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This meeting took place in 2011
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MicroRNAs and Non-Coding RNAs and Cancer (J5)
Organizer(s) Gregory J. Hannon, Curtis C. Harris and Martine F. Roussel
February 11—16, 2011
Fairmont Banff Springs • Banff, AB Canada
Abstract Deadline: Oct 12, 2010
Late Abstract Deadline: Nov 16, 2010
Scholarship Deadline: Oct 12, 2010
Early Registration Deadline: Dec 10, 2010
Sponsored by Astellas Pharma Inc. and Regulus Therapeutics Inc.
Joint Meeting:
MicroRNAs and Human Disease (J6)
Summary of Meeting:
Studies of tumor-associated genetic alterations and expression profiling normal and tumor cells, disease-associated stroma, and immune cells increasingly point to non-coding RNAs as key players in cancer biology. Since strategies that intervene in non-coding RNA pathways for therapeutic purposes are moving rapidly into the clinic, it is critical to deepen our understanding of the biology of small RNAs in the context of cancer. The goal of the proposed meeting is to bring together biologists studying the basic principles of non-coding RNA-based regulation and those studying the roles of non-coding RNAs in cancer with both industrial and clinical researchers focused on translating non-coding RNA-based therapies into the clinic. It is our hope that the resulting synergy will create both a deeper understanding of gene regulatory mechanisms and how they are altered in cancer and new opportunities to exploit this understanding for the benefit of cancer patients.
View Scholarships/Awards
Studies of tumor-associated genetic alterations and expression profiling normal and tumor cells, disease-associated stroma, and immune cells increasingly point to non-coding RNAs as key players in cancer biology. Since strategies that intervene in non-coding RNA pathways for therapeutic purposes are moving rapidly into the clinic, it is critical to deepen our understanding of the biology of small RNAs in the context of cancer. The goal of the proposed meeting is to bring together biologists studying the basic principles of non-coding RNA-based regulation and those studying the roles of non-coding RNAs in cancer with both industrial and clinical researchers focused on translating non-coding RNA-based therapies into the clinic. It is our hope that the resulting synergy will create both a deeper understanding of gene regulatory mechanisms and how they are altered in cancer and new opportunities to exploit this understanding for the benefit of cancer patients.
View Scholarships/Awards
No registration fees are used to fund entertainment or alcohol at this conference
FRIDAY, FEBRUARY 11
SATURDAY, FEBRUARY 12
SUNDAY, FEBRUARY 13
MONDAY, FEBRUARY 14
TUESDAY, FEBRUARY 15
WEDNESDAY, FEBRUARY 16
Conference Program Print | View meeting in 24 hr (international) time
FRIDAY, FEBRUARY 11
7:15—9:30 PM
Welcome and Keynote Session (Joint)
*
Eric N. Olson,
University of Texas Southwestern Medical Center, USA
Victor R. Ambros,
University of Massachusetts, USA
MicroRNA Pathways in C. elegans
MicroRNA Pathways in C. elegans
*
Gregory J. Hannon,
University of Cambridge, UK
Scott W. Lowe,
Memorial Sloan Kettering Cancer Center, USA
Identifying Tumor Suppressor and Tumor Maintenance Genes using Mouse Models and RNAi
Identifying Tumor Suppressor and Tumor Maintenance Genes using Mouse Models and RNAi
8:00—11:15 AM
MicroRNA Mechanisms (Joint)
Stefan L. Ameres,
Institute of Molecular Biotechnology, Austria
Mehanism and Application of Small RNAi Mediated Decay
Mehanism and Application of Small RNAi Mediated Decay
Elisa Izaurralde,
Max Planck Institute for Developmental Biology, Germany
Structural and Mechanistic Insights into Silencing Pathways
Structural and Mechanistic Insights into Silencing Pathways
John L. Rinn,
University of Colorado Boulder, USA
Some Missing lincRNAs in Chromatin, Cancer, and Cellular Identity
Some Missing lincRNAs in Chromatin, Cancer, and Cellular Identity
Steven G. Chaulk,
University of Alberta, Canada
