Fairmont Chateau Whistler Floorplan
This meeting took place in 2023
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Genomic Instability and DNA Repair (X1)
Organizer(s) Katharina Schlacher, Irene Chiolo and Ralph Scully
March 19—23, 2023
Fairmont Chateau Whistler • Whistler, BC Canada
Abstract Deadline: Dec 28, 2022
Scholarship Deadline: Dec 28, 2022
Discounted Registration Deadline: Jan 18, 2023
Sponsored by (Cell Research), Chinese Society for Cell Biology and Pfizer Inc.
Joint Meeting:
Precision Genome Engineering (X2)
Summary of Meeting:
DNA replication and repair are critical processes that initiate, orchestrate, and affect a broad range of fundamental physiological reactions, ultimately promoting cell division, genome stability, and proper cellular physiology. Reflected in this, genes acting in DNA replication/repair and genome stability are required for disease suppression, and direct therapy responses. Their failure is correlated with genome instability, cancer, neurological defects, developmental delays, aging, metabolic disorders, inflammation and immune responses, and therapeutic drug reactions. Rooting in and extending from the rich history of deep mechanistic understanding of the field, this Keystone conference will highlight the latest advances and emerging concepts in the field, aspiring to prompt rich discussions in particular with its implications for medical biology, disease and treatment strategies.
View Scholarships/Awards
DNA replication and repair are critical processes that initiate, orchestrate, and affect a broad range of fundamental physiological reactions, ultimately promoting cell division, genome stability, and proper cellular physiology. Reflected in this, genes acting in DNA replication/repair and genome stability are required for disease suppression, and direct therapy responses. Their failure is correlated with genome instability, cancer, neurological defects, developmental delays, aging, metabolic disorders, inflammation and immune responses, and therapeutic drug reactions. Rooting in and extending from the rich history of deep mechanistic understanding of the field, this Keystone conference will highlight the latest advances and emerging concepts in the field, aspiring to prompt rich discussions in particular with its implications for medical biology, disease and treatment strategies.
View Scholarships/Awards
No registration fees are used to fund entertainment or alcohol at this conference
The meeting will begin on Sunday, March 19 with registration from 16:00 to 20:00 and a welcome mixer from 18:00 to 20:00. Conference events conclude on Thursday, March 23 with a closing plenary session from 17:00 to 19:00, followed by a social hour. We recommend return travel on Friday, March 24 in order to fully experience the meeting.
SUNDAY, MARCH 19
MONDAY, MARCH 20
TUESDAY, MARCH 21
WEDNESDAY, MARCH 22
THURSDAY, MARCH 23
FRIDAY, MARCH 24
Conference Program Print | View meeting in 12 hr (am/pm) time
The meeting will begin on Sunday, March 19 with registration from 16:00 to 20:00 and a welcome mixer from 18:00 to 20:00. Conference events conclude on Thursday, March 23 with a closing plenary session from 17:00 to 19:00, followed by a social hour. We recommend return travel on Friday, March 24 in order to fully experience the meeting.
SUNDAY, MARCH 19
18:00—20:00
Welcome Mixer
No registration fees are used to fund alcohol served at this function.
