Keystone Symposia

Fairmont Hotel Vancouver Floorplan

This meeting took place in 2022


Here are the related meetings in 2024:
Ubiquitin Biology and Disease (J6)

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Ubiquitin Biology - RESCHEDULED (RJ5)


Organizer(s) Eric J. Bennett, Nicolas H. Thomä and Niels Mailand
November 6—9, 2022
Fairmont Hotel Vancouver • Vancouver, BC Canada
Abstract Deadline: Sep 19, 2022
Scholarship Deadline: Nov 26, 2021
Discounted Registration Deadline: Sep 6, 2022

Sponsored by Astellas Pharma Inc. and Genentech, Inc.


Summary of Meeting:
Protein ubiquitylation regulates nearly every critical cellular pathway and emerging evidence has demonstrated that defects within the ubiquitin proteasome system can directly lead human disease, most notably neurodegenerative disorders. This has fueled a recent expansion of drug development efforts to harness the ubiquitin proteasome system to both aid in its functionality during disease progression and to specify individual targets for degradation. Several key questions regarding ubiquitin biology remain unanswered. Can individual cellular pathways, like DNA repair, be specifically manipulated by altering the activity of ubiquitin pathway enzymes? What are the major factors that limit ubiquitin proteasome function during disease pathogenesis? How do infectious diseases impact the ubiquitin system, and can we utilize these diverse mechanisms to develop new tools and paradigms to manipulate the ubiquitin system? The specific goals of the proposed meeting are: 1- Establish detailed connections between the diverse cellular pathways regulated by the ubiquitin system. 2- Determine the structural rules defining how individual proteins are specifically targeted by ubiquitin pathway enzymes. 3- Identify emerging themes using by pathogens to subvert the ubiquitin system 4- Foster enhanced collaboration between academia and the biotechnology industry toward the goal of developing therapeutics targeting the ubiquitin system. This joint meeting with “Targeted Protein Degradation” will provide a cross-disciplinary understanding of the various genetic and chemical approaches to identify mechanisms to specifically target individual proteins for degradation. One key outcome will be the establishment of collaborations between ubiquitin biologists studying how individual pathways are regulated by ubiquitin and industry leaders developing tools to both activate and inhibit ubiquitin pathway components.

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No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


The meeting will begin on Sunday, November 6 with registration from 16:00 to 20:00 and a welcome mixer from 18:00 to 20:00. Conference events conclude on Wednesday, November 9 with a closing plenary session from 17:00 to 19:00, followed by a social hour. We recommend return travel on Thursday, November 10 in order to fully experience the meeting.

SUNDAY, NOVEMBER 6

16:00—20:00
Arrival and Registration

British/Columbia Foyer
18:00—20:00
Welcome Mixer
No registration fees are used to fund alcohol served at this function.

British/Columbia Foyer

MONDAY, NOVEMBER 7

07:00—08:00
Breakfast

Pacific Ballroom
08:00—09:00
Welcome and Keynote Address

British Ballroom
* Eric J. Bennett, University of California, San Diego, USA
Session Chair

Ivan Dikic, Goethe University Medical School, Germany
Ubiquitination and Remodeling of Organelles

08:00—09:00
Welcome and Keynote Address

Columbia Ballroom
* Rajesh Chopra, Apple Tree Partners, USA

Benjamin L. Ebert, Dana-Farber Cancer Institute, USA
Targeted Protein Degradation for the Treatment of Cancer

09:00—11:30
Regulating Nuclear Function with Ubiquitin

British Ballroom
* Achim Werner, NIDCR, National Institutes of Health, USA

Goran Kokic, Max Planck Institute for Biophysical Chemistry, Germany
Transcription-coupled DNA Repair: Lessons Learned on the Ubiquitylation of Complex Substrates

Coffee Break

Jo R. Morris, University of Birmingham, UK
SUMOylation in the DNA Double-Strand Break Response

Niels Mailand, University of Copenhagen, Denmark
Ubiquitin-Dependent Signaling in the DNA Damage Response

