Keystone Symposia

This meeting took place in 2015

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Mitochondria, Metabolism and Heart Failure (J5)

Organizer(s) Richard N. Kitsis, Gerald W. Dorn II and Rong Tian
January 27—February 1, 2015
Santa Fe Community Convention Center • Santa Fe, NM USA
Discounted Abstract Deadline: Oct 1, 2014
Abstract Deadline: Oct 28, 2014
Scholarship Deadline: Oct 1, 2014
Discounted Registration Deadline: Nov 25, 2014

Sponsored by Bayer HealthCare Pharmaceuticals and Takeda Pharmaceutical Company Limited. Supported by an educational donation provided by Amgen.

Summary of Meeting:
The most common causes of heart failure are coronary artery disease, high blood pressure and diabetes. Mitochondrial perturbations have been associated with heart failure itself, and with most of the other preceding risk factors. In some cases, mitochondrial dysfunction may play a causal role while in others mitochondria are a central target responsible for organ dysfunction. nderstanding mitochondrial pathophysiology and identifying ways to ameliorate mitochondrial dysfunction are critical to therapy for cardiovascular disease. Therefore, the overall objectives of this meeting are to: (1) Mechanistically connect the fundamental biology of metabolism and mitochondrial function with the pathogenesis of heart failure, a major cause of morbidity and mortality in the world; and (2) Increase basic understanding of metabolism and mitochondrial function using observations in cardiac muscle, a traditional platform for these studies. The ongoing convergence of the cardiac metabolism and mitochondrial biology fields provides a particularly cogent rationale for this meeting; moreover, large gaps of knowledge exist in this area such as the precise molecular signaling that connects metabolism and energy sensing with mitochondrial function, and the roles of basic mitochondrial processes (e.g., biogenesis, fission, fusion, mitophagy, maintenance of mitochondrial genome integrity) in metabolism and heart failure. These deficiencies in fundamentally important scientific knowledge and their clinical implications for a common and lethal disease confer exceptional significance on this conference. Opportunities for interdisciplinary interactions will be significantly enhanced by the concurrent meeting on “Diabetes and Metabolic Dysfunction,” which will share a keynote address and three plenary sessions.

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National Heart, Lung, and Blood Institute (NHLBI) Scholarship Recipients

Rebeca Acín Pérez
National Center of Cardiovascular Research, Spain

Edward T. Chouchani
Dana-Farber Cancer Institute, USA

Anja Karlstaedt
University of Texas Medical School at Houston, USA

Chi Fung Lee
University of Washington, USA

Ekaterina Legchenko
Hannover Medical School, Germany

Ruya Liu
University of Pittsburgh, USA

Yaxin Liu
SUNY Upstate Medical University, USA

Thomas Nicol
Medical Research Council, UK

The Barrie Hesp Scholarship on behalf of Ashley Rebecca Cukier Scholarship Recipients

Jason Karch
Cincinnati Children's Hospital Medical Center, USA