Keystone Symposia

This meeting took place in 2006

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Determinants of Host Resistance, Susceptibility or Immunopathology to Pathogens: Integrating Knowledge from Experimental Models to Human Disease (J2)

Organizer(s) Anne O'Garra, Anne E. Goldfeld, Alan Sher and Bruce D. Walker
January 6—11, 2006
Keystone Resort • Keystone, CO USA
Abstract Deadline: Sep 13, 2005
Late Abstract Deadline: Oct 3, 2005
Scholarship Deadline: Sep 13, 2005
Early Registration Deadline: Nov 4, 2005

Supported by the Burroughs Wellcome Fund and The Director's Fund

Summary of Meeting:
The type of immune response that is elicited upon infection of a host with a pathogen is critical in determining whether the pathogen is eradicated or whether chronic infection ensues. Successful protective effector responses to intracellular pathogens such as parasites, bacteria and viruses are initiated by cells of the innate immune response which produce effector cytokines such as TNF, IL-12 or IFN-alpha. These, in turn, stimulate antigen-specific Th1 cells producing IFN-alpha and CD8+ T cytotoxic T cells (CTL). Humoral immune responses also offer protection against pathogens, however rapid mutations in the organisms and/or the lack of immunizing regimens which lead to long-term protection impede successful vaccination. Host mutations in cytokine signaling pathways and signaling pathways downstream of pattern recognition receptors on host immune cells result in profound susceptibility to a number of pathogens. Furthermore, many organisms -- such as Leishmania, Schistosoma or Mycobacteria -- inhibit protective immune responses via the induction of suppressive cytokines, whereas influenza has developed molecular mechanisms to interfere directly with signaling pathways important for the induction of the host antiviral response. Overall, major reasons why we have failed to-date in eliminating human pathogens are 1) successful strategies of immunoevasion developed by pathogens to dampen an immune response and, conversely, 2) pathogen-induced immunopathologies further complicate infections. Furthermore, the emergence and re-emergence of many infectious pathogens throughout human history, the difficulty in producing effective vaccines to protect against numerous pathogens, and the inability to intervene immunologically to abrogate many chronic infectious diseases such as HIV, malaria, TB, and schistosomiasis highlight the need for a deeper understanding of the immune response to infectious challenge. Cross-fertilization of knowledge gained from animal models of infectious disease with our understanding of human immune responses to a broad range of pathogens is critical to advance the treatment and prevention of devastating pathogens.

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Scholarship / Award Information

Scholarship Deadline: September 13, 2005 (11:59 PM US Mountain Standard Time)
*All deadlines end at 11:59 PM US Mountain Standard Time
NOTE: Please use the button above to Apply for a Scholarship


Keystone Symposia is offering scholarships of up to 1,200 USD to Students and Postdoctoral fellows. These scholarships are to be used to help defray the expenses associated with conference attendance, including airfare (restrictions may apply based on funding source), ground transportation, lodging costs, and a portion of meeting registration. Receipts will be required to receive reimbursement.

Abstracts submitted for poster presentation will be used as the basis for awarding the scholarships. Scholarship recipients will be selected based on the quality of science of the abstract and the relevance of the abstract to the conference topic. Only one application per abstract is accepted. Only one award per lab will be allocated.


To be eligible for a scholarship, you must be:

A graduate student or postdoctoral fellow currently enrolled in an academic institute at the start of the meeting for which you are applying. Note: a graduate student is defined as a student who is studying for a higher degree at an academic institution. A postdoctoral fellow is defined as an individual with a Ph.D., M.D., or DVM degree who is engaged in a temporary period of mentored research and/or scholarly training for the purpose of acquiring the professional skills needed to pursue their desired career path, and is within 6 years of these degrees.

Review Criteria

Criteria for Abstract Review:

  1. Relevance to the meeting topic
  2. Significance of the scientific question and results
  3. Style
    • Organization (e.g. the abstract has a clear beginning, middle and end)
    • Grammar and spelling
  4. Clarity of scientific presentations
    • Clear question or hypothesis
    • Sufficient background
    • The experimental approach and rationale for the approach are clear
    • The results are clearly presented
    • The interpretation and conclusions are reasonable and logical

Application Process

If you are eligible and wish to be considered for a scholarship, you should complete all of the following by the scholarship deadline for the meeting you wish to attend. It is recommended you begin these steps in advance of the deadline date to ensure completion.

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Underrepresented Trainee Scholarships are also available...
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