Keystone Symposia

This meeting took place in 2015

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Cell Biology of the Heart: Beyond the Myocyte-Centric View (X2)

Organizer(s) Peter Kohl, Robert G. Gourdie and Stefanie Dimmeler
March 1—6, 2015
Copper Mountain Resort • Copper Mountain, CO USA
Discounted Abstract Deadline: Nov 4, 2014
Abstract Deadline: Dec 3, 2014
Scholarship Deadline: Nov 4, 2014
Discounted Registration Deadline: Jan 6, 2015

Supported by the Directors' Fund

Summary of Meeting:
The heart is a muscle, and as such, much of the basic and applied research into cardiac structure and function has focused on cardiac myocytes. However, the majority of heart cells are non-myocytes. Prominent examples include cells comprising the coronary vasculature, fat, connective tissue (e.g., fibroblasts), nerves and immune cells. It has become increasingly clear that these cells are not merely bystanders of myocyte function, but active participants with important signaling roles that contribute to cardiac development, cell differentiation and function of the healthy and diseased heart. This Keystone Symposia meeting is unique, in that, for the first time, it brings together internationally-leading experts in the field of non-myocyte contributions to cardiac structure and function. It aims to address: 1) Roles of non-myocytes for cardiac cell fate determination and development; 2) Mechanisms of non-myocyte – myocyte signaling interactions; 3) Effects of these interactions in normal and diseased heart; and 4) Relevance of non-myocytes as targets for therapeutic interventions. Participants should leave this meeting with a more holistic understanding of the heart as a multi-cellular organ, and a broadened horizon to support their individual research. This is the first high-level symposium with an explicit focus on reviewing the current state of a new frontier of cardiac cell biology: non-myocyte roles in the development, regulation and adaptation of cardiac performance. The symposium should contribute to a paradigm shift that is taking place in the field, driven by the appreciation that a myocyte-centric view of the heart will always be limited in its ability to deliver the mechanistic understanding of cardiac structure and function that is required for improved predictive and therapeutic action.

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Keystone Symposia Future of Science Fund Scholarship Recipients

Burcu Duygu
Maastricht University, Netherlands

National Heart, Lung, and Blood Institute (NHLBI) Scholarship Recipients

Jan Fiedler
Hannover Medical School, Germany

Margaux A. Horn
University of Manchester, UK

Rugmani Iyer
University of Mississippi Medical Center, USA

Emily L. Ongstad
MedImmune, USA

Emily K. Pugach
University of Colorado, USA