Short Talk: pri-miRNA Tertiary Structure Modulation of miRNA Biogenesis
Short Talk: pri-miRNA Tertiary Structure Modulation of miRNA Biogenesis
5:00—7:15 PM
MicroRNA Targets and Polymorphisms (Joint)
Nikolaus Rajewsky,
Max Delbruck Center for Molecular Medicine, Germany
Post-Transcriptional Gene Regulation by small RNAs and RNA Binding Proteins
Post-Transcriptional Gene Regulation by small RNAs and RNA Binding Proteins
Robert B. Darnell,
HHMI/Rockefeller University, USA
Decoding protein-RNA regulation with HITS-CLIP maps
Decoding protein-RNA regulation with HITS-CLIP maps
Karen P. Steel,
Wellcome Trust Sanger Institute, UK
miR-96 Regulates the Maturation of Mammalian Hair Cells
miR-96 Regulates the Maturation of Mammalian Hair Cells
Danilo Allegra,
University Hospital of Ulm, Germany
Short Talk: A Drosha Processing Defect Contributes to Down-Regulation of miR-15a/-16 in a Subset of CLL Patients
Short Talk: A Drosha Processing Defect Contributes to Down-Regulation of miR-15a/-16 in a Subset of CLL Patients
Pieter Mestdagh,
Ghent University Hospital, Belgium
Short Talk: The miR-17-92 MicroRNA Cluster Regulates Multiple Components of the TGF-β Pathway in Neuroblastoma
Short Talk: The miR-17-92 MicroRNA Cluster Regulates Multiple Components of the TGF-β Pathway in Neuroblastoma
8:00—11:15 AM
MicroRNAs as Oncogenes and Tumor Suppressors I
Mark E. Hatley,
St. Jude Children's Research Hospital, USA
Modulation of K-ras-Dependent Lung Tumorigenesis by microRNA-21
Modulation of K-ras-Dependent Lung Tumorigenesis by microRNA-21
*
Martine F. Roussel,
St. Jude Children's Research Hospital, USA
MicroRNAs during Cerebellum Development and in Pediatric Medulloblastoma
MicroRNAs during Cerebellum Development and in Pediatric Medulloblastoma
Varda Rotter,
Weizmann Institute of Science, Israel
p53-Repressed miRNAs are involved with E2F in a feed-forward loop promoting proliferation.
p53-Repressed miRNAs are involved with E2F in a feed-forward loop promoting proliferation.
Jean-Christophe W. Marine,
Vlaams Interuniversitair Instituut, Katholieke Universiteit Leuven, Belgium
Short Talk: Dicer1 is a Synthetic Lethal Partner of Tumor Suppressor p53 and is Required for Retinoblastoma Formation
Short Talk: Dicer1 is a Synthetic Lethal Partner of Tumor Suppressor p53 and is Required for Retinoblastoma Formation
Kalpana Ghoshal,
Ohio State University Comprehensive Cancer Center, USA
Short Talk: Loss of microRNA-122 Affects Lipid Metabolism and Promotes Hepatocarcinogenesis in Mice
Short Talk: Loss of microRNA-122 Affects Lipid Metabolism and Promotes Hepatocarcinogenesis in Mice
8:00—11:15 AM
MicroRNAs in Muscle Development and Disease
Eric N. Olson,
University of Texas Southwestern Medical Center, USA
MicroRNA Control of Cardiovascular Development and Disease
MicroRNA Control of Cardiovascular Development and Disease
Gerald W. Dorn, II,
Washington University School of Medicine, USA
Genetic Variation and microRNA Targeting of Cardiac mRNAs
Genetic Variation and microRNA Targeting of Cardiac mRNAs
Thomas Thum,
Medical School Hannover, Germany
A microRNA Involved in Cardiac Remodeling
A microRNA Involved in Cardiac Remodeling
Francisco J. Naya,
Boston University, USA
Short Talk: MEF2A Regulation of a miRNA Mega-Cluster is Required for Proper Skeletal Muscle Regeneration
Short Talk: MEF2A Regulation of a miRNA Mega-Cluster is Required for Proper Skeletal Muscle Regeneration
Kasey C. Vickers,
National Institutes of Health, USA
Short Talk: High-Density Lipoproteins Transport and Delivery of MicroRNA: A Novel Intercellular Communication Pathway in Cardiovascular Disease
Short Talk: High-Density Lipoproteins Transport and Delivery of MicroRNA: A Novel Intercellular Communication Pathway in Cardiovascular Disease
5:00—7:00 PM
MicroRNAs as Oncogenes and Tumor Suppressors II
*
Joshua T. Mendell,
HHMI/University of Texas Southwestern Medical Center, USA
MicroRNA Reprogramming by Oncogenic and Tumor Suppressor Pathways
MicroRNA Reprogramming by Oncogenic and Tumor Suppressor Pathways
Carlo M. Croce,
