Keystone Symposia

This meeting took place in 2019

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Origins of Allergic Disease: Microbial, Epithelial and Immune Interactions (M3)

Organizer(s) Marsha Wills-Karp, Donald Y.M. Leung and Kari Nadeau
March 24—27, 2019
Granlibakken Tahoe • Tahoe City, CA USA
Discounted Abstract Deadline: Dec 4, 2018
Abstract Deadline: Dec 13, 2018
Scholarship Deadline: Dec 4, 2018
Discounted Registration Deadline: Jan 23, 2019

Supported by the Directors' Fund

Summary of Meeting:
Allergic diseases have been on the rise globally in recent decades. Although it has long been known that IgE-mediated immune responses are associated with the manifestations of a wide spectrum of allergic disorders (asthma, atopic dermatitis, atopic rhinitis, food allergy, eosinophilic esophagitis), the exact factors leading to these aberrant immune responses are not well understood. Recent insights into disease origins support a broader realm of factors that may predispose, initiate or exacerbate altered immunity in allergic diseases such as inherent epithelial barrier dysfunction, loss of immune tolerance at central and specific sites, disturbances in gut and organ specific microbiomes, diet and age. However, these studies are in their infancy and have only been considered in a reductionist, disease or tissue-specific manner to date. Few studies have addressed the cross-talk between various organs leading to the concept of allergy as a system disease. A better understanding of the distinct or shared complex web of factors underlying the spectrum of allergic disorders and the successes/failures of the current armature of therapies may lead to the development of safer, disease-modifying interventions in the future. Thus the major goal of this meeting is to explore the potential microbial-epithelial-immune interactions underlying the etiology of allergic disorders in order to promote the development of novel disease prevention or intervention strategies.

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National Institute of Allergy and Infectious Diseases (NIAID) Scholarship Recipients

Olivier Bernard
University of California, San Francisco, USA

Cedric Bosteels
Universiteit Gent, Belgium

Mélodie Bouté
Institut Pasteur de Lille, France

Rozlyn C.T. Boutin
University of British Columbia, Canada

Erin Cathleen Steinbach
University of North Carolina at Chapel Hill, USA