Keystone Symposia

This meeting took place in 2017

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Cell Plasticity within the Tumor Microenvironment (A1)

Organizer(s) Sergei Grivennikov, Florian R. Greten and Mikala Egeblad
January 8—12, 2017
Big Sky Resort • Big Sky, MT USA
Discounted Abstract Deadline: Sep 19, 2016
Abstract Deadline: Oct 6, 2016
Scholarship Deadline: Sep 19, 2016
Discounted Registration Deadline: Nov 8, 2016

Sponsored by Journal of Molecular Cell Biology (JMCB) and Roche

Summary of Meeting:
During the last decade, it has become unequivocally evident that tumor development is not a cell-autonomous process but rather depends on the intricate reciprocal interplay of mutant tumor cells with their local and distant environments. Composition and polarization of cells in the tumor microenvironment depends on genetic as well as environmental factors and is directly influenced by tumor therapy. Indeed, therapies that aim to shape the local immune milieu and consecutive signaling pathways in both stromal and tumor/stem cells address the complex pathophysiology of tumors more adequately and may therefore add substantial benefits for therapy. An absolute pre-requisite for such an endeavor is a comprehensive understanding of the exact molecular basis of the complex signaling networks in the tumor microenvironment that control the plasticity of both stromal and tumor cells, thereby shaping the complex cellular contexture, which ultimately forms a pro- or anti-tumorigenic milieu. Thus, this symposium aims to gather a comprehensive functional understanding of mediator-dependent cellular and molecular events that are responsible for the plasticity of both stromal and tumor/stem cells. It will bring together experts in cancer, stromal and immune cells to synthesize scientific knowledge about the phenomenon of cell plasticity within the tumor microenvironment, to define molecular and cellular pathways mediating plasticity and to propose approaches to interfere with cell plasticity for a new generation of effective therapeutic approaches in cancer and chronic injury. Importantly, it will bring together interdisciplinary groups of scientists or investigators who normally would not have an opportunity to meet (classical cancer biologists, tumor immunobiologists, stem cell experts and scientists working on stromal cells).

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Biogen ECITA Scholarship Recipients

Diana M. Cittelly
University of Colorado Anschutz Medical Campus, USA

Gustavo A. Miranda-Carboni
University of Tenessee Health Science Center, USA

Keystone Symposia Future of Science Fund Scholarship Recipients

Julia Varga
Georg Speyer Haus, Germany

National Cancer Institute (NCI) Scholarship Recipients

Toni Celia-Terrassa
Princeton University, USA

Ekrem Emrah Er
Memorial Sloan Kettering Cancer Center, USA

Melissa A. Meyer
La Jolla Institute for Immunology, USA

Annelise Snyder
University of Washington, USA