Keystone Symposia

This meeting took place in 2018

Here are the related meetings in 2020:
Tissue Organoids as Models of Host Physiology and Pathophysiology of Disease (J1)
Brain Therapeutics: Disruptive Technologies and Opportunities (Q3)

For a complete list of the meetings for the upcoming/current season, see our meeting list, or search for a meeting.

Organs- and Tissues-on-Chips (D1)

Organizer(s) Christopher P. Austin, Danilo Tagle, Christine L. Mummery and Brian R. Berridge
April 8—12, 2018
Big Sky Resort • Big Sky, MT USA
Discounted Abstract Deadline: Dec 6, 2017
Abstract Deadline: Jan 9, 2018
Scholarship Deadline: Dec 6, 2017
Discounted Registration Deadline: Feb 6, 2018

Sponsored by Merck & Co., Inc.

Summary of Meeting:
More than 30% of promising medications have failed in human clinical trials because they are determined to be toxic despite promising pre-clinical studies in 2-D cell culture and animal models. Another 60% fail due to lack of efficacy. Consequently, though several thousand diseases affect humans, only about 500 have approved treatments. However, with the growing understanding of human biology, along with increased availability of innovative technologies, there is now an unprecedented opportunity to translate scientific discoveries more efficiently into new, more effective and safer health interventions. Organs- or Tissues-on-Chips are innovative, alternative approaches that would enable early indications and potentially more reliable readouts of toxicity and efficacy. These microfabricated devices recapitulate the multicellular architectures, tissue-tissue interfaces, physicochemical microenvironments, vascular perfusion and innervation, producing in essence microphysiological systems that mimic human tissue and organ functionality not possible with conventional 2D or 3D culture systems. Through innovative biosensing and readout approaches, these devices employ high-resolution, real-time imaging and non-invasive analysis of biochemical, genetic and metabolic activities of living cells in a functional tissue and organ context. This technology has great potential to advance the study of tissue development, organ physiology and disease etiology. In the context of drug discovery and development, it should be especially valuable for the study of molecular mechanisms of action, prioritization of lead candidates, toxicity testing and biomarker identification. These microfabricated devices have also proven to be useful for modeling human diseases. This conference will touch on ongoing efforts and various applications of tissue-on-chips technology to studies in precision medicine, environmental exposures, reproduction and development, cancer and for use at the International Space Station.

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National Institute of Biomedical Imaging and Bioengineering (NIBIB) Scholarship Recipients

Leigh Joan Atchison
Duke University, USA

Idit Goldfracht
Technion – Israel Institute of Technology, Israel

Valentina Paloschi
Technical University of Munich, Germany

Christopher Probst
Fraunhofer IGB, Germany

Woojung Shin
University of Texas at Austin, USA

Sijie Sun
University of Washington, USA

Berend J. van Meer
Leiden University Medical Center, Netherlands

Dimitrios Voulgaris
KTH Royal Institute of Technology, Sweden