Keystone Symposia

This meeting took place in 2016

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Nuclear Receptors: Full Throttle (J1)

Organizer(s) Carol A. Lange, Jennifer K. Richer and Karen E. Knudsen
January 10—14, 2016
Snowbird Resort • Snowbird, UT USA
Discounted Abstract Deadline: Sep 23, 2015
Abstract Deadline: Oct 22, 2015
Scholarship Deadline: Sep 23, 2015
Discounted Registration Deadline: Nov 12, 2015

Sponsored by Intercept Pharmaceuticals, Inc.

Summary of Meeting:
Nuclear receptors (NRs) represent a large superfamily of ligand-dependent transcription factor “sensors” for a diverse set of fat-soluble hormones, vitamins and dietary lipids. NRs orchestrate genetic response programs critical for normal homeostasis, and are required for reproduction, development, metabolism and immune function. For this reason, NRs have been investigated for over 30 years as promising targets for drugs to treat a broad spectrum of diseases including cancer, diabetes and other endocrine or metabolic disorders, obesity, cardiovascular disease, hypertension, inflammation and cholestasis. Research on NRs has led to numerous successful therapies for deadly diseases that have improved both longevity and quality of life. However, significant hurdles remain that involve further detailed understanding of the major gene regulatory networks regulated by NRs, how these differ in normal relative to pre-disease and disease states, and the complex problems associated with targeting tissue-specific effects (to reduce side effects) and circumventing mechanisms of resistance. Thus, further insight into the full range of NR functions and interactions with co-regulatory molecules and signaling pathways is necessary for combinatorial approaches involving NRs in health and disease, and development of next-generation therapies. This meeting on “Nuclear Receptors: Full Throttle” continues the Keystone Symposia tradition of bringing together a diverse array of our leading scientists, including senior and junior investigators and their trainees, from academic, clinical and pharmaceutical settings, to showcase the latest science, highlight the use of innovative and emerging technologies, explore new directions, and develop collaborative and synergistic efforts in the exciting field of NR biology.

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Keystone Symposia Future of Science Fund Scholarship Recipients

Chanel Griggs
University of Arizona, USA

National Cancer Institute (NCI) Scholarship Recipients

Sagar P. Bapat
University of California, San Francisco, USA

Coralie Poulard
University of Southern California, USA

Hari Singhal
University of Chicago, USA