs Spatial Patterns of Epithelial Differentiation in the Developing Lung
Short Talk: On Fate and Form: Branching Morphogenesis Instructs Spatial Patterns of Epithelial Differentiation in the Developing Lung
19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
08:00—11:00
Increasing Complexity in Organoids by Leveraging Development
Barbara Treutlein,
ETH Zürich, Switzerland
Remote Presentation: Single Cell Genomics to Guide Human Stem Cell and Tissue Engineering
Remote Presentation: Single Cell Genomics to Guide Human Stem Cell and Tissue Engineering
Prisca Liberali,
Friedrich Miescher Institute for Biomedical Research, Switzerland
Remote Presentation: Regenerative Landscape of Intestinal Organoids
Remote Presentation: Regenerative Landscape of Intestinal Organoids
Coffee Break
*
Giorgia Quadrato,
University of Southern California, USC Stem Cell, USA
Modeling Human Brain Development and Disease at Single Cell Resolution with Brain Organoids
Modeling Human Brain Development and Disease at Single Cell Resolution with Brain Organoids
*
Madeline Lancaster,
Medical Research Council Laboratory of Molecular Biology, UK
Using Brain Organoids to Identify Conserved or Unique Factors in Human Brain Size Evolution
Using Brain Organoids to Identify Conserved or Unique Factors in Human Brain Size Evolution
Anna Meier,
Technical University of Munich, Germany
Short Talk: Epicardioid Single-cell Genomics Uncover Principles of Human Epicardium Biology in Heart Development and Disease
Short Talk: Epicardioid Single-cell Genomics Uncover Principles of Human Epicardium Biology in Heart Development and Disease
Nicole Pek,
Cincinnati Childrens Hospital Medical Center, USA
Short Talk: Reconstructing Pulmonary Circulation to Study Lung Alveologenesis in a Dish
Short Talk: Reconstructing Pulmonary Circulation to Study Lung Alveologenesis in a Dish
08:00—11:15
Microphysiological Systems and Drug Discovery Platforms
*
Adam W. Feinberg,
Carnegie Mellon University, USA
Session Chair
Session Chair
*
Alex Hughes,
University of Pennsylvania, USA
Session Chair
Session Chair
Christine L. Mummery,
Leiden University Medical Center, Netherlands
Remote Presentation: Characterization and Functional Analysis of Cardiovascular Derivatives of Human Pluripotent Stem Cells
Remote Presentation: Characterization and Functional Analysis of Cardiovascular Derivatives of Human Pluripotent Stem Cells
Roger D. Kamm,
Massachusetts Institute of Technology, USA
Microphysiological Models for Neurological Disease
Microphysiological Models for Neurological Disease
Coffee Break
Sandra J. Engle,
Biogen, USA
In vitro Models to Enable Drug Discovery
In vitro Models to Enable Drug Discovery
Danilo A. Tagle,
NCATS, National Institutes of Health, USA
Tissue Chips for Drug Screening
Tissue Chips for Drug Screening
Sylvia F. Boj,
Hubrecht Organoid Technology, Netherlands
Patient-Derived Organoids for Drug Development and Screening
Patient-Derived Organoids for Drug Development and Screening
Alice E. Stanton,
MIT, USA
Short Talk: Engineering Vascularized Mini-Brain-Tissue for Accelerating Drug Discovery and Translation with Cell-Instructive Materials
Short Talk: Engineering Vascularized Mini-Brain-Tissue for Accelerating Drug Discovery and Translation with Cell-Instructive Materials
14:30—16:30
Career Roundtable (Joint)
Sandra J. Engle,
Biogen, USA
Anjelica L. Gonzalez,
Yale University, USA
Meritxell Huch,
Max Planck Institute of Molecular Cell Biology and Genetics, Germany
Nuria Montserrat Pulido,
Institute for Bioengineering of Catalonia, Spain
17:00—19:00
Improvements in Organoid Maturation
*
J. Gray Camp,
University of Basel, Switzerland
Interrogating Evolution using Single Cell Genomics and Genome Engineering
