Keystone Resort Floorplan
This meeting took place in 2022
For a complete list of the meetings for the upcoming/current season, see our meeting list, or search for a meeting.
Resolution of Inflammation (Z3)
Organizer(s) Carla V. Rothlin, Kodi S. Ravichandran, Ashley W. Seifert and Gabrielle Fredman
June 12—16, 2022
Keystone Resort • Keystone, CO USA
Abstract Deadline: Apr 20, 2022
Scholarship Deadline: Mar 31, 2022
Discounted Registration Deadline: Apr 12, 2022
Sponsored by AstraZeneca, BioLegend, Inc., Genentech, Inc., Merck & Co., Inc., Novo Nordisk A/S and PhenoVista Biosciences
Summary of Meeting:
This meeting will bring together an interdisciplinary group of scientists studying interactions between immune and stromal cells, and neuroimmune interactions to better understand the resolution of inflammation, and subsequent repair and regeneration. The meeting will explore the function of myeloid cells and fibroblasts, as well as contrasting roles of neuroimmune interactions in resolution of inflammation and pathological inflammation. In addition, this conference will examine our current understanding of diseases that impact the resolution of inflammation, with the goal of conceptualizing and developing pro-resolution therapies. We aim to provide a forum for the exchange of ideas that will strengthen the community of scientists interested in the fundamental mechanisms of resolution of inflammation and their translation into pharmacological approaches for the treatment of diseases driven by either lack of or aberrant resolution and repair responses.
View Scholarships/Awards
This meeting will bring together an interdisciplinary group of scientists studying interactions between immune and stromal cells, and neuroimmune interactions to better understand the resolution of inflammation, and subsequent repair and regeneration. The meeting will explore the function of myeloid cells and fibroblasts, as well as contrasting roles of neuroimmune interactions in resolution of inflammation and pathological inflammation. In addition, this conference will examine our current understanding of diseases that impact the resolution of inflammation, with the goal of conceptualizing and developing pro-resolution therapies. We aim to provide a forum for the exchange of ideas that will strengthen the community of scientists interested in the fundamental mechanisms of resolution of inflammation and their translation into pharmacological approaches for the treatment of diseases driven by either lack of or aberrant resolution and repair responses.
View Scholarships/Awards
No registration fees are used to fund entertainment or alcohol at this conference
The meeting will begin on Sunday, June 12 with registration from 16:00 to 20:00 and a welcome mixer from 18:00 to 20:00. Conference events conclude on Thursday, June 16 with a closing plenary session from 17:00 to 19:00, followed by a social hour. We recommend return travel on Friday, June 17 in order to fully experience the meeting.
SUNDAY, JUNE 12
MONDAY, JUNE 13
TUESDAY, JUNE 14
WEDNESDAY, JUNE 15
THURSDAY, JUNE 16
FRIDAY, JUNE 17
Conference Program Print | View meeting in 12 hr (am/pm) time
The meeting will begin on Sunday, June 12 with registration from 16:00 to 20:00 and a welcome mixer from 18:00 to 20:00. Conference events conclude on Thursday, June 16 with a closing plenary session from 17:00 to 19:00, followed by a social hour. We recommend return travel on Friday, June 17 in order to fully experience the meeting.
SUNDAY, JUNE 12
18:00—20:00
Welcome Mixer
No registration fees are used to fund alcohol served at this function.
