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This meeting took place in 2011
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Transmembrane Signaling by GPCRs and Channels (B1)
Organizer(s) Oliver P. Ernst and U. Benjamin Kaupp
January 23—28, 2011
Sagebrush Inn & Suites • Taos, NM USA
Abstract Deadline: Sep 23, 2010
Late Abstract Deadline: Oct 25, 2010
Scholarship Deadline: Sep 23, 2010
Early Registration Deadline: Nov 23, 2010
Sponsored by Takeda Pharmaceutical Company Limited
Summary of Meeting:
Cellular membranes present natural borders for signal transduction between cells and their environment. Nature developed different strategies to enable signals to cross the membrane barrier. The goal of this meeting is to discuss the molecular mechanisms of transmembrane signaling on the basis of three protein classes, i.e. G protein-coupled receptors, ion channels and transporters. Available protein structures together with biophysical and functional approaches will provide guidance to explore similarities and differences of the underlying mechanisms. Exemplified will be receptors and channels as well as proteins with dual or modified functions, such as channelrhodopsin. A comparative view is thought to bring researchers from diverse fields together and to stimulate further development of transmembrane signaling proteins in drug discovery and fighting disease.
View Scholarships/Awards
Cellular membranes present natural borders for signal transduction between cells and their environment. Nature developed different strategies to enable signals to cross the membrane barrier. The goal of this meeting is to discuss the molecular mechanisms of transmembrane signaling on the basis of three protein classes, i.e. G protein-coupled receptors, ion channels and transporters. Available protein structures together with biophysical and functional approaches will provide guidance to explore similarities and differences of the underlying mechanisms. Exemplified will be receptors and channels as well as proteins with dual or modified functions, such as channelrhodopsin. A comparative view is thought to bring researchers from diverse fields together and to stimulate further development of transmembrane signaling proteins in drug discovery and fighting disease.
View Scholarships/Awards
No registration fees are used to fund entertainment or alcohol at this conference
SUNDAY, JANUARY 23
MONDAY, JANUARY 24
TUESDAY, JANUARY 25
WEDNESDAY, JANUARY 26
THURSDAY, JANUARY 27
FRIDAY, JANUARY 28
Conference Program Print | View meeting in 24 hr (international) time
SUNDAY, JANUARY 23
7:15—9:30 PM
Welcome and Keynote Session
Brian K. Kobilka,
Stanford University School of Medicine, USA
Structure and Dynamics of G Protein Coupled Receptors: Insights From the Human Beta 2 Adrenoceptor
Structure and Dynamics of G Protein Coupled Receptors: Insights From the Human Beta 2 Adrenoceptor
8:00—11:15 AM
GPCR Structure and Intramolecular Signal Transduction
*
Krzysztof Palczewski,
Case Western Reserve University, USA
Oliver P. Ernst,
University of Toronto, Canada
Structure and Dynamics of Rhodopsin
Structure and Dynamics of Rhodopsin
Steven O. Smith,
Stony Brook University, USA
Activation of Rhodopsin: Insights from Solid-State NMR Spectroscopy
Activation of Rhodopsin: Insights from Solid-State NMR Spectroscopy
Jörg Standfuss,
Paul Scherrer Institut, Switzerland
Short Talk: Crystal Structure of Constitutively Active Rhodopsins: How an Agonist can Activate its GPCR
Short Talk: Crystal Structure of Constitutively Active Rhodopsins: How an Agonist can Activate its GPCR
Philippe Rondard,
Institut de Génomique Fonctionnelle, France
Short Talk: Intramolecular Signal Transduction in Metabotropic Glutamate Receptors