08:00—09:30
Welcome and Keynote Session (Joint) (8am Start)
*
Katharina Schlacher,
MD Anderson Cancer Center, USA
*
Laura Sepp-Lorenzino,
Intellia Therapeutics, USA
Titia de Lange,
Rockefeller University, USA
APOBEC3-Dependent Kataegis and TREX1-Driven Chromothripsis During Telomere Crisis
APOBEC3-Dependent Kataegis and TREX1-Driven Chromothripsis During Telomere Crisis
Jennifer A. Doudna,
University of California, Berkeley, USA
The CRISPR Revolution: The Power and Promise of Gene Editing
The CRISPR Revolution: The Power and Promise of Gene Editing
Coffee Break
09:50—11:30
Genome Instability and Cancer (Joint) (9:50am Start)
*
Katharina Schlacher,
MD Anderson Cancer Center, USA
André Nussenzweig,
NCI, National Institutes of Health, USA
Genome Instability in Post-Mitotic Cells
Genome Instability in Post-Mitotic Cells
Stephen C. West,
Francis Crick Institute, UK
DNA Repair – Structures and Mechanisms
DNA Repair – Structures and Mechanisms
Agnel Sfeir,
Memorial Sloan Kettering Cancer Center, USA
Restricting MMEJ to Mitosis: The Role of RHINO
Restricting MMEJ to Mitosis: The Role of RHINO
14:30—16:30
Workshop 1: The Past and Future of DNA Repair/Replication (2:30pm Start)
*
Kristina Schmidt,
University of South Florida, USA
Michelle Swift,
Dana-Farber Cancer Institute, USA
Dynamics of the DYNLL1/MRE11 Complex Regulates DNA End Resection and Recruitment of the Shieldin Complex to DSBs
Dynamics of the DYNLL1/MRE11 Complex Regulates DNA End Resection and Recruitment of the Shieldin Complex to DSBs
Yuan He,
Northwestern University, USA
Structure Basis of DNA Double-Strand Break Repair by NHEJ
Structure Basis of DNA Double-Strand Break Repair by NHEJ
Sinem Usluer,
Medical University of Graz, Austria
Disordered Regions Mediate the Interaction of p53 and MRE11
Disordered Regions Mediate the Interaction of p53 and MRE11
Justine Sitz,
University of Copenhagen, Denmark
Untangling the Genome Maintenance Functions of BRCA1 during Unperturbed Cell Cycle
Untangling the Genome Maintenance Functions of BRCA1 during Unperturbed Cell Cycle
Brian B. Rodemoyer,
University of South Florida, USA
A Novel Interaction between the Bloom's Syndrome DNA Helicase BLM and an Interphase-specific Condensin II Complex Aids in Maintaining Genome Stability
A Novel Interaction between the Bloom's Syndrome DNA Helicase BLM and an Interphase-specific Condensin II Complex Aids in Maintaining Genome Stability
14:30—16:30
Roundtable Discussion: Genome Editing Ethics (2:30pm Start)
*
Fyodor D. Urnov,
University of California, Berkeley, USA
Sekar Kathiresan,
Verve Therapeutics, USA
Jennifer A. Doudna,
University of California, Berkeley, USA
Anna Kwilas,
Food and Drug Administration, USA
Natalia Gomez-Ospina,
Stanford University, USA
17:00—19:00
Fork Protection and Cancer Therapy (5pm Start)
*
Alessandro Vindigni,
Washington University, USA
Mechanisms of Replication Fork Recovery in BRCA-deficient Tumors
Mechanisms of Replication Fork Recovery in BRCA-deficient Tumors
*
Sharon B. Cantor,
University of Massachusetts Medical School, USA
Replication Gaps Underlie BRCA Deficiency and Therapy Response
Replication Gaps Underlie BRCA Deficiency and Therapy Response
Li Lan,
Massachusetts General Hospital, USA
Understanding and Targeting R-Loops and mRNA-Dependent DNA Repair in Cancer
Understanding and Targeting R-Loops and mRNA-Dependent DNA Repair in Cancer
Andrew Elia,
Massachusetts General Hospital, Harvard Medical School, USA
Short Talk: Regulation of Replication Fork Remodeling by RFWD3
Short Talk: Regulation of Replication Fork Remodeling by RFWD3
Priyanka Verma,
Washington University, USA
