Keystone Symposia

This meeting took place in 2016

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Small RNA Silencing: Little Guides, Big Biology (A6)

Organizer(s) Phillip D. Zamore, Yukihide Tomari and Mihaela Zavolan
January 24—28, 2016
Keystone Resort • Keystone, CO USA
Discounted Abstract Deadline: Sep 28, 2015
Abstract Deadline: Oct 28, 2015
Scholarship Deadline: Sep 28, 2015
Discounted Registration Deadline: Nov 23, 2015

Supported by the Directors' Fund

Summary of Meeting:
Small RNAs have emerged as remarkably pervasive and versatile regulators of gene expression in species ranging from viruses to animals. Although diverse in biogenesis and mode of action, these small, ~21 nucleotide riboregulators, including microRNAs, small interfering RNAs (siRNAs) and PIWI-interacting RNAs, act as guides for Argonaute proteins. As part of these ribonucleoprotein complexes, small RNAs regulate virtually every step of gene expression, playing key roles in nearly every biological process. Nucleic acid-guided Argonautes can be found in eubacteria, archaea, and eukaryotes, suggesting ancient origins of the RNA interference (RNAi) mechanisms. Furthermore, prokaryotes have an RNA-guided immune system — the CRISPR system — that shares functional similarities with RNAi. Although our understanding of these small RNA pathways has progressed rapidly in the past decade, new questions continue to emerge, reflecting our ever more precise and comprehensive methods to quantify the abundance of molecular species and, consequently, the regulatory impact of small RNAs. This meeting seeks to catalyze the open exchange of ideas about the molecular mechanisms by which small RNAs are made and function, the quantitative interplay among small RNAs, between small RNAs and targets, and, ultimately, the consequences of these interactions for cellular function, in normal and pathological states. Special emphasis is placed on showcasing the work of young investigators, and on complementary approaches for studying gene regulation by small RNAs. Finally, the meeting seeks to continue the intellectually rigorous but congenial atmosphere that is the tradition of this exciting field.

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Keystone Symposia Future of Science Fund Scholarship Recipients

Dana V. Foss
University of California, Berkeley, USA

Chao-Po Lin
University of California, Berkeley, USA

Socheata Ly
University of Massachusetts Medical School, USA

Kyung-Won Min
Medical University of South Carolina, USA

Virginia Teijeiro
Memorial Sloan Kettering Cancer Center, USA