Ohio State University, USA
Causes and Consequences of microRNA Dysregulation in Cancer
Causes and Consequences of microRNA Dysregulation in Cancer
5:00—7:00 PM
MicroRNAs and Vascular Disease
Thomas Braun,
, Germany
The Role of miRNAs and RNA Binding Proteins in Post-Transcriptional Regulation of the Cardiovascular System
The Role of miRNAs and RNA Binding Proteins in Post-Transcriptional Regulation of the Cardiovascular System
Anne Yaël Nossent,
Leiden University Medical Center, Netherlands
Short Talk: Insulin Receptor Substrate 1 is a Direct Target of MicroRNA-487b, which is Up-Regulated in the Aortic Wall under Chronic Angiotensin II Induced Hypertension in Rats
Short Talk: Insulin Receptor Substrate 1 is a Direct Target of MicroRNA-487b, which is Up-Regulated in the Aortic Wall under Chronic Angiotensin II Induced Hypertension in Rats
Greg M. LaMonte,
Duke University, USA
Short Talk: Erythrocytic microRNA as Potential Genetic Determinants of Malaria Resistance in Sickle Cell Diseases
Short Talk: Erythrocytic microRNA as Potential Genetic Determinants of Malaria Resistance in Sickle Cell Diseases
8:00—11:00 AM
MicroRNAs in the Immune Response, Angiogenesis and Metastasis
*
David Baltimore,
California Institute of Technology, USA
MicroRNAs in the Immune System
MicroRNAs in the Immune System
Elsa R. Flores,
Moffitt Cancer Center, USA
TAp63 Suppresses Metastasis through Coordinate Regulation of Dicer and miRNAs
TAp63 Suppresses Metastasis through Coordinate Regulation of Dicer and miRNAs
Gemma E.M. Bridge,
University College London Cancer Institute, UK
Short Talk: MicroRNA-Mediated Regulation of DLL4 Influences Endothelial Cell Behavior and Vascular Integrity during Developmental Angiogenesis
Short Talk: MicroRNA-Mediated Regulation of DLL4 Influences Endothelial Cell Behavior and Vascular Integrity during Developmental Angiogenesis
Desire Bonci,
Istituto Superiore di Sanità, Italy
Short Talk: Control of Tumor and Microenvironment Crosstalk by miR-15a and miR-16 in Prostate Cancer
Short Talk: Control of Tumor and Microenvironment Crosstalk by miR-15a and miR-16 in Prostate Cancer
8:00—11:15 AM
MicroRNAs in CNS Disorders
Gerhard Schratt,
Philipps-University-Marburg, Germany
Activity-Dependent Regulation of Neuronal microRNAs
Activity-Dependent Regulation of Neuronal microRNAs
Bart De Strooper,
University College London, UK
miRNA Deregulation in the Pathogenesis of Alzheimer's Disease
miRNA Deregulation in the Pathogenesis of Alzheimer's Disease
Beverly L. Davidson,
Children’s Hospital of Philadelphia and University of Pennsylvania, USA
Noncoding RNAs and Huntington's Disease
Noncoding RNAs and Huntington's Disease
Claes Wahlestedt,
University of Miami, Miller School of Medicine, USA
Regulatory Natural Antisense Transcripts
Regulatory Natural Antisense Transcripts
Angela Anderegg,
Northwestern University, USA
Short Talk: The Role of MicroRNAs in Midbrain Dopaminergic Neurogenesis
Short Talk: The Role of MicroRNAs in Midbrain Dopaminergic Neurogenesis
Eva Maria Jimenez-Mateos,
Royal College of Surgeons in Ireland, Ireland
Short Talk: MicroRNA Regulation in Hippocampus Following Status Epilepticus in Mice
Short Talk: MicroRNA Regulation in Hippocampus Following Status Epilepticus in Mice
5:00—7:00 PM
MicroRNAs as Cancer Biomarkers
*
Curtis C. Harris,
NCI, National Institutes of Health, USA
Inflammation and Cancer: Microenvironment, Cytokines, MicroRNA and p53
Inflammation and Cancer: Microenvironment, Cytokines, MicroRNA and p53
Frank J. Slack,
BIDMC Cancer Center/Harvard Medical School, USA
MicroRNAs as Diagnostics and Therapeutics in Cancer
MicroRNAs as Diagnostics and Therapeutics in Cancer
Xin Wei Wang,
NCI, National Institutes of Health, USA
MicroRNA and Hepatocellular Carcinoma: Biology and Prognostic Significance
MicroRNA and Hepatocellular Carcinoma: Biology and Prognostic Significance
Jason D. Arroyo,
Pfizer, USA
Short Talk: Circulating MicroRNAs Are Carried by Argonaute2 Complexes in Human Plasma
Short Talk: Circulating MicroRNAs Are Carried by Argonaute2 Complexes in Human Plasma