08:00—09:00
Welcome and Keynote Address (8:00 am Start)
*
Carla V. Rothlin,
Yale University, USA
Session Chair
Session Chair
Yasmine Belkaid,
Pasteur Institut, France
Commensal Specific T Cell in Tissue Repair Responses
Commensal Specific T Cell in Tissue Repair Responses
08:00—09:00
Welcome and Keynote Address (8:00 am Start)
*
Shelia M. Violette,
Q32 Bio, USA
Session Chair
Session Chair
*
Neil C. Henderson,
University of Edinburgh, Queen's Medical Research Institute, UK
Session Chair
Session Chair
Scott L. Friedman,
Icahn School of Medicine at Mount Sinai, USA
Advances in the Field of Fibrosis: Linking our Understanding of Injury and Repair Mechanisms to the Development of Novel Therapies
Advances in the Field of Fibrosis: Linking our Understanding of Injury and Repair Mechanisms to the Development of Novel Therapies
09:00—11:15
Rethinking Myeloid Cells in Resolution, Repair and Regeneration I (9:00 am Start)
*
Carla V. Rothlin,
Yale University, USA
Session Chair
Session Chair
Kodi S. Ravichandran,
Washington University School of Medicine, USA
Can We Chat and Resolve This? Metabolite-Based Communication between Myeloid Cells and Others
Can We Chat and Resolve This? Metabolite-Based Communication between Myeloid Cells and Others
Coffee Break
Elina I. Zuniga,
University of California, San Diego, USA
Silencing Plasmacytoid Dendritic Cell Derived Interferons
Silencing Plasmacytoid Dendritic Cell Derived Interferons
Andrés Hidalgo,
Yale School of Medicine, USA
Macrophages Network Keep a Healthy Heart
Macrophages Network Keep a Healthy Heart
Andrew J. Davidson,
University of Edinburgh, UK
Short Talk: Into the Void: in vivo Imaging of Wounds Reveals Ferroptosis and its Role in the Inflammatory Response
Short Talk: Into the Void: in vivo Imaging of Wounds Reveals Ferroptosis and its Role in the Inflammatory Response
09:00—11:15
Regulation of Fibrosis by Altering Senescence and Aging (9:00 am Start)
*
Melanie Koenigshoff,
University of Pittsburgh, USA
Session Chair
Session Chair
*
Sarah L. Doyle,
Trinity College Dublin, Ireland
Session Chair
Session Chair
Anne Brunet,
Stanford University, USA
Heterogeneity in Old Fibroblasts is Linked to Variability in Reprogramming and Wound Healing
Heterogeneity in Old Fibroblasts is Linked to Variability in Reprogramming and Wound Healing
Coffee Break
Lesley A. Hill,
University of British Columbia, Canada
Mechanisms Regulating Mesenchymal Progenitor Quiescence and their Impact on Liver Regeneration and Fibrosis
Mechanisms Regulating Mesenchymal Progenitor Quiescence and their Impact on Liver Regeneration and Fibrosis
David Lagares,
Massachusetts General Hospital/Harvard Medical School, USA
Novel Therapeutic Targets to Modulate Fibroblast Senescence and Apoptosis in Fibrotic Disease
Novel Therapeutic Targets to Modulate Fibroblast Senescence and Apoptosis in Fibrotic Disease
Nunzia Caporarello,
Mayo Clinic, USA
Short Talk: Rejuvenation of the Pulmonary Vasculature by Circulating Extracellular Vesicles as an Anti-fibrotic Strategy
Short Talk: Rejuvenation of the Pulmonary Vasculature by Circulating Extracellular Vesicles as an Anti-fibrotic Strategy
14:30—16:30
Workshop 1 (2:30 pm Start)
*
Maria E. Mercau,
Yale University – School of Medicine, USA
*
Christopher J. Cowley,
Rockefeller University, USA
Establishment, Maintenance, and Recall of Inflammatory Memory
Establishment, Maintenance, and Recall of Inflammatory Memory
Julia L M Dunn,
Cincinnati Children's Hospital Medical Center, USA
Better Off Dead? The Promise of Polarizing Rather Than Depleting Eosinophils in Chronic Inflammation
Better Off Dead? The Promise of Polarizing Rather Than Depleting Eosinophils in Chronic Inflammation
Wendy JM Huang,
University of California San Diego, USA
RORγt Phosphorylation in T Cells Promotes Inflammation Resolution
RORγt Phosphorylation in T Cells Promotes Inflammation Resolution
Manikandan Subramanian,
Queen Mary University of London, UK
Disentangling NETs to Promote Resolution of Inflammation
Disentangling NETs to Promote Resolution of Inflammation
Josephine J. Trichka,
Case Western Reserve University School of Medicine, USA
The ESCRT Protein CHMP5 Controls Skeletal Muscle Homeostasis and Coordination of Myeloid Cell-mediated Tissue Repair
The ESCRT Protein CHMP5 Controls Skeletal Muscle Homeostasis and Coordination of Myeloid Cell-mediated Tissue Repair
14:30—16:30
Workshop 1: Cutting Edge Models of Fibrosis (2:30 pm Start)
Highlights the tremendous progress in human tissue based modeling of fibrosis over the past years, which opened up novel avenues for drug discovery and validation. Likely to attract basic, clinical, and applied researchers across all disciplines.
