Keystone Symposia

This meeting took place in 2020

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AAA+ Proteins: From Atomic Structures to Organisms (A5)

Organizer(s) Walid A. Houry, James Shorter, Antonina Roll-Mecak and Phyllis I. Hanson
January 26—29, 2020
Granlibakken Tahoe • Tahoe City, CA USA
Discounted Abstract Deadline: Sep 26, 2019
Abstract Deadline: Nov 6, 2019
Scholarship Deadline: Sep 26, 2019
Discounted Registration Deadline: Nov 21, 2019

Supported by the Directors' Fund

Summary of Meeting:
AAA+ proteins are ATPases Associated with Diverse Cellular Activities. They form a large superfamily and have been found to carry out a very diverse range of functions including DNA replication, chromatin remodeling, rRNA processing, and membrane fusion. In recent years, there has been substantial progress in identifying the structure and cellular function of a large number of AAA+ proteins. However, little is known of the unique features underlying this mechano-chemical coupling mechanism used to apply forces to various substrates. There is also a lack of understanding for many AAA+ proteins regarding how substrates are recognized, regulation of their activities in vivo, and how their functions are coordinated with other competing and overlapping reactions. Recent findings demonstrate the importance of AAA+ proteins in the biology of cancer and neurodegeneration and as virulence factors in pathogenic microorganisms. However, we know very little of the biochemical pathways leading to diseases arising from mutations in these proteins. The conference will bring together an interdisciplinary group of scientists interested in understanding the structure, function, and disease aspects of these proteins. The conference comes at an opportune time of great developments in structural biology, especially cryoEM, and cell biology. We aim to provide a very interactive and collegial atmosphere to discuss the latest advances in this important field. In addition to having invited speakers, we will also provide the opportunity to many attendees to give an oral presentation about their research. Poster sessions will also be held for all attendees.

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Keystone Symposia Future of Science Fund Scholarship Recipients

Chad A. Brambley
Middle Tennessee State University, USA

Zev A. Ripstein
Hospital for Sick Children, Canada