Interrogating Evolution using Single Cell Genomics and Genome Engineering
*
James M. Wells,
Cincinnati Children's Hospital Research Foundation, USA
Engineering Complexity into PSC-derived Gastrointestinal Organoids
Engineering Complexity into PSC-derived Gastrointestinal Organoids
Meghan Capeling,
University of Michigan, USA
Short Talk: Suspension Culture Promotes Serosal Mesothelial Development in Human Intestinal Organoids
Short Talk: Suspension Culture Promotes Serosal Mesothelial Development in Human Intestinal Organoids
Ana Uzquiano Lopez,
Harvard University, USA
Short Talk: Single-cell Atlas of Human Cortical Development in vitro and in vivo Reveals Longitudinal Molecular Programs of Human Cortex Diversification
Short Talk: Single-cell Atlas of Human Cortical Development in vitro and in vivo Reveals Longitudinal Molecular Programs of Human Cortex Diversification
Julien G. Roth,
Stanford University, USA
Short Talk: Spatially Controlled Construction of Multi-organoid Neural Tissues using Bioprinting
Short Talk: Spatially Controlled Construction of Multi-organoid Neural Tissues using Bioprinting
17:00—19:00
Advanced Technologies for Engineering Multi Cellular Living Systems: Computation
*
Rashid Bashir,
University of Illinois, USA
Session Chair
Session Chair
Yoshihiro Morishita,
RIKEN, Japan
Remote Presentation: Quantitative Analysis of Tissue and Cell Dynamics Towards Revealing Design Principles for Organ Morphogenesis
Remote Presentation: Quantitative Analysis of Tissue and Cell Dynamics Towards Revealing Design Principles for Organ Morphogenesis
*
Melissa L. Kemp,
Georgia Institute of Technology, USA
Modeling Self-Organization in Multi-Cellular Engineered Living Systems
Modeling Self-Organization in Multi-Cellular Engineered Living Systems
Elebeoba E. May,
University of Houston, USA
Multiscale Models of Spatiotemporal Response to Mycobacterium Infection
Multiscale Models of Spatiotemporal Response to Mycobacterium Infection
Dennis A. Norfleet,
Georgia Institute of Technology, USA
Short Talk: Model-driven Prediction of Novel Emergent Bioelectric Patterns in hiPSCs
Short Talk: Model-driven Prediction of Novel Emergent Bioelectric Patterns in hiPSCs
Aric Lu,
Harvard University, USA
Short Talk: Orthogonal Induced Differentiation for Programming Stem Cells, Organoids, and Printed Tissues
Short Talk: Orthogonal Induced Differentiation for Programming Stem Cells, Organoids, and Printed Tissues
19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
08:00—11:00
Organoids for Disease Modeling
Samira Musah,
Duke University, USA
Remote Presentation: Stem Cell-Derived Organ Chips for Disease Modeling
Remote Presentation: Stem Cell-Derived Organ Chips for Disease Modeling
*
Meritxell Huch,
Max Planck Institute of Molecular Cell Biology and Genetics, Germany
Liver Organoids for Human Biology and Disease
Liver Organoids for Human Biology and Disease
Coffee Break
Mina Gouti,
Max-Delbrück Center for Molecular Medicine, Germany
Neuromuscular Organoids to Model Human Development and Disease
Neuromuscular Organoids to Model Human Development and Disease
Pleun Hombrink,
Hubrecht Organoid Technology, Netherlands
Short Talk: Organoid Co-cultures with Autologous TIL to Model Personalized Tumor Specific Immune-responses
Short Talk: Organoid Co-cultures with Autologous TIL to Model Personalized Tumor Specific Immune-responses
Jean-Paul Urenda,
University of Southern California, USA
Short Talk: A Next-generation Human Multi-organoids-based Platform to Model Neurodevelopmental Disorders Following Physiological Stimulation
Short Talk: A Next-generation Human Multi-organoids-based Platform to Model Neurodevelopmental Disorders Following Physiological Stimulation
08:00—11:00
