Herrenhausen Palace Floorplan
This meeting took place in 2023
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New Frontiers in Reconstructing Human Evolution History (E3)
Organizer(s) Sarah A. Tishkoff and Joshua M. Akey
May 29—June 1, 2023
Herrenhausen Palace • Hannover, Germany
Abstract Deadline: Apr 11, 2023
Scholarship Deadline: Mar 13, 2023
Discounted Registration Deadline: Mar 29, 2023
Supported by the Directors' Fund
Summary of Meeting:
This meeting will shed light on the latest innovations in the field of Human Evolutionary Genomics which has broad implications across diverse fields including Anthropology, Evolutionary Biology, Genomics, and Biomedicine. The goals of the meeting are to: (1) bring together interdisciplinary researchers to address critical questions about genomic diversity, human origins, recent population histories, and the genetic basis of adaptation to diverse environments, (2) highlight the importance and challenges of including minority and indigenous populations in human genomics research, and (3) develop interdisciplinary approaches for using ancient DNA to reconstruct human history. The anticipated outcomes will be to: (1) Facilitate novel collaborative efforts among researchers who may not normally have an opportunity to interact, (2) Develop a set of standards based on ethical approaches for research on indigenous populations and ancient DNA from global populations, and (3) Determine novel approaches for identifying and characterizing functionally important variation in the human genome and the role of gene regulation in shaping human phenotypic diversity. This meeting will bring together researchers with expertise in computational biology, anthropology, evolutionary biology, functional genomics, and bioethics to address fundamental questions about human evolutionary history. These individuals would typically attend meetings in their own scientific specialties; thus, this meeting will play a critical role in fostering novel interdisciplinary approaches for solving complex problems about human evolutionary history. We will discuss novel methods for identifying ancient introgression in modern human genomes, reconstructing ancient phenotypes, identifying how gene regulation has shaped adaptive traits, and reconstructing complex demographic histories.
View Scholarships/Awards
This meeting will shed light on the latest innovations in the field of Human Evolutionary Genomics which has broad implications across diverse fields including Anthropology, Evolutionary Biology, Genomics, and Biomedicine. The goals of the meeting are to: (1) bring together interdisciplinary researchers to address critical questions about genomic diversity, human origins, recent population histories, and the genetic basis of adaptation to diverse environments, (2) highlight the importance and challenges of including minority and indigenous populations in human genomics research, and (3) develop interdisciplinary approaches for using ancient DNA to reconstruct human history. The anticipated outcomes will be to: (1) Facilitate novel collaborative efforts among researchers who may not normally have an opportunity to interact, (2) Develop a set of standards based on ethical approaches for research on indigenous populations and ancient DNA from global populations, and (3) Determine novel approaches for identifying and characterizing functionally important variation in the human genome and the role of gene regulation in shaping human phenotypic diversity. This meeting will bring together researchers with expertise in computational biology, anthropology, evolutionary biology, functional genomics, and bioethics to address fundamental questions about human evolutionary history. These individuals would typically attend meetings in their own scientific specialties; thus, this meeting will play a critical role in fostering novel interdisciplinary approaches for solving complex problems about human evolutionary history. We will discuss novel methods for identifying ancient introgression in modern human genomes, reconstructing ancient phenotypes, identifying how gene regulation has shaped adaptive traits, and reconstructing complex demographic histories.
View Scholarships/Awards
No registration fees are used to fund entertainment or alcohol at this conference
The meeting will begin on Monday, May 29 with registration from 16:00 to 20:00 and a welcome mixer from 18:00 to 20:00. Conference events conclude on Thursday, June 1 with a closing plenary session from 14:30 to 17:00, followed by dinner. We recommend return travel on Friday, June 2 in order to fully experience the meeting.
MONDAY, MAY 29
TUESDAY, MAY 30
WEDNESDAY, MAY 31
THURSDAY, JUNE 1
FRIDAY, JUNE 2
Conference Program Print | View meeting in 12 hr (am/pm) time
The meeting will begin on Monday, May 29 with registration from 16:00 to 20:00 and a welcome mixer from 18:00 to 20:00. Conference events conclude on Thursday, June 1 with a closing plenary session from 14:30 to 17:00, followed by dinner. We recommend return travel on Friday, June 2 in order to fully experience the meeting.
MONDAY, MAY 29
16:00—20:00
Arrival and Registration
Grand Mussmann Hotel, Tivoli Room
18:00—20:00
Welcome Mixer
No registration fees are used to fund alcohol served at this function.