*
Melanie Koenigshoff,
University of Pittsburgh, USA
Session Chair
Session Chair
*
Shelia M. Violette,
Q32 Bio, USA
Session Chair
Session Chair
*
Allie M. Roach,
Gilead Sciences, USA
Session Chair
Session Chair
Yixiao Cui,
Boehringer Ingelheim, USA
WNT Signaling Regulates the Emergence of Aberrant Cell Populations and Mediates Protective Mechanisms in Idiopathic Pulmonary Fibrosis
WNT Signaling Regulates the Emergence of Aberrant Cell Populations and Mediates Protective Mechanisms in Idiopathic Pulmonary Fibrosis
Leilani Astrab,
University of Virginia, USA
Macrophage Soluble Signals and Hydrogel Viscoelasticity Influence Fibroblast Activation
Macrophage Soluble Signals and Hydrogel Viscoelasticity Influence Fibroblast Activation
Christian Stockmann,
University of Zurich, Switzerland
Vaccination-based Immunotherapy to Target Organ Fibrosis
Vaccination-based Immunotherapy to Target Organ Fibrosis
Elizabeth A. Caves,
Yale University, USA
Adipocyte Lipolysis Protects against Early Dermal Fibrosis Development in Mice
Adipocyte Lipolysis Protects against Early Dermal Fibrosis Development in Mice
Chao He,
University of Alabama at Birmingham, USA
Matrix Stiffness Regulates Macrophage Immunometabolism in Pulmonary Fibrosis
Matrix Stiffness Regulates Macrophage Immunometabolism in Pulmonary Fibrosis
17:00—19:00
Rethinking Myeloid Cells in Resolution, Repair and Regeneration II (5:00 pm Start)
*
Ashley W. Seifert,
University of Kentucky, USA
Macrophage Heterogeneity during Musculoskeletal Regeneration in Spiny Mice
Macrophage Heterogeneity during Musculoskeletal Regeneration in Spiny Mice
Will Wood,
University of Edinburgh, UK
Drosophila Hemocytes in Tissue Repair and Regeneration
Drosophila Hemocytes in Tissue Repair and Regeneration
*
Benedicte Chazaud,
Université Claude Bernard Lyon, France
Myeloid Cells in Muscle Repair and Regeneration
Myeloid Cells in Muscle Repair and Regeneration
Amiram Ariel,
University of Haifa, Israel
Short Talk: STING Promotes Macrophage-mediated Resolution of Inflammation through IFNß Production
Short Talk: STING Promotes Macrophage-mediated Resolution of Inflammation through IFNß Production
Zaida G. Ramirez Ortiz,
University of Massachusetts Medical School, USA
Short Talk: Mechanisms of SCARF1 in the Inflammatory Response
Short Talk: Mechanisms of SCARF1 in the Inflammatory Response
17:00—19:00
Fibroblast Diversity in Fibrotic Disease (5:00 pm Start)
*
Benjamin D. Humphreys,
Washington University, USA
Session Chair
Session Chair
*
Jeffrey C. Horowitz,
Ohio State University, USA
Session Chair
Session Chair
*
Heather D. Lynn,
Cedars-Sinai, USA
Session Chair
Session Chair
Rachel C. Chambers,
University College London, UK
Remote Presentation: Damping Critical Signaling Nodes that Drive Fibrosis
Remote Presentation: Damping Critical Signaling Nodes that Drive Fibrosis
Rebekka Schneider-Kramann,
Uniklinik RWTH Aachen, Germany
Targeting Heterogeneous Bone-marrow Stromal Progenitors in Bone Marrow Fibrosis
Targeting Heterogeneous Bone-marrow Stromal Progenitors in Bone Marrow Fibrosis
Neil C. Henderson,
University of Edinburgh, Queen's Medical Research Institute, UK
Spatiotemporal Regulation of Liver Fibrosis
Spatiotemporal Regulation of Liver Fibrosis
Joan Chang,
Wellcome Centre for Cell-Matrix Research, UK
Short Talk: The Circadian Endosome Control of Collagen Fibrillogenesis, in Health and Disease
