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This meeting took place in 2023



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Organoids as Models of Development and Disease, and their Impact on Drug Discovery (Q2)


Organizer(s) Ajamete Kaykas, Aron B. Jaffe and Prisca Liberali
February 5—8, 2023
Keystone Resort • Keystone, CO USA
Abstract Deadline: Dec 29, 2022
Scholarship Deadline: Nov 3, 2022
Discounted Registration Deadline: Dec 29, 2022

Sponsored by (Cell Research), Chinese Society for Cell Biology, GlaxoSmithKline Biologicals and Merck & Co., Inc.


Summary of Meeting:
Stem cell and tissue-derived organoids are three-dimensional, in vitro cellular models that faithfully recapitulate many features of a variety of organ systems. As such, they represent human tissue avatars, and have been used to study stem cell biology, organ development, the earliest stages of organismal development, and disease. The goals of this symposium are to highlight the impact of organoids in our understanding of development and disease, how organoids are being used in drug discovery, and their potential as therapeutics. Attendees will be exposed to the latest advances and discoveries that have resulted from the establishment and use of organoids in basic research and drug discovery. Together with the Stem Cell meeting, we expect that attendees will also form new connections and collaborations with researchers across the academic and industry communities.

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No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


The meeting will begin on Sunday, February 5 with registration from 16:00 to 20:00 and a welcome mixer from 18:00 to 20:00. Conference events conclude on Wednesday, February 8 with a closing plenary session from 17:00 to 19:00, followed by a social hour. We recommend return travel on Thursday, February 9 in order to fully experience the meeting.

SUNDAY, FEBRUARY 5

16:00—20:00
Arrival and Registration (4pm Start)

Longs Peak Foyer
18:00—20:00
Welcome Mixer
No registration fees are used to fund alcohol served at this function.

Longs Peak Foyer

MONDAY, FEBRUARY 6

07:00—08:00
Breakfast

Quandary Peak
08:00—09:30
Welcoming Remarks from Organizers and Keynote Session (Joint) (8am Start)

Longs Peak
* Prisca Liberali, Friedrich Miescher Institute for Biomedical Research, Switzerland

* Elly M. Tanaka, IMP - Research Institute of Molecular Pathology, Austria

Botond Roska, Institute of Ophthalmology Basel, Switzerland
Human Retinal Organoids

Coffee Break

Olivier Pourquié, Harvard Medical School, USA
Deconstructing and Reconstructing the Human Musculo-skeletal System in vitro

09:50—11:15
Models of Early Embryonic Development (Joint) (9:50am Start)

Longs Peak
* Margherita Y. Turco, Friedrich Miescher Institute, Switzerland

Nicolas Rivron, Institute of Molecular Biotechnology, Austrian Academy of Sciences, Austria
Blastoids: Shaping the Mouse and Human Blastocysts for Implantation

Jesse V. Veenvliet, Max Planck Institute of Molecular Cell Biology and Genetics, Germany
Shaping up the Stembryo

Oscar J. Abilez, Stanford University, USA
Short Talk: Using Gastruloids to Model the Earliest Stages of Human Cardiac and Hepatic Vascularization

11:15—17:00
On Own for Lunch

11:15—13:00
Poster Setup

Quandary Peak
13:00—22:00
Poster Viewing

Quandary Peak
14:30—16:30
Workshop: Translatability of the 3D Models into the Clinic (2:30pm Start)

Longs Peak
* Robert J. Ihry, Novartis Institutes for BioMedical Research, USA

Javier Bregante, Max Planck Institute of Molecular Cell Biology and Genetics, Germany
Human Liver Ductal Cell Heterogeneity and Cell-state Transitions in an Organoid System

Hina Usman, University of Chicago, USA
Transcriptomic and Cellular Effects of Aspirin on Human Normal Colonic Organoids from Diverse Individuals

Masayuki Yazawa, Columbia University, USA
Using Human Organoid Models to Develop Novel Inhibitory Peptides against Human Coronavirus Envelopes

Magdalena Lorenowicz, Biomedical Primate Research Center’, Netherlands
Mesenchymal Stromal/Stem Cells Promote Intestinal Epithelium Regeneration after Chemotherapy-induced Damage

Ashley Westerfield, MIT, USA
Multiscale Control of Human Cholangiocyte Microarchitecture in Organoid Culture and Microfluidic Devices

Lucia Tellez Perez, Cold Spring Harbor Laboratory, USA
Differential Effect of Female Sex Hormones in the Mammary Gland of Males and Females Using Organoids as a Study Model

Shawn Luttrell, Curi Bio, USA
Mantarray 3D Engineered Muscle Tissue Platform Demonstrates Clinically-Relevant Disease Stratification of an in vitro DMD Model

16:30—17:00
Coffee Available

Longs Peak Foyer
17:00—19:00
Organoid Models of Development and Regeneration (5pm Start)

