Keystone Symposia

This meeting took place in 2012

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Sirtuins in Metabolism, Aging and Disease (B2)

Organizer(s) Aleksey G. Kazantsev, Antonello Mai and Tiago Fleming Outeiro
February 12—16, 2012
Granlibakken Tahoe • Tahoe City, CA USA
Abstract Deadline: Oct 12, 2011
Late Abstract Deadline: Nov 11, 2011
Scholarship Deadline: Oct 12, 2011
Early Registration Deadline: Dec 12, 2011

Supported by the Directors' Fund

Summary of Meeting:
Sirtuins comprise a unique class of NAD+-dependent enzymes that modify multiple protein substrates to execute diverse biological functions. Sirtuins are key regulators of clinically important cellular and organismal processes including metabolism, cell division and aging. The desire to understand the important determinants of human health and lifespan has resulted in a firestorm of work on the seven mammalian sirtuins in the past decade. The implication of sirtuins in medically important areas such as diabetes, cancer, cardiovascular dysfunction and neurodegenerative disease has catapulted them to a prominent status as potential targets for nutritional and therapeutic development. The Keystone Symposia meeting on Sirtuins in Metabolism, Aging and Disease will address fundamental questions on the regulation, biochemical, molecular and cellular mechanisms and pathways of sirtuins. The significance of sirtuin-dependent regulation of homeostasis with respect to diverse biological organisms will be discussed. We envision that this meeting will evaluate the relevance of sirtuin biology in various human conditions, and provide a unique environment for discussing specific therapeutic strategies.

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Keystone Symposia Future of Science Fund Scholarship Recipients

Hanna Artsi
Hadassah Ein Kerem, Israel

National Institute of General Medical Sciences (NIGMS) Ancillary Training Program Scholarship Recipients

Cecilia G. Sanchez
Tulane University, USA

National Institute on Aging (NIA)/National Institute of Neurological Disorders and Stroke (NINDS) Scholarship Recipients

Yana Cen
University of Texas Medical Branch, USA

Antonella Di Domenico
Institute for Genetics, Germany

John E. Dominy
Dana Farber Cancer Institute, USA

Rita Machado de Oliveira
Instituto de Medicina Molecular, Portugal

Yana V. Miteva
Princeton University, USA