Keystone Resort Floorplan
This meeting took place in 2023
For a complete list of the meetings for the upcoming/current season, see our meeting list, or search for a meeting.
Organoids as Models of Development and Disease, and their Impact on Drug Discovery (Q2)
Organizer(s) Ajamete Kaykas, Aron B. Jaffe and Prisca Liberali
February 5—8, 2023
Keystone Resort • Keystone, CO USA
Abstract Deadline: Dec 29, 2022
Scholarship Deadline: Nov 3, 2022
Discounted Registration Deadline: Dec 29, 2022
Sponsored by (Cell Research), Chinese Society for Cell Biology, GlaxoSmithKline Biologicals and Merck & Co., Inc.
Summary of Meeting:
Stem cell and tissue-derived organoids are three-dimensional, in vitro cellular models that faithfully recapitulate many features of a variety of organ systems. As such, they represent human tissue avatars, and have been used to study stem cell biology, organ development, the earliest stages of organismal development, and disease. The goals of this symposium are to highlight the impact of organoids in our understanding of development and disease, how organoids are being used in drug discovery, and their potential as therapeutics. Attendees will be exposed to the latest advances and discoveries that have resulted from the establishment and use of organoids in basic research and drug discovery. Together with the Stem Cell meeting, we expect that attendees will also form new connections and collaborations with researchers across the academic and industry communities.
View Scholarships/Awards
Stem cell and tissue-derived organoids are three-dimensional, in vitro cellular models that faithfully recapitulate many features of a variety of organ systems. As such, they represent human tissue avatars, and have been used to study stem cell biology, organ development, the earliest stages of organismal development, and disease. The goals of this symposium are to highlight the impact of organoids in our understanding of development and disease, how organoids are being used in drug discovery, and their potential as therapeutics. Attendees will be exposed to the latest advances and discoveries that have resulted from the establishment and use of organoids in basic research and drug discovery. Together with the Stem Cell meeting, we expect that attendees will also form new connections and collaborations with researchers across the academic and industry communities.
View Scholarships/Awards
No registration fees are used to fund entertainment or alcohol at this conference
The meeting will begin on Sunday, February 5 with registration from 16:00 to 20:00 and a welcome mixer from 18:00 to 20:00. Conference events conclude on Wednesday, February 8 with a closing plenary session from 17:00 to 19:00, followed by a social hour. We recommend return travel on Thursday, February 9 in order to fully experience the meeting.
SUNDAY, FEBRUARY 5
MONDAY, FEBRUARY 6
Following Session is for Stem Cells: Advances in the Application of Stem Cells and their Role in vivo (Q1)
TUESDAY, FEBRUARY 7
Following Session is for Stem Cells: Advances in the Application of Stem Cells and their Role in vivo (Q1)
WEDNESDAY, FEBRUARY 8
Following Session is for Stem Cells: Advances in the Application of Stem Cells and their Role in vivo (Q1)
Following Session is for Stem Cells: Advances in the Application of Stem Cells and their Role in vivo (Q1)
THURSDAY, FEBRUARY 9
Conference Program Print | View meeting in 12 hr (am/pm) time
The meeting will begin on Sunday, February 5 with registration from 16:00 to 20:00 and a welcome mixer from 18:00 to 20:00. Conference events conclude on Wednesday, February 8 with a closing plenary session from 17:00 to 19:00, followed by a social hour. We recommend return travel on Thursday, February 9 in order to fully experience the meeting.
SUNDAY, FEBRUARY 5
18:00—20:00
Welcome Mixer
No registration fees are used to fund alcohol served at this function.