Short Talk: The Circadian Endosome Control of Collagen Fibrillogenesis, in Health and Disease
Jessica Cook,
UCSF, USA
Short Talk: Uncovering Distinctions between the Regenerative and Fibrotic Programs of the Oral Mucosa and Skin
Short Talk: Uncovering Distinctions between the Regenerative and Fibrotic Programs of the Oral Mucosa and Skin
19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
08:00—11:00
Stromal Cells Spanning Inflammation to Resolution (Joint) (8:00 am Start)
*
Oliver Eickelberg,
Pulmonary, Allergy and Critical Care Medicine, USA
Session Chair
Session Chair
Jonathan Kipnis,
Washington University School of Medicine, USA
Remote Presentation:Advantageous Brain Drain: Lymphatics of the Brain and its Communication with the Immune System
Remote Presentation:Advantageous Brain Drain: Lymphatics of the Brain and its Communication with the Immune System
Coffee Break
*
Valerie Horsley,
Yale University, USA
Myofibroblast Proliferation and Heterogeneity in Skin Repair
Myofibroblast Proliferation and Heterogeneity in Skin Repair
Andreas Ramming,
University of Erlangen-Nuremberg, Germany
Regulation of Fibroblast Polarization in Tissue Fibrosis
Regulation of Fibroblast Polarization in Tissue Fibrosis
Martin Direder,
Medical University of Vienna, Austria
Short Talk: A Unique Schwann Cell Subtype with Repair-like and Pro-fibrotic Properties Contributes to Keloid Formation
Short Talk: A Unique Schwann Cell Subtype with Repair-like and Pro-fibrotic Properties Contributes to Keloid Formation
14:30—16:30
Workshop 2 (2:30 pm Start)
*
Lindsey Hughes,
Yale University – School of Medicine, USA
Mélissa Maraux,
University of Bourgogne Franche-Comté, France
Identification of New Markers of Human Macrophage Reprogramming After Efferocytosis
Identification of New Markers of Human Macrophage Reprogramming After Efferocytosis
Bikash Mishra,
Weill Cornell Medical College, USA
Regulation of Inflammatory NF-kB Target Gene Activation by Jak-STAT Signaling
Regulation of Inflammatory NF-kB Target Gene Activation by Jak-STAT Signaling
Katherine H. Walker,
Brigham and Women's Hospital, USA
Substrate-Dependent Production of SPM Pathways in Human Tissue Inflammation
Substrate-Dependent Production of SPM Pathways in Human Tissue Inflammation
Shelby Compton,
Van Andel Institute, USA
LKB1 Loss Promotes Inflammatory Cytokine Responses through Deregulated SIK-CRTC2 Signaling
LKB1 Loss Promotes Inflammatory Cytokine Responses through Deregulated SIK-CRTC2 Signaling
*
Xavier Revelo,
University of Minnesota, USA
T Follicular Helper Cells Restrain Obesity-Induced Intestinal Inflammation
T Follicular Helper Cells Restrain Obesity-Induced Intestinal Inflammation
Andrea Francesca M. Salvador,
Washington University St. Louis, USA
Cellular and Transcriptomic Analysis of immune and Lymphatic Signatures after Spinal Cord Injury
Cellular and Transcriptomic Analysis of immune and Lymphatic Signatures after Spinal Cord Injury
Xun Wu,
Columbia University, USA
WDFY3 is a Novel Regulator of Efferocytosis Required for both the Uptake and Degradation of Dying Cells by Macrophages
WDFY3 is a Novel Regulator of Efferocytosis Required for both the Uptake and Degradation of Dying Cells by Macrophages
14:30—16:30
Workshop 2: Next Generation Multi-Ome Technologies (2:30 pm Start)
An area which has transformed the biomedical field and the workshop will provide theoretical and practical education and training in this essential field.
