Keystone Symposia

Fairmont Empress Victoria / Victoria Conference Centre Floorplan

This meeting took place in 2023



For a complete list of the meetings for the upcoming/current season, see our meeting list, or search for a meeting.

Chromatin Architecture in Development and Human Health (Q8)


Organizer(s) Joanna Wysocka, Clodagh C. O'Shea and Eileen E.M. Furlong
March 12—15, 2023
Fairmont Empress Victoria / Victoria Conference Centre • Victoria, BC Canada
Abstract Deadline: Dec 6, 2022
Scholarship Deadline: Dec 6, 2022
Discounted Registration Deadline: Jan 11, 2023

Sponsored by Chinese Society for Cell Biology, (Cell Research)


Summary of Meeting:
The science behind chromatin architecture spans across multiple processes and scales from local DNA polymer folding and chromatin loops, to the organization of the genome into domains and chromosome territories. Such three-dimensional (3D) organization is an important component in the regulation of gene expression, with more recent implications emerging for DNA replication and repair. Furthermore, it has been discovered that genome rearrangements that alter chromatin architecture can lead to devasting developmental defects. This has led to many exciting developments in recent years in the field such as an understanding of the biophysical properties of chromatin organization and function, as well as genetic dissection of topologically associated domains. Therefore, this conference will bring together leaders in the field to discuss fundamental mechanisms driving formation of 3D chromatin structure and its regulation during development as well as how these processes can go awry, leading to human disease. The conference will showcase the interdisciplinary nature of the field, with talks combining state-of-the-art super resolution imaging, sophisticated genetics and single cell regulatory genomics. Additionally, this conference is being held jointly with Epigenetics, Chromatin, Development and Disease, which will encompass themes of chromatin mechanisms, including DNA and RNA modifications, histone modifications, ATP-dependent nucleosome remodeling complexes, histone variants, and chaperones. These two complementary symposia will elucidate the importance of chromatin and epigenetics in cell identity, cellular and transgenerational memory, and will explore functional aspects of nuclear structure and its impact on fundamental biological processes and disease. There will be joint Keynote speakers, as well as joint sessions. By pairing these two conferences together, it is anticipated that there will be a strong interest from researchers and scientists who are working in both fields.

View Scholarships/Awards
No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


The meeting will begin on Sunday, March 12 with registration from 16:00 to 20:00 and a welcome mixer from 18:00 to 20:00. Conference events conclude on Wednesday, March 15 with a closing plenary session from 17:00 to 19:00, followed by a social hour. We recommend return travel on Thursday, March 16 in order to fully experience the meeting.

SUNDAY, MARCH 12

16:00—20:00
Arrival and Registration (4pm Start)

Palm Court
18:00—20:00
Welcome Mixer
No registration fees are used to fund alcohol served at this function.

Palm Court

MONDAY, MARCH 13

07:30—08:30
Breakfast

Salon B/C
08:00—08:30
Poster Setup

Salon B/C
08:30—19:00
Poster Viewing

Salon B/C
08:30—09:30
Welcome and Keynote Address (Joint) (8:30am Start)

Salon A
* Shelley L. Berger, University of Pennsylvania, USA

* Eileen E.M. Furlong, European Molecular Biology Laboratory, Germany

Geeta J. Narlikar, University of California, San Francisco, USA
Genome Regulation by Chromatin Remodeling

09:30—11:15
Chromatin Architecture and Gene Transcription in Development (Joint) (9:30am Start)

Salon A
* Karen Adelman, Harvard Medical School, USA

Kenneth S. Zaret, University of Pennsylvania, USA
Pioneer Factors in Gene Regulation

Coffee Break

* Maria-Elena Torres-Padilla, Helmholtz Centre Munich, Germany
Heterochromatin Mechanisms Programming Early Developmental Cell Fate

Yun Nancy Huang, Texas A&M University, USA
Short Talk: Heterochromatin Deregulation during Hematopoietic Stem Progenitor Cell (HSPC) Aging

11:15—12:15
Lunch

Salon B/C
12:15—14:30
Poster Session 1 (12:15pm Start)

Salon B/C
14:30—16:30
Workshop 1: Chemical Tools and Technologies (2:30pm Start)
Panel: When will the new epigenetic therapeutics come into the clinic?