Stefan Müller, Goethe-University Frankfurt, Germany
Short Talk: Safeguarding Proteome and Genome Integrity by Sumo-ubiquitin Networks

Imke Leonie Lemmer, LMU Munich, Germany
Short Talk: Nfe2l1 Shapes the Muscle Ubiquitome to Regulate Fiber Type and Metabolic Fitness

09:00—11:15
Proteolysis Targeting Chimeras (PROTACs)

Columbia Ballroom
Alessio Ciulli, University of Dundee, School of Life Sciences, UK
Structural Chemical Biology and Insights into PROTAC Mechanism of Action

Coffee Break

* Nathanael Gray, Stanford University, USA
Targeting Kinases Via Protein Degradation

Shaomeng Wang, University of Michigan, USA
Targeting Transcriptional Factor STAT3 and Other STAT Proteins by PROTAC

Bikash Adhikari, University of Wuerzburg, Germany
Short Talk: Targeted Protein Degradation of Oncogenic Proteins using PROTACs

Charlotte Crowe, University of Dundee, UK
Short Talk: Novel Biophysical Assays for Small-Molecule Mediated Ternary Complex Formation and Ubiquitination

11:30—17:00
On Own for Lunch

11:30—13:00
Poster Setup

Pacific Ballroom
13:00—22:00
Poster Viewing

Pacific Ballroom
15:00—16:30
Career Roundtable (Joint)

British/Columbia Ballroom
Ivan Dikic, Goethe University Medical School, Germany

Benjamin L. Ebert, Dana-Farber Cancer Institute, USA

Sonya Neal, University of California, San Diego, USA

Eva d'Hennezel, Novartis Institutes of Biomedical Research, USA

16:30—17:00
Coffee Available

British/Columbia Foyer
17:00—19:00
Mechanisms of Protein Ubiquitylation and Degradation (Joint)

British/Columbia Ballroom
* Ingrid E. Wertz, Lyterian Therapeutics, USA
Session Chair

Brenda A. Schulman, Max Planck Institute of Biochemistry, Germany
Cullin-RING E3 Ligation Mechanisms

Weaam Ibrahim Mohamed, Institute of Biochemistry, Switzerland
Short Talk: Regulation of RING E3 Ubiquitin Ligases by Oligomerization: What do we Learn from CRL4(DCAF1) and the hGID Complexes?

Kylie J. Walters, NCI, National Institutes of Health, USA
Proteasome Substrate Receptor hRpn13 as an Anti-Cancer Target

Nicolas H. Thomä, Friedrich Miescher Institute for Biomedical Research, Switzerland
The Zinc Finger Degrome

Hadir Marei, Genentech, Roche, USA
Short Talk: Leveraging E3 Ubiquitin Ligases as Cell Surface Protein Degraders

19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Pacific Ballroom
19:30—22:00
Poster Session 1

Pacific Ballroom

TUESDAY, NOVEMBER 8

07:00—08:00
Breakfast

Pacific Ballroom
08:00—11:00
Strategies for Therapeutic Targeting of the Ubiquitin Proteasome System (Joint)

British/Columbia Ballroom
* Brenda A. Schulman, Max Planck Institute of Biochemistry, Germany
Session Chair

Sara Buhrlage, Dana-Farber Cancer Institute, USA
Approaches to Identify New DUB Inhibitors

Mikko Taipale, University of Toronto, Canada
Functional Proteomics by Induced Proximity

Coffee Break

Eva d'Hennezel, Novartis Institutes of Biomedical Research, USA
Discovery and Characterization of a First-in-class Selective IKZF2 Glue Degrader for Immuno-oncology Applications

Ingrid E. Wertz, Lyterian Therapeutics, USA
Identification, Development, and Characterization of Inhibitors for Deubiquitinating Enzymes

Mandeep Kaur Mann, University of Toronto, Canada
Short Talk: Discovery of First-in-class USP5 Inhibitors

