Keystone Symposia

This meeting took place in 2016

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Purinergic Signaling (J5)

Organizer(s) Joel Linden, Mark J. Smyth, Simon C. Robson and Kenneth A. Jacobson
January 24—28, 2016
Fairmont Hotel Vancouver • Vancouver, BC Canada
Discounted Abstract Deadline: Sep 29, 2015
Abstract Deadline: Oct 29, 2015
Scholarship Deadline: Sep 29, 2015
Discounted Registration Deadline: Nov 24, 2015

Sponsored by Bayer HealthCare Pharmaceuticals and Roche

Summary of Meeting:
Purines including ATP and adenosine play dual roles as intracellular mediators of metabolism and as critical extracellular signaling molecules, the latter via 19 purinergic receptors that control responses to stress and injury. This meeting will integrate rapidly emerging information about the regulation of purine release from cells (in vesicles and via channels and transporters); signaling via membrane-associated receptors (adenosine, P2X and P2Y) and extracellular metabolism (via CD73, CD39 and other ecto-enzymes); and new structural information that is facilitating drug discovery. These processes mediate tissue responses to a continual flux of signaling purines in the extracellular space that profoundly influence inflammatory diseases, tissue repair and immune function. A focus on the effects of hypoxia, metabolic stress and cytokines will fill gaps in our current knowledge of how these factors influence signaling during the evolution of acute and chronic inflammation. An understanding of how purinergic signals are dynamically regulated is needed to identify improved therapies, e.g., for cancer immunotherapy, since tumors exploit these pathways to avoid immune surveillance. Of particular interest is the growing realization that purinergic regulation controls remodeling of inflamed tissues and the functions of innate and adaptive immune cells, endothelial cells and platelets. The significance of extracellular purines in multiple tissues will be covered. The meeting should generate new mechanistic and therapeutic concepts. Prior meetings have defined the triad of purinergic "players" (channels, receptors and enzymes) generally in unstressed animals. The meeting will focus on the paradigm-shifting realization of dynamic purinergic regulation in the setting of disease progression.

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Keystone Symposia Future of Science Fund Scholarship Recipients

Miki Kamiyama
University of Tokyo, Japan

Arabella Young
QIMR Berghofer Medical Research Institute, Australia