Salon A
* Irfan Asangani, University of Pennsylvania, USA
Epigenetic Remodeling of Cancer by Nicotinamide N-methyltransferase (NNMT) - A S-adenosylmethionine (SAM) Sink

Zachary A. Drum, University of North Carolina at Chapel Hill, USA
Mechanisms of Phase-separation-driven Chromatin Loop Formation

Stamatis Papathanasiou, Dana-Farber Cancer Institute, Harvard Medical School, USA
Micronuclei are a Source of Inherited Epigenetic Instability

Vincent Lapointe-Roberge, IRCM, Canada
Pioneer Action Permissiveness: A Matter of Chromatin Structure or DNA Affinity?

Yihao Yang, Rockefeller University, USA
Pioneer Factor SOX9 Hijacks Epigenetic Factors to Efficiently Achieve Stem Cell Fateswitching

Shiri Levy, University of Washington, USA
The First Computer Design Epigenetic Inhibitor EBdCas9 Directs iPSCs in Lineage Differentiation

16:30—17:00
Coffee Available

Prefunction
17:00—19:00
Transcriptional Regulation in Health and Disease (5pm Start)

Crystal Ballroom
Richard A. Young, Whitehead Institute for Biomedical Research, USA
Remote Presentation: Roles for Biomolecular Condensates in Gene Regulation

* Jussi Taipale, University of Cambridge, UK
Towards Predicting Gene Expression from DNA Sequence

Xavier Darzacq, University of California, Berkeley, USA
Diffusion Limited Processes as a Knob to Regulate Spatial and Temporal Functions in the Nucleus

Marielle L. Bond, UNC Chapel Hill, USA
Short Talk: Chromatin Loop Dynamics during Cellular Differentiation are Associated with Changes to both Anchor and Internal Regulatory Features

Jing Luan, University of Pennsylvania, USA
Short Talk: CTCF Blocks Antisense Transcription Initiation at Divergent Promoters

17:00—19:00
Inheritance of Chromatin States (5pm Start)

Salon A
* Anja Groth, University of Copenhagen, Denmark
Histone Modification Inheritance through Mitosis

Danny F. Reinberg, University of Miami, USA
Histone Repressive Signature through Mitosis

Yael David, Memorial Sloan Kettering Cancer Center, USA
Epigenetic Dysregulation from Chromosomal Transit in Micronuclei

Yadira M. Soto-Feliciano, MIT, USA
Short Talk: A Molecular Switch between Mammalian MLL Complexes Dictates Response to Menin-MLL Inhibition

19:00
On Own for Dinner


TUESDAY, MARCH 14

07:30—08:30
Breakfast

Salon B/C
08:30—11:30
Visualizing 3D Chromatin Structures and Nuclear Architecture (8:30am Start)

Crystal Ballroom
* Alistair Boettiger, Stanford University, USA

Ralf Jungmann, Max Planck Institute of Biochemistry, Germany
DNA-PAINTs, SOMAmers and Ultra-Resolution Fluorescence Localizomics of DNA, RNA and Protein Interactions

Ibrahim Cissé, Max Planck Institute of Immunobiology and Epigenetics, Germany
Super-Resolution Imaging of RNA Polymerase and Transcription in Living Cells

Coffee Break

Jennifer E. Phillips-Cremins, University of Pennsylvania, USA
Inducible DNA-Looping and Genome Misfolding in Neurological Disease

Mark Pownall, Yale University School of Medicine, USA
Short Talk: Chromatin Expansion Microscopy Reveals Nanoscale Organization of Transcription And Chromatin

Chen Davidovich, Monash University, Australia
Short Talk: The Three-dimensional Structure of Chromatin Condensed by PRC1 is Porous and Accessible

Martin Stortz, NIH, USA
Short Talk: Engineering Genome Organization to Explore TAD Function in Living Cells

08:30—11:30
Non-Coding RNA and Epitranscriptomics (8:30am Start)

Salon A
* Geneviève Almouzni, Centre National de la Recherche Scientifique, France

Deborah Bourc'his, Institut Curie, France
Transposon Control in Spermatogenesis

François Fuks, Université Libre de Bruxelles, Belgium
Transcriptome-Wide Distribution and Function of RNA Modifications

Coffee Break

Ramin Shiekhattar, University of Miami, USA
Integrator Role in Coordinating Transcriptional Initiation and Elongation