08:00—09:30
Welcoming Remarks from Organizers and Keynote Session (Joint) (8am Start)
*
Prisca Liberali,
Friedrich Miescher Institute for Biomedical Research, Switzerland
*
Elly M. Tanaka,
IMP - Research Institute of Molecular Pathology, Austria
Botond Roska,
Institute of Ophthalmology Basel, Switzerland
Human Retinal Organoids
Human Retinal Organoids
Coffee Break
Olivier Pourquié,
Harvard Medical School, USA
Deconstructing and Reconstructing the Human Musculo-skeletal System in vitro
Deconstructing and Reconstructing the Human Musculo-skeletal System in vitro
09:50—11:15
Models of Early Embryonic Development (Joint) (9:50am Start)
*
Margherita Y. Turco,
Friedrich Miescher Institute, Switzerland
Nicolas Rivron,
Institute of Molecular Biotechnology, Austrian Academy of Sciences, Austria
Blastoids: Shaping the Mouse and Human Blastocysts for Implantation
Blastoids: Shaping the Mouse and Human Blastocysts for Implantation
Jesse V. Veenvliet,
Max Planck Institute of Molecular Cell Biology and Genetics, Germany
Shaping up the Stembryo
Shaping up the Stembryo
Oscar J. Abilez,
Stanford University, USA
Short Talk: Using Gastruloids to Model the Earliest Stages of Human Cardiac and Hepatic Vascularization
Short Talk: Using Gastruloids to Model the Earliest Stages of Human Cardiac and Hepatic Vascularization
14:30—16:30
Workshop: Translatability of the 3D Models into the Clinic (2:30pm Start)
*
Robert J. Ihry,
Novartis Institutes for BioMedical Research, USA
Javier Bregante,
Max Planck Institute of Molecular Cell Biology and Genetics, Germany
Human Liver Ductal Cell Heterogeneity and Cell-state Transitions in an Organoid System
Human Liver Ductal Cell Heterogeneity and Cell-state Transitions in an Organoid System
Hina Usman,
University of Chicago, USA
Transcriptomic and Cellular Effects of Aspirin on Human Normal Colonic Organoids from Diverse Individuals
Transcriptomic and Cellular Effects of Aspirin on Human Normal Colonic Organoids from Diverse Individuals
Masayuki Yazawa,
Columbia University, USA
Using Human Organoid Models to Develop Novel Inhibitory Peptides against Human Coronavirus Envelopes
Using Human Organoid Models to Develop Novel Inhibitory Peptides against Human Coronavirus Envelopes
Magdalena Lorenowicz,
Biomedical Primate Research Center’, Netherlands
Mesenchymal Stromal/Stem Cells Promote Intestinal Epithelium Regeneration after Chemotherapy-induced Damage
Mesenchymal Stromal/Stem Cells Promote Intestinal Epithelium Regeneration after Chemotherapy-induced Damage
Ashley Westerfield,
MIT, USA
Multiscale Control of Human Cholangiocyte Microarchitecture in Organoid Culture and Microfluidic Devices
Multiscale Control of Human Cholangiocyte Microarchitecture in Organoid Culture and Microfluidic Devices
Lucia Tellez Perez,
Cold Spring Harbor Laboratory, USA
Differential Effect of Female Sex Hormones in the Mammary Gland of Males and Females Using Organoids as a Study Model
Differential Effect of Female Sex Hormones in the Mammary Gland of Males and Females Using Organoids as a Study Model
Shawn Luttrell,
Curi Bio, USA
Mantarray 3D Engineered Muscle Tissue Platform Demonstrates Clinically-Relevant Disease Stratification of an in vitro DMD Model
Mantarray 3D Engineered Muscle Tissue Platform Demonstrates Clinically-Relevant Disease Stratification of an in vitro DMD Model
17:00—19:00
Organoid Models of Development and Regeneration (5pm Start)
*
Prisca Liberali,
Friedrich Miescher Institute for Biomedical Research, Switzerland
Intestinal Organoids
Intestinal Organoids
Jason R. Spence,
University of Michigan Health System, USA
Lung and Gut Organoids
Lung and Gut Organoids
Margherita Y. Turco,
Friedrich Miescher Institute, Switzerland
Organoids for the Study of Maternal-fetal Interactions Underlying Human Placentation
Organoids for the Study of Maternal-fetal Interactions Underlying Human Placentation
Melisa Jovita Andrade,
University of California Irvine, USA
Short Talk: iPSC-derived Vascularized Liver Organoids
Short Talk: iPSC-derived Vascularized Liver Organoids
Andrea P. Alvarez Maldonado,
University of Michigan, USA
Short Talk: Characterization of the Developing Human Esophagus in vivo and in vitro
Short Talk: Characterization of the Developing Human Esophagus in vivo and in vitro
Following Session is for Stem Cells: Advances in the Application of Stem Cells and their Role in vivo (Q1)
17:00—19:00
Causes and Consequences of Cell Competition and Clonal Selection (5pm Start)
Thomas P. Zwaka,
Icahn School of Medicine at Mount Sinai, USA
Discord Arising from Within: Genome-to-Genome Competition in Stem Cells
Discord Arising from Within: Genome-to-Genome Competition in Stem Cells
*
Kristin Baldwin,
Columbia University, USA
Building a Brain from Two Species - Who Decides?
Building a Brain from Two Species - Who Decides?
