Keystone Symposia

This meeting took place in 2012



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Innate Immunity: Sensing the Microbes and Damage Signals (Q7)


Organizer(s) Gabriel Nuñez and Akiko Iwasaki
March 4—9, 2012
Keystone Resort • Keystone, CO USA
Abstract Deadline: Nov 3, 2011
Late Abstract Deadline: Dec 8, 2011
Scholarship Deadline: Nov 3, 2011
Early Registration Deadline: Jan 5, 2012

Sponsored by Gilead Sciences, Inc. Supported by an educational donation provided by Amgen.

Joint Meeting: The Microbiome (Q8)

Summary of Meeting:
In recent years there have been major advances in our understanding of the mechanisms that are involved in the recognition of microbes and subsequent activation of host immune defenses. Several classes of membrane-bound and cytosolic pattern recognition receptors (PRRs) have been identified and partially characterized. These include the Toll-like receptors (TLRs), NOD-like receptors (NLRs) and RIG-I-like receptors (RLRs). Activation of PRRs leads to the production of a large array of pro-inflammatory and anti-microbial molecules that are critical for the elimination of invading pathogens, and activation of adaptive immune responses. A class of cytosolic PRRs is involved in the assembly of the inflammasome, a molecular platform that mediates activation of caspase-1 and secretion of mature IL-1beta and IL-18. Importantly, activation of the inflammasome is also induced by non-microbial mechanisms including endogenous molecules involved in the pathogenesis of metabolic and inflammatory diseases. In addition, there is evidence that autophagy, a cellular process that mediates recycling of intracellular components, is involved in microbial recognition and plays a key role in host defense. The initial sensing of microbes often occurs at mucosal surfaces, but the interplay between recognition of commensal vs. pathogenic microbes on the host immune system is only beginning to be uncovered. The goal of the Keystone Symposia meeting on Innate Immunity: Sensing the Microbes and Damage Signals is to gather scientists working on innate immunity to discuss cutting edge research on the mechanisms that regulate the activation of the immune system by microbes as well as by endogenous damage signals, and to integrate such knowledge in the context of inflammation, homeostasis, host defense, and disease. Opportunities for interdisciplinary interactions will be significantly enhanced by the concurrent meeting on The Microbiome, which will share a keynote address and three plenary sessions with this meeting.

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Scholarships/Awards


Early Career Investigator Travel Award Recipients
made possible by National Institute for General Medical Sciences (NIGMS) Ancillary Training Program Funding


Jonathan A. Deane
Genomics Institute of the Novartis Research Foundation, USA

Maria Antonieta Guerrero-Plata
Louisiana State University, USA

David J. Vigerust
MyGenetx Clinical Labs, USA

Keystone Symposia Future of Science Fund Scholarship Recipients


Gretchen E. Diehl
Baylor College of Medicine, USA

Fabianno F. Dutra
Universidade Federal do Rio de Janei, Institute of Microbiology, Brazil

Aaron R. Everitt
Wellcome Trust Sanger Institute, UK

Yayoi Izu
Pennsylvania State University, Milton S. Hershey College of Medicine, USA

Gerard E. Kaiko
University of Newcastle, Australia

Adriana R. Mantegazza
Children's Hospital of Philadelphia, USA

Maulik Patel
Vanderbilt University, USA

Naeha Subramanian
Institute for Systems Biology, USA

National Institute of General Medical Sciences (NIGMS) Ancillary Training Program Scholarship Recipients


Devyn D. Gillette
Ohio State University, USA

Crystal L. Jones
Emory University, USA

Marvin A. Lai
University of Washington, USA

Ngozi Monu
New York University, USA

Crystal Morales
Medical University of South Carolina, USA

Marisela Rodriguez
Washington University in St. Louis, USA

National Institute of Allergy and Infectious Diseases (NIAID)/National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) Scholarship Recipients


Simone A. Beckham
Monash University, Australia

Amanda Mercedes Jamieson
Max F. Perutz Laboratories, University of Vienna, Austria

Stefanie Kirchberger
University of Oxford, UK

Matthew T. Sorbara
University of Toronto, Canada

Ty D. Troutman
University of California, San Diego, USA

Jakob H. von Moltke
University of Washington, USA

Haitao Wen
University of North Carolina at Chapel Hill, USA