5:00—7:15 PM
MicroRNAs in the Immune Response and Viral Infections
Peter Sarnow,
Stanford University School of Medicine, USA
Modulation of Hepatitis C Virus and Insig1 RNA Abundances by MicroRNA 122
Modulation of Hepatitis C Virus and Insig1 RNA Abundances by MicroRNA 122
Stephane Heymans,
Maastricht University, Netherlands
Inflammation-MicroRNAs Mediate Cardiac Failure
Inflammation-MicroRNAs Mediate Cardiac Failure
Emma-Kate Loveday,
University of British Columbia, Canada
Short Talk: Strain Specific Modulation of the Host Cell MicroRNA-ome by High Pathogenic H5N1, H7N7, and Swine-Origin 2009 H1N1 Influenza A Viruses
Short Talk: Strain Specific Modulation of the Host Cell MicroRNA-ome by High Pathogenic H5N1, H7N7, and Swine-Origin 2009 H1N1 Influenza A Viruses
Joseph Luna,
Rockefeller University, USA
Short Talk: Argonaute HiTS-CLIP Defines a Dynamic miRNA:mRNA Interaction Map for Hepatitis C Virus Infection
Short Talk: Argonaute HiTS-CLIP Defines a Dynamic miRNA:mRNA Interaction Map for Hepatitis C Virus Infection
8:00—11:15 AM
MicroRNAs and Stem Cells (Joint)
Gregory J. Hannon,
University of Cambridge, UK
DNA Methylation in the Germ Line
DNA Methylation in the Germ Line
Scott M. Hammond,
University of North Carolina at Chapel Hill, USA
Regulation of miRNA Production
Regulation of miRNA Production
Deepak Srivastava,
Gladstone Institutes, USA
MicroRNA Regulation of Cardiac Cell Fate, Morphogenesis and Function
MicroRNA Regulation of Cardiac Cell Fate, Morphogenesis and Function
Robert H. Blelloch,
University of California, San Francisco, USA
MicroRNA Regulation of Induced Pluripotency
MicroRNA Regulation of Induced Pluripotency
Emily K. Pugach,
University of Colorado, USA
Short Talk: The Role of miR-205 in Embryonic Skin Development and Stem Cells
Short Talk: The Role of miR-205 in Embryonic Skin Development and Stem Cells
Edward E. Morrisey,
University of Pennsylvania, USA
Short Talk: Highly Efficient and Hdac2 Regulated Pluripotential Stem Cell Reprogramming by miR302/367
Short Talk: Highly Efficient and Hdac2 Regulated Pluripotential Stem Cell Reprogramming by miR302/367
2:30—4:30 PM
Workshop: MicroRNA Therapeutics: Medicinal Chemistry and Delivery (Joint)
Muthiah Manoharan,
Alnylam Pharmaceuticals, Inc., USA
Medicinal Chemistry and Delivery of siRNAs and Antagomirs
Medicinal Chemistry and Delivery of siRNAs and Antagomirs
David R. Corey,
University of Texas Southwestern Medical Center, USA
Unusual Targets for Duplex RNAs
Unusual Targets for Duplex RNAs
Sarah-Louise Gill,
Royal College of Surgeons in Ireland (RCSI), Ireland
Short Talk: Delivery of MicroRNA Mimics to Cardiomyocytes using Ultrasound Responsive Microbubbles
Short Talk: Delivery of MicroRNA Mimics to Cardiomyocytes using Ultrasound Responsive Microbubbles
Eric Marcusson,
Providence Therapeutics, USA
Short Talk: microRNA-21 as a Novel Therapeutic Target in Hepatocellular Carcinoma
Short Talk: microRNA-21 as a Novel Therapeutic Target in Hepatocellular Carcinoma
5:00—7:15 PM
MicroRNA Therapeutics: Applications (Joint)
*
Eric N. Olson,
University of Texas Southwestern Medical Center, USA
Eva van Rooij,
Hubrecht Institute, Netherlands
Therapeutic Regulation of MiRNAs to Treat Cardiovascular Disease
Therapeutic Regulation of MiRNAs to Treat Cardiovascular Disease
Anders M. Näär,
University of California, Berkeley, USA
Therapeutic Targeting of MicroRNAs to Control Cholesterol/Lipid Homeostasis
Therapeutic Targeting of MicroRNAs to Control Cholesterol/Lipid Homeostasis
Shelly Adi-Harel,
Weizmann Institute of Science, Israel
Short Talk: Epigenetic Silencing of p53-Regulated microRNAs in Lung Cancer
Short Talk: Epigenetic Silencing of p53-Regulated microRNAs in Lung Cancer
David M. Patrick,
University of Texas Southwestern Medical Center, USA
Short Talk: Regulation of Erythroid Differentiation and Disease by MicroRNA-451
Short Talk: Regulation of Erythroid Differentiation and Disease by MicroRNA-451
*Session Chair †Invited, not yet responded.
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