Short Talk: Communication between Base Damage and Replication-fork Remodeling Dictate Responses to PARP Inhibitor Therapy in BRCA-mutant Cancer
Short Talk: Communication between Base Damage and Replication-fork Remodeling Dictate Responses to PARP Inhibitor Therapy in BRCA-mutant Cancer
17:00—19:00
Natural Editing and Repair Mechanisms (5pm Start)
*
Toni Cathomen,
University Medical Center Freiburg, Germany
Quantitative Evaluation of Chromosomal Rearrangements in Gene-Edited Human Stem Cells by CAST-Seq
Quantitative Evaluation of Chromosomal Rearrangements in Gene-Edited Human Stem Cells by CAST-Seq
Anna Kwilas,
Food and Drug Administration, USA
Regulatory Approach for Gene Therapies Incorporating Human Somatic Genome Editing A CBER Perspective
Regulatory Approach for Gene Therapies Incorporating Human Somatic Genome Editing A CBER Perspective
Jacob E. Corn,
ETH Zürich, Switzerland
Short Talk: TREX1 Restricts CRISPR-Cas9 Genome Editing in Human Cells
Short Talk: TREX1 Restricts CRISPR-Cas9 Genome Editing in Human Cells
Chance Meers,
Columbia University, USA
Short Talk: Transposon-encoded DNA Endonucleases use Guide RNAs to Selfishly Bias their Inheritance
Short Talk: Transposon-encoded DNA Endonucleases use Guide RNAs to Selfishly Bias their Inheritance
Dahlia Rohm,
Duke University, USA
Short Talk: Targeted Activation of the Imprinted PWS Locus via CRISPR/Cas9-based Epigenome Editing
Short Talk: Targeted Activation of the Imprinted PWS Locus via CRISPR/Cas9-based Epigenome Editing
19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
08:00—11:00
Nuclear and Chromatin Dynamics in DNA Repair (8am Start)
*
Irene Chiolo,
University of Southern California, USA
DNA Repair Mechanisms in Heterochromatin
DNA Repair Mechanisms in Heterochromatin
Matthias Altmeyer,
University of Zurich, Switzerland
Dynamics and Functions of DNA Repair Compartments
Dynamics and Functions of DNA Repair Compartments
Coffee Break
Karim Mekhail,
University of Toronto, Canada
Nuclear Dynamics in DSB Repair from Yeast to Humans
Nuclear Dynamics in DSB Repair from Yeast to Humans
Philipp Oberdoerffer,
Johns Hopkins University, USA
Epigenetic Control of Base Excision Repair as a Cancer Vulnerability
Epigenetic Control of Base Excision Repair as a Cancer Vulnerability
Marton Tibor Kovacs,
Institut Curie, France
Short Talk: DNA Damage-induced Nuclear Envelope Rupture: A New Cancer Vulnerability
Short Talk: DNA Damage-induced Nuclear Envelope Rupture: A New Cancer Vulnerability
Aline Marnef,
CNRS, France
Short Talk: DSB-induced RNA:DNA Hybrid Accumulation Arise from Transcriptional Repression Correlates with Resection
Short Talk: DSB-induced RNA:DNA Hybrid Accumulation Arise from Transcriptional Repression Correlates with Resection
08:00—11:00
Plant and Animal Science Gene Editing Applications and Regulatory Path (8am Start)
Yi Jin,
Inari Agriculture, USA
Seeding Change through Genome Editing with Inari's SEEDesign (TM) platform
Seeding Change through Genome Editing with Inari's SEEDesign (TM) platform
*
Rodolphe Barrangou,
North Carolina State University, USA
CRISPR Applications and Implications in Ag and Forestry
CRISPR Applications and Implications in Ag and Forestry
Coffee Break
Irina A. Polejaeva,
Utah State University, USA
Advancing Large Animal Model Development using CRISPR/Cas 9 Dditing
Advancing Large Animal Model Development using CRISPR/Cas 9 Dditing
John D. Laurie,
Agriculture and Agri-Food Canada, Canada
Improved Plant Regeneration and Cas9 Cleavage Detection for Gene Editing in Wheat
Improved Plant Regeneration and Cas9 Cleavage Detection for Gene Editing in Wheat
Katie Willis,
Imperial College London, UK
Autosomal Editors for Efficient Genetic Biocontrol
Autosomal Editors for Efficient Genetic Biocontrol
