Keystone Symposia

This meeting took place in 2010

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Tolerance and Autoimmunity (B7)

Organizer(s) Betty Diamond and Diane J. Mathis
February 21—26, 2010
Taos Convention Center (meeting only) • Taos, New Mexico USA
Abstract Deadline: Oct 21, 2009
Late Abstract Deadline: Nov 20, 2009
Scholarship Deadline: Oct 21, 2009
Early Registration Deadline: Dec 21, 2009

Sponsored by Novo Nordisk A/S

Summary of Meeting:
Elegant studies of central T and B cell tolerance have been performed, leading to the identification of multiple mechanisms that remove or silence autoreactive cells during their maturation, but also reminding us that some autoreactive cells do mature to immunocompetence in all individuals. Furthermore, studies of the B cell response to antigen have clearly demonstrated that autoreactivity can arise de novo in antigen-activated cells, which also requires silencing. Finally, it has now been established in studies of multiple autoimmune diseases that a critical checkpoint exists between autoreactivity and tissue injury, one of the issues about which we remain most ignorant. Understanding peripheral mechanisms for maintaining self-tolerance offers promise for better therapies for autoimmune disease. The proper implementation of this new knowledge requires an understanding of similarities and differences between animal models and human disease. Specific Issues: • Translating results from studies of animal models to human studies • Peripheral and central tolerance • T cells and B cells • The relationship between autoimmunity and immunodeficiency • The role of dendritic cells in autoimmunity • What dictates generation of autoreactive antibody in one individual and not in another? • How much autoreactivity must occur in order to progress to disease and what governs this? • What exactly is "pathogenic autoreactivity", i.e, are all investigators talking about the same thing? • How much of pathogenesis is due to autoreacting antibodies per se versus the tissue's response to antibody? • What role is innate immunity playing in all of this?

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Scholarship / Award Information

Scholarship Deadline: October 21, 2009 (11:59 PM US Mountain Standard Time)
*All deadlines end at 11:59 PM US Mountain Standard Time
NOTE: Please use the button above to Apply for a Scholarship


Keystone Symposia is offering scholarships of up to 1,200 USD to Students and Postdoctoral fellows. These scholarships are to be used to help defray the expenses associated with conference attendance, including airfare (restrictions may apply based on funding source), ground transportation, lodging costs, and a portion of meeting registration. Receipts will be required to receive reimbursement.

Abstracts submitted for poster presentation will be used as the basis for awarding the scholarships. Scholarship recipients will be selected based on the quality of science of the abstract and the relevance of the abstract to the conference topic. Only one application per abstract is accepted. Only one award per lab will be allocated.


To be eligible for a scholarship, you must be:

A graduate student or postdoctoral fellow currently enrolled in an academic institute at the start of the meeting for which you are applying. Note: a graduate student is defined as a student who is studying for a higher degree at an academic institution. A postdoctoral fellow is defined as an individual with a Ph.D., M.D., or DVM degree who is engaged in a temporary period of mentored research and/or scholarly training for the purpose of acquiring the professional skills needed to pursue their desired career path, and is within 6 years of these degrees.

Review Criteria

Criteria for Abstract Review:

  1. Relevance to the meeting topic
  2. Significance of the scientific question and results
  3. Style
    • Organization (e.g. the abstract has a clear beginning, middle and end)
    • Grammar and spelling
  4. Clarity of scientific presentations
    • Clear question or hypothesis
    • Sufficient background
    • The experimental approach and rationale for the approach are clear
    • The results are clearly presented
    • The interpretation and conclusions are reasonable and logical

Application Process

If you are eligible and wish to be considered for a scholarship, you should complete all of the following by the scholarship deadline for the meeting you wish to attend. It is recommended you begin these steps in advance of the deadline date to ensure completion.

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