Margaret A. Goodell,
Baylor College of Medicine, USA
How to Win: Strategies for Competitive Advantage In the Stem Cell Niche
How to Win: Strategies for Competitive Advantage In the Stem Cell Niche
Anne Brunet,
Stanford University, USA
Aging of the Stem Cell Niche
Aging of the Stem Cell Niche
19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
08:00—11:00
Organoid Models of Development and Disease (Joint) (8am Start)
*
Samira Musah,
Duke University, USA
*
Max Salick,
Insitro, USA
CRISPR Screening to the Nth Dimension: Pooled Optical Screening for Genetic Modifiers of Tuberous Sclerosis in iPSC-Derived Neurons
CRISPR Screening to the Nth Dimension: Pooled Optical Screening for Genetic Modifiers of Tuberous Sclerosis in iPSC-Derived Neurons
Fides Zenk,
ETH Zürich, Switzerland
Single-Cell Multi-Omic Analysis of Organoids to Understand Development and Disease
Single-Cell Multi-Omic Analysis of Organoids to Understand Development and Disease
Coffee Break
Thomas Eschenhagen,
University Medical Center Hamburg-Eppendorf, Germany
Engineered Heart Tissue for Studying Cardiac Disease
Engineered Heart Tissue for Studying Cardiac Disease
Elly M. Tanaka,
IMP - Research Institute of Molecular Pathology, Austria
Molecular Control of Organoid Self-Patterning
Molecular Control of Organoid Self-Patterning
Titilola Dayo Kalejaiye,
, USA
Short Talk: Vascularized Human Kidney Organoids with Enhanced Cell Lineage Specification
Short Talk: Vascularized Human Kidney Organoids with Enhanced Cell Lineage Specification
Jose M. Polo,
University of Adelaide, Australia
Short Talk: Integration and Comparison of Different in vitro Generated Human Blastocyst- like Structures
Short Talk: Integration and Comparison of Different in vitro Generated Human Blastocyst- like Structures
Kate A. Miroshnikova,
National Institutes of Health, USA
Short Talk: Impact of Nuclear Mechanics and Genome-lamina Interactions on Stem Cell Fate Transitions
Short Talk: Impact of Nuclear Mechanics and Genome-lamina Interactions on Stem Cell Fate Transitions
15:00—16:30
Career Roundtable (Joint) (3pm Start)
Alejandro Sánchez Alvarado,
Stowers Institute for Medical Research/HHMI, USA
Karuna Ganesh,
Memorial Sloan Kettering Cancer Center, USA
Sergii Kyrychenko,
Prime Medicine, USA
Novella Guidi,
Life Science Alliance, Germany
17:00—19:00
Organoid Models of Disease (5pm Start)
*
Jeffrey Beekman,
University Medical Center Utrecht, Netherlands
Senthil K. Muthuswamy,
NCI, National Institutes of Health, USA
Commitment and Oncogene-Induced Plasticity of Human Stem-Cell Derived Pancreatic Acinar and Ductal Organoids
Commitment and Oncogene-Induced Plasticity of Human Stem-Cell Derived Pancreatic Acinar and Ductal Organoids
Karuna Ganesh,
Memorial Sloan Kettering Cancer Center, USA
Patient Derived Colorectal Cancer Organoids to Dissect Metastatic Plasticity
Patient Derived Colorectal Cancer Organoids to Dissect Metastatic Plasticity
Following Session is for Stem Cells: Advances in the Application of Stem Cells and their Role in vivo (Q1)
17:00—19:15
Exerting Epigenetic Control Over Cells and Tissues (5pm Start)
Aviv Regev,
Genentech, USA
Remote Presentation: Cell Atlases as Roadmaps in Health and Disease
Remote Presentation: Cell Atlases as Roadmaps in Health and Disease
Justin Langerman,
University of California, Los Angeles, USA
SECseq- A New High throughput Method for Pairing Secretion and Single Cell Transcriptions
SECseq- A New High throughput Method for Pairing Secretion and Single Cell Transcriptions
Lorenz Studer,
Memorial Sloan Kettering Cancer Center, USA
Directing Fate, Time and in vivo Survival in hPSC-Derived Lineages
Directing Fate, Time and in vivo Survival in hPSC-Derived Lineages
Don W. Cleveland,
University of California, San Diego, USA
The Promise and Perils of Generating New Neurons in the Aging Nervous System
The Promise and Perils of Generating New Neurons in the Aging Nervous System
*
Joe Q. Zhou,
Weill Cornell Medical College, USA
Short Talk: The Molecular Machinery Controlling Stem Cell and Tissue Plasticity Between Adult Colon and Small Intestine
Short Talk: The Molecular Machinery Controlling Stem Cell and Tissue Plasticity Between Adult Colon and Small Intestine
19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
08:00—12:00
Stem Cells and Organoid Models in Drug Discovery (Joint) (8am Start)
*
Margaret A. Goodell,
Baylor College of Medicine, USA
Jeffrey Beekman,
University Medical Center Utrecht, Netherlands
Intestinal Organoids as a Platform for Personalized CF Therapies
Intestinal Organoids as a Platform for Personalized CF Therapies
Robert J. Ihry,
Novartis Institutes for BioMedical Research, USA
Autism Organoid Models
Autism Organoid Models
Coffee Break
Takanori Takebe,