Supriya Vartak, National Institutes of Health, USA
Short Talk: ‘‘Stripe'' Transcription Factors Provide Accessibility to Co-binding Partners in Mammalian Genomes

Capucine Van Rechem, Stanford University, USA
Short Talk: Chromatin Remodelers Lost in Translation

Kaixiang Cao, Case Western Reserve University, USA
Short Talk: Novel Molecular Mechanisms Underlying the Regulation of Enhancer and Cell Identity

11:30—17:00
On Own for Lunch

11:30—13:00
Poster Setup

Salon B/C
13:00—22:00
Poster Viewing

Salon B/C
15:00—16:30
Workshop (3pm Start)

Crystal Ballroom
* Pedro Rocha, National Institutes of Health, USA

Tessa Popay, The Salk Institute for Biological Studies, USA
Refolding of the 3D Genome as a Precursor to Post-mitotic Transcriptional Reactivation

Eric S. Davis, University of North Carolina at Chapel Hill, USA
Mariner: Explore the Hi-C's

Ryan Pellow, University of Iowa, USA
New Biological Insights of the 3D Nuclear Architecture using WaveTAD, a Probabilistic, Resolution-free, and Hierarchical TAD Caller

Jennifer Herrmann, University of Oxford, UK
Studying Chromatin Accessibility at High Temporal Resolution throughout the Mammalian Cell Cycle

Maike Steindel, University of Cambridge, UK
The Histone Methyltransferase KMT2B Sets up the Genome for Lineage Differentiation by Altering Chromatin Movement during Priming

Alex Buckley, University of California, San Francisco, USA
WAPL Functions as a Rheostat of Protocadherin Isoform Diversity that Controls Neural Wiring

14:30—16:30
Workshop 2: Models and Nontraditional Models (2:30pm Start)
Panel: What insights have new genomics and technologies provided into evolution?

Salon A
Adrian P. Bracken, Trinity College Dublin, Ireland
Interplay between PRC2 Subcomplexes and Canonical PRC1 in Development and Disease

* Erica N. Larschan, Brown University, USA
Competition Between Different GA-binding Pioneer Transcription Factors that Bind to Tethering Elements Drives Coregulation of Specific Gene Sets

Gerard L. Brien, University of Edinburgh, UK
H3K27me3 Links Specific cPRC1 Complexes and Oncogenic Gene Repression in Diffuse Midline Glioma

Sam D. Krabbenhoft, University of Wisconsin-Madison, USA
Leveraging Drosophila Melanogaster to Identify Conserved Modifiers of PRC2-mediated Pediatric Glioma

Simone S. Riedel, Children's Hospital of Philadelphia, USA
The Intrinsically Disordered Protein MN1 Causes AML through the Formation of Stable Transcriptional Hubs

Danilo Polizzese, IEO, Italy
The Restrictor Complex and the Control of Extragenic Transcription

16:30—17:00
Coffee Available

Prefunction
17:00—19:00
Cis-Regulatory Elements in Development (5pm Start)

Crystal Ballroom
* Ann Dean, NIDDK, National Institutes of Health, USA

Joanna Wysocka, Stanford University, USA
Gene Regulation by Enhancers

Alexander Stark, Research Institute of Molecular Pathology - IMP, Austria
Cracking the Genome-Wide Transcriptional Regulatory Code

Alistair Boettiger, Stanford University, USA
Mechanisms of Border Bypass for Long-range Enhancers

Pedro Rocha, National Institutes of Health, USA
Short Talk: Enhancer Clustering Facilitates Bypassing of CTCF-mediated Boundaries and Contributes to Phenotypic Robustness

Evgeny Z. Kvon, University of California, Irvine, USA
Short Talk: Widespread Increase in Enhancer—Promoter Interactions during Developmental Enhancer Activation in Mammals

17:00—19:00
Cancer Epigenetics (5pm Start)

Salon A
* Luciano Di Croce, CRG - Center for Genomic Regulation, Spain
Function of Polycomb in Cancer

Shelley L. Berger, University of Pennsylvania, USA
Epigenetic Mechanisms of Wildtype and Mutant p53

Weiwei Dang, Baylor College of Medicine, USA
Short Talk: Altered Super Enhancer – Promoter Interactions Mediated by YY1 Underlie Age-induced Transcriptome

