Keystone Symposia

This meeting took place in 2019

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Proteomics and its Application to Translational and Precision Medicine (D3)

Organizer(s) Matthias Mann, Emma K. Lundberg, Albert J.R. Heck and Mathias Uhlén
April 7—11, 2019
Clarion Hotel Sign • Stockholm, Sweden
Discounted Abstract Deadline: Dec 12, 2018
Abstract Deadline: Jan 9, 2019
Scholarship Deadline: Dec 12, 2018
Discounted Registration Deadline: Feb 6, 2019

Organized in collaboration with Knut and Alice Wallenberg Foundation
and Science for Life Laboratory

Sponsored by BioLegend, Inc., Novo Nordisk A/S, Roche and Thermo Fisher Scientific Inc.

Summary of Meeting:
Proteomics methods have advanced tremendously in just the last few years. Apart from increasingly powerful mass-spectrometric methods, global antibody based methods, chemical biology approaches and genetics/genomics approaches and their combinations are now offering a rich toolbox to study the proteome in many different dimensions. Given this background and the recent completion of in depth proteomes, it is now time to apply proteomics in a more translational context to patient derived primary cells, organoids, xenograft models and indeed to the clinic. MS based proteomics, in particular, interaction proteomics in combination with chemical and structural proteomics, is making crucial contributions to drug development and deeper molecular understanding of disease mechanisms. The analysis of post-translational modifications has become orders of magnitude more comprehensive, quantitative and accessible, now enabling in-vivo and time-resolved studied of a large range of signaling processes. In combination with genome engineering, this opens up entirely new perspectives in precision investigation of deregulated signaling processes in models of oncology, immunology or metabolic diseases. Finally, proteomic profiling of body fluids has matured to a degree that it enables informative ‘phenotyping’ of humans in health and disease, supporting ‘wellness’ and patient stratification/biomarker studies.

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Burroughs Wellcome Fund ECITA Scholarship Recipients

Samira Musah
Duke University, USA

Keystone Symposia Future of Science Fund Scholarship Recipients

Ireshyn S. Govender
Council for Scientific and Industrial Research, South Africa

Kosuke Ogata
Kyoto University, Japan

Cecilia Rossetti
Technical University of Denmark, Denmark

Alok K. Shah
QIMR Berghofer Medical Research Institute, Australia