Keystone Symposia

This meeting took place in 2015



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Hybrid Methods in Structural Biology (C2)


Organizer(s) Jens Meiler, Patrick Cramer and Ron A. Milligan
March 4—8, 2015
Granlibakken Tahoe • Tahoe City, CA USA
Discounted Abstract Deadline: Nov 6, 2014
Abstract Deadline: Dec 9, 2014
Scholarship Deadline: Nov 6, 2014
Discounted Registration Deadline: Jan 8, 2015

Sponsored by Vertex Pharmaceuticals Incorporated

Summary of Meeting:
As we study the structure and dynamics of more and more complex systems to better understand their biological function, each individual technology in the structural biology toolbox approaches its limitations. These limitations include size of the system, timeline of motions, spatial and/or temporal resolution and ensemble averaging. Further, each individual method perturbs the system in a different way to enable or facilitate its analysis. This includes, for example, the introduction of spin labels to perform EPR experiments, the reconstitution of membrane proteins in micelles for NMR spectroscopy, the introduction of entire domains to stabilize proteins in certain conformations for crystallization, or a simplified force field in computation. As systems become more challenging, the perturbations tend to get more drastic, complicating the interpretation of results. Only at the intersection of several techniques does it become possible to distinguish information that is biologically relevant from perturbations introduced by any individual approach. Moving forward, hybrid methods and integrated methods in structural biology play a key role in studying complex systems verifying each other’s results. The objective of this Keystone Symposia meeting is two-fold: 1) To discuss novel and potentially disruptive technologies and/or combinations thereof to be added to the hybrid methods toolbox; and 2) To illustrate and discuss application of hybrid methods to important biological systems. These objectives will be achieved through oral presentations, poster sessions, discussions in panel format and tutorial sessions introducing new software algorithms.

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Scholarships/Awards


National Institute of General Medical Sciences (NIGMS) Scholarship Recipients


Alexey Amunts
Stockholm University, Sweden

Melody G. Campbell
The Scripps Research Institute, USA

Matthew T. Eddy
University of Florida, USA

Seung Joong Kim
University of California, San Francisco, USA

Philip Lössl
Utrecht University, Netherlands