Keystone Symposia

This meeting took place in 2016

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Cytokine JAK-STAT Signaling in Immunity and Disease (A2)

Organizer(s) Curt M. Horvath, John J. O'Shea and Stephanie S. Watowich
January 10—14, 2016
Sheraton Steamboat Resort • Steamboat Springs, Colorado USA
Discounted Abstract Deadline: Sep 21, 2015
Abstract Deadline: Oct 20, 2015
Scholarship Deadline: Sep 21, 2015
Discounted Registration Deadline: Nov 10, 2015

Sponsored by Incyte Corporation, Pfizer Inc. and Theravance Biopharma

Summary of Meeting:
Cytokines are important extracellular factors that direct a variety of biological responses in normal physiology and disease. Cytokine signaling is mediated in large part through four Janus kinase (JAK) proteins and seven Signal Transducer and Activator of Transcription (STAT) proteins, and these molecules intersect with a wide array of additional intracellular signals to drive significant global alterations in gene expression. Cytokine JAK-STAT pathways are intimately associated with innate and adaptive immunity, inflammation, stem cell and developmental biology, and diverse aspects of cancer biology. As JAK-STAT pathways produce both common and unique phenotypes critical for a vast range of biological phenomena, the basic understanding of how these signal transduction cascades are regulated, function and integrate with additional cellular responses has been continuously refined by discoveries of general and pathway-specific mechanisms. Furthermore, drug discovery efforts have produced small molecules targeting JAKs and STATs that are promising agents in clinical treatment of inflammation, arthritis and a variety of cancers. This meeting, coinciding with the 25th year of the discovery of JAK-STAT signaling, will couple invited speakers who have made significant contributions to allied disciplines with cytokine JAK-STAT veterans, with ample opportunities for short talks selected from submitted abstracts.

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First Time Meeting Travel Award Recipients

Joseph Larkin III
University of Florida, USA

Keystone Symposia Future of Science Fund Scholarship Recipients

Teresa D. Collins
University of Florida, USA

National Institute of Allergy and Infectious Diseases (NIAID) Scholarship Recipients

Jesse Balic
Hudson Institute of Medical Research, Australia

Christine Delgado
University of Colorado Anschutz Medical Campus, USA

Zachary C. Murphy
University of Rochester, USA

Tiphanie Vogel
Washington University in St. Louis, USA