Central-Hotel Kaiserhof
09:00—10:00
Welcome and Keynote Address
Auditorium
*
Sarah A. Tishkoff,
University of Pennsylvania, USA
Svante Pääbo,
Max Planck Institute for Evolutionary Anthropology, Germany
Impact of Neanderthals and Denisovans on Human Evolutionary History
Impact of Neanderthals and Denisovans on Human Evolutionary History
10:00—12:15
Computational Approaches for Reconstructing Human Demographic History
Auditorium
*
Rasmus Nielsen,
University of California, Berkeley, USA
Inference of Human History using Ancestral Recombination Graphs
Inference of Human History using Ancestral Recombination Graphs
Coffee Break
Ben Peter,
Max Planck Institute for Evolutionary Anthropology, Germany
Towards Computational Approaches for Studying Non-discrete Human Population Structure
Towards Computational Approaches for Studying Non-discrete Human Population Structure
Andrew H. Vaughn,
UC Berkeley, USA
Short Talk: Bayesian Inference of Admixture Graphs on Native American and Arctic Populations
Short Talk: Bayesian Inference of Admixture Graphs on Native American and Arctic Populations
Yilei Huang,
Max Planck Institute for Evolutionary Anthropology, Germany
Short Talk: Demographic Inference with IBD Segments in Ancient DNA
Short Talk: Demographic Inference with IBD Segments in Ancient DNA
Xinjun Zhang,
University of Michigan, USA
Short Talk: Novel Adaptive Introgression Candidates in Worldwide Human Populations Revealed by Machine Learning Method MaLAdapt
Short Talk: Novel Adaptive Introgression Candidates in Worldwide Human Populations Revealed by Machine Learning Method MaLAdapt
12:15—13:30
Lunch
Ballroom
13:30—15:00
Workshop
Auditorium
Craig B. Lowe,
Duke University School of Medicine, USA
Forging New Regulatory Elements In The Human Genome
Forging New Regulatory Elements In The Human Genome
*
Elise Kerdoncuff,
University California Berkeley, USA
Reconstructing 50,000 Years of Evolutionary History in India: Insights from 3,000 Whole Genome Sequences
Reconstructing 50,000 Years of Evolutionary History in India: Insights from 3,000 Whole Genome Sequences
Cristina de Guzman Strong,
Henry Ford Health/Michigan State University, USA
Discovery of Recent Evolution in the Human Skin Epidermis for the Involucrin/Ck1e/Vitamin D Receptor Axis using Integrative Multi-omics Strategies
Discovery of Recent Evolution in the Human Skin Epidermis for the Involucrin/Ck1e/Vitamin D Receptor Axis using Integrative Multi-omics Strategies
David Gokhman,
Weizmann Institute of Science, Israel
Uncovering the Regulatory Function of Variants that Shaped Human Evolution
Uncovering the Regulatory Function of Variants that Shaped Human Evolution
Ayken Askapuli,
University of Wisconsin-Madison, USA
Genomes of the Golden Horde Elites and their Implications for the Human Population Dynamics in Central Eurasia
Genomes of the Golden Horde Elites and their Implications for the Human Population Dynamics in Central Eurasia
15:00—15:30
Coffee Available
Foyer
15:30—17:30
Evolution of Complex Traits
Auditorium
*
Priya Moorjani,
University of California, Berkeley, USA
Evolution of Human Germline Mutation Rate
Evolution of Human Germline Mutation Rate
Iain Mathieson,
University of Pennsylvania, USA
Evolution of Complex Traits in Human Populations based on Studies of Ancient DNA
Evolution of Complex Traits in Human Populations based on Studies of Ancient DNA
Alan R. Shuldiner,
Regeneron Pharmaceuticals, Inc, USA
New Insights into Health and Disease and the Identification of Therapeutic Targets from Large-scale Genetics in Under-Studied Populations
New Insights into Health and Disease and the Identification of Therapeutic Targets from Large-scale Genetics in Under-Studied Populations
Gili Greenbaum,
Hebrew University of Jerusalem, Israel
Short Talk: Reconstructing the Direction of Phenotypic Difference in Complex Traits
Short Talk: Reconstructing the Direction of Phenotypic Difference in Complex Traits
Dan Ju,
University of Pennsylvania, USA
Short Talk: Investigating the Evolution of Height in Central African Rainforest Hunter-gatherers
Short Talk: Investigating the Evolution of Height in Central African Rainforest Hunter-gatherers
17:30—18:30
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
Ballroom
08:30—09:00
Poster Setup
Ballroom
09:00—15:00
Poster Viewing
Ballroom
09:00—12:00
Early History of Modern Humans
Auditorium
*
Qiaomei Fu,
Chinese Academy of Sciences, China
The Genetic Population History in Northern and Southern China
The Genetic Population History in Northern and Southern China
Liran Carmel,
Hebrew University of Jerusalem, Israel
The Epigenetics of Ancient Populations