Jonathan Michael Tsai, Harvard Medical School, USA
Short Talk: UBR5 Forms Ligand-Dependent Complexes on Chromatin to Regulate Nuclear Hormone Receptor Stability

11:00—17:00
On Own for Lunch

11:00—13:00
Poster Setup

Pacific Ballroom
13:00—22:00
Poster Viewing

Pacific Ballroom
14:30—16:30
Workshop: Emerging Themes in Ubiquitin Biology

British Ballroom
* Eric J. Bennett, University of California, San Diego, USA
Session Chair

Thang V. Nguyen, University of Missouri, School of Medicine, USA
Suppressing the Action of Molecular Glues and PROTACs by the Deubiquitylating Enzyme USP15

Darren M. O'Hara, Almac Discovery, UK
Discovery of a Novel USP19 Inhibitor with Muscle Sparing Activity in vivo

Jason Q. Tang, University of Toronto, Canada
Expanding the Druggable Space for USPs by Targeting Accessory Domains

Sammy Villa, University of California, USA
The OTUD6 Deubiquitinase Associates with the 40S Ribosome to Regulate Translation and the Response to Stressors in Drosophila

Alexa Nadine Wilson, Dalhousie University, Canada
Stressed Out: How a Herpesvirus E3 Ubiquitin Ligase Targets the Cellular Stress Response

Avraham Ashkenazi, Tel Aviv University, Israel
Regulation of the Ubiquitin-activating Enzyme UBA6 by Polyalanine Tracts in Health and Disease

Kevin Mark, University of California, Berkeley, USA
Ubiquitin-Dependent Control of Network Dynamics Shapes Gene Expression and Cell Identity

Elijah Mena, Brigham and Women's Hospital, USA
Mapping E3-substrate Interactions through Multiplex CRISPR Screening

16:30—17:00
Coffee Available

British/Columbia Foyer
17:00—19:00
Ubiquitin-Dependent Quality Control Mechanisms

British Ballroom
* Mikko Taipale, University of Toronto, Canada

Eric J. Bennett, University of California, San Diego, USA
Ribosome Associated Quality Control Mechanisms

Miguel A. Prado, Harvard Medical School - USA & ISPA-FINBA, Spain
Short Talk: Global Remodeling of the Proteome in Terminal Differentiation

Sonya Neal, University of California, San Diego, USA
Derlins Employ a Chaperone-like Function for Resolving Misfolded Membrane Protein Stress

Olivia Rissland, University of Colorado School of Medicine, USA
Short Talk: Clearance of Maternal Proteins during Early Embryogenesis

Susan Shao, Harvard Medical School, USA
Mechanisms of Ribosome-Associated Protein Degradation

17:00—19:00
Novel Approaches to Protein Degradation/Homeostasis for Therapeutics

Columbia Ballroom
* Eric S. Fischer, Dana-Farber Cancer Institute, USA
How Structural Biology will Transform Targeted Protein Degradation?

Hannah B L Jones, University of Oxford, UK
Cell Based High-throughput Screening of DUB Inhibitors using Activity-based Probe Profiling (ABPP-HT)

Erika Maria Lopez-Alfonzo, University of California, Berkeley, USA
Mechanistic Dissection of Functional Asymmetries in the Proteasomal AAA+ Motor Using smFRET

Pranam Chatterjee, Duke University, USA
Short Talk: Design of Peptide-Guided Protein Degraders via Contrastive Deep Learning

19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Pacific Ballroom
19:30—22:00
Poster Session 2

Pacific Ballroom

WEDNESDAY, NOVEMBER 9

07:00—08:00
Breakfast

Pacific Ballroom
08:00—11:00
New Paradigms in Protein Ubiquitylation

British Ballroom
* Susan Shao, Harvard Medical School, USA
Session Chair

Satpal Virdee, University of Dundee, UK
Non-lysine Ubiquitination and Deubiquitination

Joshua L. Andersen, Brigham Young University, USA
Short Talk: TNK1 is a Ubiquitin-sensing Kinase that can be Targeted to Block Tumor Growth