Short Talk: Intramolecular Signal Transduction in Metabotropic Glutamate Receptors
William P. Clarke,
University of Texas Health Science Center, USA
Short Talk: Functional Selectivity of Ligands at 7-TMs Receptors: Evidence for Multiple Active Receptor Conformations
Short Talk: Functional Selectivity of Ligands at 7-TMs Receptors: Evidence for Multiple Active Receptor Conformations
4:00—4:30 PM
Data Blitz Session 1
Sviatoslav N. Bagriantsev,
University of California, San Francisco, USA
Protons, Heat, and Mechanical Force Converge to Gate Two-Pore Potassium Channels
Protons, Heat, and Mechanical Force Converge to Gate Two-Pore Potassium Channels
Jana Brejchova,
Academy of Sciences of the Czech Republic, Czech Republic
FLIM, TCSPC and Laurdan Generalized Polarization Studies of the Effect of Cholesterol Depletion on Hydrophobic Interior and Polar-Head Group Region of the Cell Membrane
FLIM, TCSPC and Laurdan Generalized Polarization Studies of the Effect of Cholesterol Depletion on Hydrophobic Interior and Polar-Head Group Region of the Cell Membrane
Steve Briddon,
University of Nottingham, UK
Evidence for Pathway-Specific Active Conformations of the Adenosine-A3 Receptor
Evidence for Pathway-Specific Active Conformations of the Adenosine-A3 Receptor
Moritz Bünemann,
Phillips University Marburg, Germany
Dynamics of Gq Protein Interactions with PLCbeta3 Studied by TIRF Microscopy
Dynamics of Gq Protein Interactions with PLCbeta3 Studied by TIRF Microscopy
Ines Claudia Heinrich,
Max Planck Institute of Molecular Physiology, Germany
Signal Transduction in Chemo- and Photoreceptor Arrays
Signal Transduction in Chemo- and Photoreceptor Arrays
5:00—7:00 PM
Interaction of GPCRs with Signaling Proteins
Wayne L. Hubbell,
University of California, Los Angeles, USA
Structural and Dynamical Orgins of G Protein Activation as Revealed by Site Directed Spin Labeling
Structural and Dynamical Orgins of G Protein Activation as Revealed by Site Directed Spin Labeling
Vsevolod V. Gurevich,
Vanderbilt University, USA
Structural Determinants of Receptor Binding and the Conformation of Active Receptor-Bound Arrestin
Structural Determinants of Receptor Binding and the Conformation of Active Receptor-Bound Arrestin
John J.G. Tesmer,
University of Michigan, USA
Molecular Basis for the Activation of G Protein-Coupled Receptor Kinases by GPCRs
Molecular Basis for the Activation of G Protein-Coupled Receptor Kinases by GPCRs
Oleg G. Kisselev,
St. Louis University, USA
Short Talk: Role of Transducin beta-gamma Complex in Rod Phototransduction Pathway
Short Talk: Role of Transducin beta-gamma Complex in Rod Phototransduction Pathway
Daniel Fourmy,
INSERM U858, France
Short Talk: A Unique Conformation of the CCK2R Recruits beta-Arrestin2
Short Talk: A Unique Conformation of the CCK2R Recruits beta-Arrestin2
8:00—11:00 AM
Signal Transduction by Microbial Rhodopsins
*
Ulrike Alexiev†,
Freie Universitaet Berlin, Germany
Martin Engelhard,
Max Planck Institute for Molecular Physiology, Germany
Sensory Rhodopsins: Transmembrane Signal Transfer
Sensory Rhodopsins: Transmembrane Signal Transfer
Hideki Kandori,
Nagoya Institute of Technology, Japan
Active Internal Waters in Visual and Microbial Rhodopsins
Active Internal Waters in Visual and Microbial Rhodopsins
Karl Deisseroth,
Stanford University, USA
Retinal Proteins as Neural State Switches
Retinal Proteins as Neural State Switches
4:00—4:30 PM
Data Blitz Session 2
Gerd Krause,
Leibniz-Institut für Molekulare Pharmakologie, Germany
From Transmembrane Interactions in the Thyroptropin Receptor to General Aspects of Intramolecular Signal Transduction in GPCRs
From Transmembrane Interactions in the Thyroptropin Receptor to General Aspects of Intramolecular Signal Transduction in GPCRs
Christophe J.W. Moreau,
Structural Biology Institute, France