*
Amy Zhao,
Yale University, USA
Session Chair
Session Chair
*
Wilder Scott,
University of British Columbia, Canada
Session Chair
Session Chair
Christian Hinze,
Charité-Universitätsmedizin, Germany
Acute Kidney Injury Induces Pro-fibrotic Gene Expression Programs throughout the Kidney Tubule
Acute Kidney Injury Induces Pro-fibrotic Gene Expression Programs throughout the Kidney Tubule
Nicolas Ledru,
Washington University in St. Louis, USA
Single Nucleus Multiomic Sequencing of Human Kidney Identifies Potential Drivers of Fibrosis and Injury in Chronic Kidney Disease
Single Nucleus Multiomic Sequencing of Human Kidney Identifies Potential Drivers of Fibrosis and Injury in Chronic Kidney Disease
Chang-Ru Tsai,
Baylor College of Medicine, USA
Hippo Deficient Cardiac Fibroblasts Regulate Heart Fibrosis and Inflammation via Csf1 Signaling
Hippo Deficient Cardiac Fibroblasts Regulate Heart Fibrosis and Inflammation via Csf1 Signaling
Yupeng (David) He,
AbbVie, Inc., USA
Laser Capture Microdissection Assisted Spatial Proteomics Analysis of Human Tissues for Fibrosis-Related Diseases
Laser Capture Microdissection Assisted Spatial Proteomics Analysis of Human Tissues for Fibrosis-Related Diseases
Michael Jeffrey Podolsky,
Weill Cornell Medical College, USA
Genome-wide Screens Identify a Collagen-sensor that Controls Cell-mediated Collagen Turnover
Genome-wide Screens Identify a Collagen-sensor that Controls Cell-mediated Collagen Turnover
Asish K. Ghosh,
Northwestern University, USA
Cardiomyocyte PAI-1 Influences the Cardiac Transcriptome and Limits the Extent of Cardiac Fibrosis in Response to Left Ventricular Pressure Overload
Cardiomyocyte PAI-1 Influences the Cardiac Transcriptome and Limits the Extent of Cardiac Fibrosis in Response to Left Ventricular Pressure Overload
17:00—19:00
Interface of Inflammation, Resolution and Disease (5:00 pm Start)
Nicola L. Harris,
Monash University, Australia
Remote Presentation: Small Intestinal Resident Eosinophils Maintain Gut Homeostasis Following Microbial Colonisation
Remote Presentation: Small Intestinal Resident Eosinophils Maintain Gut Homeostasis Following Microbial Colonisation
Bruce D. Levy,
Brigham and Women's Hospital, USA
Dysregulated Inflammation Resolution Mechanisms in Lung Infection and Asthma
Dysregulated Inflammation Resolution Mechanisms in Lung Infection and Asthma
*
Ai Ing Lim,
NIAID, National Institutes of Health, USA
Short Talk: Maternal Infection Promotes Offspring Tissue-specific Immunity and Inflammation
Short Talk: Maternal Infection Promotes Offspring Tissue-specific Immunity and Inflammation
Adri Chakraborty,
Boston University, USA
Short Talk: Erg Deficiency in Lymphatic Endothelial Cells Drives Pulmonary Fibrosis and Lymphatic Dysfunction
Short Talk: Erg Deficiency in Lymphatic Endothelial Cells Drives Pulmonary Fibrosis and Lymphatic Dysfunction
17:00—19:00
Using Spatial Transcriptomics to Define Pathways Regulating Tissue Injury and Fibrosis (5:00 pm Start)
*
Neil C. Henderson,
University of Edinburgh, Queen's Medical Research Institute, UK
Session Chair
Session Chair
*
Pierre-Louis Tharaux,
INSERM, France
Session Chair
Session Chair
Naftali Kaminski,
Yale University School of Medicine, USA
Remote Presentation: Cell-Based Precision Medicine in Pulmonary Fibrosis: The Future is Now
Remote Presentation: Cell-Based Precision Medicine in Pulmonary Fibrosis: The Future is Now
Rafael Kramann,
RWTH Aachen University, Germany
Spatial Transcriptomics Define Pathways Regulating Myocardial and Kidney Fibrosis
