Keystone Symposia

This meeting took place in 2019

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Signal Dynamics and Signal Integration in Development and Disease (J4)

Organizer(s) Nicolas Tapon, Liliana Attisano and Raphael Kopan
January 27—31, 2019
Keystone Resort • Keystone, CO USA
Discounted Abstract Deadline: Oct 17, 2018
Abstract Deadline: Oct 25, 2018
Scholarship Deadline: Oct 17, 2018
Discounted Registration Deadline: Nov 28, 2018

Supported by the Directors' Fund

Summary of Meeting:
The discovery and study of the major developmental signaling pathways (Notch, Hh, Wnt, RTK) has illuminated how patterning and growth are controlled in metazoans. These pathways are reiteratively used during development and adult life, acting to maintain stem cells and direct tissue repair and regeneration. When they are disrupted, cancer develops. This conference embraces recent progress in quantitative biology, mathematical modelling, single cell analysis and intravital imaging. It also presents a major opportunity to bring together knowledge from developmental systems with adult homeostasis, regeneration and cancer, as well as to elucidate how different developmental signals are integrated to influence cellular decision-making processes. The pairing with the conference on Cellular Plasticity: Reprogramming, Regeneration, and Metaplasia enables an in-depth exploration of the parallels between plasticity/pluripotency in development, regeneration and disease. In summary, the conference aims to: 1) Explore the commonalities between signaling in development, regeneration, and homeostasis, 2) Leverage quantitative, single cell and systems biology to study the dynamics and integration of developmental signaling across scales, and 3) Highlight how perturbations in developmental pathways cause diseases such as cancer.

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Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) Scholarship Recipients

Ekrem Emrah Er
Memorial Sloan Kettering Cancer Center, USA

Margaret E. Magaletta
University of Massachusetts Medical School, USA

Victoria Ng
Vanderbilt University, USA