Keystone Symposia

This meeting took place in 2018

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Mobile Genetic Elements and Genome Plasticity (B7)

Organizer(s) Marlene Belfort, Evan E. Eichler, Henry L. Levin and Lynne E. Maquat
February 11—15, 2018
Eldorado Hotel & Spa • Santa Fe, NM USA
Discounted Abstract Deadline: Oct 12, 2017
Abstract Deadline: Nov 14, 2017
Scholarship Deadline: Oct 12, 2017
Discounted Registration Deadline: Dec 14, 2017

Sponsored by Boehringer Ingelheim Pharmaceuticals, Inc.

Summary of Meeting:
Transposable elements are potent sources of genetic variation that also regulate the expression of large gene networks. They constitute the majority of genomic DNA in many eukaryotes, and they dramatically shape genetic content by causing insertions, deletions, rearrangements and sequence duplications. Of increasing significance is the link of these mobile elements to diseases such as cancer and neurodegeneration. Sequencing of human populations demonstrates that active transposable elements are substantially more prevalent than previously appreciated. The aims of this conference are to: 1) Apply recent innovations in high-throughput sequencing and genome analysis to the study of transposon biology and genome dynamics; 2) Discuss the discovery of cellular systems that inhibit transposon activity as examples of the evolutionary arms race between mobile DNA and their hosts; 3) Describe active transposition during neurogenesis and in tumor cells and raise questions about the role of mobile DNA in brain development and cancer; and 4) Discern mechanistic aspects of element mobility from bacteria to humans. This symposium is designed to foster ties between leaders in the field of transposon function and biology with the pioneers of genome analysis, a link that is still tenuous and nascent. Discussions of transposon activity and genome dynamics will focus on mechanistic models. Methods applied to these problems will include molecular structures, biochemistry, expression studies and bioinformatic analyses. The transposons and hosts represented in this conference include diverse examples from eubacteria, archaea, protists, plants and mammals.

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National Cancer Institute (NCI)/National Institute on Aging (NIA) Scholarship Recipients

Jasmine N. Baker
Louisiana State University, USA

Laura Blanco-Berdugo
Texas Tech University, USA

Di Chen
Penn State University, USA

Rachel Cosby
Cornell University, USA

Patricia Gerdes
University of Queensland, Australia

The RNA Society Scholarship Recipients

Patricia Goerner-Potvin
McGill University, Canada