Advanced Technologies for Engineering Multi-Cellular Living Systems: Imaging, Biomaterials, and 3D Printing
*
Matthias Lutolf,
EPF Lausanne, Switzerland
Session Chair
Session Chair
*
Kevin Kit Parker,
Harvard University, USA
Session Chair
Session Chair
Rashid Bashir,
University of Illinois, USA
3D Printed Cellular Machines for Engineering and Biology
3D Printed Cellular Machines for Engineering and Biology
Adam W. Feinberg,
Carnegie Mellon University, USA
3D Bioprinting of Collagen to Rebuild Components of the Human Heart
3D Bioprinting of Collagen to Rebuild Components of the Human Heart
Coffee Break
Anjelica L. Gonzalez,
Yale University, USA
Development of Biomaterials for Use As Investigational Tools
Development of Biomaterials for Use As Investigational Tools
Michael Blatchley,
University of Colorado Boulder, USA
Short Talk: In Situ Super-resolution Imaging of Organoids and Extracellular Matrix Interactions via Photo-expansion Microscopy
Short Talk: In Situ Super-resolution Imaging of Organoids and Extracellular Matrix Interactions via Photo-expansion Microscopy
Sarah M. Hull,
Stanford University, USA
Short Talk: UNIversal Orthogonal Network (UNION) Bioinks Enable Multi-material, Multi-cellular 3D Bioprinting
Short Talk: UNIversal Orthogonal Network (UNION) Bioinks Enable Multi-material, Multi-cellular 3D Bioprinting
17:00—19:00
Bioengineering of Organoids (Joint)
*
Jianping Fu,
University of Michigan, Ann Arbor, USA
Session Chair
Session Chair
Nuria Montserrat Pulido,
Institute for Bioengineering of Catalonia, Spain
Engineering Solutions for Pluripotent Stem Cell Derived Kidney Organoids
Engineering Solutions for Pluripotent Stem Cell Derived Kidney Organoids
Ryuji Morizane,
Harvard Medical School, USA
Vascularized Kidney Organoids for Disease Modeling and Regenerative Medicine
Vascularized Kidney Organoids for Disease Modeling and Regenerative Medicine
*
Todd C. McDevitt,
Gladstone Institutes, USA
Talk Title to be Announced
Talk Title to be Announced
Deepak Mishra,
Massachusetts Institute of Technology, USA
Short Talk: Genetically Engineered Human Pluripotent Stem Cells Utilizing Multi-step Automated Differentiation for Development of 3D Liver Bud-like Organoids
Short Talk: Genetically Engineered Human Pluripotent Stem Cells Utilizing Multi-step Automated Differentiation for Development of 3D Liver Bud-like Organoids
Adriana Mulero-Russe,
Georgia Tech, USA
Short Talk: Engineered Synthetic Platform for Human Intestinal Organoid Delivery
Short Talk: Engineered Synthetic Platform for Human Intestinal Organoid Delivery
19:00—19:15
Meeting Wrap-Up: Outcomes and Future Directions (Organizers) (Joint)
19:15—20:15
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
*Session Chair †Invited, not yet responded.
Keystone Symposia thanks our Sponsors(s) for generously supporting this meeting:
We gratefully acknowledge additional support from these exhibitors at this conference:
Please stop by to meet these exhibitors during the conference.
We gratefully acknowledge the generous grant for this conference provided by:
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:
Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:
Click here to view more of these organizations
If your organization is interested in joining these entities in support of Keystone
Symposia, please contact: John Monson,
Director of Corporate Relations, Email: johnm@keystonesymposia.org, Phone:+1 970-262-2690 Click here for more information on Industry Support and Recognition Opportunities. If you are interested in becoming an advertising/marketing in-kind partner, please contact: Josh May, Director, Technology and Digital Media, Email: joshuam@keystonesymposia.org, Phone:+1 970-262-1179 |