14:30—16:30
Workshop 2: New Approaches and Technologies to Study Genome Stability (2:30pm Start)
Maga Rowicka,
University of Texas Medical Branch, USA
Quantitative DSB Mapping and Computational Modeling of Mechanisms of DSB Formation
Quantitative DSB Mapping and Computational Modeling of Mechanisms of DSB Formation
Jeroen van den Berg,
Hubrecht Institute, Netherlands
Acceleration of Genome Replication Uncovered by Single-cell Nascent DNA Sequencing
Acceleration of Genome Replication Uncovered by Single-cell Nascent DNA Sequencing
Neesha Kara,
Babraham Institute, UK
Genome-wide Mapping of DNA Replication and Damage in Senescence using TrAELseq
Genome-wide Mapping of DNA Replication and Damage in Senescence using TrAELseq
Robin Sebastian,
NIH/NCI/CCR, USA
Chromatin Topology Restricts DNA Replication at Double-strand Breaks
Chromatin Topology Restricts DNA Replication at Double-strand Breaks
Xia Ding,
Pfizer, Inc., USA
Cohesin Instability at Replication Forks Leads to Accumulation of Toxic G-quadruplex Structures and Confers PARPi Sensitivity
Cohesin Instability at Replication Forks Leads to Accumulation of Toxic G-quadruplex Structures and Confers PARPi Sensitivity
Anoek Friskes,
Netherlands Cancer Institute, Netherlands
Dynamic, Higher-order Filament Formation to Facilitate DNA Repair
Dynamic, Higher-order Filament Formation to Facilitate DNA Repair
*
Kyungjae Myung,
Institute for Basic Science, South Korea
Precision Targeting Tumor Cells using Cancer specific InDel-mutations with CRISPR
Precision Targeting Tumor Cells using Cancer specific InDel-mutations with CRISPR
Peter Ly,
University of Texas Southwestern Medical Center, USA
Mitotic Clustering of Pulverized Chromosomes from Micronuclei
Mitotic Clustering of Pulverized Chromosomes from Micronuclei
17:00—19:00
Inflammation and Genomic Instability (5pm Start)
Karl-Peter Hopfner,
Ludwig-Maximilians-University Munich, Germany
Structures of MRE11 and cGAS
Structures of MRE11 and cGAS
Katharina Schlacher,
MD Anderson Cancer Center, USA
Mitochondrial and Nuclear BRCA/FANC DNA Replication Stability in Disease and Cancer
Mitochondrial and Nuclear BRCA/FANC DNA Replication Stability in Disease and Cancer
*
Roger Greenberg,
University of Pennsylvania, USA
Genome Instability and Inflammation
Genome Instability and Inflammation
*
Julia Sidorova,
University of Washington, USA
Short Talk: Innate Immunity Mediator STING Modulates Nascent DNA Metabolism at Stalled Forks in Human Cells
Short Talk: Innate Immunity Mediator STING Modulates Nascent DNA Metabolism at Stalled Forks in Human Cells
Julia Li,
University of California San Diego, USA
Short Talk: Hidden in our Own Genome: A Previously Missing Link between Epstein Barr Virus and Cancer
Short Talk: Hidden in our Own Genome: A Previously Missing Link between Epstein Barr Virus and Cancer
17:00—19:00
Delivery of Gene Editors: Potency, Biodistribution, Safety (5pm Start)
*
Christian Dombrowski,
Intellia Therapeutics, USA
Daniel J. Siegwart,
University of Texas Southwestern Medical Center, USA
Multiplexed SORT LNPs for Enhancing CRISPR/Cas Gene Editing Cancer Therapy through Modulating Tumor Mechanical Properties
Multiplexed SORT LNPs for Enhancing CRISPR/Cas Gene Editing Cancer Therapy through Modulating Tumor Mechanical Properties
Charles Gersbach,
Duke University, USA
Intended and Unintended Consequences of in vivo Editing
Intended and Unintended Consequences of in vivo Editing
Jennifer R. Hamilton,
University of California, Berkeley, USA
Short Talk: Cell Type-programmable CRISPR-Cas9 Delivery for Human T Cell Engineering
Short Talk: Cell Type-programmable CRISPR-Cas9 Delivery for Human T Cell Engineering