Spatial Transcriptomics Define Pathways Regulating Myocardial and Kidney Fibrosis
Rachana N. Pradhan,
Genentech, USA
Cross-Tissue Organization of the Fibroblast Lineage: Across Health and Disease
Cross-Tissue Organization of the Fibroblast Lineage: Across Health and Disease
Wilder Scott,
University of British Columbia, Canada
Short Talk: Integrated scRNA- and scATAC-seq Analysis Reveals Latent Potential of Mesenchymal Progenitors Across Tissues
Short Talk: Integrated scRNA- and scATAC-seq Analysis Reveals Latent Potential of Mesenchymal Progenitors Across Tissues
Sathish Subramanian,
MGH / Broad Institute, USA
Short Talk: Spatio-cellular Dissection of Crohn's Disease Strictures Reveal Distinct Features of the Intestinal Fibrosis Microenvironment
Short Talk: Spatio-cellular Dissection of Crohn's Disease Strictures Reveal Distinct Features of the Intestinal Fibrosis Microenvironment
08:00—11:00
Neuroimmune Interactions in Resolution of Inflammation (8:00 am Start)
Daniel Mucida,
Rockefeller University, USA
Neuroimmune Interactions in the Resolution of Intestinal Inflammation
Neuroimmune Interactions in the Resolution of Intestinal Inflammation
*
Jochem H.J. Bernink,
Hubrecht Institute, Netherlands
Repair Mechanisms of the Human Intestinal Epithelium
Repair Mechanisms of the Human Intestinal Epithelium
Coffee Break
Florent Ginhoux,
Singapore Immunology Network, Singapore
Remote Presentation: Macrophage Heterogeneity in Tissue Repair
Remote Presentation: Macrophage Heterogeneity in Tissue Repair
Jan Schwab,
Ohio State University College of Medicine, USA
Resolution of Inflammation in the Lesioned Central Nervous System
Resolution of Inflammation in the Lesioned Central Nervous System
*
Tal Burstyn-Cohen,
Hebrew University Jerusalem, Israel
Short Talk: PROS1 Enhances the Resolution of Inflammation and Debris Clearance by Microglia
Short Talk: PROS1 Enhances the Resolution of Inflammation and Debris Clearance by Microglia
08:00—11:00
Epithelial Injury, Repair and Fibrosis (8:00 am Start)
*
Sunad Rangarajan,
University of Colorado Anschutz Medical Campus, USA
Session Chair
Session Chair
*
Jennifer Y. Chen,
University of California, San Francisco, USA
Session Chair
Session Chair
Anna Greka,
Harvard Medical School, USA
Remote Presentation: Targeting Toxic Proteinopathy to Treat Progressive Fibrosis
Remote Presentation: Targeting Toxic Proteinopathy to Treat Progressive Fibrosis
Benjamin D. Humphreys,
Washington University, USA
Failed Epithelial Repair after Injury and Fibrosis: A Multimodal Single Cell Analysis
Failed Epithelial Repair after Injury and Fibrosis: A Multimodal Single Cell Analysis
Coffee Break
Melanie Koenigshoff,
University of Pittsburgh, USA
Reprogrammed Epithelial Cells Modify the ECM Niche in Pulmonary Fibrosis
Reprogrammed Epithelial Cells Modify the ECM Niche in Pulmonary Fibrosis
Purushothama Rao Tata,
Duke University School of Medicine, USA
Epithelial Cell Plasticity Associated with Lung Repair and Regeneration in Fibrosis
Epithelial Cell Plasticity Associated with Lung Repair and Regeneration in Fibrosis
Christopher D. Lucas,
University of Edinburgh, UK
Short Talk: Pannexin 1 Drives Efficient Epithelial Repair After Tissue Injury
Short Talk: Pannexin 1 Drives Efficient Epithelial Repair After Tissue Injury
14:30—16:30
Career Roundtable (Joint) (2:30 pm Start)
Christine Kim Garcia,
Columbia University Medical Center, USA
Thomas A. Wynn,
Pfizer, USA
David Lagares,