Longs Peak
* Prisca Liberali, Friedrich Miescher Institute for Biomedical Research, Switzerland
Intestinal Organoids

Jason R. Spence, University of Michigan Health System, USA
Lung and Gut Organoids

Margherita Y. Turco, Friedrich Miescher Institute, Switzerland
Organoids for the Study of Maternal-fetal Interactions Underlying Human Placentation

Melisa Jovita Andrade, University of California Irvine, USA
Short Talk: iPSC-derived Vascularized Liver Organoids

Andrea P. Alvarez Maldonado, University of Michigan, USA
Short Talk: Characterization of the Developing Human Esophagus in vivo and in vitro

17:00—19:00
Causes and Consequences of Cell Competition and Clonal Selection (5pm Start)

Grays Peak
Thomas P. Zwaka, Icahn School of Medicine at Mount Sinai, USA
Discord Arising from Within: Genome-to-Genome Competition in Stem Cells

* Kristin Baldwin, Columbia University, USA
Building a Brain from Two Species - Who Decides?

Margaret A. Goodell, Baylor College of Medicine, USA
How to Win: Strategies for Competitive Advantage In the Stem Cell Niche

Anne Brunet, Stanford University, USA
Aging of the Stem Cell Niche

19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Quandary Peak
19:30—22:00
Poster Session 1 (7:30pm Start)

Quandary Peak

TUESDAY, FEBRUARY 7

07:00—08:00
Breakfast

Quandary Peak
08:00—11:00
Organoid Models of Development and Disease (Joint) (8am Start)

Longs Peak
* Samira Musah, Duke University, USA

* Max Salick, Insitro, USA
CRISPR Screening to the Nth Dimension: Pooled Optical Screening for Genetic Modifiers of Tuberous Sclerosis in iPSC-Derived Neurons

Fides Zenk, ETH Zürich, Switzerland
Single-Cell Multi-Omic Analysis of Organoids to Understand Development and Disease

Coffee Break

Thomas Eschenhagen, University Medical Center Hamburg-Eppendorf, Germany
Engineered Heart Tissue for Studying Cardiac Disease

Elly M. Tanaka, IMP - Research Institute of Molecular Pathology, Austria
Molecular Control of Organoid Self-Patterning

Titilola Dayo Kalejaiye, , USA
Short Talk: Vascularized Human Kidney Organoids with Enhanced Cell Lineage Specification

Jose M. Polo, University of Adelaide, Australia
Short Talk: Integration and Comparison of Different in vitro Generated Human Blastocyst- like Structures

Kate A. Miroshnikova, National Institutes of Health, USA
Short Talk: Impact of Nuclear Mechanics and Genome-lamina Interactions on Stem Cell Fate Transitions

11:00—17:00
On Own for Lunch

11:00—13:00
Poster Setup

Quandary Peak
13:00—22:00
Poster Viewing

Quandary Peak
15:00—16:30
Career Roundtable (Joint) (3pm Start)

Longs Peak
Alejandro Sánchez Alvarado, Stowers Institute for Medical Research/HHMI, USA

Karuna Ganesh, Memorial Sloan Kettering Cancer Center, USA

Sergii Kyrychenko, Prime Medicine, USA

Novella Guidi, Life Science Alliance, Germany

16:30—17:00
Coffee Available

Longs Peak Foyer
17:00—19:00
Organoid Models of Disease (5pm Start)

Longs Peak
* Jeffrey Beekman, University Medical Center Utrecht, Netherlands

Senthil K. Muthuswamy, NCI, National Institutes of Health, USA
Commitment and Oncogene-Induced Plasticity of Human Stem-Cell Derived Pancreatic Acinar and Ductal Organoids

Samira Musah, Duke University, USA
Next-Gen Kidney Models

Karuna Ganesh, Memorial Sloan Kettering Cancer Center, USA
Patient Derived Colorectal Cancer Organoids to Dissect Metastatic Plasticity

Cloud P. Paweletz, Dana Farber Cancer Institute, USA
Lung Cancer Organoids

17:00—19:15
Exerting Epigenetic Control Over Cells and Tissues (5pm Start)

Grays Peak
Aviv Regev, Genentech, USA
Remote Presentation: Cell Atlases as Roadmaps in Health and Disease

Justin Langerman, University of California, Los Angeles, USA
SECseq- A New High throughput Method for Pairing Secretion and Single Cell Transcriptions

Lorenz Studer, Memorial Sloan Kettering Cancer Center, USA
Directing Fate, Time and in vivo Survival in hPSC-Derived Lineages

Don W. Cleveland, University of California, San Diego, USA
The Promise and Perils of Generating New Neurons in the Aging Nervous System

* Joe Q. Zhou, Weill Cornell Medical College, USA
Short Talk: The Molecular Machinery Controlling Stem Cell and Tissue Plasticity Between Adult Colon and Small Intestine