Geneviève Almouzni, Centre National de la Recherche Scientifique, France
Chaperone and Histone Variants, a Partnership to Shape Chromatin

19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Salon B/C
19:30—22:00
Poster Session 2 (7:30pm Start)

Salon B/C

WEDNESDAY, MARCH 15

07:30—08:30
Breakfast

Salon B/C
08:30—09:30
Keynote Address (Joint) (8:30am Start)

Salon A
* Eileen E.M. Furlong, European Molecular Biology Laboratory, Germany

Michael S. Levine, Princeton University, USA
Imaging Long-Range Gene Regulation

09:30—12:00
Genome Regulation Across Scales (Joint) (9:30am Start)

Salon A
* Joanna Wysocka, Stanford University, USA

Benjamin R. Sabari, University of Texas Southwestern Medical Center, USA
Short Talk: Functional Partitioning of Transcriptional Regulators by Patterned Charge Blocks

Coffee Break

* Eileen E.M. Furlong, European Molecular Biology Laboratory, Germany
Features of Enhancer-promoter Communication during Embryonic Development

Karen Adelman, Harvard Medical School, USA
Enhancer and Promoter Interaction Regulatory Networks

Tony Kouzarides, University of Cambridge, UK
RNA Methylation Enzymes and Dysfunction in Cancer

Liling Wan, University of Pennsylvania, USA
Short Talk: Decoding Pathogenic Condensates on Chromatin

11:30—17:00
On Own for Lunch

15:00—16:30
Career Roundtable (Joint) (3pm Start)

Salon A
Karen Adelman, Harvard Medical School, USA

Ann Dean, NIDDK, National Institutes of Health, USA

Ramon J. Whitson, Genomics Institute, Novartis Research Foundation, GNF, USA

16:30—17:00
Coffee Available

Prefunction
17:00—18:45
3D Epigenome Organization in Single Cells, Tissues and Disease (5pm Start)

Crystal Ballroom
* Ibrahim Cissé, Max Planck Institute of Immunobiology and Epigenetics, Germany

Ann Dean, NIDDK, National Institutes of Health, USA
Enhancers, Chromosome Folding and Lineage-Specific Gene Regulation

Jan Lammerding, Cornell University, USA
Mechanically Induced Changes in Chromatin Organization and Transcription

Yike Huang, Hubrecht Institute, Netherlands
Short Talk: Targeted Cohesin Loading Characterizes the Entry and Exit Sites of Loop Extrusion Trajectories

17:00—18:45
Genomics, Proteomics, Computational Modeling (5pm Start)

Salon A
Ali Shilatifard, Northwestern University, USA
Mechanisms and Therapeutics of Super Elongation Complex

Chunaram Choudhary, University of Copenhagen, Denmark
Exploring the Dependency and the Role of Lysine Acetylation in Gene Regulation

* Bing Ren, Ludwig Institute for Cancer Research, USA
Single-Cell, Comparative Epigenomic Analysis of Gene Regulatory Programs in the Mammalian Brain

Alon Goren, University of California, San Diego, USA
Short Talk: A Novel Framework for Multiplex Measurements of the Abundance and Interaction of Proteins

18:45—19:00
Meeting Wrap-Up: Outcomes and Future Directions (Organizers) (6:45pm Start)

Salon A
18:45—19:00
Meeting Wrap-Up: Outcomes and Future Directions (Organizers) (6:45pm Start)

Crystal Ballroom
19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Salon B/C

THURSDAY, MARCH 16

08:00—08:00
Departure


*Session Chair †Invited, not yet responded.



Keystone Symposia thanks our Sponsor(s) for generously supporting this meeting:

Chinese Society for Cell Biology, (Cell Research)

We gratefully acknowledge additional support from these exhibitors at this conference:

Arima Genomics, Inc.
Please stop by to meet these exhibitors during the conference.


We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:


Click here to view more of these organizations


Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


Click here to view more of these organizations


If your organization is interested in joining these entities in support of Keystone Symposia, please contact: John Monson, Director of Corporate Relations, Email: johnm@keystonesymposia.org,
Phone:+1 970-262-2690

Click here for more information on Industry Support and Recognition Opportunities.

If you are interested in becoming an advertising/marketing in-kind partner, please contact:
Josh May, Director, Technology and Digital Media, Email: joshuam@keystonesymposia.org,
Phone:+1 970-262-1179