Keystone Symposia

This meeting took place in 2012

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Mutations, Malignancy and Memory - Antibodies and Immunity (C6)

Organizer(s) F. Nina Papavasiliou and Sebastian D. Fugmann
March 18—22, 2012
Boston Park Plaza • Boston, MA USA
Abstract Deadline: Nov 15, 2011
Late Abstract Deadline: Dec 15, 2011
Scholarship Deadline: Nov 15, 2011
Early Registration Deadline: Jan 17, 2012

Supported by an educational donation provided by Amgen

Summary of Meeting:
Mutations in the human genome are regarded as potentially disastrous events that lead to carcinogenesis. From the vantage point of B cell immunology, however, programmed DNA alterations at the antibody gene loci are essential for efficient antibody responses. A plethora of recent findings are beginning to illuminate open questions about the precise molecular mechanisms of these diversification processes, their regulation, and how errors in these pathways lead to cancer. Furthermore, the very same class of mutator enzymes plays an underappreciated role in non-lymphoid cancers, in antiviral responses and in epigenetic reprogramming. Antibody diversification not only shapes the repertoires of the immunological memory, but also those of auto-antibodies. The Keystone Symposia meeting on Mutations, Malignancy and Memory – Antibodies and Immunity will provide both a platform to integrate these more or less isolated fields and an opportunity to identify interfaces that could be relevant for therapeutic approaches in malignancies and autoimmune diseases.

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Keystone Symposia Future of Science Fund Scholarship Recipients

Sau Kuen Lee
Australia National University, Australia

Cesare Sala
Istituto Toscano Tumori, Italy

National Institute of Allergy and Infectious Diseases (NIAID) Scholarship Recipients

Klaus Fortschegger
St. Anna Kinderkrebsforschung, Austria

Sébastien Landry
The Salk Institute, USA

Denise P. Muñoz
Children's Hospital Oakland Research Institute, USA

Christopher Nabel
Perelman School of Medicine, University of Pennsylvania, USA