Lauren Goetsch,
Mekonos, Inc, USA
Short Talk: Utilizing Surface-Functionalized Nanoneedles for Physical Cargo Delivery into Cells
Short Talk: Utilizing Surface-Functionalized Nanoneedles for Physical Cargo Delivery into Cells
19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
08:00—11:00
Genome Editing and DNA Repair (Joint) (8am Start)
*
Matthew Porteus,
Stanford University School of Medicine, USA
Maria Jasin,
Memorial Sloan Kettering Cancer Center, USA
Genome Modification by Natural and Artificial DNA Breaks
Genome Modification by Natural and Artificial DNA Breaks
*
Tanya T. Paull,
University of Texas at Austin, USA
Regulation of DNA Double-Strand Break Repair and Oxidative Stress Signaling
Regulation of DNA Double-Strand Break Repair and Oxidative Stress Signaling
Coffee Break
Daniel Durocher,
Lunenfeld-Tanenbaum Research Institute, Canada
Genome Kintsugi
Genome Kintsugi
David Pellman,
Dana-Farber Cancer Institute, USA
Mechanisms Driving Rapid Genome Evolution
Mechanisms Driving Rapid Genome Evolution
Petr Cejka,
Institute for Research in Biomedicine, Switzerland
Short Talk: Mechanism of DNA End Sensing by the MRE11 Complex: Implications for CRISPR Based Genome Editing and Telomeres
Short Talk: Mechanism of DNA End Sensing by the MRE11 Complex: Implications for CRISPR Based Genome Editing and Telomeres
Gregory Davis,
Sangamo Therapeutics, USA
Short Talk: Epigenetic Editing and Gene Regulation Using Designed Zinc Finger Proteins
Short Talk: Epigenetic Editing and Gene Regulation Using Designed Zinc Finger Proteins
14:30—16:30
Panel Discussion: Addressing COVID-19-Related Challenges for Women in Science (2:30pm Start)
Tanya T. Paull,
University of Texas at Austin, USA
*
Irene Chiolo,
University of Southern California, USA
*
Katharina Schlacher,
MD Anderson Cancer Center, USA
Xiaolan Zhao,
Memorial Sloan Kettering Cancer Center, USA
Helle D. Ulrich,
Institute of Molecular Biology, Germany
Titia de Lange,
Rockefeller University, USA
14:30—16:30
Workshop (2:30pm Start)
*
Matthew Porteus,
Stanford University School of Medicine, USA
*
Laura Sepp-Lorenzino,
Intellia Therapeutics, USA
Romina Marone,
University of Basel, DBM, Switzerland
Function-preserving Single Amino Acid Substitutions Shield Hematopoietic Stem and Progenitor Cells from CD117 Targeted Immunotherapy in vivo
Function-preserving Single Amino Acid Substitutions Shield Hematopoietic Stem and Progenitor Cells from CD117 Targeted Immunotherapy in vivo
Gabriele Casirati,
Boston Children's Hospital/Dana Farber Cancer Institute, USA
Multiplex Epitope-Engineered HSPCs to Enable multi-target CAR-T Cell Immunotherapy for Acute Myeloid Leukemia
Multiplex Epitope-Engineered HSPCs to Enable multi-target CAR-T Cell Immunotherapy for Acute Myeloid Leukemia
Samuele Ferrari,
Vita-Salute San Raffaele University, Italy
Uncovering Upsides and Pitfalls of Base and Prime Editing in Hematopoietic Stem Cells
Uncovering Upsides and Pitfalls of Base and Prime Editing in Hematopoietic Stem Cells
Ayal Hendel,
Bar Ilan, Israel
Multiplex HDR for Correction Simulation of SCID by CRISPR Genome Editing in Healthy Donor Human HSPCs
Multiplex HDR for Correction Simulation of SCID by CRISPR Genome Editing in Healthy Donor Human HSPCs
Sean McCutcheon,
Duke University, USA
CRISPR-based Epigenome Editing Screens Identify Transcriptional and Epigenetic Regulators of Human CD8 T Cell Function
CRISPR-based Epigenome Editing Screens Identify Transcriptional and Epigenetic Regulators of Human CD8 T Cell Function
17:00—19:00
Replication Coupled Repair (5pm Start)
*
Helle D. Ulrich,
Institute of Molecular Biology, Germany
When the Fork Meets the Cytoskeleton - Functions of Myosin VI in DNA Repair and Replication Stress