19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Quandary Peak
19:30—22:00
Poster Session 2 (7:30pm Start)

Quandary Peak

WEDNESDAY, FEBRUARY 8

07:00—08:00
Breakfast

Quandary Peak
08:00—12:00
Stem Cells and Organoid Models in Drug Discovery (Joint) (8am Start)

Longs Peak
* Margaret A. Goodell, Baylor College of Medicine, USA

Jeffrey Beekman, University Medical Center Utrecht, Netherlands
Intestinal Organoids as a Platform for Personalized CF Therapies

Robert J. Ihry, Novartis Institutes for BioMedical Research, USA
Autism Organoid Models

Coffee Break

Takanori Takebe, Cincinnati Children's Hospital Medical Center, USA
Modeling Hepato-Biliary-Pancreatic Organogenesis

* Kevin C. Eggan, BioMarin Pharmaceutical Inc., USA
Therapeutic Reprogramming of RNA Metabolism in ALS

Alexander Meissner, Max Planck Institute for Molecular Genetics, Germany
Epigenetic Regulation of Developmental Events

Emily M. Lee, NCATS/NIH, USA
Short Talk: Brain Region Specific Spheroids for HTS Drug Discovery: from Neurodegenerative Diseases to Neurotropic Viral Infections

Jasper Rubin-Sigler, USC, USA
Short Talk: CASC3 Suppression Promotes Neuron Survival and Mitigates TDP-43 Pathology in Models of ALS/FTD

Charles Jian Zhang, University of Michigan, USA
Short Talk: Generation of Human Liver Organoids from Idiosyncratic DILI Patients

Alec Simon Tulloch Smith, University of Washington, USA
Short Talk: Magnetic Sensing of Tissue Contraction Facilitates High throughput Analysis of Stem Cell-derived Skeletal Muscle Function

12:00—17:00
On Own for Lunch

16:30—17:00
Coffee Available

Longs Peak Foyer
17:00—18:45
The Potential of Organoids as Therapeutics (5pm Start)

Longs Peak
* Jason R. Spence, University of Michigan Health System, USA

Toshiro Sato, Keio University, Japan
Understanding of Human Gastrointestinal Diseases using Organoid Technology

Ludovic Vallier, Berlin Institute of Health at Charité, Germany
Repairing Bile Ducts with Cholangiocyte Organoids

Magdalene J. Seiler, University of California, Irvine, USA
Morphological and Functional Integration of Stem Cell Derived Retina Organoid Sheets into Degenerating Retina Models

Yasminye D. Pettway, Vanderbilt University, USA
Short Talk: Human Pancreatic Islet Organoid System Reveals Cell-to-cell Contact and Hypoglycemia as Mechanisms Underlying α Cell Dysfunction in Type 1 Diabetes (T1D)

17:00—18:45
Molecular Circuitry Underlying Self-Renewal and Differentiation Decisions II (5pm Start)

Grays Peak
* Sean J. Morrison, University of Texas Southwestern Medical Center, USA
Modeling the Impact of Alzheimer's Disease Genetic Risk on Microglia States and Functions

Alejandro Sánchez Alvarado, Stowers Institute for Medical Research/HHMI, USA
Planarian Regeneration

Peter K. Jackson, Stanford University, USA
Primary Cilia on Muscle Stem Cells are Critical to Maintain Regenerative Capacity and are Lost during Aging

18:45—19:00
Meeting Wrap-Up: Outcomes and Future Directions (Organizers) (6:45pm Start)

Longs Peak
18:45—19:00
Meeting Wrap-Up: Outcomes and Future Directions (Organizers) (6:45pm Start)

Grays Peak
19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Quandary Peak

THURSDAY, FEBRUARY 9

08:00—08:00
Departure


*Session Chair †Invited, not yet responded.



Keystone Symposia thanks our Sponsors(s) for generously supporting this meeting:

Chinese Society for Cell Biology, (Cell Research) GlaxoSmithKline Biologicals
Merck & Co., Inc.
 

We gratefully acknowledge additional support from these exhibitors at this conference:

BioLegend, Inc. STEMCELL Technologies, Inc.
Please stop by to meet these exhibitors during the conference.


We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1R13TR004343-01

Funding for this conference was made possible (in part) by 1R13TR004343-01 from the National Institutes of Health. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention by trade names, commercial practices, or organizations imply endorsement by the U.S. Government.


We gratefully acknowledge additional support for this conference from:

Science Signaling / AAAS

We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:


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Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


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If your organization is interested in joining these entities in support of Keystone Symposia, please contact: John Monson, Director of Corporate Relations, Email: johnm@keystonesymposia.org,
Phone:+1 970-262-2690

Click here for more information on Industry Support and Recognition Opportunities.

If you are interested in becoming an advertising/marketing in-kind partner, please contact:
Josh May, Director, Technology and Digital Media, Email: joshuam@keystonesymposia.org,
Phone:+1 970-262-1179