Keystone Symposia

This meeting took place in 2013

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The Hippo Tumor Suppressor Network: From Organ Size Control to Stem Cells and Cancer (E2)

Organizer(s) Marius Sudol, Helen McNeill, Georg A. Halder and Giovanni Blandino
May 19—23, 2013
Hyatt Regency Monterey • Monterey, CA USA
Abstract Deadline: Jan 17, 2013
Late Abstract Deadline: Feb 18, 2013
Scholarship Deadline: Jan 17, 2013
Early Registration Deadline: Mar 19, 2013

Supported by the Directors' Fund

Summary of Meeting:
Over the past several years, the Hippo tumor suppressor pathway has emerged as a complex signaling network that has significant implications for our understanding of the molecular mechanisms of cancer development and stem cell biology. The main effectors of this pathway, YAP and TAZ, are transcriptional co- activators, which act as stemness factors and potent oncogenes. Recent studies have revealed that abnormal expression of components of the network can lead to cancer. Therefore, the pathway and its networking molecules are attractive targets for the development of cancer drugs and unconventional therapeutic interventions. Several paradoxes have emerged in the field in recent years, and fast progress in this field is due, in large part, to an active dialog between Drosophila geneticists and mammalian signalers. The overwhelming interest of researchers in the function of the Hippo pathway in stem cells and cancer prompted us to seek a larger forum. At the Keystone Symposia meeting on The Hippo Tumor Suppressor Network we aim to: (i) Define why YAP and TAZ function as either oncogenes or tumor suppressors; (ii) Identify membrane complexes, which activate the Hippo pathway in mammals, as the orthology with the fly receptors is not clear; (iii) Define targets for small molecule inhibitors and activators within pathway components based on structured modules, including WW, PDZ and SARAH domains. The meeting will be unique in bringing together Drosophila geneticists, basic and clinical cancer researchers, and the stem cell research community. We anticipate that this meeting will help to consolidate the emerging field and have an impact on development of new cancer therapies.

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Keystone Symposia Future of Science Fund Scholarship Recipients

Jacob J. Adler
Indiana University School of Medicine, USA

Maryam Jahanshahi
Icahn School of Medicine at Mount Sinai, USA

Diane D. Shao
Harvard Medical School, USA

National Cancer Institute (NCI) Scholarship Recipients

Samantha E. Hiemer
Rheos Medicines, USA

Jeffrey Schindler
Massachusetts Institute of Technology, USA