Massachusetts General Hospital/Harvard Medical School, USA
Bruce D. Koppelman,
Cell Press, USA
Linde Meyaard,
University Medical Center Utrecht, Netherlands
17:00—19:00
Emerging Concepts in Inflammation and Tissue Repair (Joint) (5:00 pm Start)
*
Megan Ballinger,
Ohio State University, USA
Session Chair
Session Chair
Carla V. Rothlin,
Yale University, USA
Integration of Cell Death Sensing in Tissue Repair Responses
Integration of Cell Death Sensing in Tissue Repair Responses
*
Gabrielle Fredman,
Albany Medical Center, USA
New Mechanisms for Specialized Pro-Resolving Mediators in Atherosclerosis and Aging
New Mechanisms for Specialized Pro-Resolving Mediators in Atherosclerosis and Aging
Konrad Hoeft,
RWTH Aachen University, Germany
Short Talk: Platelet-instructed SPP1+ Macrophages Drive Myofibroblast Activation in Fibrosis in a CXCL4 Dependent Manner
Short Talk: Platelet-instructed SPP1+ Macrophages Drive Myofibroblast Activation in Fibrosis in a CXCL4 Dependent Manner
Kai Mesa,
New York University, USA
Short Talk: Spatiotemporal Uncoupling of Perivascular Macrophage Proliferation and Niche Organization Contributes to Capillary Aging
Short Talk: Spatiotemporal Uncoupling of Perivascular Macrophage Proliferation and Niche Organization Contributes to Capillary Aging
19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
08:00—11:00
Translating Inflammation and Resolution to Therapies (8:00 am Start)
*
Meera Ramanujam,
, USA
Session Chair
Session Chair
Didier Stainier,
Max Planck Institute for Heart and Lung Research, Germany
Macrophages in Heart Regeneration
Macrophages in Heart Regeneration
*
Linde Meyaard,
University Medical Center Utrecht, Netherlands
Inhibitory Receptors as Therapeutic Targets to Dampen Inflammation
Inhibitory Receptors as Therapeutic Targets to Dampen Inflammation
Coffee Break
Nan Chiang,
Harvard Medical School, USA
The Resolution of Inflammation: Origins and New Directions
The Resolution of Inflammation: Origins and New Directions
Shelia M. Violette,
Q32 Bio, USA
Targeting Complement in Chronic Inflammatory Disease
Targeting Complement in Chronic Inflammatory Disease
Catherine Godson,
University College Dublin, Ireland
Novel Agents to Attenuate Inflammation and Suppress Fibrosis
Novel Agents to Attenuate Inflammation and Suppress Fibrosis
Gaëtan Juban,
Institut NeuroMyoGène, France
Short Talk: Pushing the Resolution of Inflammation through AMPK Activation to Improve Muscle Homeostasis in Degenerative Myopathies
Short Talk: Pushing the Resolution of Inflammation through AMPK Activation to Improve Muscle Homeostasis in Degenerative Myopathies
08:00—11:00
Translational Prognostic and Diagnostic Biomarker Strategies (8:00 am Start)
*
Thomas A. Wynn,
Pfizer, USA
Session Chair
Session Chair
*
Neil C. Henderson,
University of Edinburgh, Queen's Medical Research Institute, UK
Session Chair
Session Chair
Christine Kim Garcia,
Columbia University Medical Center, USA
Genetic Markers of Susceptibility and Prognosis in Pulmonary Fibrosis
Genetic Markers of Susceptibility and Prognosis in Pulmonary Fibrosis
Oliver Eickelberg,
Pulmonary, Allergy and Critical Care Medicine, USA
Combined Genomic and Proteomic Analysis Identified Novel Markers and Mechanisms of Fibrotic Disease
Combined Genomic and Proteomic Analysis Identified Novel Markers and Mechanisms of Fibrotic Disease
Coffee Break
Andrzej S. Krolewski,
Joslin Diabetes Center, USA
Circulating Proteins as Biomarkers of Progressive Kidney Disease
Circulating Proteins as Biomarkers of Progressive Kidney Disease