Engineering of GPCR-Ion Channel Fusion Proteins for Direct Characterization of Ligand Binding and Gating Regulation
Engineering of GPCR-Ion Channel Fusion Proteins for Direct Characterization of Ligand Binding and Gating Regulation
Sven Schünke,
Institute of Complex Systems, Research Centre Jülich, Germany
Structural Insights into Conformational Changes of a Cyclic Nucleotide-Binding Domain in Solution from a Bacterial CNG Channel (MloK1)
Structural Insights into Conformational Changes of a Cyclic Nucleotide-Binding Domain in Solution from a Bacterial CNG Channel (MloK1)
Peter Nollert,
Bio Data Bridges, USA
Expanded Sampling of Membrane Protein Crystallization Experiments with Plugs and Lipid Matrices
Expanded Sampling of Membrane Protein Crystallization Experiments with Plugs and Lipid Matrices
Gregory M. Pask,
Vanderbilt University, USA
A Novel Characterization of an Insect Odorant Receptor as an Ion Channel
A Novel Characterization of an Insect Odorant Receptor as an Ion Channel
5:00—7:00 PM
Role of Lipids in Transmembrane Signaling
Roger K. Sunahara,
University of California, San Diego, USA
Structure and Function of the G-Protein Coupled Receptor Cascade
Structure and Function of the G-Protein Coupled Receptor Cascade
Marc Baldus,
Utrecht University, Netherlands
Membrane Protein Structure in a Cellular(-Like) environment
Membrane Protein Structure in a Cellular(-Like) environment
Pontus Gourdon,
Aarhus University, Denmark
Crystal Structure of the Copper Pump
Crystal Structure of the Copper Pump
Vladimir Ladizhansky,
University of Guelph, Canada
Short Talk: Conformation of a Seven-Helical Transmembrane Photosensor in the Lipid Environment
Short Talk: Conformation of a Seven-Helical Transmembrane Photosensor in the Lipid Environment
8:00—11:00 AM
Novel Approaches
*
Steven O. Smith,
Stony Brook University, USA
Thomas P. Sakmar,
Rockefeller University, USA
Using Genetically Encoded Non-Natural Amino Acids to Examine the GPCR Signalosome
Using Genetically Encoded Non-Natural Amino Acids to Examine the GPCR Signalosome
Krzysztof Palczewski,
Case Western Reserve University, USA
Role of Integral Waters in GPCR Activation
Role of Integral Waters in GPCR Activation
Helmut Grubmüller,
Max Planck Institute for Biophysical Chemistry, Germany
Forces and Non-Equilibrium-Dynamics in Biological Macromolecules
Forces and Non-Equilibrium-Dynamics in Biological Macromolecules
Kenneth E. Carlson,
Ironwood Pharmaceuticals, USA
Short Talk: GPCR Ligand Binding Prediction Assessment for CXCR4 and D3 and Implications for Structure based Drug Discovery
Short Talk: GPCR Ligand Binding Prediction Assessment for CXCR4 and D3 and Implications for Structure based Drug Discovery
Klaus Gawrisch,
NIAAA, National Institutes of Health, USA
Short Talk: Global Fold of Human Peripheral Cannabinoid Receptor CB2 probed by Solid-State 13C,15N-MAS NMR and Molecular Dynamics Simulations
Short Talk: Global Fold of Human Peripheral Cannabinoid Receptor CB2 probed by Solid-State 13C,15N-MAS NMR and Molecular Dynamics Simulations
Irina Kufareva,
University of California, San Diego, USA
Short Talk: GPCR Ligand Binding Prediction Assessment for CXCR4 and D3 and Implications for Structure Based Drug Discovery
Short Talk: GPCR Ligand Binding Prediction Assessment for CXCR4 and D3 and Implications for Structure Based Drug Discovery
4:00—4:30 PM
Data Blitz Session 3
Steffen Wolf,
Partner Institute for Computational Biology, China
Directional Proton-Transfer in Membrane Proteins Via Protein-Bound Internal Water Molecules: A Proton-Diode
Directional Proton-Transfer in Membrane Proteins Via Protein-Bound Internal Water Molecules: A Proton-Diode
David M. Thal,
Monash Institute of Pharmaceutical Sciences, Australia
