Keystone Symposia

This meeting took place in 2019



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Why So Many Ways to Die? Apoptosis, Necroptosis, Pyroptosis and Beyond (T3)


Organizer(s) Karina R. Bortoluci, Vishva M. Dixit and Andreas E. Strasser
November 19—23, 2019
Casa Grande Hotel • Guarujá, São Paulo Brazil
Discounted Abstract Deadline: Jul 18, 2019
Abstract Deadline: Aug 20, 2019
Scholarship Deadline: Jul 30, 2019
Discounted Registration Deadline: Sep 19, 2019

Organized in collaboration with the São Paulo Research Foundation (FAPESP)
Part of the Keystone Symposia Global Health Series, supported by the Bill & Melinda Gates Foundation

Supported by a grant from Genentech

Summary of Meeting:
Cell death is linked to diverse physiological and pathological conditions. In addition to the well-defined apoptosis versus accidental necrosis paradigm, novel processes of programmed cell death, necroptosis and pyroptosis, in particular, have been described over the last years. Our knowledge about the molecular machineries that control these cell death processes has expanded substantially with the discovery of key regulators and effectors, such as the gasdermins, mixed-lineage kinase domain-like protein (MLKL), and receptor-interacting protein (RIP) kinases. We have learned that apoptosis, pyroptosis, necroptosis, ferroptosis, autophagic cell death and other cell death processes are all equipped with individual sets of regulatory and effector molecules but can also share constituents that can interconnect the distinct cell death pathways. Moreover, several alternative cell death programs may operate in any given circumstances with distinct consequences to the immune response and to the development of inflammatory disorders. Last, but not least, cell death may not be the sole or even the major fate/purpose of cells that engage inflammatory cell death pathways. Understanding of the role of the different regulators and effectors of each cell death processes is essential for the development of therapeutic tools for cancer, autoimmune diseases and inflammatory pathologies. Thus, this conference proposes to bring together specialists from diverse areas of cell death research from around world to explore these crucial issues to develop a better understanding of the relative, additive and/or redundant contributions of the distinct cell death pathways in health and disease.

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Scholarships/Awards


Keystone Symposia Future of Science Fund Scholarship Recipients


Antonia R. Bass
University of Pennsylvania, USA

Carolyn Ann Lacey
University of North Carolina at Chapel Hill, USA

Bart Tummers
St. Jude Children's Research Hospital, USA

Dania Zhivaki
, USA

FAPESP Keystone Symposia Travel Awards Recipients
Funded by FAPESP Keystone Symposia Travel Awards


Olufemi Emmanuel Akanni
Ladoke Akintola University of Technology, Nigeria

Warrison A. Andrade
Faculdade de Medicina de Ribeirão Preto - FMRP-USP, Brazil

Paula K. Bautista-Nino
Fundacion Cardiovascular de Colombia, Colombia

Gabriela Brumatti
Walter and Eliza Hall Institute, Australia

Silvina Odete Bustos
Instituto do Câncer do Estado de São Paulo, Brazil

Renan Villanova Homem de Carvalho
University of São Paulo, Brazil

Ancely F. dos Santos
University of São Paulo, Brazil

Maia Lina Elizagaray
IIFP-Universidad Nacional de La Plata, Argentina

Erika Guimaraes
Federal University of Minas Gerais, Brazil

Seruyange Joseph
Makerere University, Uganda

Praiscillia Kia
Makerere University, Uganda

Namita Parikshit Mahalle
Deenanath Mangeshkar Hospital and Research Center, India

Bayanika Manunu
University of Stellenbosch, South Africa

Pedro Elias Marques
KU Leuven, Belgium

Bruna dos Santos Mendonça
Brazilian National Cancer Institute, Brazil

Ilze Lauren Mentoor
Stellenbosch University, South Africa

Laura Migliari Branco
University of São Paulo, Brazil

Moses Luutu Nsubuga
Makerere University, Uganda

Oluwaseyi Paul Olaniyan
Osun State University, Nigeria

Larissa Marina Nogueira Pereira
Instituto René Rachou, Brazil

Marcelo Pires Amaral
Federal University of São Paulo UNIFESP, Brazil

Daria Raquel Queiroz de Almeida
University of São Paulo, Brazil

Ramesh Chandra Rai
International Centre for Genetic Engineering and Biotechnology, India

Dina María Alondra Ramírez Cubas
Universidad Peruana Cayetano Heredia, Peru

María Isabel Ramírez Orellana
Universidad Técnica Particular de Loja, Ecuador

Analía Gabriela Ricci
National Research Council, CONICET, Argentina

Lucas Secchim Ribeiro
University of Bonn, Germany

Flavia da Cunha Vasconcelos
Instituto Nacional de Cancer, Brazil

Eskinder Kebede Weldetensaye
Addis Ababa University, Ethiopia

Keystone Symposia Global Health Travel Award Recipients, funded by the Bill & Melinda Gates Foundation


Oluwole Busayo Akinola
University of Ilorin, Nigeria

Ruby John Anto
Rajiv Gandhi Centre for Biotechnology, India

Fernando Gabriel Chirdo
Instituto de Estudios Inmunologicos y Fisiopatologicos - IIFP, Argentina

Luciane Alarcão Dias-Melicio
UNESP - Botucatu Medical School, Brazil

Angelica Beate Winter Boldt
Universidade Federal do Paraná, Brazil