Keystone Symposia

This meeting took place in 2013

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New Frontiers in Neurodegenerative Disease Research (J8)

Organizer(s) Li-Huei Tsai, Steven M. Paul and Michael Hutton
February 3—8, 2013
Santa Fe Community Convention Center • Santa Fe, NM USA
Abstract Deadline: Oct 4, 2012
Late Abstract Deadline: Nov 1, 2012
Scholarship Deadline: Oct 4, 2012
Early Registration Deadline: Dec 4, 2012

Sponsored by Janssen R&D, Pharmaceutical Companies of Johnson & Johnson, Takeda Pharmaceutical Company Limited and Vertex Pharmaceuticals Incorporated. Supported by an educational donation provided by Amgen.

Joint Meeting: Neurogenesis (J7)

Summary of Meeting:
It has been more than two decades since genes causing familial Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, motor neuron disease and other neurodegenerative disorders were identified. While numerous molecular and cellular events contributing to these devastating illnesses have been revealed, key pathological events and feasible targets for therapeutic intervention still elude us. Increasing evidence supports that mechanisms underlying neuronal demise may be shared amongst multiple neurodegenerative disorders. For example, compromised mitochondria function, although prominent in Parkinson’s disease, is also shared in Alzheimer’s and amyotrophic lateral sclerosis. Emerging evidence also indicates a negative influence of neurotoxic stress upon the epigenome, and that the restoration of the epigenome can be beneficial for cognition. Recent insights into the relationship between genome integrity and the aging brain have emphasized the role of DNA damage and repair in neuronal function. Particularly intriguing are the recent observations that protein misfolding can have either beneficial or detrimental effects and that misfolded proteins implicated in several neurodegenerative disease can propagate themselves. New tools for the study of neurodegenerative disorders include the use of human neurons derived from induced pluripotent stem cells (iPSCs) in addition to advances in the field of biomarkers and functional imaging. This meeting aims to address emerging areas in neurodegenerative disease research that may reveal novel mechanisms and targets for therapeutic intervention. It bring together experts studying various degenerative diseases using diverse approaches to provide reviews of up-and-coming areas in these fields and inspire new insights and approaches to the battle against neurodegenerative disease. Opportunities for interdisciplinary interactions will be significantly enhanced by the concurrent meeting on Neurogenesis, which will share two plenary sessions with this meeting.

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Keystone Symposia Future of Science Fund Scholarship Recipients

Amarallys Cintron
Emory University, USA

Héctor José De Jesús-Cortés
University of Texas Southwestern Medical Center, USA

Edwin F. Vazquez-Rosa
Case Western Reserve University, USA

National Institute of Neurological Disorders and Stroke (NINDS)/National Institute on Aging (NIA) Scholarship Recipients

Liviu Aron
Harvard Medical School, USA

Nadine Brehm
University Clinic Frankfurt, Germany

Elena Fusar Poli
Fondazione IRCCS Istituto Nazionale dei Tumori, Italy

Yves Maury

Christina Muratore
Harvard Institutes of Medicine, USA

Jeehye Park
SickKids Research Institute, Canada

Tassa Saldi
University of Colorado, USA

Mazell Tetruashvily
Princeton University, USA