Keystone Symposia

This meeting took place in 2014

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Chromatin Mechanisms and Cell Physiology (C5)

Organizer(s) Thomas Jenuwein and Shelley L. Berger
March 23—28, 2014
Oberstdorf Haus • Oberstdorf, Germany
Discounted Abstract Deadline: Nov 20, 2013
Abstract Deadline: Dec 19, 2013
Scholarship Deadline: Nov 20, 2013
Discounted Registration Deadline: Jan 22, 2014

Sponsored by Bayer HealthCare Pharmaceuticals, Constellation Pharmaceuticals and the German Ministry of Education and Research (BMBF).

Summary of Meeting:
Chromatin is the physiological form of DNA in eukaryotic cells and thus serves as a template for many basic DNA related processes (e.g., transcription, repair, replication, recombination). Dynamic changes in chromatin structure are essential for the organization and utilization of our genetic information and are mediated by epigenetic mechanisms such as histone/DNA modifications, non-coding RNAs and chromatin remodeling. The establishment, maintenance and plasticity of distinct chromatin states are crucial for embryonic development, cell differentiation and cell type identity, as well as allowing response to environmental cues such as hormones, stress or nutrients. Chromatin dysfunction also significantly contributes to cell transformation and perturbed development. This Keystone meeting will highlight novel findings in mechanisms of dynamic chromatin regulation and their translation into cellular physiology. In particular, we will focus on four fundamental chromatin processes (RNA regulation, transcription and remodeling, DNA damage and repair, DNA replication) in conjunction with normal and perturbed cellular states (cell fate, signal response, cell transformation, epigenetic inheritance). Sessions feature basic and applied research in model systems ranging from plants to fungi to mammals. This open and inclusive program should generate intense discussions, interesting synergies and a strong bridge connecting basic chromatin research with cellular physiology. This link is beneficial to further explore the dynamic (mis)-regulation of chromatin-based processes in medically relevant research fields investigating complex human disorders or stem cell therapy.

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Keystone Symposia Future of Science Fund Scholarship Recipients

Federica Federici
Erasmus MC, Netherlands

Jack S. Hsiao
Coriell Institute for Medical Research, USA

German Ministry of Education and Research (BMBF) Scholarship Recipients

Kristina Ivanauskiene
Oslo University Hospital, Norway

Papita Mandal
Indian Institute of Science Education and Research, India

Anna T. Rolicka
University of Warsaw, Poland

The Elkes Foundation Scholarship Recipients

Kathryn E. Malecek
Whitehead Institute, USA