Keystone Symposia

This meeting took place in 2014

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Tissue-Resident Memory T Cells (A4)

Organizer(s) Cornelia L. Trimble, Rachael A. Clark, Leo Lefran├žois (in memoriam) and David Masopust
January 12—16, 2014
Snowbird Resort • Snowbird, UT USA
Discounted Abstract Deadline: Oct 3, 2013
Abstract Deadline: Oct 28, 2013
Scholarship Deadline: Oct 3, 2013
Discounted Registration Deadline: Nov 13, 2013

Sponsored by BioLegend, Inc. Supported by an educational donation provided by Amgen.

Summary of Meeting:
Infections that are encountered through epithelial barrier tissues such as the skin, gut, lung and genitourinary tract generate a population of tissue-resident T cells that remain sessile long-term in the affected tissue, and are protective against re-infection. Indeed, most effector memory T cells reside in non-sterile barrier epithelial tissues, as opposed to the circulation. While tissue-resident T cells play a critical role in defending against infections and cancer, aberrant activation of these cells gives rise to inflammatory and autoimmune conditions, including psoriasis, multiple sclerosis and inflammatory bowel disease. Tissue-resident T cells are not simply T cells in an unexpected location; these cells have many phenotypic and functional differences that distinguish them from circulating T cells. This conference will bring together basic and translational immunologists to discuss tissue-localized mechanisms of immune cell recruitment, retention, activation and homeostasis. The major objectives will be to: 1) Explore the roles that tissue immune cells play in immune surveillance, including recall responses to infectious pathogens, and mechanisms of dysregulation leading to autoimmune disease; 2) Examine the mechanisms by which immune responses can be shaped by the local tissue microbiome; 3) Investigate the mechanisms by which immune responses can be subverted by chronic infections or early neoplastic lesions; and 4) Discuss the rationale for immunotherapeutic strategies targeting specific tissue sites. A better understanding of the biology of tissue-resident T cells will inform vaccination strategies for both infections and cancer, as well as novel therapies for inflammatory and autoimmune diseases.

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Early Career Investigator Travel Award Recipients

Gislaine A. Martins
Cedars-Sinai IBIRI, USA

Mucosal Immunology Studies Team (MIST) scholarships in memory of Dr. Leo LeFrancois Scholarship Recipients

Norifumi Iijima
Yale University School of Medicine, USA

Tyler A. Landrith
University of California, Riverside, USA

National Institute of General Medical Sciences (NIGMS) Ancillary Training Program Scholarship Recipients

Pablo A. Romagnoli
University of Connecticut Health Center, USA

Damian L. Turner
Columbia University Medical Center, USA

National Institute of Allergy and Infectious Diseases (NIAID) Scholarship Recipients

Nelson Glennie
University of Pennsylvania, USA

Shruti Naik
New York University, USA

Shalini Sharma
St. Jude Children's Research Hospital, USA

Corinne J. Smith
Thomas Jefferson University, USA

Georg Stary
Harvard Medical School, USA