Cincinnati Children's Hospital Medical Center, USA
Modeling Hepato-Biliary-Pancreatic Organogenesis
Modeling Hepato-Biliary-Pancreatic Organogenesis
*
Kevin C. Eggan,
BioMarin Pharmaceutical Inc., USA
Therapeutic Reprogramming of RNA Metabolism in ALS
Therapeutic Reprogramming of RNA Metabolism in ALS
Alexander Meissner,
Max Planck Institute for Molecular Genetics, Germany
Epigenetic Regulation of Developmental Events
Epigenetic Regulation of Developmental Events
Emily M. Lee,
NCATS/NIH, USA
Short Talk: Brain Region Specific Spheroids for HTS Drug Discovery: from Neurodegenerative Diseases to Neurotropic Viral Infections
Short Talk: Brain Region Specific Spheroids for HTS Drug Discovery: from Neurodegenerative Diseases to Neurotropic Viral Infections
Jasper Rubin-Sigler,
USC, USA
Short Talk: CASC3 Suppression Promotes Neuron Survival and Mitigates TDP-43 Pathology in Models of ALS/FTD
Short Talk: CASC3 Suppression Promotes Neuron Survival and Mitigates TDP-43 Pathology in Models of ALS/FTD
Charles Jian Zhang,
University of Michigan, USA
Short Talk: Generation of Human Liver Organoids from Idiosyncratic DILI Patients
Short Talk: Generation of Human Liver Organoids from Idiosyncratic DILI Patients
Alec Simon Tulloch Smith,
University of Washington, USA
Short Talk: Magnetic Sensing of Tissue Contraction Facilitates High throughput Analysis of Stem Cell-derived Skeletal Muscle Function
Short Talk: Magnetic Sensing of Tissue Contraction Facilitates High throughput Analysis of Stem Cell-derived Skeletal Muscle Function
17:00—18:45
The Potential of Organoids as Therapeutics (5pm Start)
*
Jason R. Spence,
University of Michigan Health System, USA
Toshiro Sato,
Keio University, Japan
Understanding of Human Gastrointestinal Diseases using Organoid Technology
Understanding of Human Gastrointestinal Diseases using Organoid Technology
Ludovic Vallier,
Berlin Institute of Health at Charité, Germany
Repairing Bile Ducts with Cholangiocyte Organoids
Repairing Bile Ducts with Cholangiocyte Organoids
Magdalene J. Seiler,
University of California, Irvine, USA
Morphological and Functional Integration of Stem Cell Derived Retina Organoid Sheets into Degenerating Retina Models
Morphological and Functional Integration of Stem Cell Derived Retina Organoid Sheets into Degenerating Retina Models
Yasminye D. Pettway,
Vanderbilt University, USA
Short Talk: Human Pancreatic Islet Organoid System Reveals Cell-to-cell Contact and Hypoglycemia as Mechanisms Underlying α Cell Dysfunction in Type 1 Diabetes (T1D)
Short Talk: Human Pancreatic Islet Organoid System Reveals Cell-to-cell Contact and Hypoglycemia as Mechanisms Underlying α Cell Dysfunction in Type 1 Diabetes (T1D)
Following Session is for Stem Cells: Advances in the Application of Stem Cells and their Role in vivo (Q1)
17:00—18:45
Molecular Circuitry Underlying Self-Renewal and Differentiation Decisions II (5pm Start)
*
Sean J. Morrison,
University of Texas Southwestern Medical Center, USA
Modeling the Impact of Alzheimer's Disease Genetic Risk on Microglia States and Functions
Modeling the Impact of Alzheimer's Disease Genetic Risk on Microglia States and Functions
Alejandro Sánchez Alvarado,
Stowers Institute for Medical Research/HHMI, USA
Planarian Regeneration
Planarian Regeneration
Peter K. Jackson,
Stanford University, USA
Primary Cilia on Muscle Stem Cells are Critical to Maintain Regenerative Capacity and are Lost during Aging
Primary Cilia on Muscle Stem Cells are Critical to Maintain Regenerative Capacity and are Lost during Aging
Following Session is for Stem Cells: Advances in the Application of Stem Cells and their Role in vivo (Q1)
19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
*Session Chair †Invited, not yet responded.
Keystone Symposia thanks our Sponsors(s) for generously supporting this meeting:
We gratefully acknowledge additional support from these exhibitors at this conference:
Please stop by to meet these exhibitors during the conference.
We gratefully acknowledge the generous grant for this conference provided by:
We gratefully acknowledge additional support for this conference from:
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:
Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:
Click here to view more of these organizations
If your organization is interested in joining these entities in support of Keystone
Symposia, please contact: John Monson,
Director of Corporate Relations, Email: johnm@keystonesymposia.org, Phone:+1 970-262-2690 Click here for more information on Industry Support and Recognition Opportunities. If you are interested in becoming an advertising/marketing in-kind partner, please contact: Josh May, Director, Technology and Digital Media, Email: joshuam@keystonesymposia.org, Phone:+1 970-262-1179 |