Luis Gerardo Villa-Diaz, Oakland University, USA
Short Talk: Enhanced Ubiquitin Pathway Regulation in Human Pluripotent Stem Cells Cultured in Microgravity Conditions

Coffee Break

Heran Darwin, New York University School of Medicine, USA
Regulating Pup-dependent Degradation: Work in Progress

Emily Troemel, University of California, San Diego, USA
Ubiquitin Signaling within the Intracellular Pathogen Response Pathway

08:00—11:00
Novel Approaches to the Development and Discovery of Molecular Glues

Columbia Ballroom
* Anita K. Gandhi, Bristol-Myers Squibb, USA
Emerging CELMoDs in Hematological Malignancies

Georg E. Winter, CeMM Research Center for Molecular Medicine, Austria
Chemical Genomics Approaches to Targeted Protein Degradation

Coffee Break

Ekaterina Vinogradova, Rockefeller University, USA
Covalent Small-Molecule Protein Degraders

Zuzanna Kozicka, Friedrich Miescher Institute for Biomedical Research, Switzerland
Short Talk: Molecular Glue Degraders of Cyclin K and the Emerging Rules for Molecular Glue Design

Carles Galdeano, University of Barcelona, Spain
Short Talk: Expanding the Toolbox of E3 Ligases with Structure-based Approaches

11:00—17:00
On Own for Lunch

16:30—17:00
Coffee Available

British/Columbia Foyer
17:00—18:45
Ubiquitin System Dysregulation in Disease

British Ballroom
* Sonya Neal, University of California, San Diego, USA
Session Chair

Achim Werner, NIDCR, National Institutes of Health, USA
Dissecting Ubiquitin-dependent Cell-fate Decisions through Human Diseases

Lu Barnsby-Greer, University of Dundee, UK
Short Talk: An Atypical E3 Ligase Module in UBR4 Mediates Destabilization of N-degron Substrates

Judith Dönig, Goethe University Frankfurt, University Hospital, Germany
Short Talk: Characterization of Nucleolar SUMO Isopeptidases Unveils a p53-independent Checkpoint of Impaired Ribosome Biogenesis

Varvara Folimonova, NIH, USA
Short Talk: Structural Studies and Optimization of CAR Hinge Regions

Christina Liem, University of California, San Diego, USA
Short Talk: Mallosteric Control of the Sterol Pathway by GGPP, a Natural Monovalent Degrader

Mikolaj Slabicki, Dana-Farber Cancer Institute, USA
Short Talk: The Human E3 Ligase RNF185 is a Regulator of the SARS-CoV-2 Envelope Protein

17:00—18:45
Methodologies and Technologies for the Investigation of Protein Degradation

Columbia Ballroom
* Georg E. Winter, CeMM Research Center for Molecular Medicine, Austria

Rajesh Chopra, Apple Tree Partners, USA
Phenotypic Screens for Identifying Modulators of E3 Ligase Function

Christian Dillon, PhoreMost Ltd., UK
Discovery of Novel Degraders for TPD Applications Utilising PROTEINi®-based Functional Screening

Yuehan Feng, Biognosys AG, Switzerland
Expanding the Mass Spectrometry-based Proteomics Toolbox for TPD Development from Early Discovery to the Clinics

Kirill Bersuker, Calico, USA
Short Talk: PROTAC-induced Degradation of Plasma Membrane Proteins is Mediated by the Endolysosomal System

18:45—19:00
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)

British Ballroom
18:45—19:00
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)

Columbia Ballroom
19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Pacific Ballroom

THURSDAY, NOVEMBER 10

 
Departure


*Session Chair †Invited, not yet responded.



Keystone Symposia thanks our Sponsors(s) for generously supporting this meeting:

Astellas Pharma Inc. Chinese Society for Cell Biology, (Cell Research)
Genentech, Inc.
 

We gratefully acknowledge additional support for this conference from:

AdipoGen Life Sciences Science Signaling / AAAS

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