When the Fork Meets the Cytoskeleton - Functions of Myosin VI in DNA Repair and Replication Stress
Xiaolan Zhao,
Memorial Sloan Kettering Cancer Center, USA
Integrative Analysis Reveals Unique Structural and Functional Features of the Smc5/6 Complex
Integrative Analysis Reveals Unique Structural and Functional Features of the Smc5/6 Complex
*
Ralph Scully,
Beth Israel Deaconess Medical Center, USA
Stalled Fork Repair in Health and Disease
Stalled Fork Repair in Health and Disease
Shyam K. Sharan,
National Cancer Institute, USA
Short Talk: DNA Mismatch Repair Independent Role of MLH1 in Suppressing Genomic Instability in BRCA2-Deficient Cells
Short Talk: DNA Mismatch Repair Independent Role of MLH1 in Suppressing Genomic Instability in BRCA2-Deficient Cells
Anna Malkova,
University of Iowa, USA
Short Talk: Unraveling Mutagenic Potential of Break-induced Replication
Short Talk: Unraveling Mutagenic Potential of Break-induced Replication
17:00—19:00
Editing Technology Development (5pm Start)
*
Gregory Davis,
Sangamo Therapeutics, USA
Alex Marson,
Gladstone Institutes, University of California, San Francisco, USA
A Functional CRISPR Dissection of Gene Networks Controlling Human Regulatory T Cell Identity
A Functional CRISPR Dissection of Gene Networks Controlling Human Regulatory T Cell Identity
Cecilia Cotta-Ramusino,
Tessera Therapeutics, USA
Gene Writing: A New Genome Engineering Technology
Gene Writing: A New Genome Engineering Technology
Avencia Sanchez-Mejias,
Integra Therapeutics, Spain
Short Talk: Characterization and Deployment in vivo of FiCAT Genome Writer
Short Talk: Characterization and Deployment in vivo of FiCAT Genome Writer
Steve E. Glenn,
Integrated DNA Technologies, USA
Short Talk: Engineering an Improved Protein-Based HDR Enhancer
Short Talk: Engineering an Improved Protein-Based HDR Enhancer
Y. Bill Kim,
Pairwise, USA
Short Talk: A Novel Mechanistic Framework for Precise Sequence Replacement Using Reverse Transcriptase and Diverse CRISPR-Cas Systems
Short Talk: A Novel Mechanistic Framework for Precise Sequence Replacement Using Reverse Transcriptase and Diverse CRISPR-Cas Systems
19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
08:00—11:00
RNA Functions in Genome Stability (8am Start)
*
Karlene A. Cimprich,
Stanford University, USA
A Novel Function for the DNA Replication Fork Remodeler HLTF in Genome Maintenance
A Novel Function for the DNA Replication Fork Remodeler HLTF in Genome Maintenance
Fabrizio d'Adda di Fagagna,
IFOM ETS – The AIRC Institute of Molecular Oncology, Italy
RNA Synthesis at DNA Lesions
RNA Synthesis at DNA Lesions
Coffee Break
*
Francesca Storici,
Georgia Institute of Technology, USA
RNA-Directed DNA Double-Strand Break Repair in Yeast and Human Cells
RNA-Directed DNA Double-Strand Break Repair in Yeast and Human Cells
Eric J. Brown,
Perelman School of Medicine, University of Pennsylvania, USA
Impact of DNA Repeat Transcription on ATR Inhibitor-driven Genomic Breaks
Impact of DNA Repeat Transcription on ATR Inhibitor-driven Genomic Breaks
Clara Bonnet,
Institut Curie, France
Short Talk: An RNA-protein Interaction at DNA Replication Forks
Short Talk: An RNA-protein Interaction at DNA Replication Forks
Amélie Fradet-Turcotte,
Université Laval, Canada
Short Talk: FIRRM is a Novel Regulator of Interstrand Crosslink Repair
Short Talk: FIRRM is a Novel Regulator of Interstrand Crosslink Repair
08:00—11:00
Ex vivo Gene Edited Cell Therapies (8am Start)
*
Pietro Genovese,
Dana-Farber Cancer Institute, USA
Fyodor D. Urnov,
University of California, Berkeley, USA
From N=1 to N=all: a Platform Approach to CRISPR-Cas Therapies for Disorders of Hematopoiesis