Molecular Mechanism of Selectivity Among G Protein-Coupled Receptor Kinase 2 Inhibitors
Molecular Mechanism of Selectivity Among G Protein-Coupled Receptor Kinase 2 Inhibitors
Kalyan C. Tirupula,
University of Pittsburgh, USA
Role of Conserved Transmembrane Domain Cysteines in Activation of Metabotropic Glutamate Receptor Type 6
Role of Conserved Transmembrane Domain Cysteines in Activation of Metabotropic Glutamate Receptor Type 6
Friederike Winkhaus,
Center of Advanced European Studies and Research (CAESAR), Germany
HCN2 Channels: Cyclic Nucleotide Binding and Oligomerization
HCN2 Channels: Cyclic Nucleotide Binding and Oligomerization
5:00—7:15 PM
Late-Breaking News
Luis G. Cuello,
Texas Tech University Health Science Center, USA
Structural Mechanism of C-Type Inactivation in Potassium Channels
Structural Mechanism of C-Type Inactivation in Potassium Channels
Wayne A. Hendrickson,
Columbia University, USA
Structural Analysis of SLAC1-Family Anion Channel Activity
Structural Analysis of SLAC1-Family Anion Channel Activity
Polina V. Lishko,
University of California, San Francisco, USA
Short Talk: Female Sex Hormone Progesterone and Sperm Specific Calcium Channel CatSper: An Intimate Relationship
Short Talk: Female Sex Hormone Progesterone and Sperm Specific Calcium Channel CatSper: An Intimate Relationship
Normann Goodwin,
Center of Advanced European Studies and Research (CAESAR), Germany
Short Talk: The Chemoattractant Progesterone Activates CatSper Channels in Human Sperm
Short Talk: The Chemoattractant Progesterone Activates CatSper Channels in Human Sperm
8:00—11:00 AM
Ion Channel Structure and Function
*
Wayne A. Hendrickson,
Columbia University, USA
Leslie B. Vosshall,
Rockefeller University, USA
Structure-Function Analysis of the Insect Odorant Receptors: Odor-Gated Ion Channels Modulated by Insect Repellents
Structure-Function Analysis of the Insect Odorant Receptors: Odor-Gated Ion Channels Modulated by Insect Repellents
Uhtaek Oh,
Seoul National University, South Korea
Anoctamin 1, A Cloned Calcium-Activated Chloride Channel and its Physiological Implications
Anoctamin 1, A Cloned Calcium-Activated Chloride Channel and its Physiological Implications
U. Benjamin Kaupp,
Center of Advanced European Studies and Research (CAESAR), Germany
Novel Cyclic Nucleotide-Gated Channels
Novel Cyclic Nucleotide-Gated Channels
Crina M. Nimigean,
Weill Cornell Medical College, USA
Mechanism of Proton Sensing in KcsA Potassium Channels
Mechanism of Proton Sensing in KcsA Potassium Channels
Elena O. Gracheva,
Yale University School of Medicine, USA
Short Talk: Molecular Basis of Infrared Sensation by Snakes
Short Talk: Molecular Basis of Infrared Sensation by Snakes
5:00—7:00 PM
Mechanisms of Channels and Transporters
*
Crina M. Nimigean,
Weill Cornell Medical College, USA
Pierre-Jean Corringer,
Institut Pasteur - CNRS, France
Allosteric Transition and Regulation of Bacterial Pentameric Channel- Receptors
Allosteric Transition and Regulation of Bacterial Pentameric Channel- Receptors
Hassane S. Mchaourab,
Vanderbilt University, USA
Structural Dynamics of the Leucine Transporter: Spin Labeling and EPR Spectroscopy
Structural Dynamics of the Leucine Transporter: Spin Labeling and EPR Spectroscopy
Olga Boudker,
Weill Cornell Medical College, USA
Conformational Ensemble and Molecular Mechanism of Glutamate Transporters
Conformational Ensemble and Molecular Mechanism of Glutamate Transporters
Eitan Reuveny,
Weizmann Institute of Science, Israel
Short Talk: Nonenzymatic Rapid Control of GIRK Channel Function by a G Protein-Coupled Receptor Kinase
Short Talk: Nonenzymatic Rapid Control of GIRK Channel Function by a G Protein-Coupled Receptor Kinase
*Session Chair †Invited, not yet responded.
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