Keystone Symposia

This meeting took place in 2012

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Advances in Islet Biology (C8)

Organizer(s) Lori Sussel, Jorge Ferrer and Andrew F. Stewart
March 25—30, 2012
Portola Hotel & Spa • Monterey, CA USA
Abstract Deadline: Nov 22, 2011
Late Abstract Deadline: Jan 3, 2012
Scholarship Deadline: Nov 22, 2011
Early Registration Deadline: Jan 25, 2012

Sponsored by Merck & Co., Inc. and Sanofi US

Summary of Meeting:
During the past 10 to 15 years, there has been significant progress in our understanding of pancreatic islet development and islet biology. This knowledge has been complemented and accelerated by major advances in diverse fields including islet transplantation, stem cells, small molecule screening, high-throughput sequencing, epigenetics and human genetics. The integration of these divergent disciplines has allowed us to develop a clearer definition of a functional b cell and has elucidated many of the mechanisms underlying the differentiation, survival and death of the b cell. Furthermore, these studies have revealed the potential to generate new b cells through replication or neogenesis. Improvements in differentiation and transdifferentiation protocols have also illustrated the potential of using stem cells and some somatic cell types as sources of islet cells, but these studies have also revealed the challenges associated with generating functional b cells. The purpose of this Keystone Symposia meeting is to highlight the areas of islet biology that have seen the most remarkable advances and to address some of the controversies that still exist in the field, especially with regards to the generation and maintenance of functionally mature b cells for therapeutic purposes. In addition, where it is possible, comparative mouse and human studies will be discussed to illustrate if and when mouse studies can be applied to the human situation.

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National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)/National Institute on Aging (NIA) Scholarship Recipients

Olov Andersson
Karolinska Institutet, Sweden

Diego Balboa
Centre for Genomic Regulation, Spain

Brett K. Baumgartner
University of Utah, USA

Benjamin Neal Ediger
University of Pennsylvania, USA

Rachel E. Jennings
University of Manchester, UK

Tomas Koblas
Institute of Clinical and Experimental Medicine, Czech Republic

Bryan O'Sullivan-Murphy
Fumi Urano/LRB-522 - University of Massachusetts Medical School, USA

Fong Cheng Pan
Vanderbilt University Medical Center, USA

Anica Schraenen
KU Leuven, Belgium

Hung Ping Shih
City of Hope, Diabetes & Metabolism Research Institute, USA

Risheng Ye
University of Texas Southwestern Medical Center, USA

Jia Zhang
University of Pennsylvania, USA

The Barrie Hesp Scholarship on behalf of Ashley Rebecca Cukier Scholarship Recipients

Sara Cervantes
August Pi i Sunyer Biomedical Research Institute (IDIBAPS), Spain

Candy Hsin-Hua Cho
University of Cambridge, UK

Vishal Parekh
UmeƄ Center for Molecular Medicine, Sweden