The Epigenetics of Ancient Populations
Coffee Break
John A. Capra,
UCSF, USA
Resurrecting Ancient Molecular Phenotypes using Machine Learning
Resurrecting Ancient Molecular Phenotypes using Machine Learning
Daniel N. Harris,
University of Pennsylvania, USA
Short Talk: Neanderthal Homologous Regions in African Populations Arose Predominantly through Ancient African to Neanderthal Admixture
Short Talk: Neanderthal Homologous Regions in African Populations Arose Predominantly through Ancient African to Neanderthal Admixture
Claudio Quilodran,
University of Geneva, Switzerland
Short Talk: Past Human Expansions Shaped the Spatial Pattern of Neanderthal Ancestry
Short Talk: Past Human Expansions Shaped the Spatial Pattern of Neanderthal Ancestry
Martin M. Corcoran,
Karolinska Institutet, Sweden
Short Talk: Archaic Humans have Contributed to Large-scale Variation in Modern Human T Cell Receptor Genes
Short Talk: Archaic Humans have Contributed to Large-scale Variation in Modern Human T Cell Receptor Genes
12:00—13:00
Lunch
Ballroom
13:00—15:00
Poster Session
Ballroom
15:00—15:30
Coffee Available
Foyer
15:30—17:30
Ethical Issues of Working with Indigenous Population Samples
Auditorium
Katrina G. Claw,
University of Colorado Denver, USA
Remote Presentation: Ethics and Best Practices in Research with Indigenous Communities
Remote Presentation: Ethics and Best Practices in Research with Indigenous Communities
*
Emma Kowal,
Deakin University, Australia
Indigenous Australians, 20th Century Physiology, Evolutionary Genomics, and the Possibility of Human Hibernation
Indigenous Australians, 20th Century Physiology, Evolutionary Genomics, and the Possibility of Human Hibernation
Angelica Beate Winter Boldt,
Universidade Federal do Paraná, Brazil
Short Talk: How the Past Shapes Current Stories: Genetic Epidemiological Profiles of South American Mennonites
Short Talk: How the Past Shapes Current Stories: Genetic Epidemiological Profiles of South American Mennonites
17:30—18:30
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
Ballroom
09:00—12:00
Genomic Basis of Human Adaptation
Auditorium
*
Emilia Huerta-Sanchez,
Brown University, USA
Impact of Archaic Introgression on Human Adaptive Traits
Impact of Archaic Introgression on Human Adaptive Traits
Aida Andres,
University College London, UK
Genomics of Local Human Adaptation
Genomics of Local Human Adaptation
Coffee Break
Sarah A. Tishkoff,
University of Pennsylvania, USA
Evolution of Complex Traits in African Populations
Evolution of Complex Traits in African Populations
Jasmin Rees,
University College London, UK
Short Talk: Local Adaptation to Micronutrients in Modern Humans
Short Talk: Local Adaptation to Micronutrients in Modern Humans
Elena Bosch,
Universitat Pompeu Fabra, Spain
Short Talk: Adaptive Archaic Introgression Related to Cellular Zinc Homeostasis in Humans
Short Talk: Adaptive Archaic Introgression Related to Cellular Zinc Homeostasis in Humans
Yilan Wang,
Harvard University, USA
Short Talk: grnTea, A Machine Learning Tool to Detect Transposable Element Insertions in Ancient Human Whole-genome Sequencing Data
Short Talk: grnTea, A Machine Learning Tool to Detect Transposable Element Insertions in Ancient Human Whole-genome Sequencing Data
12:00—13:00
Lunch
Ballroom
13:00—14:00
Career Roundtable
Christina Warinner,
Max Planck Institute for the Science of Human History and Harvard University, Germany
Cristina de Guzman Strong,
Henry Ford Health/Michigan State University, USA
14:00—14:30
Coffee Available
Foyer
14:30—16:15
Impact of Infectious Disease on Human Evolution
Auditorium
*
Christina Warinner,
Max Planck Institute for the Science of Human History and Harvard University, Germany
Evolution of the Human Microbiome and Impact for Health and Disease
Evolution of the Human Microbiome and Impact for Health and Disease
Lluis Quintana-Murci,
Institut Pasteur, CNRS UMR2000 and Collège de France, France
From Neanderthals to COVID-19: Evolutionary Sources of Immune Response Variation in Humans
From Neanderthals to COVID-19: Evolutionary Sources of Immune Response Variation in Humans
Kirsten Bos,
Max Planck Institute for Evolutionary Anthropology, Germany
Prehistoric Epidemics and Plagues Inferred from Ancient DNA
Prehistoric Epidemics and Plagues Inferred from Ancient DNA
16:15—16:30
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
Auditorium
16:30—17:00
Refreshments
No registration fees are used to fund alcohol served at this function.
Foyer
17:00
On Own for Dinner
08:00—08:00
Departure
*Session Chair †Invited, not yet responded.
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