Peter Caravan,
Harvard Medical School, Massachusetts General Hospital, USA
Boston Use of Non-Invasive Imaging to Monitor Progression of Fibrosis in Disease
Boston Use of Non-Invasive Imaging to Monitor Progression of Fibrosis in Disease
Paul Hoover,
Brigham and Women's Hospital, USA
Short Talk: Intrarenal Myeloid Cells are Altered in Patients and Mice with Lupus Nephritis and are Associated with Distinct Forms of Kidney Damage
Short Talk: Intrarenal Myeloid Cells are Altered in Patients and Mice with Lupus Nephritis and are Associated with Distinct Forms of Kidney Damage
Amy Zhao,
Yale University, USA
Short Talk: Peripheral Blood Single-Cell RNA-Sequencing of Patients with Fibrotic Interstitial Lung Diseases Reveals Fibrosis-Driving Monocytes and Etiology-Specific T Cells Responses
Short Talk: Peripheral Blood Single-Cell RNA-Sequencing of Patients with Fibrotic Interstitial Lung Diseases Reveals Fibrosis-Driving Monocytes and Etiology-Specific T Cells Responses
17:00—18:45
New Approaches to Regeneration (5 :00 pm Start)
*
Kodi S. Ravichandran,
Washington University School of Medicine, USA
Session Chair
Session Chair
*
Ophir Klein,
University of California, San Francisco, USA
Regenerative Strategies of the Intestinal Epithelium
Regenerative Strategies of the Intestinal Epithelium
Edward Botchwey,
Georgia Tech & Emory University, USA
Lipid Mediators in Regenerative Immunotherapy
Lipid Mediators in Regenerative Immunotherapy
Bola Hanna,
Harvard Medical School, USA
Remote Presentation: Short Talk: The Gut Microbiota Promotes Distal Tissue Regeneration via RORγ+ Regulatory T Cell Emissaries
Remote Presentation: Short Talk: The Gut Microbiota Promotes Distal Tissue Regeneration via RORγ+ Regulatory T Cell Emissaries
17:00—18:45
Fibrosis: Advances in the Development of Novel Therapies (5:00 pm Start)
*
Shelia M. Violette,
Q32 Bio, USA
Session Chair
Session Chair
*
Paul J. Yaworsky,
Mediar Therapeutics, USA
Session Chair
Session Chair
Thomas A. Wynn,
Pfizer, USA
Major Advances, Ongoing Challenges, and New Therapeutic Strategies for Fibrotic Disease
Major Advances, Ongoing Challenges, and New Therapeutic Strategies for Fibrotic Disease
Matthew Thomas,
Boehringer Ingelheim, Germany
Lessons Learned with Nintedanib Regulating Fibrosis across Multiple Diseases
Lessons Learned with Nintedanib Regulating Fibrosis across Multiple Diseases
Timothy P. Rolph,
Akero Therapeutics, USA
Efruxifermin a Long-Acting FGF21 Analog as a Therapy for NASH
Efruxifermin a Long-Acting FGF21 Analog as a Therapy for NASH
Darren Yuen,
St. Michael's Hospital, Canada
Short Talk: AXL Inhibition Disrupts Fibrosis by Modulating YAP/TAZ-SMAD Signalling and Stiffness in Myofibroblasts
Short Talk: AXL Inhibition Disrupts Fibrosis by Modulating YAP/TAZ-SMAD Signalling and Stiffness in Myofibroblasts
19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
*Session Chair †Invited, not yet responded.
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If your organization is interested in joining these entities in support of Keystone
Symposia, please contact: John Monson,
Director of Corporate Relations, Email: johnm@keystonesymposia.org, Phone:+1 970-262-2690 Click here for more information on Industry Support and Recognition Opportunities. If you are interested in becoming an advertising/marketing in-kind partner, please contact: Josh May, Director, Technology and Digital Media, Email: joshuam@keystonesymposia.org, Phone:+1 970-262-1179 |