Keystone Symposia

This meeting took place in 2011

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The Evolution of Protein Phosphorylation (F1)

Organizer(s) Tony Hunter and Tony Pawson
January 23—28, 2011
Keystone Resort • Keystone, CO USA
Abstract Deadline: Sep 27, 2010
Late Abstract Deadline: Oct 28, 2010
Scholarship Deadline: Sep 27, 2010
Early Registration Deadline: Nov 29, 2010

Supported by the Directors' Fund

Summary of Meeting:
Major progress has been made in defining the basis of signaling in eukaryotic cells both with respect to the function and structure of protein modules that are involved in signaling and how these proteins are organized into pathways and networks that are used to regulate cellular responses to extracellular and intracellular stimuli. Through intensive studies over the past 40 years protein phosphorylation has become one of the best understood signaling mechanisms. Most of what has been learned has been derived from studies of a few model organisms, which have taught us that several major signal transduction pathways are conserved in evolution. The recent flood of new eukaryotic genome sequences has engendered significant interest in understanding the evolution of the protein kinases and phosphatases and other signaling proteins involved in protein phosphorylation (e.g. where did tyrosine kinases come from?). In addition, the explosion of phosphoproteomic data from multiple organisms (including prokaryotes) indicates that the majority of proteins in the cell may be phosphorylated, leading to questions such as whether all the detected phosphorylation events are functional, and how this can be addressed, especially for highly phosphorylated proteins. Our increasingly systems-based understanding of the genes involved in phosphorylation signaling and the identification of the full spectrum of proteins that are reversibly phosphorylated now makes it possible to ask to what extent phosphorylation of specific sites or regions is conserved during evolution, which may provide important functional insights. In addition to these topics, the meeting will cover the evolution of protein kinases and phosphatases and key signaling modules, such as the SH2 and SH3 domains, and the evolution of protein phosphorylation in prokaryotes and plants and how their systems differ from those in animals. A number of other topics, such as the functional conservation of orthologous proteins involved in phosphorylation, whether phosphorylation network architecture has been conserved, and the evolutionary function of conserved pseudokinases, will be discussed. Clearly for this topic it is particularly important to have as broad a representation as possible from the different areas of protein phosphorylation, we have selected speakers working on a wide range of eukaryotic and prokaryotic organisms in order to emphasize the evolution and conservation of protein phosphorylation.

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Scholarship / Award Information

Scholarship Deadline: September 27, 2010 (11:59 PM US Mountain Standard Time)
*All deadlines end at 11:59 PM US Mountain Standard Time
NOTE: Please use the button above to Apply for a Scholarship


Keystone Symposia is offering scholarships of up to 1,200 USD to Students and Postdoctoral fellows. These scholarships are to be used to help defray the expenses associated with conference attendance, including airfare (restrictions may apply based on funding source), ground transportation, lodging costs, and a portion of meeting registration. Receipts will be required to receive reimbursement.

Abstracts submitted for poster presentation will be used as the basis for awarding the scholarships. Scholarship recipients will be selected based on the quality of science of the abstract and the relevance of the abstract to the conference topic. Only one application per abstract is accepted. Only one award per lab will be allocated.


To be eligible for a scholarship, you must be:

A graduate student or postdoctoral fellow currently enrolled in an academic institute at the start of the meeting for which you are applying. Note: a graduate student is defined as a student who is studying for a higher degree at an academic institution. A postdoctoral fellow is defined as an individual with a Ph.D., M.D., or DVM degree who is engaged in a temporary period of mentored research and/or scholarly training for the purpose of acquiring the professional skills needed to pursue their desired career path, and is within 6 years of these degrees.

Review Criteria

Criteria for Abstract Review:

  1. Relevance to the meeting topic
  2. Significance of the scientific question and results
  3. Style
    • Organization (e.g. the abstract has a clear beginning, middle and end)
    • Grammar and spelling
  4. Clarity of scientific presentations
    • Clear question or hypothesis
    • Sufficient background
    • The experimental approach and rationale for the approach are clear
    • The results are clearly presented
    • The interpretation and conclusions are reasonable and logical

Application Process

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