From N=1 to N=all: a Platform Approach to CRISPR-Cas Therapies for Disorders of Hematopoiesis
Natalia Gomez-Ospina,
Stanford University, USA
Engineering the Blood to Treat the Brain Genome Editing
Engineering the Blood to Treat the Brain Genome Editing
Coffee Break
Simon N. Chu,
University of California, San Francisco, USA
Developing a Genome Editing Strategy to Deliver Alpha-globin Transgene to Alpha Thalassemia Major Hematopoietic Stem Cells
Developing a Genome Editing Strategy to Deliver Alpha-globin Transgene to Alpha Thalassemia Major Hematopoietic Stem Cells
Dave Vereide,
Umoja Biopharma, USA
Short Talk: Arming Induced Pluripotent Stem Cells with a Synthetic Receptor Enables Massive Production of Cytotoxic Innate Lymphocytes for “off-the-shelf” Cancer Immunotherapies
Short Talk: Arming Induced Pluripotent Stem Cells with a Synthetic Receptor Enables Massive Production of Cytotoxic Innate Lymphocytes for “off-the-shelf” Cancer Immunotherapies
Matthew Porteus,
Stanford University School of Medicine, USA
Sickle Cell Disease Clinical Program
Sickle Cell Disease Clinical Program
15:00—16:30
Career Roundtable (Joint) (3pm Start)
Tanya T. Paull,
University of Texas at Austin, USA
Cecilia Cotta-Ramusino,
Tessera Therapeutics, USA
Karl-Peter Hopfner,
Ludwig-Maximilians-University Munich, Germany
Anna Kwilas,
Food and Drug Administration, USA
17:00—18:45
Genomic Instability and Cancer II (5pm Start)
*
Susan M. Rosenberg,
Baylor College of Medicine, USA
The DNA Damageome and Cancer
The DNA Damageome and Cancer
Filippo Rosselli,
Gustave Roussy, France
From DNA Repair to Translation: When the Maintenance of Genetic Stability Turns to the Maintenance of Proteostasis
From DNA Repair to Translation: When the Maintenance of Genetic Stability Turns to the Maintenance of Proteostasis
George Galea,
European Molecular Biology Laboratory, Germany
Short Talk: The Golgi Complex is a Regulatory Hub for DNA Repair
Short Talk: The Golgi Complex is a Regulatory Hub for DNA Repair
Junjie Chen,
University of Texas MD Anderson Cancer Center, USA
Short Talk: Targeting DNA Damage Responsive Pathways in Cancer Therapy
Short Talk: Targeting DNA Damage Responsive Pathways in Cancer Therapy
Susi Bantele,
University of Copenhagen - CPR, Denmark
Short Talk: Heritable Changes in Chromatin Function after DNA Double-Strand Break Repair
Short Talk: Heritable Changes in Chromatin Function after DNA Double-Strand Break Repair
Xabier Vergara,
Netherlands Cancer Institute, Netherlands
Short Talk: Widespread Chromatin Context-dependencies of DNA Double-strand Break Repair Proteins
Short Talk: Widespread Chromatin Context-dependencies of DNA Double-strand Break Repair Proteins
17:00—18:45
In vivo Gene Editing Drug Development (5pm Start)
*
Laura Sepp-Lorenzino,
Intellia Therapeutics, USA
Realizing the Promise of CRISPR Therapeutics: Clinical Update from In Vivo Programs
Realizing the Promise of CRISPR Therapeutics: Clinical Update from In Vivo Programs
Sekar Kathiresan,
Verve Therapeutics, USA
Clinical Programs of Base Editors for Cardiovascular Disease
Clinical Programs of Base Editors for Cardiovascular Disease
Christiano Alves,
Massachusetts General Hospital, USA
A Permanent Genetic Treatment for Spinal Muscular Atrophy using Base Editors
A Permanent Genetic Treatment for Spinal Muscular Atrophy using Base Editors
18:45—19:00
Meeting Wrap-Up: Outcomes and Future Directions (Organizers) (6:45pm Start)
18:45—19:00
Meeting Wrap-Up: Outcomes and Future Directions (Organizers) (6:45pm Start)
19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
*Session Chair †Invited, not yet responded.
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